Aliases for ADCYAP1 Gene
External Ids for ADCYAP1 Gene
Previous GeneCards Identifiers for ADCYAP1 Gene
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
GeneCards Summary for ADCYAP1 Gene
ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1) is a Protein Coding gene. Diseases associated with ADCYAP1 include Persian Gulf Syndrome and Holoprosencephaly 3. Among its related pathways are RET signaling and Renin secretion. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is VIP.
UniProtKB/Swiss-Prot Summary for ADCYAP1 Gene
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.