Aliases for ADCYAP1R1 Gene
External Ids for ADCYAP1R1 Gene
Previous GeneCards Identifiers for ADCYAP1R1 Gene
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
GeneCards Summary for ADCYAP1R1 Gene
ADCYAP1R1 (ADCYAP Receptor Type I) is a Protein Coding gene. Diseases associated with ADCYAP1R1 include Post-Traumatic Stress Disorder and Persian Gulf Syndrome. Among its related pathways are RET signaling and Renin secretion. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is VIPR2.
UniProtKB/Swiss-Prot Summary for ADCYAP1R1 Gene
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.