This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for t... See more...

Aliases for ADCY7 Gene

Aliases for ADCY7 Gene

  • Adenylate Cyclase 7 2 3 5
  • Adenylate Cyclase Type VII 3 4
  • ATP Pyrophosphate-Lyase 7 3 4
  • Adenylate Cyclase Type 7 3 4
  • Adenylyl Cyclase 7 3 4
  • EC 4.6.1.1 4 54
  • KIAA0037 4
  • EC 4.6.1 54
  • AC7 3

External Ids for ADCY7 Gene

Previous GeneCards Identifiers for ADCY7 Gene

  • GC16P040735
  • GC16P050347
  • GC16P050045
  • GC16P050099
  • GC16P048880
  • GC16P036209
  • GC16P050280

Summaries for ADCY7 Gene

Entrez Gene Summary for ADCY7 Gene

  • This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

GeneCards Summary for ADCY7 Gene

ADCY7 (Adenylate Cyclase 7) is a Protein Coding gene. Among its related pathways are Oxytocin signaling pathway and Adenylate cyclase inhibitory pathway. Gene Ontology (GO) annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY2.

UniProtKB/Swiss-Prot Summary for ADCY7 Gene

  • Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).

Tocris Summary for ADCY7 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY7 Gene

Additional gene information for ADCY7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADCY7 Gene

Genomics for ADCY7 Gene

GeneHancer (GH) Regulatory Elements for ADCY7 Gene

Promoters and enhancers for ADCY7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J050243 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 756.1 +0.9 939 3.4 ZNF24 ZBTB40 CTCF SMARCE1 ZNF362 MYC CC2D1A L3MBTL2 MAX POLR2A ADCY7 HSALNG0111328 HEATR3 piR-43105-235
GH16J050287 Promoter/Enhancer 0.5 EPDnew dbSUPER 750.3 +43.2 43174 0.1 ADCY7 BRD7 MIR6771 lnc-PAPD5-2
GH16J050693 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.4 +452.1 452083 7.7 ZNF785 SP1 MLX RBPJ USF2 NR2F6 CREB1 RELA L3MBTL2 ZFP41 NOD2 SNX20 LINC02168 ENSG00000260573 RPL10P14 ENSG00000261835 ENSG00000259843 ENSG00000261751 RPL34P29 HNRNPA1P48
GH16J050280 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +38.1 38134 4.8 GTF3C2 ZNF24 SP1 SMARCE1 NR2F1 NR2F6 MYC NFYC ETV6 RELA HEATR3 ADCY7 CYLD TENT4B NOD2 CNEP1R1 SNX20 MIR6771 lnc-PAPD5-2
GH16J050740 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.3 +499.7 499736 7.7 ZNF24 SP1 ZBTB40 CTCF SIX5 RBPJ POLR2A ATF1 FOS CREB1 CYLD ENSG00000261644 LOC102724907 NOD2 TENT4B SNX20 BRD7 ADCY7 MIR3181 ENSG00000260616
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADCY7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADCY7 gene promoter:
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • GR-beta
  • STAT3

Genomic Locations for ADCY7 Gene

Genomic Locations for ADCY7 Gene
chr16:50,244,749-50,318,135
(GRCh38/hg38)
Size:
73,387 bases
Orientation:
Plus strand
chr16:50,280,048-50,352,046
(GRCh37/hg19)
Size:
71,999 bases
Orientation:
Plus strand

Genomic View for ADCY7 Gene

Genes around ADCY7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY7 Gene

Proteins for ADCY7 Gene

  • Protein details for ADCY7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51828-ADCY7_HUMAN
    Recommended name:
    Adenylate cyclase type 7
    Protein Accession:
    P51828
    Secondary Accessions:
    • A0AVA6

    Protein attributes for ADCY7 Gene

    Size:
    1080 amino acids
    Molecular mass:
    120308 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA05021.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADCY7 Gene

Selected DME Specific Peptides for ADCY7 Gene

P51828:
  • LNELFGKFD
  • RIKILGDCYYC
  • ADIVGFT
  • TVNVASR
  • KIQVTEET
  • LPAHVAAHF
  • AGVIGARKP
  • TRYLESWGAA
  • WQYDVWS
  • GNVLCGV
  • EKIKTIG
  • ATGVDINMRVG
  • NNFHSLYVKRHQ
  • MRVGIHSG
  • ASRMEST
  • ECLRLLNEII

Post-translational modifications for ADCY7 Gene

  • Phosphorylated by PRKCD.
  • Glycosylation at Asn701, Asn776, and Asn781
  • Ubiquitination at Lys443, Lys579, and Lys1073
  • Modification sites at PhosphoSitePlus

Domains & Families for ADCY7 Gene

Gene Families for ADCY7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADCY7 Gene

Suggested Antigen Peptide Sequences for ADCY7 Gene

GenScript: Design optimal peptide antigens:
  • Adenylyl cyclase 7 (ADCY7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51828

UniProtKB/Swiss-Prot:

ADCY7_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY7: view

Function for ADCY7 Gene

Molecular function for ADCY7 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence={ECO:0000305 PubMed:18541530, ECO:0000305 PubMed:23229509};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the G protein alpha subunit (PubMed:18541530). Activated by the G protein beta and gamma subunit complex (PubMed:23229509). Activated by GNA13 and GNA12 (PubMed:18541530). Ethanol and phorbol 12,13-dibutanoate significantly potentiate adenylate cyclase activity generated in response to the activation of the prostanoid receptor by the agonist prostaglandin E1(1-) in a PKC-dependent manner (PubMed:12454008). Inhibited by lithium (By similarity).
GENATLAS Biochemistry:
adenylyl cyclase,type VII

Enzyme Numbers (IUBMB) for ADCY7 Gene

Phenotypes From GWAS Catalog for ADCY7 Gene

Gene Ontology (GO) - Molecular Function for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IMP,IBA 18541530
GO:0005524 ATP binding IEA --
GO:0016829 lyase activity IEA --
GO:0016849 phosphorus-oxygen lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADCY7: view
genes like me logo Genes that share phenotypes with ADCY7: view

Animal Models for ADCY7 Gene

MGI Knock Outs for ADCY7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY7

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY7 Gene

Localization for ADCY7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY7 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 11113152
genes like me logo Genes that share ontologies with ADCY7: view

Pathways & Interactions for ADCY7 Gene

PathCards logo

SuperPathways for ADCY7 Gene

genes like me logo Genes that share pathways with ADCY7: view

SIGNOR curated interactions for ADCY7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002819 regulation of adaptive immune response ISS --
GO:0003091 renal water homeostasis TAS --
GO:0006171 cAMP biosynthetic process IDA 11113152
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADCY7: view

Drugs & Compounds for ADCY7 Gene

(17) Drugs for ADCY7 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphoric acid Approved Pharma 0
Calcium Approved Nutra 7773
NADH Approved Nutra 0
Pyruvic acid Approved, Investigational Nutra 0

(1) Additional Compounds for ADCY7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8

(5) Tocris Compounds for ADCY7 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
KH 7 Selective soluble adenylyl cyclase inhibitor 330676-02-3
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9
genes like me logo Genes that share compounds with ADCY7: view

Transcripts for ADCY7 Gene

mRNA/cDNA for ADCY7 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: -
SP3: - - - - -
SP4:
SP5:

ExUns: 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ADCY7 Gene

GeneLoc Exon Structure for
ADCY7
ECgene alternative splicing isoforms for
ADCY7

Expression for ADCY7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCY7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY7 Gene

This gene is overexpressed in Whole Blood (x6.5).

Protein differential expression in normal tissues from HIPED for ADCY7 Gene

This gene is overexpressed in Monocytes (27.6), Peripheral blood mononuclear cells (12.2), Placenta (11.3), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADCY7 Gene



Protein tissue co-expression partners for ADCY7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADCY7 Gene:

ADCY7

SOURCE GeneReport for Unigene cluster for ADCY7 Gene:

Hs.513578

Evidence on tissue expression from TISSUES for ADCY7 Gene

  • Bone marrow(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ADCY7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY7 Gene

Orthologs for ADCY7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY7 33 32
  • 98.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADCY7 33 32
  • 85.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY7 33 32
  • 85.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy7 32
  • 83.38 (n)
mouse
(Mus musculus)
Mammalia Adcy7 17 33 32
  • 83.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY7 33
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCY7 33
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCY7 33 32
  • 64.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY7 33
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy7 32
  • 61.75 (n)
Str.13076 32
African clawed frog
(Xenopus laevis)
Amphibia LOC399055 32
zebrafish
(Danio rerio)
Actinopterygii adcy7 33 32
  • 61.37 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 33 34
  • 32 (a)
OneToMany
ACXD 34
  • 28 (a)
ACXB 34
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-4 34
  • 50 (a)
acy-2 33 34
  • 29 (a)
OneToMany
Species where no ortholog for ADCY7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY7 Gene

ENSEMBL:
Gene Tree for ADCY7 (if available)
TreeFam:
Gene Tree for ADCY7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADCY7: view image

Paralogs for ADCY7 Gene

(22) SIMAP similar genes for ADCY7 Gene using alignment to 7 proteins:

  • ADCY7_HUMAN
  • F5H4D1_HUMAN
  • F5H699_HUMAN
  • H3BMA5_HUMAN
  • H3BQ93_HUMAN
  • I3L2Y1_HUMAN
  • I3L3Q5_HUMAN

Pseudogenes.org Pseudogenes for ADCY7 Gene

genes like me logo Genes that share paralogs with ADCY7: view

Variants for ADCY7 Gene

Sequence variations from dbSNP and Humsavar for ADCY7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000025031 -- 50,254,565(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000048117 -- 50,294,012(+) C/A intron_variant
rs1000121288 -- 50,312,450(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000164472 -- 50,277,426(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000183954 -- 50,316,571(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY7 Gene

Variant ID Type Subtype PubMed ID
nsv1805 CNV deletion 18451855
nsv952672 CNV deletion 24416366

Variation tolerance for ADCY7 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADCY7 Gene

Human Gene Mutation Database (HGMD)
ADCY7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY7 Gene

Disorders for ADCY7 Gene

Additional Disease Information for ADCY7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADCY7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY7 Gene

Publications for ADCY7 Gene

  1. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. (PMID: 15581358) Beeler JA … Tang WJ (Biochemistry 2004) 3 4 23 56
  2. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. (PMID: 12454008) Nelson EJ … Tabakoff B (The Journal of biological chemistry 2003) 3 4 23 56
  3. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. (PMID: 7860067) Hellevuo K … Tabakoff B (Human genetics 1995) 2 3 23 56
  4. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells. (PMID: 23842570) Ehrlich AT … Narumiya S (Molecular pharmacology 2013) 3 4 56
  5. Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway. (PMID: 23229509) Jiang LI … Sternweis PC (Molecular pharmacology 2013) 3 4 56

Products for ADCY7 Gene

Sources for ADCY7 Gene