Aliases for ADD1 Gene
External Ids for ADD1 Gene
Previous GeneCards Identifiers for ADD1 Gene
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
GeneCards Summary for ADD1 Gene
ADD1 (Adducin 1) is a Protein Coding gene. Diseases associated with ADD1 include Hypertension, Essential and Gastroschisis. Among its related pathways are Apoptotic cleavage of cellular proteins and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is ADD3.
UniProtKB/Swiss-Prot Summary for ADD1 Gene
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.