This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for t... See more...

Aliases for ADCY7 Gene

Aliases for ADCY7 Gene

  • Adenylate Cyclase 7 2 3 5
  • Adenylate Cyclase Type VII 3 4
  • ATP Pyrophosphate-Lyase 7 3 4
  • Adenylate Cyclase Type 7 3 4
  • Adenylyl Cyclase 7 3 4
  • EC 4.6.1.1 4 51
  • KIAA0037 2 4
  • AC7 2 3
  • EC 4.6.1 51
  • ADCY7 5

External Ids for ADCY7 Gene

Previous GeneCards Identifiers for ADCY7 Gene

  • GC16P040735
  • GC16P050347
  • GC16P050045
  • GC16P050099
  • GC16P048880
  • GC16P036209
  • GC16P050280
  • GC16P050244

Summaries for ADCY7 Gene

Entrez Gene Summary for ADCY7 Gene

  • This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

GeneCards Summary for ADCY7 Gene

ADCY7 (Adenylate Cyclase 7) is a Protein Coding gene. Diseases associated with ADCY7 include Bronchiectasis 1 and Cutaneous Anthrax. Among its related pathways are Adenylate cyclase inhibitory pathway and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY2.

UniProtKB/Swiss-Prot Summary for ADCY7 Gene

  • Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).

Tocris Summary for ADCY7 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADCY7 Gene

Genomics for ADCY7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADCY7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J050243 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 606.1 -0.4 -449 3.4 HNRNPL PRDM10 LEF1 IKZF1 ZNF692 JUND LARP7 DDX20 PHF21A ZIC2 ADCY7 HSALNG0111328 HEATR3 TENT4B
GH16J050287 Promoter/Enhancer 0.6 EPDnew dbSUPER 600.3 +41.8 41786 0.1 POLR2A ADCY7 BRD7 MIR6771 lnc-PAPD5-2
GH16J050693 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.4 +450.7 450695 7.7 SP1 CREB1 GATAD2A PRDM10 TFE3 SOX13 IKZF1 BACH1 JUND LARP7 NOD2 SNX20 HNRNPA1P48 CYLD ADCY7 NONHSAG019425.2 piR-51401
GH16J050280 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +36.7 36746 4.8 SP1 HNRNPL GATAD2A TFE3 NFKBIZ RCOR2 BACH1 LARP7 RELA RXRB HEATR3 ADCY7 CYLD TENT4B NOD2 CNEP1R1 SNX20 MIR6771 lnc-PAPD5-2 BRD7
GH16J050250 Enhancer 0.5 ENCODE 13.7 +5.6 5580 2 HNRNPL PKNOX1 CEBPB FOS MAFK ADCY7 HEATR3 piR-43105-235 BRD7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADCY7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADCY7

Top Transcription factor binding sites by QIAGEN in the ADCY7 gene promoter:
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • GR-beta
  • STAT3

Genomic Locations for ADCY7 Gene

Genomic Locations for ADCY7 Gene
chr16:50,246,137-50,318,135
(GRCh38/hg38)
Size:
71,999 bases
Orientation:
Plus strand
chr16:50,280,048-50,352,046
(GRCh37/hg19)
Size:
71,999 bases
Orientation:
Plus strand

Genomic View for ADCY7 Gene

Genes around ADCY7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY7 Gene

Proteins for ADCY7 Gene

  • Protein details for ADCY7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51828-ADCY7_HUMAN
    Recommended name:
    Adenylate cyclase type 7
    Protein Accession:
    P51828
    Secondary Accessions:
    • A0AVA6

    Protein attributes for ADCY7 Gene

    Size:
    1080 amino acids
    Molecular mass:
    120308 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA05021.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADCY7 Gene

Selected DME Specific Peptides for ADCY7 Gene

P51828:
  • LNELFGKFD
  • RIKILGDCYYC
  • ADIVGFT
  • TVNVASR
  • KIQVTEET
  • LPAHVAAHF
  • AGVIGARKP
  • TRYLESWGAA
  • WQYDVWS
  • GNVLCGV
  • EKIKTIG
  • ATGVDINMRVG
  • NNFHSLYVKRHQ
  • MRVGIHSG
  • ASRMEST
  • ECLRLLNEII

Post-translational modifications for ADCY7 Gene

  • Phosphorylated by PRKCD.
  • Glycosylation at Asn701, Asn776, and Asn781
  • Ubiquitination at Lys443, Lys579, and Lys1073
  • Modification sites at PhosphoSitePlus

Domains & Families for ADCY7 Gene

Gene Families for ADCY7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADCY7 Gene

InterPro:
Blocks:
  • Adenylate cyclase-like
ProtoNet:

Suggested Antigen Peptide Sequences for ADCY7 Gene

GenScript: Design optimal peptide antigens:
  • Adenylyl cyclase 7 (ADCY7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51828

UniProtKB/Swiss-Prot:

ADCY7_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY7: view

Function for ADCY7 Gene

Molecular function for ADCY7 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence={ECO:0000305|PubMed:18541530, ECO:0000305|PubMed:23229509};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the G protein alpha subunit (PubMed:18541530). Activated by the G protein beta and gamma subunit complex (PubMed:23229509). Activated by GNA13 and GNA12 (PubMed:18541530). Ethanol and phorbol 12,13-dibutanoate significantly potentiate adenylate cyclase activity generated in response to the activation of the prostanoid receptor by the agonist prostaglandin E1(1-) in a PKC-dependent manner (PubMed:12454008). Inhibited by lithium (By similarity).
GENATLAS Biochemistry:
adenylyl cyclase,type VII

Enzyme Numbers (IUBMB) for ADCY7 Gene

Phenotypes From GWAS Catalog for ADCY7 Gene

Gene Ontology (GO) - Molecular Function for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004016 adenylate cyclase activity IBA,IMP 18541530
GO:0005524 ATP binding IEA --
GO:0016829 lyase activity IEA --
GO:0016849 phosphorus-oxygen lyase activity IEA --
genes like me logo Genes that share ontologies with ADCY7: view
genes like me logo Genes that share phenotypes with ADCY7: view

Animal Models for ADCY7 Gene

MGI Knock Outs for ADCY7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY7 Gene

Localization for ADCY7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY7 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 11113152
genes like me logo Genes that share ontologies with ADCY7: view

Pathways & Interactions for ADCY7 Gene

PathCards logo

SuperPathways for ADCY7 Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
.50
.38
.33
.32
.32
2 RET signaling
3 Aldosterone synthesis and secretion
4 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
5 Adenylate cyclase inhibitory pathway
genes like me logo Genes that share pathways with ADCY7: view

Pathways by source for ADCY7 Gene

12 GeneGo (Thomson Reuters) pathways for ADCY7 Gene
  • Beta-2 adrenergic-dependent CFTR expression
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
  • Development Beta-adrenergic receptors regulation of ERK
  • Development Beta-adrenergic receptors signaling via cAMP
  • Development Endothelin-1/EDNRA signaling
23 Qiagen pathways for ADCY7 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Breast Cancer Regulation by Stathmin1
  • cAMP Pathway

SIGNOR curated interactions for ADCY7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002819 regulation of adaptive immune response ISS --
GO:0003091 renal water homeostasis TAS --
GO:0006171 cAMP biosynthetic process IDA 11113152
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADCY7: view

Drugs & Compounds for ADCY7 Gene

(17) Drugs for ADCY7 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphoric acid Approved Pharma 0
NADH Approved Nutra 0
Pyruvic acid Approved, Investigational Nutra 0
cyclic amp Experimental Pharma 0

(1) Additional Compounds for ADCY7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8

(5) Tocris Compounds for ADCY7 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
KH 7 Selective soluble adenylyl cyclase inhibitor 330676-02-3
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9
genes like me logo Genes that share compounds with ADCY7: view

Transcripts for ADCY7 Gene

mRNA/cDNA for ADCY7 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY7

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: -
SP3: - - - - -
SP4:
SP5:

ExUns: 25 ^ 26 ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ADCY7 Gene

GeneLoc Exon Structure for
ADCY7

Expression for ADCY7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADCY7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY7 Gene

This gene is overexpressed in Whole Blood (x6.5).

Protein differential expression in normal tissues from HIPED for ADCY7 Gene

This gene is overexpressed in Monocytes (27.6), Peripheral blood mononuclear cells (12.2), Placenta (11.3), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADCY7 Gene



Protein tissue co-expression partners for ADCY7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADCY7

SOURCE GeneReport for Unigene cluster for ADCY7 Gene:

Hs.513578

Evidence on tissue expression from TISSUES for ADCY7 Gene

  • Bone marrow(4.3)
  • Blood(2.8)
  • Nervous system(2.7)
  • Kidney(2.4)
  • Intestine(2.3)
  • Skin(2.3)
  • Spleen(2.2)
  • Lung(2.2)
  • Pancreas(2.1)
  • Heart(2.1)
  • Liver(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ADCY7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY7 Gene

Orthologs for ADCY7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADCY7 30 31
  • 98.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADCY7 30 31
  • 85.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADCY7 30 31
  • 85.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adcy7 30
  • 83.38 (n)
Mouse
(Mus musculus)
Mammalia Adcy7 30 17 31
  • 83.04 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ADCY7 31
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADCY7 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADCY7 30 31
  • 64.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADCY7 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adcy7 30
  • 61.75 (n)
Str.13076 30
African clawed frog
(Xenopus laevis)
Amphibia LOC399055 30
Zebrafish
(Danio rerio)
Actinopterygii adcy7 30 31
  • 61.37 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Ac76E 31 32
  • 32 (a)
OneToMany
ACXD 32
  • 28 (a)
ACXB 32
  • 27 (a)
Worm
(Caenorhabditis elegans)
Secernentea acy-4 32
  • 50 (a)
acy-2 31 32
  • 29 (a)
OneToMany
Species where no ortholog for ADCY7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADCY7 Gene

ENSEMBL:
Gene Tree for ADCY7 (if available)
TreeFam:
Gene Tree for ADCY7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADCY7: view image

Paralogs for ADCY7 Gene

(22) SIMAP similar genes for ADCY7 Gene using alignment to 7 proteins:

  • ADCY7_HUMAN
  • F5H4D1_HUMAN
  • F5H699_HUMAN
  • H3BMA5_HUMAN
  • H3BQ93_HUMAN
  • I3L2Y1_HUMAN
  • I3L3Q5_HUMAN

Pseudogenes.org Pseudogenes for ADCY7 Gene

genes like me logo Genes that share paralogs with ADCY7: view

Variants for ADCY7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADCY7 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
754465 Likely Benign: not provided 50,307,133(+) C/T SYNONYMOUS_VARIANT
768778 Benign: not provided 50,314,038(+) C/T SYNONYMOUS_VARIANT
773581 Benign: not provided 50,308,801(+) C/T INTRON_VARIANT
777014 Benign: not provided 50,305,572(+) G/A SYNONYMOUS_VARIANT
781839 Benign: not provided 50,298,984(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ADCY7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADCY7 Gene

Variant ID Type Subtype PubMed ID
nsv1805 CNV deletion 18451855
nsv952672 CNV deletion 24416366

Variation tolerance for ADCY7 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADCY7 Gene

Human Gene Mutation Database (HGMD)
ADCY7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY7 Gene

Disorders for ADCY7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ADCY7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bronchiectasis 1
cutaneous anthrax
  • anthrax, skin type
inhalation anthrax
  • pulmonary anthrax
sleeping sickness
  • african sleeping sickness
- elite association - COSMIC cancer census association via MalaCards
Search ADCY7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADCY7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADCY7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADCY7 Gene

Publications for ADCY7 Gene

  1. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. (PMID: 15581358) Beeler JA … Tang WJ (Biochemistry 2004) 3 4 23
  2. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. (PMID: 12454008) Nelson EJ … Tabakoff B (The Journal of biological chemistry 2003) 3 4 23
  3. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. (PMID: 7860067) Hellevuo K … Tabakoff B (Human genetics 1995) 2 3 23
  4. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells. (PMID: 23842570) Ehrlich AT … Narumiya S (Molecular pharmacology 2013) 3 4
  5. Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway. (PMID: 23229509) Jiang LI … Sternweis PC (Molecular pharmacology 2013) 3 4

Products for ADCY7 Gene

Sources for ADCY7 Gene