This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] See more...

Aliases for ADGRB2 Gene

Aliases for ADGRB2 Gene

  • Adhesion G Protein-Coupled Receptor B2 2 3 4 5
  • Brain-Specific Angiogenesis Inhibitor 2 2 3 4
  • BAI2 3 4

External Ids for ADGRB2 Gene

Previous HGNC Symbols for ADGRB2 Gene

  • BAI2

Summaries for ADGRB2 Gene

Entrez Gene Summary for ADGRB2 Gene

  • This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for ADGRB2 Gene

ADGRB2 (Adhesion G Protein-Coupled Receptor B2) is a Protein Coding gene. Diseases associated with ADGRB2 include Vibratory Urticaria and Physical Urticaria. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB3.

UniProtKB/Swiss-Prot Summary for ADGRB2 Gene

  • Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).

Gene Wiki entry for ADGRB2 Gene

Additional gene information for ADGRB2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRB2 Gene

Genomics for ADGRB2 Gene

GeneHancer (GH) Regulatory Elements for ADGRB2 Gene

Promoters and enhancers for ADGRB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRB2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRB2

Genomic Locations for ADGRB2 Gene

Genomic Locations for ADGRB2 Gene
chr1:31,727,105-31,764,893
(GRCh38/hg38)
Size:
37,789 bases
Orientation:
Minus strand
chr1:32,192,718-32,230,494
(GRCh37/hg19)
Size:
37,777 bases
Orientation:
Minus strand

Genomic View for ADGRB2 Gene

Genes around ADGRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB2 Gene

Proteins for ADGRB2 Gene

  • Protein details for ADGRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60241-AGRB2_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor B2
    Protein Accession:
    O60241
    Secondary Accessions:
    • B9EGK9
    • Q5T6K0
    • Q8NGW8
    • Q96GZ9

    Protein attributes for ADGRB2 Gene

    Size:
    1585 amino acids
    Molecular mass:
    172656 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2 (By similarity). Interacts (via carboxy-terminus) with TAX1BP3 (PubMed:21787750). Interacts with GNAZ (PubMed:28891236). Interacts with SH3GL2 (PubMed:28891236).
    SequenceCaution:
    • Sequence=BAA25362.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRB2 Gene

Post-translational modifications for ADGRB2 Gene

  • Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.
  • Glycosylated.
  • Glycosylation at Asn106, Asn191, Asn192, Asn356, Asn437, Asn560, Asn645, and Asn867
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRB2 Gene

Domains & Families for ADGRB2 Gene

Gene Families for ADGRB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ADGRB2 Gene

Blocks:
  • Thrombospondin, type I
  • Thrombospondin type 1 repeat signature
  • G-protein coupled receptors family 2 (secretin-like)
  • GPS domain
  • Brain-specific angiogenesis inhibitor precursor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRB2 Gene

GenScript: Design optimal peptide antigens:
  • Brain-specific angiogenesis inhibitor 2 (A2A3C4_HUMAN)
  • cDNA FLJ53350, highly similar to Brain-specific angiogenesis inhibitor 2 (B4DKC3_HUMAN)
  • Brain-specific angiogenesis inhibitor 2 (BAI2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60241

UniProtKB/Swiss-Prot:

AGRB2_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRB2: view

Function for ADGRB2 Gene

Molecular function for ADGRB2 Gene

UniProtKB/Swiss-Prot Function:
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
Receptor activity is regulated by proteolytic processing. The long N-terminal has a an inhibitory effect on the constitutive signaling activity. Removal of the N-terminal region induces an increase of the receptor activity.

Phenotypes From GWAS Catalog for ADGRB2 Gene

Gene Ontology (GO) - Molecular Function for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IMP,TAS 28891236
GO:0005515 protein binding IPI 28891236
genes like me logo Genes that share ontologies with ADGRB2: view
genes like me logo Genes that share phenotypes with ADGRB2: view

Animal Models for ADGRB2 Gene

MGI Knock Outs for ADGRB2:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRB2 Gene

Localization for ADGRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRB2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA --
GO:0005886 plasma membrane IDA,IEA 28891236
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 15203201
genes like me logo Genes that share ontologies with ADGRB2: view

Pathways & Interactions for ADGRB2 Gene

PathCards logo

SuperPathways for ADGRB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IDA 28891236
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0007422 peripheral nervous system development IBA 21873635
genes like me logo Genes that share ontologies with ADGRB2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRB2 Gene

Drugs & Compounds for ADGRB2 Gene

No Compound Related Data Available

Transcripts for ADGRB2 Gene

mRNA/cDNA for ADGRB2 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - - - - - -
SP9: -
SP10: -
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:

ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ADGRB2 Gene

GeneLoc Exon Structure for
ADGRB2

Expression for ADGRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRB2 Gene

This gene is overexpressed in Cerebrospinal fluid (57.4) and Vitreous humor (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB2 Gene



Protein tissue co-expression partners for ADGRB2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRB2

mRNA Expression by UniProt/SwissProt for ADGRB2 Gene:

O60241-AGRB2_HUMAN
Tissue specificity: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Evidence on tissue expression from TISSUES for ADGRB2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with ADGRB2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRB2 Gene

Orthologs for ADGRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI2 31 30
  • 99.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BAI2 31 30
  • 92.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BAI2 31 30
  • 92.14 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bai2 30
  • 90.65 (n)
mouse
(Mus musculus)
Mammalia Bai2 31 30
  • 89.95 (n)
OneToOne
Adgrb2 17
platypus
(Ornithorhynchus anatinus)
Mammalia BAI2 31
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 46 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BAI2 31 30
  • 75.17 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 69 (a)
OneToMany
-- 31
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bai2 30
  • 67.09 (n)
zebrafish
(Danio rerio)
Actinopterygii BAI2 31
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-5 31
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T21B6.3 31
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5741 31
  • 22 (a)
ManyToMany
Species where no ortholog for ADGRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB2 Gene

ENSEMBL:
Gene Tree for ADGRB2 (if available)
TreeFam:
Gene Tree for ADGRB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRB2: view image

Paralogs for ADGRB2 Gene

Variants for ADGRB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRB2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
712827 Benign: not provided 31,756,495(-) G/T SYNONYMOUS_VARIANT
715213 Benign: not provided 31,739,579(-) T/A MISSENSE_VARIANT
718417 Benign: not provided 31,728,043(-) G/C SYNONYMOUS_VARIANT
738726 Benign: not provided 31,732,535(-) G/A SYNONYMOUS_VARIANT
740234 Likely Benign: not provided 31,728,055(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ADGRB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADGRB2 Gene

Variant ID Type Subtype PubMed ID
esv2758930 CNV loss 17122850
nsv1007390 CNV gain 25217958
nsv1007786 CNV gain 25217958
nsv1121760 CNV deletion 24896259
nsv461028 CNV loss 19166990
nsv545953 CNV loss 21841781
nsv950385 CNV deletion 24416366

Variation tolerance for ADGRB2 Gene

Residual Variation Intolerance Score: 5.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRB2 Gene

Human Gene Mutation Database (HGMD)
ADGRB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRB2 Gene

Disorders for ADGRB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADGRB2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vibratory urticaria
  • vbu
physical urticaria
  • symptomatic dermographism
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADGRB2

genes like me logo Genes that share disorders with ADGRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRB2 Gene

Publications for ADGRB2 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T … Tokino T (Cytogenetics and cell genetics 1997) 2 3 4 23 54
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 54
  3. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. (PMID: 28891236) Purcell RH … Hall RA (Human mutation 2017) 3 4 54
  4. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. (PMID: 21787750) Zencir S … Mohanty S (Biochemical and biophysical research communications 2011) 3 4 54
  5. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. (PMID: 20367554) Okajima D … Yokota H (Journal of receptor and signal transduction research 2010) 3 4 54

Products for ADGRB2 Gene

Sources for ADGRB2 Gene