Aliases for ADD1 Gene
External Ids for ADD1 Gene
Previous GeneCards Identifiers for ADD1 Gene
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
GeneCards Summary for ADD1 Gene
ADD1 (Adducin 1) is a Protein Coding gene. Diseases associated with ADD1 include Hypertension, Essential and Tracheoesophageal Fistula With Or Without Esophageal Atresia. Among its related pathways are Cytoskeletal Signaling and Diuretics Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is ADD3.
UniProtKB/Swiss-Prot Summary for ADD1 Gene
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.