Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRA1 Gene

Aliases for ADGRA1 Gene

  • Adhesion G Protein-Coupled Receptor A1 2 3 3 5
  • G-Protein Coupled Receptor 123 3 4
  • GPR123 3 4
  • Probable G-Protein Coupled Receptor 123 3
  • G Protein-Coupled Receptor 123 2
  • KIAA1828 4

External Ids for ADGRA1 Gene

Previous HGNC Symbols for ADGRA1 Gene

  • GPR123

Summaries for ADGRA1 Gene

Entrez Gene Summary for ADGRA1 Gene

  • This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for ADGRA1 Gene

ADGRA1 (Adhesion G Protein-Coupled Receptor A1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRA3.

UniProtKB/Swiss-Prot for ADGRA1 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRA1 Gene

Additional gene information for ADGRA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRA1 Gene

Genomics for ADGRA1 Gene

GeneHancer (GH) Regulatory Elements for ADGRA1 Gene

Promoters and enhancers for ADGRA1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J132962 Promoter/Enhancer 1.1 Ensembl ENCODE 11.7 -108.4 -108420 1 PKNOX1 RFX1 MAX ELF1 REST BMI1 RFX5 SP1 POLR2A RFX3 LINC01167 LINC01166 ADGRA1 GC10P132846
GH10J132930 Enhancer 0.8 Ensembl ENCODE 11.2 -139.7 -139733 2 ATF2 RELA ZFHX2 EED GLIS1 ATF7 ZFX WT1 EGR2 ADGRA1 CFAP46 PIR56661 GC10P132846
GH10J133150 Enhancer 0.6 ENCODE 11 +80.7 80728 2.1 BCOR NANOG RNF2 MNT GLI4 POLR2A HDAC2 ZNF580 KDM1A KNDC1 ADGRA1 ZNF511 TUBGCP2 NKX6-2 RPL5P28
GH10J133043 Enhancer 0.4 ENCODE 12.5 -26.4 -26380 1.2 KLF1 REST EZH2 ADGRA1 CFAP46 LINC01168
GH10J133109 Enhancer 0.4 ENCODE 11.9 +39.3 39278 1.8 ZNF26 NR2F2 SCART1 ADGRA1 PIR56333 GC10M133145
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRA1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRA1 Gene

Genomic Locations for ADGRA1 Gene
60,747 bases
Plus strand
60,747 bases
Plus strand

Genomic View for ADGRA1 Gene

Genes around ADGRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRA1 Gene

Proteins for ADGRA1 Gene

  • Protein details for ADGRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G protein-coupled receptor A1
    Protein Accession:
    Secondary Accessions:
    • A5HL16
    • A6NG50
    • Q5T234
    • Q86SN7
    • Q96JJ9

    Protein attributes for ADGRA1 Gene

    560 amino acids
    Molecular mass:
    60885 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB47457.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRA1 Gene


neXtProt entry for ADGRA1 Gene

Post-translational modifications for ADGRA1 Gene

  • Glycosylation at Asn795
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRA1 Gene

No data available for DME Specific Peptides for ADGRA1 Gene

Domains & Families for ADGRA1 Gene

Gene Families for ADGRA1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADGRA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRA1: view

Function for ADGRA1 Gene

Molecular function for ADGRA1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for ADGRA1 Gene

Gene Ontology (GO) - Molecular Function for ADGRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity NAS,TAS 12565841
genes like me logo Genes that share ontologies with ADGRA1: view
genes like me logo Genes that share phenotypes with ADGRA1: view

Animal Model Products

CRISPR Products

miRNA for ADGRA1 Gene

miRTarBase miRNAs that target ADGRA1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRA1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRA1 Gene

Localization for ADGRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRA1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRA1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ADGRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,TAS 12565841
genes like me logo Genes that share ontologies with ADGRA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRA1 Gene

Pathways & Interactions for ADGRA1 Gene

SuperPathways for ADGRA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 17212699
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with ADGRA1: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRA1 Gene

Drugs & Compounds for ADGRA1 Gene

No Compound Related Data Available

Transcripts for ADGRA1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADGRA1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - -
SP3: - - - -

Relevant External Links for ADGRA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRA1 Gene

This gene is overexpressed in Frontal cortex (29.0), Lymph node (20.1), and Adipocyte (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRA1 Gene

Protein tissue co-expression partners for ADGRA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRA1 Gene:


Evidence on tissue expression from TISSUES for ADGRA1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ADGRA1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRA1 Gene

Orthologs for ADGRA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR123 34 33
  • 83.51 (n)
(Mus musculus)
Mammalia Gpr123 34 33
  • 81.02 (n)
Adgra1 16
(Rattus norvegicus)
Mammalia Gpr123 33
  • 80.54 (n)
(Ornithorhynchus anatinus)
Mammalia GPR123 34
  • 73 (a)
(Canis familiaris)
Mammalia GPR123 34
  • 69 (a)
(Monodelphis domestica)
Mammalia GPR123 34
  • 63 (a)
(Pan troglodytes)
Mammalia GPR123 34
  • 46 (a)
(Gallus gallus)
Aves GPR123 34
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
-- 34
  • 4 (a)
-- 34
  • 1 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr123 33
  • 65.29 (n)
(Danio rerio)
Actinopterygii LOC560847 33
  • 62.25 (n)
GPR123 (2 of 4) 34
  • 47 (a)
gpr123 34
  • 43 (a)
GPR123 (3 of 4) 34
  • 32 (a)
CABZ01086759.2 34
  • 6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15744 34
  • 6 (a)
Species where no ortholog for ADGRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRA1 Gene

Gene Tree for ADGRA1 (if available)
Gene Tree for ADGRA1 (if available)
Evolutionary constrained regions (ECRs) for ADGRA1: view image

Paralogs for ADGRA1 Gene

Paralogs for ADGRA1 Gene

genes like me logo Genes that share paralogs with ADGRA1: view

Variants for ADGRA1 Gene

Sequence variations from dbSNP and Humsavar for ADGRA1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000006828 -- 133,107,282(+) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000016399 -- 133,076,695(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000020339 -- 133,129,964(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000031999 -- 133,068,928(+) G/A
rs1000038962 -- 133,118,591(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRA1 Gene

Variant ID Type Subtype PubMed ID
nsv952703 CNV deletion 24416366
nsv8749 CNV loss 18304495
nsv832036 CNV loss 17160897
nsv552568 CNV gain 21841781
nsv552567 CNV gain+loss 21841781
nsv552556 CNV gain 21841781
nsv552555 CNV loss 21841781
nsv552543 CNV gain 21841781
nsv552540 CNV loss 21841781
nsv552539 CNV loss 21841781
nsv552526 CNV gain 21841781
nsv528260 CNV loss 19592680
nsv470979 CNV loss 18288195
nsv467498 CNV gain 19166990
nsv24899 CNV deletion 16902084
nsv24013 CNV deletion 16902084
nsv1145493 CNV deletion 24896259
nsv1124631 CNV duplication 24896259
nsv1054934 CNV gain 25217958
esv3625022 CNV gain 21293372
esv3625015 CNV gain 21293372
esv2760107 CNV gain 21179565
esv2759793 CNV gain+loss 17122850
esv2743826 CNV deletion 23290073
esv2743825 CNV deletion 23290073
esv2743824 CNV deletion 23290073
esv2743823 CNV deletion 23290073
esv2743822 CNV deletion 23290073
esv2743821 CNV deletion 23290073
esv2743819 CNV deletion 23290073
esv2743818 CNV deletion 23290073
esv2743817 CNV deletion 23290073
esv2743816 CNV deletion 23290073
esv25517 CNV loss 19812545
esv2369077 CNV deletion 18987734
esv1960799 CNV deletion 18987734
esv1303257 CNV insertion 17803354
esv1201179 CNV insertion 17803354
esv1144764 CNV insertion 17803354
dgv998n100 CNV gain 25217958
dgv528e59 CNV duplication 20981092
dgv179e199 CNV deletion 23128226
dgv1469n54 CNV loss 21841781
dgv1468n54 CNV gain 21841781
dgv1467n54 CNV loss 21841781
dgv1466n54 CNV gain+loss 21841781
dgv1465n54 CNV loss 21841781
dgv1464n54 CNV gain 21841781

Variation tolerance for ADGRA1 Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRA1 Gene

Disorders for ADGRA1 Gene

Additional Disease Information for ADGRA1

No disorders were found for ADGRA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRA1 Gene

Publications for ADGRA1 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 2 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58

Products for ADGRA1 Gene

Sources for ADGRA1 Gene

Loading form....