This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct... See more...

Aliases for ADGRA3 Gene

Aliases for ADGRA3 Gene

  • Adhesion G Protein-Coupled Receptor A3 2 3 4 5
  • G-Protein Coupled Receptor 125 3 4
  • GPR125 3 4
  • PGR21 2 3
  • Probable G-Protein Coupled Receptor 125 3
  • G Protein-Coupled Receptor 125 2
  • FLJ38547 2
  • ADGRA3 5
  • TEM5L 3

External Ids for ADGRA3 Gene

Previous HGNC Symbols for ADGRA3 Gene

  • GPR125

Summaries for ADGRA3 Gene

Entrez Gene Summary for ADGRA3 Gene

  • This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]

GeneCards Summary for ADGRA3 Gene

ADGRA3 (Adhesion G Protein-Coupled Receptor A3) is a Protein Coding gene. Diseases associated with ADGRA3 include Bipolar Disorder and Retinitis Pigmentosa. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRA2.

UniProtKB/Swiss-Prot Summary for ADGRA3 Gene

  • Orphan receptor that may have a role in planar cell polarity pathway.

Gene Wiki entry for ADGRA3 Gene

Additional gene information for ADGRA3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADGRA3 Gene

Genomics for ADGRA3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADGRA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J022513 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 605.7 +0.7 726 3.8 HNRNPL GATAD2A PRDM10 TFE3 KDM1A FOXA1 PRDM1 RBFOX2 POLR2A IRF2 ADGRA3 MIR12115 lnc-KCNIP4-3 KCNIP4
GH04J022443 Promoter 0.7 EPDnew 611.1 +72.9 72911 0.1 SP1 FOXA2 ATF3 YY1 JUND HNF4A RXRA REST TAF1 ADGRA3 piR-35674-387 lnc-KCNIP4-2 KCNIP4
GH04J022517 Promoter 0.4 Ensembl 605.6 -1.4 -1434 0.2 GATAD2B ADGRA3 lnc-KCNIP4-3 piR-50437-495 GBA3
GH04J022480 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.5 +31.5 31461 8 ZNF629 BACH1 ZIC2 RXRB TCF12 IKZF2 TRIM22 PBX2 PKNOX1 SOX13 ADGRA3 piR-61945-379 piR-59422 lnc-KCNIP4-3 KCNIP4
GH04J022471 Enhancer 1 Ensembl ENCODE dbSUPER 18.4 +42.3 42335 5.3 GATAD2A TFE3 SOX13 RCOR2 ZNF7 CEBPA TCF7 EGR1 CEBPB FOXA2 ADGRA3 piR-61945-379 piR-59422 lnc-KCNIP4-3 KCNIP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADGRA3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADGRA3

Genomic Locations for ADGRA3 Gene

Genomic Locations for ADGRA3 Gene
chr4:22,345,071-22,516,066
(GRCh38/hg38)
Size:
170,996 bases
Orientation:
Minus strand
chr4:22,346,694-22,517,677
(GRCh37/hg19)
Size:
170,984 bases
Orientation:
Minus strand

Genomic View for ADGRA3 Gene

Genes around ADGRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRA3 Gene

Proteins for ADGRA3 Gene

  • Protein details for ADGRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWK6-AGRA3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor A3
    Protein Accession:
    Q8IWK6
    Secondary Accessions:
    • Q6UXK9
    • Q86SQ5
    • Q8TC55

    Protein attributes for ADGRA3 Gene

    Size:
    1321 amino acids
    Molecular mass:
    146151 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with DLG1.
    SequenceCaution:
    • Sequence=AAH35645.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
    Miscellaneous:
    • Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.

    Alternative splice isoforms for ADGRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRA3 Gene

Post-translational modifications for ADGRA3 Gene

  • Glycosylation at Asn159, Asn301, Asn81, Asn206, Asn98, Asn332, Asn433, Asn453, Asn592, Asn652, Asn687, Asn728, and Asn821
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRA3 Gene

No data available for DME Specific Peptides for ADGRA3 Gene

Domains & Families for ADGRA3 Gene

Gene Families for ADGRA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADGRA3 Gene

InterPro:
Blocks:
  • Leucine-rich repeat signature
  • Cysteine-rich flanking region, C-terminal
  • G-protein coupled receptors family 2 (secretin-like)
  • GPS domain
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRA3 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 125 (GP125_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IWK6

UniProtKB/Swiss-Prot:

AGRA3_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRA3: view

Function for ADGRA3 Gene

Molecular function for ADGRA3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that may have a role in planar cell polarity pathway.

Phenotypes From GWAS Catalog for ADGRA3 Gene

Gene Ontology (GO) - Molecular Function for ADGRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G protein-coupled receptor activity TAS,IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ADGRA3: view
genes like me logo Genes that share phenotypes with ADGRA3: view

Animal Models for ADGRA3 Gene

MGI Knock Outs for ADGRA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRA3

CRISPR Products

miRNA for ADGRA3 Gene

miRTarBase miRNAs that target ADGRA3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRA3 Gene

Localization for ADGRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRA3 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRA3 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADGRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0009897 external side of plasma membrane IEA,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRA3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRA3 Gene

Pathways & Interactions for ADGRA3 Gene

PathCards logo

SuperPathways for ADGRA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA,IBA 21873635
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with ADGRA3: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRA3 Gene

Drugs & Compounds for ADGRA3 Gene

No Compound Related Data Available

Transcripts for ADGRA3 Gene

mRNA/cDNA for ADGRA3 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRA3

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRA3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP8:
SP9:

ExUns: 21 ^ 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ADGRA3 Gene

GeneLoc Exon Structure for
ADGRA3

Expression for ADGRA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRA3 Gene

This gene is overexpressed in Bone (34.6), Colon muscle (22.5), and Pancreatic juice (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRA3 Gene



Protein tissue co-expression partners for ADGRA3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADGRA3

Evidence on tissue expression from TISSUES for ADGRA3 Gene

  • Liver(4.5)
  • Eye(4.1)
  • Nervous system(3.8)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ADGRA3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRA3 Gene

Orthologs for ADGRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRA3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR125 30 31
  • 99.27 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 91 (a)
OneToMany
-- 31
  • 89 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia GPR125 30 31
  • 90.28 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GPR125 31
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gpr125 30 31
  • 85.72 (n)
OneToOne
Adgra3 17
Rat
(Rattus norvegicus)
Mammalia Gpr125 30
  • 85.2 (n)
Dog
(Canis familiaris)
Mammalia GPR125 30 31
  • 83.48 (n)
OneToOne
Chicken
(Gallus gallus)
Aves GPR125 30 31
  • 79.78 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GPR125 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpr125 30
  • 73.51 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24458 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100003592 30
  • 63.05 (n)
GPR125 31
  • 59 (a)
OneToOne
Dr.14009 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG15744 31
  • 14 (a)
OneToMany
Species where no ortholog for ADGRA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ADGRA3 Gene

ENSEMBL:
Gene Tree for ADGRA3 (if available)
TreeFam:
Gene Tree for ADGRA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADGRA3: view image

Paralogs for ADGRA3 Gene

Variants for ADGRA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADGRA3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
636172 Uncertain Significance: Retinitis pigmentosa; not provided 22,401,520(-) G/A MISSENSE_VARIANT
713854 Benign: not provided 22,388,551(-) C/T SYNONYMOUS_VARIANT
714241 Benign: not provided 22,454,918(-) T/A MISSENSE_VARIANT
714615 Benign: not provided 22,402,734(-) G/A SYNONYMOUS_VARIANT
715972 Likely Benign: not provided 22,424,270(-) T/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ADGRA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADGRA3 Gene

Variant ID Type Subtype PubMed ID
esv1778171 CNV deletion 17803354
esv2656779 CNV deletion 23128226
esv2656963 CNV deletion 23128226
esv2667379 CNV deletion 23128226
esv2727288 CNV deletion 23290073
esv2727289 CNV deletion 23290073
esv2727290 CNV deletion 23290073
esv2741412 CNV deletion 23290073
esv3048040 CNV deletion 24192839
esv3310028 CNV mobile element insertion 20981092
esv3398780 CNV insertion 20981092
esv3563539 CNV deletion 23714750
esv3599899 CNV loss 21293372
esv3599900 CNV loss 21293372
esv3599902 CNV loss 21293372
esv3599904 CNV loss 21293372
esv5125 CNV loss 18987735
nsv1074699 CNV deletion 25765185
nsv1136824 CNV deletion 24896259
nsv1145971 CNV deletion 26484159
nsv289612 CNV deletion 16902084
nsv509881 OTHER sequence alteration 20534489
nsv510889 OTHER complex 20534489
nsv821634 CNV loss 15273396
nsv958228 CNV deletion 24416366

Variation tolerance for ADGRA3 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRA3 Gene

Human Gene Mutation Database (HGMD)
ADGRA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRA3 Gene

Disorders for ADGRA3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADGRA3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • major affective disorder 1
retinitis pigmentosa
  • retinitis pigmentosa 1
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ADGRA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRA3 Gene

Publications for ADGRA3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4
  2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. (PMID: 15021905) Yamamoto Y … Takai Y (Oncogene 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for ADGRA3 Gene

Sources for ADGRA3 Gene