Aliases for ADD2 Gene
Aliases for ADD2 Gene
External Ids for ADD2 Gene
- HGNC: 244
- Entrez Gene: 119
- Ensembl: ENSG00000075340
- OMIM: 102681
- UniProtKB: P35612
Previous GeneCards Identifiers for ADD2 Gene
- GC02M070898
- GC02M071100
- GC02M070863
- GC02M070800
Summaries for ADD2 Gene
-
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
GeneCards Summary for ADD2 Gene
ADD2 (Adducin 2) is a Protein Coding gene. Diseases associated with ADD2 include Hereditary Elliptocytosis and Capillariasis. Among its related pathways are Activation of cAMP-Dependent PKA and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is ADD3.
UniProtKB/Swiss-Prot for ADD2 Gene
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADD2 Gene
Genomics for ADD2 Gene
GeneHancer (GH) Regulatory Elements for ADD2 Gene
Promoters and enhancers for ADD2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J070766 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 656 | +0.8 | 820 | 1.8 | PKNOX1 SIN3A ZNF2 GLIS2 ZNF213 KLF7 SP3 REST ZNF592 MBD2 | ADD2 TIA1 MPHOSPH10 FIGLA PIR38094 | |
| GH02J070732 | Enhancer | 0.4 | ENCODE | 33.7 | +34.5 | 34498 | 2.6 | RFX1 POLR2A RCOR1 | ADD2 FIGLA PIR38094 | |
| GH02J070727 | Enhancer | 0.7 | ENCODE | 19.2 | +39.6 | 39637 | 1.3 | ZFP64 ZNF140 ZC3H11A CEBPB SIN3A REST ZNF623 ZNF781 ZNF518A ZNF697 | TIA1 ANKRD53 TEX261 PCBP1-AS1 MPHOSPH10 ADD2 ZNF638 CLEC4F LOC105374796 GMCL1 | |
| GH02J070522 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 9.9 | +243.4 | 243437 | 4 | PKNOX1 FOXA2 SIN3A ATF7 FOS DEK NFKBIZ REST PPARG NFIL3 | TGFA ADD2 ASPRV1 TGFA-IT1 | |
| GH02J070919 | Enhancer | 0.9 | ENCODE | 10.5 | -151.8 | -151783 | 0.2 | FOXA2 ARID4B SIN3A ZNF48 ZNF143 MXD4 REST PPARG KAT8 NFIL3 | ATP6V1B1-AS1 ADD2 CD207 ATP6V1B1 VAX2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADD2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ADD2 gene promoter:
-
- c-Ets-1
- NF-kappaB1
- NF-kappaB
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- TFIID
- TBP
Regulatory Element Products
Genomic Locations for ADD2 Gene
Genomic Locations for ADD2 Gene
- chr2:70,607,618-70,768,243
- (GRCh38/hg38)
- Size:
- 160,626 bases
- Orientation:
- Minus strand
- chr2:70,834,750-70,995,375
- (GRCh37/hg19)
- Size:
- 160,626 bases
- Orientation:
- Minus strand
Genomic View for ADD2 Gene
Genes around ADD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p13.3 by Entrez Gene
- 2p13.3 by HGNC
- 2p13.3 by Ensembl
ADD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADD2 Gene
Proteins for ADD2 Gene
-
Protein details for ADD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35612-ADDB_HUMAN
- Recommended name:
- Beta-adducin
- Protein Accession:
- P35612
- A8K4P2
- B4DM17
- D6W5G7
- D6W5G8
- Q13482
- Q16412
- Q59G82
- Q5U5P4
- Q6P0P2
- Q6PGQ4
- Q7Z688
- Q7Z689
- Q7Z690
- Q7Z691
Protein attributes for ADD2 Gene
- Size:
- 726 amino acids
- Molecular mass:
- 80854 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with SLC2A1.
- SequenceCaution:
-
- Sequence=BAD92464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ADD2 Gene
Post-translational modifications for ADD2 Gene
- The N-terminus is blocked.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ADD2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ADD2
- Novus Biologicals Antibodies for ADD2
- Invitrogen Antibodies for ADD2
- GeneTex ADD2 Antibody for ADD2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADD2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ADD2
- Origene Custom Protein Services for ADD2
- Search GeneTex for Proteins for ADD2
Assay Products
No data available for DME Specific Peptides for ADD2 Gene
Domains & Families for ADD2 Gene
Gene Families for ADD2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ADD2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADD2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35612UniProtKB/Swiss-Prot:
ADDB_HUMAN :- Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
- Belongs to the aldolase class II family. Adducin subfamily.
- Domain:
-
- Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
- Family:
-
- Belongs to the aldolase class II family. Adducin subfamily.
Function for ADD2 Gene
Molecular function for ADD2 Gene
- UniProtKB/Swiss-Prot Function:
- Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
- GENATLAS Biochemistry:
- adducin beta,actin accessory protein,calmodulin binding protein,97kDa,component of the erythrocyte membrane skeleton,also expressed in brain,kidney,liver,intestine,leukocytes,platelets
Phenotypes From GWAS Catalog for ADD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IMP | 25425738 |
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005516 | calmodulin binding | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 25425738 |
| GO:0030507 | spectrin binding | IDA | 7642559 |
Phenotypes for ADD2 Gene
- MGI mutant phenotypes for ADD2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ADD2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADD2
-
CRISPR Products
-
OriGene CRISPR knockouts for ADD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADD2
- genomics-online: gRNA clones - Search results for available ADD2 gene related products
- Applied Biological Materials CRISPR for ADD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADD2
- GenScript: Design CRISPR guide RNA sequences for ADD2
miRNA for ADD2 Gene
- miRTarBase miRNAs that target ADD2
-
- hsa-mir-1301-3p (MIRT035978)
- hsa-mir-107 (MIRT048288)
- hsa-mir-6825-5p (MIRT490824)
- hsa-mir-7106-5p (MIRT490826)
- hsa-mir-6797-5p (MIRT490827)
- hsa-mir-1249-5p (MIRT490828)
- hsa-mir-650 (MIRT490829)
- hsa-mir-765 (MIRT490830)
- hsa-mir-3612 (MIRT490831)
- hsa-mir-4644 (MIRT490832)
- hsa-mir-4306 (MIRT490833)
- hsa-mir-185-5p (MIRT490834)
- hsa-mir-4722-5p (MIRT490835)
- hsa-mir-6130 (MIRT490836)
- hsa-mir-6133 (MIRT490837)
- hsa-mir-6129 (MIRT490838)
- hsa-mir-6127 (MIRT490839)
- hsa-mir-4510 (MIRT490840)
- hsa-mir-4419a (MIRT490841)
- hsa-mir-1827 (MIRT490842)
- hsa-mir-3150b-3p (MIRT490843)
- hsa-mir-4784 (MIRT490844)
- hsa-mir-4459 (MIRT490845)
- hsa-mir-940 (MIRT490846)
- hsa-mir-6893-5p (MIRT490847)
- hsa-mir-4779 (MIRT490848)
- hsa-mir-6808-5p (MIRT490849)
- hsa-mir-4695-5p (MIRT490850)
- hsa-mir-6856-5p (MIRT490851)
- hsa-mir-6758-5p (MIRT490852)
- hsa-mir-4762-3p (MIRT539406)
- hsa-mir-384 (MIRT539407)
- hsa-mir-3685 (MIRT539408)
- hsa-mir-3192-3p (MIRT539409)
- hsa-mir-1290 (MIRT539410)
- hsa-mir-3151-3p (MIRT539411)
- hsa-mir-5009-3p (MIRT539412)
- hsa-mir-190a-3p (MIRT708213)
- hsa-mir-374b-5p (MIRT708214)
- hsa-mir-374a-5p (MIRT708215)
- hsa-mir-223-5p (MIRT708216)
- hsa-mir-511-3p (MIRT708217)
- hsa-mir-5011-5p (MIRT708218)
- hsa-mir-5692c (MIRT708219)
- hsa-mir-5692b (MIRT708220)
- hsa-mir-369-3p (MIRT708221)
- hsa-mir-3163 (MIRT708222)
- hsa-mir-5583-3p (MIRT708223)
- hsa-mir-4517 (MIRT708224)
- hsa-mir-1277-5p (MIRT708225)
- hsa-mir-410-3p (MIRT708226)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADD2
- Browse OriGene Inhibitory RNA Products For ADD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADD2
- genomics-online: shRNA clones - Search results for available ADD2 gene related products
Clone Products
-
OriGene ORF clones in human for ADD2
- RC230458L1V
- RC230458L2V
- RC230299L1V
- RC230299L2V
- RC209517L1V
- RC209517L2V
- RC212102L1V
- RC212102L2V
- RC207895L1V
- RC207895L2V
- RC230458
- RC230458L1
- RC230458L2
- RG230458
- RC230299
- RC230299L1
- RC230299L2
- RG230299
- RC209517
- RC209517L1
- RC209517L2
- RG209517
- RC212102
- RC212102L1
- RC212102L2
- RG212102
- RC207895
- RC207895L1
- RC207895L2
- RG207895
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADD2
- VectorBuilder custom plasmid, inducible vectors for ADD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADD2
- genomics-online: cdna clones - Search results for available ADD2 gene related products
- orf clones - Search results for available ADD2 gene related products
- Applied Biological Materials Clones for ADD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADD2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADD2 Gene
Localization for ADD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADD2 Gene
- Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 3 |
- Plasma membrane (3)
- Cytosol (2)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0008290 | F-actin capping protein complex | IDA | 8626479 |
Pathways & Interactions for ADD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | Miscellaneous transport and binding events | ||
| 3 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 4 | Aquaporin-mediated transport | ||
Pathways by source for ADD2 Gene
2 Reactome pathways for ADD2 Gene
1 GeneGo (Thomson Reuters) pathway for ADD2 Gene
4 Qiagen pathways for ADD2 Gene
Interacting Proteins for ADD2 Gene
GPS-Prot Interaction Network for ADD2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030036 | actin cytoskeleton organization | IC | 3693401 |
| GO:0030097 | hemopoiesis | IEA | -- |
| GO:0032092 | positive regulation of protein binding | IDA | 3693401 |
| GO:0050900 | leukocyte migration | IMP | 25425738 |
| GO:0050901 | leukocyte tethering or rolling | IMP | 25425738 |
Transcripts for ADD2 Gene
mRNA/cDNA for ADD2 Gene
- (11) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (173) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000264436 9267 bps (uc002sgz.4)
- ENST00000355733 2654 bps (uc002sgy.4)
- ENST00000403045 3745 bps (uc061kjo.1)
- ENST00000407644 3741 bps (uc021vjc.2)
- ENST00000413157 3776 bps (uc002shc.3)
CRISPR Products
-
OriGene CRISPR knockouts for ADD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADD2
- genomics-online: gRNA clones - Search results for available ADD2 gene related products
- Applied Biological Materials CRISPR for ADD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADD2
- GenScript: Design CRISPR guide RNA sequences for ADD2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADD2
- Browse OriGene Inhibitory RNA Products For ADD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADD2
- genomics-online: shRNA clones - Search results for available ADD2 gene related products
Clone Products
-
OriGene ORF clones in human for ADD2
- RC230458L1V
- RC230458L2V
- RC230299L1V
- RC230299L2V
- RC209517L1V
- RC209517L2V
- RC212102L1V
- RC212102L2V
- RC207895L1V
- RC207895L2V
- RC230458
- RC230458L1
- RC230458L2
- RG230458
- RC230299
- RC230299L1
- RC230299L2
- RG230299
- RC209517
- RC209517L1
- RC209517L2
- RG209517
- RC212102
- RC212102L1
- RC212102L2
- RG212102
- RC207895
- RC207895L1
- RC207895L2
- RG207895
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADD2
- VectorBuilder custom plasmid, inducible vectors for ADD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADD2
- genomics-online: cdna clones - Search results for available ADD2 gene related products
- orf clones - Search results for available ADD2 gene related products
- Applied Biological Materials Clones for ADD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - |
| ExUns: | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: | - | - | |||||||||||||
| SP4: | |||||||||||||||
| SP5: | |||||||||||||||
| SP6: | |||||||||||||||
| SP7: | |||||||||||||||
| SP8: | |||||||||||||||
| SP9: | |||||||||||||||
| SP10: | |||||||||||||||
| SP11: |
Expression for ADD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Cerebellum
- Medulla Oblongata
- Cerebral Cortex
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Inner Cell Mass (Early Embryonic Tissues)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Heart (Cardiovascular System)
- Endocardial Tube Cells Endocardium
- Thyroid (Endocrine System)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Liver (Hepatobiliary System)
- Ovary (Reproductive System)
-
Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for ADD2 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.0), Brain - Cerebellum (x5.9), Brain - Frontal Cortex (BA9) (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Cortex (x4.5).
This gene is overexpressed in Brain (27.3), Frontal cortex (26.1), and Fetal Brain (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADD2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADD2 Gene:
ADD2SOURCE GeneReport for Unigene cluster for ADD2 Gene:
Hs.188528mRNA Expression by UniProt/SwissProt for ADD2 Gene:
P35612-ADDB_HUMAN
Tissue specificity:
Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.
Evidence on tissue expression from TISSUES for ADD2 Gene
- Nervous system(5)
- Blood(4.5)
- Eye(4.4)
- Bone marrow(4.3)
- Heart(4.3)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ADD2
-
OriGene qPCR primer pairs for ADD2
- genomics-online: primer clones - Search results for available ADD2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADD2 Gene
Orthologs for ADD2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADD2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ADD2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ADD2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ADD2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Add2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Add2 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | ADD2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADD2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | add2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | add2 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | hts 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | add-1 34 |
|
ManyToMany | |
| add-2 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ADD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ADD2 Gene
- ENSEMBL:
- Gene Tree for ADD2 (if available)
- TreeFam:
- Gene Tree for ADD2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADD2: view image
Paralogs for ADD2 Gene
Variants for ADD2 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000023958 | -- | 70,671,589(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000055079 | -- | 70,671,379(-) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000067782 | -- | 70,755,504(-) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000117222 | -- | 70,715,453(-) | G/A | intron_variant | |
| rs1000142601 | -- | 70,709,102(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv582192 | CNV | loss | 21841781 |
| nsv2770 | CNV | insertion | 18451855 |
| nsv1146915 | OTHER | inversion | 26484159 |
| esv3892614 | CNV | gain | 25118596 |
| esv3591211 | CNV | loss | 21293372 |
| esv3583858 | CNV | loss | 25503493 |
| esv3429524 | CNV | insertion | 20981092 |
| esv2762674 | CNV | gain | 21179565 |
| esv2659183 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.42;
63.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADD2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADD2 Gene
Disorders for ADD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hereditary elliptocytosis |
|
|
| capillariasis |
|
|
| hereditary spherocytosis |
|
|
| echolalia |
|
|
| exhibitionism |
|
|
Search ADD2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADD2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ADD2 Gene
Publications for ADD2 Gene
- Primary structure and domain organization of human alpha and beta adducin. (PMID: 1840603) Joshi R … Bennett V (The Journal of cell biology 1991) 2 3 4 22 58
- alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy. (PMID: 19838659) Ferrandi M … Bianchi G (Journal of molecular medicine (Berlin, Germany) 2010) 3 22 44 58
- Arterial properties in relation to genetic variations in the adducin subunits in a white population. (PMID: 18787518) Seidlerová J … Bianchi G (American journal of hypertension 2009) 3 22 44 58
- Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Ménière's syndrome. (PMID: 18667944) Teggi R … Bussi M (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2008) 3 22 44 58
- Investigation of Adducin 2 (beta) DNA polymorphisms in genetic predisposition to diabetic nephropathy in Type 1 diabetes. (PMID: 18959617) Currie D … Warren 3/UK GoKinD Study Group (Diabetic medicine : a journal of the British Diabetic Association 2008) 3 22 44 58
Products for ADD2 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for ADD2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ADD2
- Origene Custom Protein Services for ADD2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADD2
- Browse OriGene Inhibitory RNA Products For ADD2
- OriGene qPCR primer pairs and template standards for ADD2
- OriGene qPCR primer pairs for ADD2
- OriGene CRISPR knockouts for ADD2
- OriGene ORF clones in human for ADD2
- RC230458L1V
- RC230458L2V
- RC230299L1V
- RC230299L2V
- RC209517L1V
- RC209517L2V
- RC212102L1V
- RC212102L2V
- RC207895L1V
- RC207895L2V
- RC230458
- RC230458L1
- RC230458L2
- RG230458
- RC230299
- RC230299L1
- RC230299L2
- RG230299
- RC209517
- RC209517L1
- RC209517L2
- RG209517
- RC212102
- RC212102L1
- RC212102L2
- RG212102
- RC207895
- RC207895L1
- RC207895L2
- RG207895
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADD2
- GenScript: Next-day shipping of latest version cDNA ORF clones for ADD2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ADD2
- GenScript Custom Assay Services for ADD2
- GenScript Custom overexpressing Cell Line Services for ADD2
- GenScript: Design CRISPR guide RNA sequences for ADD2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ADD2
- Sino Biological Human cDNA Clone for ADD2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ADD2
- Novus Biologicals lysates and proteins for ADD2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for ADD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 58 available ADD2 Antibodies ranked by validation data
- Compare Top ADD2 Antibodies
- antibodies-online: Search results for 3 available ADD2 Elisa Kits ranked by validation data
- Compare Top ADD2 Elisa Kits
- antibodies-online: Search results for 7 available ADD2 Proteins ranked by validation data
- Compare Top ADD2 Proteins
- GeneTex ADD2 Antibody for ADD2
- Search GeneTex for Proteins for ADD2
- Santa Cruz Biotechnology (SCBT) Antibodies for ADD2
- Search Santa Cruz Biotechnology (SCBT) for ADD2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADD2
- Horizon Cell Lines for ADD2
- genomics-online: cdna clones - Search results for available ADD2 gene related products
- orf clones - Search results for available ADD2 gene related products
- genomics-online: gRNA clones - Search results for available ADD2 gene related products
- genomics-online: primer clones - Search results for available ADD2 gene related products
- genomics-online: shRNA clones - Search results for available ADD2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADD2
- GeneCopoeia miRNA 3'UTR Target clone products for ADD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADD2
Sources for ADD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt