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Aliases for ADGRB1 Gene

Aliases for ADGRB1 Gene

  • Adhesion G Protein-Coupled Receptor B1 2 3 5
  • Brain-Specific Angiogenesis Inhibitor 1 2 3 4
  • BAI1 3 4
  • GDAIF 3

External Ids for ADGRB1 Gene

Previous HGNC Symbols for ADGRB1 Gene

  • BAI1

Summaries for ADGRB1 Gene

Entrez Gene Summary for ADGRB1 Gene

  • Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRB1 Gene

ADGRB1 (Adhesion G Protein-Coupled Receptor B1) is a Protein Coding gene. Diseases associated with ADGRB1 include Glioblastoma. Among its related pathways are DNA Damage Response and p53 Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB3.

UniProtKB/Swiss-Prot for ADGRB1 Gene

  • Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720).

  • Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner.

  • Vasculostatin-40: Inhibits angiogenesis.

Gene Wiki entry for ADGRB1 Gene

Additional gene information for ADGRB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB1 Gene

Genomics for ADGRB1 Gene

GeneHancer (GH) Regulatory Elements for ADGRB1 Gene

Promoters and enhancers for ADGRB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I142447 Enhancer 1 FANTOM5 ENCODE 550.8 -1.7 -1681 0.4 CTCF RB1 ARID4B SIN3A ZIC2 RAD21 GLIS2 SMC3 ZNF143 ZNF444 ADGRB1 TSNARE1 ENSG00000261693
GH08I142451 Enhancer 0.8 FANTOM5 dbSUPER 555.1 +1.8 1769 0.3 SP3 SUZ12 ZBTB8A ZNF335 GLIS1 CTBP2 ZBTB26 EZH2 ZBTB20 ADGRB1 LYNX1 TSNARE1 MROH4P
GH08I142450 Enhancer 0.5 dbSUPER 550.8 +1.3 1293 0.1 GLIS1 ZBTB26 ZBTB20 EZH2 ADGRB1 MROH4P
GH08I142454 Enhancer 0.5 dbSUPER 550.8 +1.2 1152 0.1 GLIS2 GLIS1 PATZ1 EZH2 ADGRB1 MROH4P
GH08I142463 Promoter 0.5 EPDnew 550.4 +14.5 14514 0.1 ADGRB1 MROH4P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRB1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRB1 Gene

Genomic Locations for ADGRB1 Gene
chr8:142,449,430-142,545,009
(GRCh38/hg38)
Size:
95,580 bases
Orientation:
Plus strand
chr8:143,530,791-143,626,370
(GRCh37/hg19)

Genomic View for ADGRB1 Gene

Genes around ADGRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB1 Gene

Proteins for ADGRB1 Gene

  • Protein details for ADGRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14514-AGRB1_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor B1
    Protein Accession:
    O14514

    Protein attributes for ADGRB1 Gene

    Size:
    1584 amino acids
    Molecular mass:
    173501 Da
    Quaternary structure:
    • Interacts with ELMO1 and DOCK (By similarity). When bound to ELMO1 and DOCK1, acts as a module to promote apoptotic cell engulfment (By similarity). Interacts with MDM2; the interaction results in inhibition of MDM2-mediated ubiquitination and degradation of DLG4/PSD95 (By similarity). Interacts with PARD3 and TIAM1; the interaction is required for correct dendritic. localization of PARD3 and TIAM1 and for dendritic spine formation (PubMed:23595754). Interacts with MAGI1 (PubMed:9647739). Interacts with MAGI3 (PubMed:10748157). Interacts with BAIAP2 (PubMed:10343108). Interacts with PHYHIP (By similarity). Interacts with DLG4 (via PDZ domain) (PubMed:23782696). Vasculostatin-120: Interacts with CD36 (PubMed:19176395). Vasculostatin-120: Interacts with ARRB2 (PubMed:23782696).

neXtProt entry for ADGRB1 Gene

Post-translational modifications for ADGRB1 Gene

  • Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120 (PubMed:15782143, PubMed:22333914, PubMed:22330140). Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327 (PubMed:22330140).
  • Ubiquitinated.

No data available for DME Specific Peptides for ADGRB1 Gene

Domains & Families for ADGRB1 Gene

Gene Families for ADGRB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADGRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14514

UniProtKB/Swiss-Prot:

AGRB1_HUMAN :
  • The TSP type-1 repeats in the extracellular domain mediate binding to phosphatidylserine. They are also required for bacterial recognition and binding to bacterial outer membrane lipopolysaccharide.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Domain:
  • The TSP type-1 repeats in the extracellular domain mediate binding to phosphatidylserine. They are also required for bacterial recognition and binding to bacterial outer membrane lipopolysaccharide.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRB1: view

Function for ADGRB1 Gene

Molecular function for ADGRB1 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720).
UniProtKB/Swiss-Prot Function:
Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner.
UniProtKB/Swiss-Prot Function:
Vasculostatin-40: Inhibits angiogenesis.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Gene Ontology (GO) - Molecular Function for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding ISS --
GO:0001786 phosphatidylserine binding ISS --
GO:0004871 signal transducer activity IEA --
GO:0004872 receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRB1: view
genes like me logo Genes that share phenotypes with ADGRB1: view

Animal Models for ADGRB1 Gene

MGI Knock Outs for ADGRB1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRB1 Gene

Localization for ADGRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB1 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, phagocytic cup. Cell junction, focal adhesion. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
Vasculostatin-120: Secreted.
Vasculostatin-40: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRB1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup ISS --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15782143
GO:0005886 plasma membrane ISS,TAS --
GO:0005887 integral component of plasma membrane TAS 9647739
genes like me logo Genes that share ontologies with ADGRB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRB1 Gene

Pathways & Interactions for ADGRB1 Gene

SuperPathways for ADGRB1 Gene

SuperPathway Contained pathways
1 DNA Damage Response
2 p53 Signaling
genes like me logo Genes that share pathways with ADGRB1: view

Pathways by source for ADGRB1 Gene

1 KEGG pathway for ADGRB1 Gene
1 Qiagen pathway for ADGRB1 Gene

Gene Ontology (GO) - Biological Process for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006909 phagocytosis IEA --
GO:0006910 phagocytosis, recognition ISS --
GO:0006911 phagocytosis, engulfment IEA --
GO:0007155 cell adhesion TAS 9647739
genes like me logo Genes that share ontologies with ADGRB1: view

No data available for SIGNOR curated interactions for ADGRB1 Gene

Drugs & Compounds for ADGRB1 Gene

(1) Drugs for ADGRB1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PHOSPHATIDYLSERINE Pharma 0
genes like me logo Genes that share compounds with ADGRB1: view

Transcripts for ADGRB1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB1 Gene

No ASD Table

Relevant External Links for ADGRB1 Gene

GeneLoc Exon Structure for
ADGRB1
ECgene alternative splicing isoforms for
ADGRB1

Expression for ADGRB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRB1 Gene

This gene is overexpressed in Fetal Brain (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB1 Gene



Protein tissue co-expression partners for ADGRB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRB1 Gene:

ADGRB1

mRNA Expression by UniProt/SwissProt for ADGRB1 Gene:

O14514-AGRB1_HUMAN
Tissue specificity: Expressed in brain (at protein level) (PubMed:12074842, PubMed:12507886). Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level) (PubMed:24509909). Expressed in normal pancreatic tissue but not in pancreatic tumor tissue (PubMed:11875720). Reduced or no expression is observed in some glioblastomas (PubMed:12507886).

Evidence on tissue expression from TISSUES for ADGRB1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ADGRB1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRB1 Gene

Orthologs for ADGRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAI1 33 34
  • 91.1 (n)
dog
(Canis familiaris)
Mammalia BAI1 33 34
  • 90.51 (n)
mouse
(Mus musculus)
Mammalia Bai1 33 34
  • 88.33 (n)
Adgrb1 16
rat
(Rattus norvegicus)
Mammalia Bai1 33
  • 87.93 (n)
oppossum
(Monodelphis domestica)
Mammalia BAI1 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAI1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAI1 33 34
  • 73.71 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 80 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bai1 33
  • 69.48 (n)
zebrafish
(Danio rerio)
Actinopterygii bai1a 34
  • 70 (a)
OneToMany
BAI1 (1 of 3) 34
  • 61 (a)
OneToMany
bai1b 34
  • 59 (a)
OneToMany
Dr.15237 33
fruit fly
(Drosophila melanogaster)
Insecta unc-5 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C36B7.5 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
ManyToMany
Species where no ortholog for ADGRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB1 Gene

ENSEMBL:
Gene Tree for ADGRB1 (if available)
TreeFam:
Gene Tree for ADGRB1 (if available)

Paralogs for ADGRB1 Gene

Paralogs for ADGRB1 Gene

genes like me logo Genes that share paralogs with ADGRB1: view

Variants for ADGRB1 Gene

Sequence variations from dbSNP and Humsavar for ADGRB1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000032621 -- 142,506,458(+) G/A intron_variant
rs1000036960 -- 142,526,324(+) G/C intron_variant
rs1000047385 -- 142,491,235(+) G/A intron_variant
rs1000061678 -- 142,478,528(+) G/A intron_variant
rs1000073848 -- 142,515,236(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRB1 Gene

Variant ID Type Subtype PubMed ID
esv3364070 CNV duplication 20981092
esv2759650 CNV gain 17122850
esv2740780 CNV deletion 23290073
esv2737909 CNV deletion 23290073
esv2737908 CNV deletion 23290073
esv2737907 CNV deletion 23290073
esv2737905 CNV deletion 23290073
esv2737904 CNV deletion 23290073
esv2737903 CNV deletion 23290073
esv2737902 CNV deletion 23290073
esv2737901 CNV deletion 23290073
esv2737900 CNV deletion 23290073
esv2737899 CNV deletion 23290073
esv2737898 CNV deletion 23290073
esv2737897 CNV deletion 23290073
esv2737896 CNV deletion 23290073
esv2737894 CNV deletion 23290073
esv2737893 CNV deletion 23290073
esv2737892 CNV deletion 23290073
esv2737891 CNV deletion 23290073
esv2737890 CNV deletion 23290073
esv2737889 CNV deletion 23290073
esv2668515 CNV deletion 23128226
esv2661137 CNV deletion 23128226
esv2202647 CNV deletion 18987734
esv1969642 CNV deletion 18987734
dgv7335n100 CNV gain 25217958
dgv7334n100 CNV gain 25217958
dgv4265e59 CNV duplication 20981092
dgv3924n106 CNV deletion 24896259
nsv950002 CNV deletion 24416366
nsv824756 CNV gain 20364138
nsv824755 CNV loss 20364138
nsv612707 CNV loss 21841781
nsv470245 CNV loss 18288195
nsv1149077 CNV insertion 26484159
nsv1137413 CNV deletion 24896259
nsv1128980 CNV duplication 24896259
nsv1125021 CNV duplication 24896259
nsv1110823 CNV insertion 24896259
nsv1076120 CNV deletion 25765185
nsv1075177 CNV deletion 25765185
nsv1031969 CNV gain 25217958
esv8930 CNV loss 19470904
esv8650 CNV loss 19470904

Variation tolerance for ADGRB1 Gene

Residual Variation Intolerance Score: 3.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRB1 Gene

Disorders for ADGRB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRB1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADGRB1

genes like me logo Genes that share disorders with ADGRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRB1 Gene

Publications for ADGRB1 Gene

  1. Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. (PMID: 19176395) Kaur B … Van Meir EG (Cancer research 2009) 3 4 22 58
  2. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (PMID: 12507886) Kaur B … Van Meir EG (The American journal of pathology 2003) 3 4 22 58
  3. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PMID: 10343108) Oda K … Tokino T (Cytogenetics and cell genetics 1999) 3 4 22 58
  4. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (PMID: 9647739) Shiratsuchi T … Tokino T (Biochemical and biophysical research communications 1998) 3 4 22 58
  5. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T … Tokino T (Cytogenetics and cell genetics 1997) 2 3 22 58

Products for ADGRB1 Gene

Sources for ADGRB1 Gene

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