Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [p... See more...

Aliases for ADCY9 Gene

Aliases for ADCY9 Gene

  • Adenylate Cyclase 9 2 3 5
  • Adenylate Cyclase Type IX 3 4
  • ATP Pyrophosphate-Lyase 9 3 4
  • Adenylate Cyclase Type 9 3 4
  • Adenylyl Cyclase 9 3 4
  • EC 4.6.1.1 4 54
  • ACIX 3 4
  • AC9 3 4
  • Type IX ATP Pyrophosphate-Lyase 3
  • KIAA0520 4

External Ids for ADCY9 Gene

Previous GeneCards Identifiers for ADCY9 Gene

  • GC16M004044
  • GC16M004015
  • GC16M003952
  • GC16M004003

Summaries for ADCY9 Gene

Entrez Gene Summary for ADCY9 Gene

  • Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY9 Gene

ADCY9 (Adenylate Cyclase 9) is a Protein Coding gene. Diseases associated with ADCY9 include Chromosome 16P13.3 Deletion Syndrome, Proximal and Malaria. Among its related pathways are Oxytocin signaling pathway and Adenylate cyclase inhibitory pathway. Gene Ontology (GO) annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY8.

UniProtKB/Swiss-Prot Summary for ADCY9 Gene

  • Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).

Tocris Summary for ADCY9 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY9 Gene

Additional gene information for ADCY9 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADCY9 Gene

Genomics for ADCY9 Gene

GeneHancer (GH) Regulatory Elements for ADCY9 Gene

Promoters and enhancers for ADCY9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J004110 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 762.4 +2.1 2142 6.6 ZNF785 ZBTB6 RBPJ POLR2A NR2F1 NR2F6 ZNF362 HLF L3MBTL2 ELF3 ADCY9 piR-51259 ZNF75A ANKS3 ZNF213-AS1 CREBBP SEC14L5 piR-61945-169
GH16J004152 Promoter 0.9 EPDnew 761.3 -36.0 -35965 0.1 GATA3 SREBF1 TCF7L2 ZNF217 MNT NCOA3 MYC CREB1 ZIC2 GATAD2B ADCY9 HSALNG0109209 piR-50437-226 DBIP3
GH16J004051 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas 20.1 +62.9 62910 3.5 POLR2A MYC HLF MAX SP1 CEBPG RXRA SMARCC1 CEBPB JUN ADCY9 CREBBP CORO7 RF00017-1941 HSALNG0109201
GH16J004230 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 -119.7 -119708 13.1 AHR REST USF1 TRIM28 ZNF26 BCL6 GLIS1 BACH1 SRL ENSG00000261938 ZNF263 ZNF500 LINC01569 ZNF75A ADCY9 CREBBP piR-57387-011
GH16J004059 Enhancer 0.6 Ensembl ENCODE 30.1 +56.3 56333 1.8 NFE2 TRIM28 GABPA ZEB2 MAX ADCY9 HSALNG0109201 RF00017-1941
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADCY9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADCY9 gene promoter:
  • c-Myb
  • CUTL1
  • GCNF
  • GCNF-1
  • GCNF-2
  • HNF-4alpha1
  • Nkx6-1

Genomic Locations for ADCY9 Gene

Genomic Locations for ADCY9 Gene
chr16:3,953,387-4,116,442
(GRCh38/hg38)
Size:
163,056 bases
Orientation:
Minus strand
chr16:4,003,388-4,166,186
(GRCh37/hg19)
Size:
162,799 bases
Orientation:
Minus strand

Genomic View for ADCY9 Gene

Genes around ADCY9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY9 Gene

Proteins for ADCY9 Gene

  • Protein details for ADCY9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60503-ADCY9_HUMAN
    Recommended name:
    Adenylate cyclase type 9
    Protein Accession:
    O60503
    Secondary Accessions:
    • A7E2V5
    • A7E2X2
    • D3DUD1
    • O60273
    • Q4ZHT9
    • Q4ZIR5
    • Q9BWT4
    • Q9UGP2

    Protein attributes for ADCY9 Gene

    Size:
    1353 amino acids
    Molecular mass:
    150701 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC24201.1; Type=Frameshift; Positions=1252; Evidence={ECO:0000305}; Sequence=BAA25446.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ADCY9 Gene

Selected DME Specific Peptides for ADCY9 Gene

O60503:
  • TYMAASGLN
  • RRQKKLPQLFER
  • ADIVGFT
  • FLLLLLVWFLNR
  • KMGYDFDYRGTVNVKGKGQMKTY
  • ADQLKGLKT
  • DHAYCCIEMGLGMI
  • EKIKTIG
  • ERCFPQTQRRFRYAL
  • ISPDIRVQVDGSIGRSPTDEI
  • DQSALLPLRFKNIREKTDAHFV
  • GVIFASIVNFSEFYEENYEGGKECYR
  • MRVGVHTGTVL

Post-translational modifications for ADCY9 Gene

  • Glycosylation at Asn206, Asn955, and Asn964
  • Ubiquitination at Lys622 and Lys1218
  • Modification sites at PhosphoSitePlus

Other Protein References for ADCY9 Gene

Domains & Families for ADCY9 Gene

Gene Families for ADCY9 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADCY9 Gene

Suggested Antigen Peptide Sequences for ADCY9 Gene

GenScript: Design optimal peptide antigens:
  • ADCY9 protein (A7E2X2_HUMAN)
  • Adenylyl cyclase 9 (ADCY9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60503

UniProtKB/Swiss-Prot:

ADCY9_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY9: view

Function for ADCY9 Gene

Molecular function for ADCY9 Gene

UniProtKB/Swiss-Prot Function:
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence={ECO:0000269 PubMed:10987815, ECO:0000269 PubMed:12972952, ECO:0000269 PubMed:15879435, ECO:0000269 PubMed:9628827};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation (PubMed:9628827). Activity is down-regulated by calcium/calcineurin (PubMed:10987815).
GENATLAS Biochemistry:
adenylyl cyclase type IX,ubiquitously,with highest levels in skeletal muscle,heart and brain

Enzyme Numbers (IUBMB) for ADCY9 Gene

Phenotypes From GWAS Catalog for ADCY9 Gene

Gene Ontology (GO) - Molecular Function for ADCY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IDA,TAS 9628827
GO:0005524 ATP binding IEA --
GO:0016829 lyase activity IEA --
GO:0016849 phosphorus-oxygen lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADCY9: view
genes like me logo Genes that share phenotypes with ADCY9: view

Animal Models for ADCY9 Gene

MGI Knock Outs for ADCY9:
  • Adcy9 Adcy9<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCY9

CRISPR Products

miRNA for ADCY9 Gene

miRTarBase miRNAs that target ADCY9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY9

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY9 Gene

Localization for ADCY9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY9 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY9 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 1
cytoskeleton 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADCY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA,TAS 10987815
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 9628827
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with ADCY9: view

Pathways & Interactions for ADCY9 Gene

PathCards logo

SuperPathways for ADCY9 Gene

genes like me logo Genes that share pathways with ADCY9: view

SIGNOR curated interactions for ADCY9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0003091 renal water homeostasis TAS --
GO:0006171 cAMP biosynthetic process IDA,IEA 9628827
GO:0007165 signal transduction TAS 9628827
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADCY9: view

Drugs & Compounds for ADCY9 Gene

(17) Drugs for ADCY9 Gene - From: PharmGKB, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphoric acid Approved Pharma 0
NADH Approved Nutra 0
Pyruvic acid Approved, Investigational Nutra 0

(2) Additional Compounds for ADCY9 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8

(5) Tocris Compounds for ADCY9 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
KH 7 Selective soluble adenylyl cyclase inhibitor 330676-02-3
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9
genes like me logo Genes that share compounds with ADCY9: view

Transcripts for ADCY9 Gene

mRNA/cDNA for ADCY9 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY9

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - - -

Relevant External Links for ADCY9 Gene

GeneLoc Exon Structure for
ADCY9
ECgene alternative splicing isoforms for
ADCY9

Expression for ADCY9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCY9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY9 Gene

This gene is overexpressed in Muscle - Skeletal (x5.8).

Protein differential expression in normal tissues from HIPED for ADCY9 Gene

This gene is overexpressed in Frontal cortex (23.6), Testis (15.6), Fetal Brain (11.1), Placenta (7.4), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADCY9 Gene



Protein tissue co-expression partners for ADCY9 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADCY9 Gene:

ADCY9

SOURCE GeneReport for Unigene cluster for ADCY9 Gene:

Hs.391860

mRNA Expression by UniProt/SwissProt for ADCY9 Gene:

O60503-ADCY9_HUMAN
Tissue specificity: Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952).

Evidence on tissue expression from TISSUES for ADCY9 Gene

  • Heart(4.3)
  • Nervous system(4.3)
  • Liver(4.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with ADCY9: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY9 Gene

Orthologs for ADCY9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY9 33 32
  • 99.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy9 32
  • 88.77 (n)
cow
(Bos Taurus)
Mammalia ADCY9 33 32
  • 88.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY9 33 32
  • 88.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy9 17 33 32
  • 86.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY9 33
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCY9 33
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCY9 33 32
  • 77.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY9 33
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy9 32
  • 66.8 (n)
Str.3341 32
African clawed frog
(Xenopus laevis)
Amphibia adcy9 32
zebrafish
(Danio rerio)
Actinopterygii LOC100333702 32
  • 64.69 (n)
adcy9 33
  • 61 (a)
OneToMany
ADCY9 (2 of 2) 33
  • 55 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000090 32
  • 57.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ac13E 33 34 32
  • 53.03 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea acy-1 33 34 32
  • 52.28 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 36 (a)
OneToOne
Cin.6556 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6556 32
Species where no ortholog for ADCY9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY9 Gene

ENSEMBL:
Gene Tree for ADCY9 (if available)
TreeFam:
Gene Tree for ADCY9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADCY9: view image

Paralogs for ADCY9 Gene

(2) SIMAP similar genes for ADCY9 Gene using alignment to 6 proteins:

  • ADCY9_HUMAN
  • A7E2X2_HUMAN
  • I3L300_HUMAN
  • I3L342_HUMAN
  • I3NI20_HUMAN
  • L0R6C2_HUMAN
genes like me logo Genes that share paralogs with ADCY9: view

Variants for ADCY9 Gene

Sequence variations from dbSNP and Humsavar for ADCY9 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000020630 -- 3,964,916(-) G/A 3_prime_UTR_variant, intron_variant
rs1000022344 -- 4,110,482(-) T/C intron_variant
rs1000037244 -- 4,012,293(-) A/T intron_variant
rs1000041583 -- 4,010,177(-) G/T intron_variant
rs1000054856 -- 4,110,171(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY9 Gene

Variant ID Type Subtype PubMed ID
dgv1289n106 CNV deletion 24896259
dgv458n67 CNV gain 20364138
esv21490 CNV gain+loss 19812545
esv2658820 CNV deletion 23128226
esv2672506 CNV deletion 23128226
esv2750422 CNV deletion 23290073
esv2750423 CNV deletion 23290073
esv3553031 CNV deletion 23714750
esv3553033 CNV deletion 23714750
esv3553035 CNV deletion 23714750
esv3570176 CNV gain 25503493
esv3637681 CNV loss 21293372
esv3637682 CNV gain 21293372
esv3637686 CNV loss 21293372
esv3637687 CNV loss 21293372
esv3637689 CNV gain 21293372
esv3892761 CNV loss 25118596
nsv1038196 CNV gain 25217958
nsv1039014 CNV gain 25217958
nsv1044973 CNV loss 25217958
nsv1046986 CNV gain 25217958
nsv1071255 CNV deletion 25765185
nsv1120317 CNV tandem duplication 24896259
nsv1718 CNV insertion 18451855
nsv1719 CNV deletion 18451855
nsv509593 CNV insertion 20534489
nsv510410 OTHER sequence alteration 20534489
nsv517942 CNV loss 19592680
nsv525374 CNV gain 19592680
nsv526024 CNV loss 19592680
nsv528573 CNV loss 19592680
nsv571271 CNV loss 21841781
nsv571272 CNV gain 21841781
nsv571273 CNV gain+loss 21841781
nsv833130 CNV gain 17160897
nsv833131 CNV loss 17160897

Variation tolerance for ADCY9 Gene

Residual Variation Intolerance Score: 2.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADCY9 Gene

Human Gene Mutation Database (HGMD)
ADCY9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY9 Gene

Disorders for ADCY9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADCY9 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chromosome 16p13.3 deletion syndrome, proximal
  • rsts
malaria
  • malaria, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search ADCY9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADCY9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADCY9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADCY9 Gene

Publications for ADCY9 Gene

  1. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). (PMID: 9628827) Hacker BM … Storm DR (Genomics 1998) 2 3 4 23 56
  2. Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment. (PMID: 20175803) Ye YM … Park HS (Journal of clinical pharmacy and therapeutics 2009) 3 23 43 56
  3. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. (PMID: 15879435) Tantisira KG … Liggett SB (Human molecular genetics 2005) 3 4 23 56
  4. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. (PMID: 12972952) Small KM … Liggett SB (Pharmacogenetics 2003) 3 4 23 56
  5. Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. (PMID: 11840511) Toyota T … Yoshikawa T (American journal of medical genetics 2002) 3 23 43 56

Products for ADCY9 Gene

Sources for ADCY9 Gene