Aliases for ADD3 Gene
Aliases for ADD3 Gene
External Ids for ADD3 Gene
- HGNC: 245
- Entrez Gene: 120
- Ensembl: ENSG00000148700
- OMIM: 601568
- UniProtKB: Q9UEY8
Previous HGNC Symbols for ADD3 Gene
- ADDL
Previous GeneCards Identifiers for ADD3 Gene
- GC10P110658
- GC10P111094
- GC10P111897
- GC10P111430
- GC10P111432
- GC10P111755
- GC10P105396
Summaries for ADD3 Gene
-
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADD3 Gene
ADD3 (Adducin 3) is a Protein Coding gene. Diseases associated with ADD3 include Cerebral Palsy, Spastic Quadriplegic, 3 and Cerebral Palsy. Among its related pathways are Activation of cAMP-Dependent PKA and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is ADD2.
UniProtKB/Swiss-Prot for ADD3 Gene
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin.
Additional gene information for ADD3 Gene
- Monarch Initiative
- Search for ADD3 at DataMed
- Search for ADD3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADD3 Gene
Genomics for ADD3 Gene
GeneHancer (GH) Regulatory Elements for ADD3 Gene
Promoters and enhancers for ADD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADD3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ADD3 Gene
Genomic Locations for ADD3 Gene
- chr10:109,996,365-110,135,565
- (GRCh38/hg38)
- Size:
- 139,201 bases
- Orientation:
- Plus strand
- chr10:111,756,126-111,895,323
- (GRCh37/hg19)
Genomic View for ADD3 Gene
Genes around ADD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.1-q25.2 by Entrez Gene
- 10q25.1-q25.2 by HGNC
- 10q25.1 by Ensembl
ADD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADD3 Gene
Proteins for ADD3 Gene
-
Protein details for ADD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UEY8-ADDG_HUMAN
- Recommended name:
- Gamma-adducin
- Protein Accession:
- Q9UEY8
- D3DRA8
- O43243
- Q5VU09
- Q92773
- Q9UEY7
Protein attributes for ADD3 Gene
- Size:
- 706 amino acids
- Molecular mass:
- 79155 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a gamma subunit.
Protein Expression for ADD3 Gene
Post-translational modifications for ADD3 Gene
- Sumoylated.
- Ubiquitination at posLast=448448
- Modification sites at PhosphoSitePlus
Other Protein References for ADD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001112.2
- XP_024303569.1
- XP_024303579.1
- NP_063968.1
- XP_024303564.1
- XP_024303574.1
- XP_024303581.1
- XP_024303571.1
- NP_001307523.1
- NP_058432.1
- XP_024303562.1
- XP_024303582.1
- XP_024303572.1
- XP_024303568.1
- XP_024303578.1
- NP_001307522.1
- XP_024303567.1
- XP_024303577.1
- NP_001307521.1
- XP_024303580.1
- XP_024303570.1
- NP_001307520.1
- XP_024303565.1
- XP_024303575.1
- XP_024303566.1
- XP_024303576.1
- XP_024303563.1
- XP_024303573.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ADD3
- Novus Biologicals Antibodies for ADD3
- Invitrogen Antibodies for ADD3
- GeneTex ADD3 Antibody for ADD3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADD3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ADD3
- Origene Custom Protein Services for ADD3
- antibodies-online: Search results for 6 available ADD3 Proteins ranked by validation data
- Compare Top ADD3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ADD3
Assay Products
- antibodies-online: Search results for available ADD3 related products ranked by validation data
No data available for DME Specific Peptides for ADD3 Gene
Domains & Families for ADD3 Gene
Gene Families for ADD3 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for ADD3 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UEY8UniProtKB/Swiss-Prot:
ADDG_HUMAN :- Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
- Belongs to the aldolase class II family. Adducin subfamily.
- Domain:
-
- Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
- Family:
-
- Belongs to the aldolase class II family. Adducin subfamily.
Function for ADD3 Gene
Molecular function for ADD3 Gene
- UniProtKB/Swiss-Prot Function:
- Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin.
- GENATLAS Biochemistry:
- adducin 3,actin accessory protein,calmodulin binding,ubiquitously expressed
Phenotypes From GWAS Catalog for ADD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005200 | structural constituent of cytoskeleton | TAS | 8893809 |
| GO:0005516 | calmodulin binding | IEA | -- |
Phenotypes for ADD3 Gene
- MGI mutant phenotypes for ADD3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ADD3:
Animal Models for ADD3 Gene
- MGI Knock Outs for ADD3:
-
- Add3 Add3<tm1.2Llp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADD3
-
CRISPR Products
-
OriGene CRISPR knockouts for ADD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADD3
- genomics-online: gRNA clones - Search results for available ADD3 gene related products
- Applied Biological Materials CRISPR for ADD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADD3
- GenScript: Design CRISPR guide RNA sequences for ADD3
miRNA for ADD3 Gene
- miRTarBase miRNAs that target ADD3
-
- hsa-mir-374b-5p (MIRT016076)
- hsa-mir-124-3p (MIRT022859)
- hsa-mir-24-3p (MIRT030536)
- hsa-mir-23a-3p (MIRT110336)
- hsa-mir-23b-3p (MIRT110338)
- hsa-mir-130a-5p (MIRT110339)
- hsa-mir-374a-5p (MIRT110340)
- hsa-mir-23c (MIRT110344)
- hsa-mir-155-5p (MIRT125863)
- hsa-mir-1202 (MIRT125869)
- hsa-mir-3972 (MIRT125875)
- hsa-mir-5006-5p (MIRT125880)
- hsa-mir-145-5p (MIRT437436)
- hsa-mir-5692c (MIRT561030)
- hsa-mir-5692b (MIRT561031)
- hsa-mir-369-3p (MIRT561032)
- hsa-mir-129-5p (MIRT636737)
- hsa-mir-4776-3p (MIRT636738)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADD3
- Browse OriGene Inhibitory RNA Products For ADD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADD3
- genomics-online: shRNA clones - Search results for available ADD3 gene related products
Clone Products
-
OriGene ORF clones in human for ADD3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for ADD3 in any vector
- NM_016824.4
- NM_019903.4
- NM_001121.3
- XM_005269534.3
- XM_005269531.3
- XM_005269534.3
- XM_005269531.3
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269533.1
- NM_001320591.1
- NM_001320593.1
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269533.1
- NM_001320591.1
- NM_001320593.1
- NM_001320594.1
- XM_005269529.1
- NM_001320592.1
- XM_011539288.1
- XM_011539287.1
- Sino Biological Human cDNA Clone for ADD3
- VectorBuilder custom plasmid, inducible vectors for ADD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADD3
- genomics-online: cdna clones - Search results for available ADD3 gene related products
- orf clones - Search results for available ADD3 gene related products
- Applied Biological Materials Clones for ADD3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADD3
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADD3 Gene
Localization for ADD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADD3 Gene
- Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000794 | condensed nuclear chromosome | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for ADD3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | Miscellaneous transport and binding events | ||
| 3 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
Pathways by source for ADD3 Gene
2 Reactome pathways for ADD3 Gene
4 Qiagen pathways for ADD3 Gene
Interacting Proteins for ADD3 Gene
GPS-Prot Interaction Network for ADD3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0055085 | transmembrane transport | TAS | -- |
No data available for SIGNOR curated interactions for ADD3 Gene
Transcripts for ADD3 Gene
mRNA/cDNA for ADD3 Gene
- (565) Selected AceView cDNA sequences:
- (13) Additional mRNA sequences :
- (28) REFSEQ mRNAs :
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000277900 4337 bps (uc001kyw.4)
- ENST00000356080 3081 bps (uc001kyv.4)
- ENST00000360162 3114 bps (uc001kys.5)
- ENST00000459738 229 bps (uc057vxs.1)
- ENST00000468251 697 bps (uc057vxn.1)
CRISPR Products
-
OriGene CRISPR knockouts for ADD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADD3
- genomics-online: gRNA clones - Search results for available ADD3 gene related products
- Applied Biological Materials CRISPR for ADD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADD3
- GenScript: Design CRISPR guide RNA sequences for ADD3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADD3
- Browse OriGene Inhibitory RNA Products For ADD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADD3
- genomics-online: shRNA clones - Search results for available ADD3 gene related products
Clone Products
-
OriGene ORF clones in human for ADD3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for ADD3 in any vector
- NM_016824.4
- NM_019903.4
- NM_001121.3
- XM_005269534.3
- XM_005269531.3
- XM_005269534.3
- XM_005269531.3
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269533.1
- NM_001320591.1
- NM_001320593.1
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269533.1
- NM_001320591.1
- NM_001320593.1
- NM_001320594.1
- XM_005269529.1
- NM_001320592.1
- XM_011539288.1
- XM_011539287.1
- Sino Biological Human cDNA Clone for ADD3
- VectorBuilder custom plasmid, inducible vectors for ADD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADD3
- genomics-online: cdna clones - Search results for available ADD3 gene related products
- orf clones - Search results for available ADD3 gene related products
- Applied Biological Materials Clones for ADD3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | · | 14c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP25: | - |
| ExUns: | 14d | · | 14e | · | 14f | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP25: |
Expression for ADD3 Gene
This gene is overexpressed in Spinal cord (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADD3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADD3 Gene:
ADD3SOURCE GeneReport for Unigene cluster for ADD3 Gene:
Hs.501012mRNA Expression by UniProt/SwissProt for ADD3 Gene:
Q9UEY8-ADDG_HUMAN
Tissue specificity:
Isoform 1 is ubiquitously expressed.
Evidence on tissue expression from TISSUES for ADD3 Gene
- Nervous system(4.9)
- Blood(4.5)
- Liver(4.4)
- Kidney(3.6)
- Lung(3.6)
- Eye(2.9)
- Intestine(2.8)
- Pancreas(2)
- Thyroid gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ADD3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- face
- head
- skull
Thorax:
- lung
- rib
- rib cage
Pelvis:
- pelvis
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs and template standards for ADD3
-
OriGene qPCR primer pairs for ADD3
- genomics-online: primer clones - Search results for available ADD3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ADD3 Gene
Orthologs for ADD3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADD3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ADD3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ADD3 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ADD3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADD3 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Add3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Add3 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | ADD3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADD3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | add3 33 |
|
||
| Str.5919 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | add3a 34 33 |
|
OneToMany | |
| add3b 34 |
|
OneToMany | |||
| wufc16e06 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | hts 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | add-1 34 |
|
ManyToMany | |
| add-2 34 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8742 34 |
|
ManyToMany |
- Species where no ortholog for ADD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ADD3 Gene
- ENSEMBL:
- Gene Tree for ADD3 (if available)
- TreeFam:
- Gene Tree for ADD3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADD3: view image
Paralogs for ADD3 Gene
Variants for ADD3 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs564185858 | pathogenic, Cerebral palsy, spastic quadriplegic, 3, Cerebral palsy, Cerebral palsy, spastic quadriplegic 3 (CPSQ3) [MIM:617008] | 110,122,249(+) | G/A | coding_sequence_variant, missense_variant | |
| rs41291886 | likely-benign, not provided | 110,112,885(+) | T/C | coding_sequence_variant, missense_variant | |
| rs753541585 | uncertain-significance, not provided | 110,133,616(+) | TAAATAAA/TAAA | 3_prime_UTR_variant, terminator_codon_variant | |
| rs765847432 | uncertain-significance, not provided | 110,133,598(+) | AAG/ | coding_sequence_variant, inframe_deletion | |
| rs1000004262 | -- | 110,041,785(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2501162 | CNV | deletion | 19546169 |
| esv2676886 | CNV | deletion | 23128226 |
| esv3546845 | CNV | deletion | 23714750 |
| esv3624531 | CNV | loss | 21293372 |
| esv3624532 | CNV | loss | 21293372 |
| nsv1052255 | CNV | gain | 25217958 |
| nsv7211 | OTHER | inversion | 18451855 |
| nsv7547 | CNV | deletion | 18451855 |
| nsv951845 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.11;
61.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADD3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADD3 Gene
Disorders for ADD3 Gene
(8) MalaCards diseases for ADD3 Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cerebral palsy, spastic quadriplegic, 3 |
|
|
| cerebral palsy |
|
|
| inherited congenital spastic tetraplegia |
|
|
| dyscalculia |
|
|
| bile duct cysts |
|
|
Search ADD3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ADDG_HUMAN- Cerebral palsy, spastic quadriplegic 3 (CPSQ3) [MIM:617008]: A form of cerebral palsy, a group of non-progressive disorders of movement and/or posture resulting from defects in the developing central nervous system. CPSQ3 is an autosomal recessive neurodevelopmental disorder characterized by variable spasticity and cognitive impairment. {ECO:0000269 PubMed:23836506}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ADD3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ADD3 Gene
Publications for ADD3 Gene
- Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin. (PMID: 8893809) Katagiri T … Hirai Y (Cytogenetics and cell genetics 1996) 2 3 4 22 58
- Arterial properties in relation to genetic variations in the adducin subunits in a white population. (PMID: 18787518) Seidlerová J … Bianchi G (American journal of hypertension 2009) 3 22 44 58
- Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Ménière's syndrome. (PMID: 18667944) Teggi R … Bussi M (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2008) 3 22 44 58
- Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population. (PMID: 18475162) Kuznetsova T … Staessen JA (Journal of hypertension 2008) 3 22 44 58
- Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans. (PMID: 15834281) Cwynar M … European Project On Genes in Hypertension (EPOGH) Investigators (Journal of hypertension 2005) 3 22 44 58
Products for ADD3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ADD3
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ADD3
- Origene Custom Protein Services for ADD3
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADD3
- Browse OriGene Inhibitory RNA Products For ADD3
- OriGene qPCR primer pairs and template standards for ADD3
- OriGene qPCR primer pairs for ADD3
- OriGene CRISPR knockouts for ADD3
- OriGene ORF clones in human for ADD3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADD3
- GenScript: Next-day shipping of latest version cDNA ORF clones for ADD3 in any vector
- NM_016824.4
- NM_019903.4
- NM_001121.3
- XM_005269534.3
- XM_005269531.3
- XM_005269534.3
- XM_005269531.3
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269533.1
- NM_001320591.1
- NM_001320593.1
- XM_005269530.1
- XM_006717626.1
- XM_006717627.1
- XM_005269533.1
- NM_001320591.1
- NM_001320593.1
- NM_001320594.1
- XM_005269529.1
- NM_001320592.1
- XM_011539288.1
- XM_011539287.1
- GenScript Custom Purified and Recombinant Proteins Services for ADD3
- GenScript Custom Assay Services for ADD3
- GenScript Custom overexpressing Cell Line Services for ADD3
- GenScript: Design CRISPR guide RNA sequences for ADD3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ADD3
- Sino Biological Human cDNA Clone for ADD3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ADD3
- Novus Biologicals lysates and proteins for ADD3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for ADD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 55 available ADD3 Antibodies ranked by validation data
- Compare Top ADD3 Antibodies
- antibodies-online: Search results for available ADD3 related products ranked by validation data
- antibodies-online: Search results for 6 available ADD3 Proteins ranked by validation data
- Compare Top ADD3 Proteins
- Quality Products:
- GeneTex ADD3 Antibody for ADD3
- Search GeneTex for Proteins for ADD3
- Santa Cruz Biotechnology (SCBT) Antibodies for ADD3
- Search Santa Cruz Biotechnology (SCBT) for ADD3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADD3
- Horizon Cell Lines for ADD3
- genomics-online: cdna clones - Search results for available ADD3 gene related products
- orf clones - Search results for available ADD3 gene related products
- genomics-online: gRNA clones - Search results for available ADD3 gene related products
- genomics-online: primer clones - Search results for available ADD3 gene related products
- genomics-online: shRNA clones - Search results for available ADD3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADD3
- GeneCopoeia miRNA 3'UTR Target clone products for ADD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADD3
Sources for ADD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio