Aliases for ADGRB2 Gene
External Ids for ADGRB2 Gene
Previous HGNC Symbols for ADGRB2 Gene
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for ADGRB2 Gene
ADGRB2 (Adhesion G Protein-Coupled Receptor B2) is a Protein Coding gene. Diseases associated with ADGRB2 include Vibratory Urticaria and Spastic Paraparesis. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB3.
UniProtKB/Swiss-Prot Summary for ADGRB2 Gene
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).