Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTP... See more...

Aliases for ADCY8 Gene

Aliases for ADCY8 Gene

  • Adenylate Cyclase 8 2 3 5
  • Ca(2+)/Calmodulin-Activated Adenylyl Cyclase 3 4
  • Adenylate Cyclase Type VIII 3 4
  • Adenylate Cyclase 8 (Brain) 2 3
  • ATP Pyrophosphate-Lyase 8 3 4
  • Adenylate Cyclase Type 8 3 4
  • Adenylyl Cyclase 8 3 4
  • EC 4.6.1.1 4 52
  • AC8 3 4
  • Epididymis Secretory Sperm Binding Protein Li 172mP 3
  • Adenylyl Cyclase-8, Brain 3
  • HEL-S-172mP 3
  • HBAC1 3
  • ADCY3 3

External Ids for ADCY8 Gene

Previous HGNC Symbols for ADCY8 Gene

  • ADCY3

Previous GeneCards Identifiers for ADCY8 Gene

  • GC08M130592
  • GC08M131808
  • GC08M131463
  • GC08M131749
  • GC08M131725
  • GC08M131861
  • GC08M127112

Summaries for ADCY8 Gene

Entrez Gene Summary for ADCY8 Gene

  • Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY8 Gene

ADCY8 (Adenylate Cyclase 8) is a Protein Coding gene. Diseases associated with ADCY8 include Dissociative Amnesia and Mood Disorder. Among its related pathways are Signaling by GPCR and Oocyte meiosis. Gene Ontology (GO) annotations related to this gene include nucleotide binding and adenylate cyclase activity. An important paralog of this gene is ADCY6.

UniProtKB/Swiss-Prot Summary for ADCY8 Gene

  • Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.

Tocris Summary for ADCY8 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY8 Gene

Additional gene information for ADCY8 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADCY8 Gene

Genomics for ADCY8 Gene

GeneHancer (GH) Regulatory Elements for ADCY8 Gene

Promoters and enhancers for ADCY8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J131041 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.3 -303 1.4 USF1 EZH2 POLR2A CREB1 SMC3 PHF8 SIN3A JUN JUND RNF2 ADCY8 LOC105375760 lnc-EFR3A-2 piR-51592
GH08J131040 Promoter 0.7 Ensembl 500.7 +1.1 1097 0.2 SMC3 RNF2 CTCF EZH2 SUZ12 RAD21 RBBP5 ADCY8 LOC105375760 lnc-EFR3A-2
GH08J130852 Enhancer 0.4 FANTOM5 3.9 +189.2 189197 0.4 CTCF RAD21 SMARCA4 ADCY8 LOC105375762 LOC105375761
GH08J131032 Enhancer 0.7 Ensembl ENCODE 0.4 +8.7 8697 2.6 TEAD4 ZNF316 MAFF YY1 MAFK ETS1 EP300 SP1 NANOG RBBP5 ADCY8 lnc-EFR3A-2 ENSG00000253992
GH08J131028 Enhancer 0.4 ENCODE 0.4 +12.7 12668 0.1 CTCF ZNF610 RAD21 ZNF143 ADCY8 lnc-EFR3A-2 ENSG00000253992
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADCY8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADCY8

Top Transcription factor binding sites by QIAGEN in the ADCY8 gene promoter:
  • C/EBPalpha
  • Egr-4
  • FOXO1
  • FOXO1a
  • FOXO4
  • LCR-F1
  • Pax-4a
  • Pax-5
  • Sp1

Genomic Locations for ADCY8 Gene

Genomic Locations for ADCY8 Gene
chr8:130,780,300-131,041,598
(GRCh38/hg38)
Size:
261,299 bases
Orientation:
Minus strand
chr8:131,792,547-132,054,672
(GRCh37/hg19)
Size:
262,126 bases
Orientation:
Minus strand

Genomic View for ADCY8 Gene

Genes around ADCY8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY8 Gene

Proteins for ADCY8 Gene

  • Protein details for ADCY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40145-ADCY8_HUMAN
    Recommended name:
    Adenylate cyclase type 8
    Protein Accession:
    P40145

    Protein attributes for ADCY8 Gene

    Size:
    1251 amino acids
    Molecular mass:
    140122 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer; via transmembrane domain. Monomer. Heterodimer. Oligemer; via transmembrane domain. Interacts with PRKAR2A and AKAP5; inhibits adenylate cyclase activity through PKA phosphorylation. Interacts with PPP2CA and PPP2R1A; does not mediate the inhibitory effects of PKA on adenylate cyclase activity; interaction is dependent of catalytically active PPP2CA; antagonizes interaction with calmodulin. Interacts with AKAP5 (palmitoylated form); promotes the phosphorylation of ADCY8 after store-operated calcium entry (SOCE) stimulation at membrane raft. Interacts with ORAI1; interaction is calcium store depletion independent; interaction occurs in membrane raft; interaction increases markedly after store depletion; positively regulates SOCE-induced adenylate cyclase activity; contributes to the targeting of ADCY8 to discrete regions of the plasma membrane that are shielded from other calcium events. Interacts with STIM1. Interacts with actin; interaction is calcium independent; interaction is affected by calcium-calmodulin; interaction controls the distribution and regulation of ADCY8. Interacts with calmodulin; at rest, interacts via N-terminal domain; upon a calcium rise, calmodulin becomes calcium-saturated and subsequently binds to the C-terminal domain forming an autoinhibitory complex; fully calcium-saturated calmodulin leaves the N-terminal domain, binding solely to the C-terminal domain leading to dissociation of autoinhibitory complex and resulting in activation of adenylate cyclase; antagonizes interaction with PPP2CA; interaction is calcium dependent. Interacts with PPP2R5D.

neXtProt entry for ADCY8 Gene

Selected DME Specific Peptides for ADCY8 Gene

P40145:
  • VLCGVLGLRKWQ
  • LERLYQRYF
  • SRMDSTGV
  • RIKILGDCYYC
  • TYMAVSGL
  • EKIKTIG
  • VDMRIGIH
  • EELYSQSYD
  • CGVLGLRKWQFDVWS
  • DHAHCCVEMG
  • ECLRLLNEII

Post-translational modifications for ADCY8 Gene

  • Phosphorylated by PKA; mediates inhibition of adenylate cyclase activity at membrane raft; does not influence either CALM1 or PPP2CA interaction with ADCY8.
  • N-glycosylated; N-glycosylation is responsible for raft-targeting; is not necessary for CCE-stimulated adenylate cyclase activity.
  • Glycosylation at Asn817, Asn821, and Asn888
  • Modification sites at PhosphoSitePlus

Other Protein References for ADCY8 Gene

Domains & Families for ADCY8 Gene

Gene Families for ADCY8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADCY8 Gene

Blocks:
  • Adenylate cyclase-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADCY8 Gene

GenScript: Design optimal peptide antigens:
  • Ca(2+)/calmodulin-activated adenylyl cyclase (ADCY8_HUMAN)
  • Brain adenylate cyclase 8 (Q4F7X0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40145

UniProtKB/Swiss-Prot:

ADCY8_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. The two transmembrane clusters are necessary and suficient for the plasma membrane targeting and oligomers assembly. The N-terminal and C-terminal domains interact at rest as part of a larger autoinhibitory complex, with calmodulin pre-associated at the N-terminal domain; the binding is specifically inhibited by fully calcium-saturated calmodulin, resulting in activation of AC8.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. The two transmembrane clusters are necessary and suficient for the plasma membrane targeting and oligomers assembly. The N-terminal and C-terminal domains interact at rest as part of a larger autoinhibitory complex, with calmodulin pre-associated at the N-terminal domain; the binding is specifically inhibited by fully calcium-saturated calmodulin, resulting in activation of AC8.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY8: view

Function for ADCY8 Gene

Molecular function for ADCY8 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
At rest, the N- and C-terminal domains interact, as part of a larger autoinhibitory complex, with calmodulin pre-associated at the N-terminal domain. Upon a calcium rise, calmodulin becomes calcium-saturated and subsequently binds to the C-terminal domain. Fully calcium-saturated calmodulin then leaves the N-terminal domain, binding solely to the C-terminal domain, and the whole autoinhibitory complex dissociates, resulting in activation of adenylate cyclase. As local calcium concentrations decrease, the calmodulin becomes calcium free and binds once more to the N-terminal domain, whereupon the whole system returns to rest with the re-association of the autoinhibitory complex. In non-excitable cells, activated by capacitative calcium entry (CCE) through store-operated channels, namely through interaction with ORAI1 and STIM1; membrane raft and caveolae localization and membrane integrity are indispensable. CCE-mediated adenylate cyclase activity is decreased by AKAP5 and AKAP7. CCE-mediated adenylate cyclase activity is up-regulated by AKAP9 and the mitochondrially targeted AKAP1. In excitable cells, activated during membrane depolarization through L-type voltage-gated calcium channels (VGCC), leading to calcium entry; the L-type alpha subunit is sufficient. Activated via stimulation of the GLP1R. Synergistically activated by calcium/calmodulin and GNAS. Stimulated by forskolin. Inhibited by PKA directly bound to AKAP5 at membrane raft. Inhibition by acute activation of OPRM1 and activation by chronic activation of OPRM1 is mediated by pertussis toxin-sensitive G(i) and G(o) G alpha proteins and G beta-gamma dimer. Activity is inhibited by G beta-gamma dimer.
GENATLAS Biochemistry:
adenylyl cyclase type VIII,brain

Enzyme Numbers (IUBMB) for ADCY8 Gene

Phenotypes From GWAS Catalog for ADCY8 Gene

Gene Ontology (GO) - Molecular Function for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0004016 adenylate cyclase activity IEA,TAS --
GO:0005516 calmodulin binding ISS --
GO:0005524 ATP binding IEA --
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity TAS,ISS --
genes like me logo Genes that share ontologies with ADCY8: view
genes like me logo Genes that share phenotypes with ADCY8: view

Animal Models for ADCY8 Gene

MGI Knock Outs for ADCY8:

Animal Model Products

CRISPR Products

miRNA for ADCY8 Gene

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY8 Gene

Localization for ADCY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY8 Gene

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Apical cell membrane. Cell junction, synapse. Cell projection, dendrite. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic density. Membrane raft. Membrane, coated pit. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, caveola. Note=Localized to dendritic arbors (By similarity). Monomeric N-glycosylated species localizes in membrane raft. In contrast, monomeric unglycosylated forms are enriched in clathrin-coated pits and vesicles. Dimers are also localized outside of membrane rafts. Membrane raft localization and integrity is indispensable for CCE-stimulated adenylate cyclase activity (By similarity). {ECO:0000250 UniProtKB:P40146, ECO:0000250 UniProtKB:P97490}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY8 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0005901 caveola ISS --
GO:0005905 clathrin-coated pit ISS --
genes like me logo Genes that share ontologies with ADCY8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADCY8 Gene

Pathways & Interactions for ADCY8 Gene

PathCards logo

SuperPathways for ADCY8 Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
.50
.38
.33
.32
.32
2 RET signaling
3 Aldosterone synthesis and secretion
4 Aquaporin-mediated transport
.40
5 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
genes like me logo Genes that share pathways with ADCY8: view

Pathways by source for ADCY8 Gene

12 GeneGo (Thomson Reuters) pathways for ADCY8 Gene
  • Beta-2 adrenergic-dependent CFTR expression
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
  • Development Beta-adrenergic receptors regulation of ERK
  • Development Beta-adrenergic receptors signaling via cAMP
  • Development Endothelin-1/EDNRA signaling
23 Qiagen pathways for ADCY8 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Breast Cancer Regulation by Stathmin1
  • cAMP Pathway

SIGNOR curated interactions for ADCY8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006171 cAMP biosynthetic process IBA,IEA 21873635
GO:0007165 signal transduction TAS 8076676
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADCY8: view

Drugs & Compounds for ADCY8 Gene

(15) Drugs for ADCY8 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphoric acid Approved Pharma 0
Calcium Approved Nutra 7884
NADH Approved Nutra 0
Pyruvic acid Approved, Investigational Nutra 0

(1) Additional Compounds for ADCY8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8

(5) Tocris Compounds for ADCY8 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
KH 7 Selective soluble adenylyl cyclase inhibitor 330676-02-3
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9

(1) ApexBio Compounds for ADCY8 Gene

Compound Action Cas Number
Forskolin 66575-29-9
genes like me logo Genes that share compounds with ADCY8: view

Drug Products

Transcripts for ADCY8 Gene

mRNA/cDNA for ADCY8 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2: - - -

Relevant External Links for ADCY8 Gene

GeneLoc Exon Structure for
ADCY8

Expression for ADCY8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADCY8 Gene

mRNA differential expression in normal tissues according to GTEx for ADCY8 Gene

This gene is overexpressed in Brain - Amygdala (x5.4), Brain - Hippocampus (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for ADCY8 Gene

This gene is overexpressed in Liver, secretome (32.4) and Spinal cord (26.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCY8 Gene



Protein tissue co-expression partners for ADCY8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADCY8

SOURCE GeneReport for Unigene cluster for ADCY8 Gene:

Hs.591859

mRNA Expression by UniProt/SwissProt for ADCY8 Gene:

P40145-ADCY8_HUMAN
Tissue specificity: Detected in brain cortex (PubMed:1715695). Expressed in islet (PubMed:25403481).

Evidence on tissue expression from TISSUES for ADCY8 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ADCY8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY8 Gene

Orthologs for ADCY8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY8 31 30
  • 99.19 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY8 31
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCY8 31
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY8 31 30
  • 92.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADCY8 31 30
  • 91.79 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy8 30
  • 90.28 (n)
mouse
(Mus musculus)
Mammalia Adcy8 17 31 30
  • 90.21 (n)
chicken
(Gallus gallus)
Aves ADCY8 31 30
  • 81.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY8 31
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy8 30
  • 79.42 (n)
zebrafish
(Danio rerio)
Actinopterygii adcy8 31 30
  • 74.61 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002262 30
  • 53.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ac78C 32 30
  • 52.28 (n)
rut 32
  • 45 (a)
Ac3 32
  • 36 (a)
ACXB 32
  • 30 (a)
ACXC 32
  • 29 (a)
ACXA 32
  • 28 (a)
ACXD 32
  • 28 (a)
ACXE 32
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-2 32
  • 36 (a)
acy-4 31 32
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToMany
-- 31
  • 40 (a)
OneToMany
Species where no ortholog for ADCY8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY8 Gene

ENSEMBL:
Gene Tree for ADCY8 (if available)
TreeFam:
Gene Tree for ADCY8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADCY8: view image

Paralogs for ADCY8 Gene

(9) SIMAP similar genes for ADCY8 Gene using alignment to 5 proteins:

  • ADCY8_HUMAN
  • E5RFR2_HUMAN
  • E7EVL1_HUMAN
  • L8E7I7_HUMAN
  • Q4F7X0_HUMAN
genes like me logo Genes that share paralogs with ADCY8: view

Variants for ADCY8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADCY8 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
VAR_036328 A colorectal cancer sample p.Phe881Leu
rs2228949 - p.Ala80Thr

Additional dbSNP identifiers (rs#s) for ADCY8 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADCY8 Gene

Variant ID Type Subtype PubMed ID
dgv1195n67 CNV gain 20364138
dgv12333n54 CNV loss 21841781
dgv12334n54 CNV loss 21841781
dgv12335n54 CNV loss 21841781
dgv12336n54 CNV loss 21841781
dgv12337n54 CNV loss 21841781
dgv3904n106 CNV deletion 24896259
dgv7311n100 CNV gain 25217958
esv1000595 CNV deletion 20482838
esv1011202 CNV deletion 20482838
esv1235416 CNV deletion 17803354
esv25237 CNV gain+loss 19812545
esv2655219 CNV insertion 19546169
esv2669733 CNV deletion 23128226
esv2675868 CNV deletion 23128226
esv2737587 CNV deletion 23290073
esv2761471 CNV gain 21179565
esv3270163 CNV deletion 24192839
esv3362459 CNV duplication 20981092
esv3379880 CNV duplication 20981092
esv3385643 CNV duplication 20981092
esv3544214 CNV deletion 23714750
esv3572992 CNV loss 25503493
esv3572993 CNV loss 25503493
esv3618837 CNV loss 21293372
esv3618838 CNV gain 21293372
esv3618839 CNV loss 21293372
esv3618840 CNV loss 21293372
esv6594 CNV loss 19470904
nsv1016494 CNV gain 25217958
nsv1028579 CNV gain 25217958
nsv1122202 CNV deletion 24896259
nsv1142034 OTHER inversion 24896259
nsv396197 CNV deletion 16902084
nsv472660 CNV novel sequence insertion 20440878
nsv475802 CNV novel sequence insertion 20440878
nsv478549 CNV novel sequence insertion 20440878
nsv512069 CNV loss 21212237
nsv512966 CNV insertion 21212237
nsv525692 CNV gain 19592680
nsv612294 CNV gain 21841781
nsv612295 CNV loss 21841781
nsv6397 CNV insertion 18451855
nsv819677 CNV gain 19587683
nsv821256 CNV deletion 20802225
nsv824732 CNV loss 20364138
nsv831462 CNV gain 17160897
nsv957657 CNV deletion 24416366
nsv972586 CNV deletion 23825009

Variation tolerance for ADCY8 Gene

Residual Variation Intolerance Score: 2.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADCY8 Gene

Human Gene Mutation Database (HGMD)
ADCY8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY8 Gene

Disorders for ADCY8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADCY8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dissociative amnesia
  • psychogenic amnesia
mood disorder
  • episodic mood disorder
joubert syndrome 24
  • jbts24
- elite association - COSMIC cancer census association via MalaCards
Search ADCY8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADCY8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADCY8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADCY8 Gene

Publications for ADCY8 Gene

  1. Molecular cloning of the human type VIII adenylyl cyclase. (PMID: 8076676) Defer N … Hanoune J (FEBS letters 1994) 2 3 4 54
  2. Multilevel control of glucose homeostasis by adenylyl cyclase 8. (PMID: 25403481) Raoux M … Lang J (Diabetologia 2015) 3 4 54
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 41 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41 54

Products for ADCY8 Gene

Sources for ADCY8 Gene