Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADCY4 Gene

Aliases for ADCY4 Gene

  • Adenylate Cyclase 4 2 3 5
  • Adenylate Cyclase Type IV 3 4
  • ATP Pyrophosphate-Lyase 4 3 4
  • Adenylyl Cyclase 4 3 4
  • Adenylate Cyclase Type 4 3
  • EC 4.6.1.1 4
  • AC4 3

External Ids for ADCY4 Gene

Previous GeneCards Identifiers for ADCY4 Gene

  • GC14M022160
  • GC14M018574
  • GC14M022777
  • GC14M023857
  • GC14M024787
  • GC14M004902

Summaries for ADCY4 Gene

Entrez Gene Summary for ADCY4 Gene

  • This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for ADCY4 Gene

ADCY4 (Adenylate Cyclase 4) is a Protein Coding gene. Among its related pathways are Ovarian steroidogenesis and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY2.

UniProtKB/Swiss-Prot for ADCY4 Gene

  • Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Tocris Summary for ADCY4 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY4 Gene

Additional gene information for ADCY4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY4 Gene

Genomics for ADCY4 Gene

GeneHancer (GH) Regulatory Elements for ADCY4 Gene

Promoters and enhancers for ADCY4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J024333 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 660.7 +0.6 583 2.4 ARID4B SIN3A ZNF48 SLC30A9 ZNF121 ARID2 ZNF207 ZNF143 RUNX3 SP3 ADCY4 RIPK3 LTB4R ENSG00000258973 PIR32510
GH14J024364 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.9 -32.9 -32913 6.1 HDGF PKNOX1 MLX ARID4B NEUROD1 SIN3A DMAP1 YBX1 ZNF2 ZBTB7B NFATC4 KHNYN ADCY4 SDR39U1 RNA5SP383 RIPK3 RNF31 TINF2 TM9SF1 CIDEB
GH14J024422 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -92.7 -92652 10.3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 NFYC CBLN3 KHNYN SDR39U1 NGDN RNA5SP383 NYNRIN TINF2 RNF31 ENSG00000259321 LOC102724814
GH14J024397 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 15.6 -65.7 -65723 6.7 KLF17 PLRG1 ZNF48 ZNF335 GLIS2 FOS SP3 ZHX2 ZNF398 PCBP2 KHNYN NYNRIN ADCY4 RNA5SP383 RNF31 TINF2 TM9SF1 CIDEB NGDN RIPK3
GH14J024375 Enhancer 0.9 Ensembl ENCODE dbSUPER 16.6 -41.3 -41320 1.2 CTCF POLR2A SIN3A PRDM10 ADCY4 RIPK3 NYNRIN KHNYN CBLN3 DHRS1 NFATC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADCY4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADCY4 gene promoter:

Genomic Locations for ADCY4 Gene

Genomic Locations for ADCY4 Gene
chr14:24,318,349-24,335,093
(GRCh38/hg38)
Size:
16,745 bases
Orientation:
Minus strand
chr14:24,787,555-24,804,299
(GRCh37/hg19)

Genomic View for ADCY4 Gene

Genes around ADCY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY4 Gene

Proteins for ADCY4 Gene

  • Protein details for ADCY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFM4-ADCY4_HUMAN
    Recommended name:
    Adenylate cyclase type 4
    Protein Accession:
    Q8NFM4
    Secondary Accessions:
    • B3KV74
    • D3DS75
    • Q17R40
    • Q6ZTM6
    • Q96ML7

    Protein attributes for ADCY4 Gene

    Size:
    1077 amino acids
    Molecular mass:
    119794 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71270.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ADCY4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY4 Gene

Post-translational modifications for ADCY4 Gene

  • Glycosylation at Asn704 and Asn697
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADCY4 Gene

Domains & Families for ADCY4 Gene

Gene Families for ADCY4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADCY4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFM4

UniProtKB/Swiss-Prot:

ADCY4_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY4: view

Function for ADCY4 Gene

Molecular function for ADCY4 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by forskolin. Insensitive to calcium/calmodulin. Stimulated by GNAS and by the G-protein beta and gamma subunit complex.
GENATLAS Biochemistry:
adenylate cyclase,type IV

Enzyme Numbers (IUBMB) for ADCY4 Gene

Phenotypes From GWAS Catalog for ADCY4 Gene

Gene Ontology (GO) - Molecular Function for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity ISS,IEA --
GO:0004383 guanylate cyclase activity IBA --
GO:0005080 protein kinase C binding IDA 17081159
GO:0005515 protein binding IPI 17081159
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ADCY4: view
genes like me logo Genes that share phenotypes with ADCY4: view

Animal Models for ADCY4 Gene

MGI Knock Outs for ADCY4:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADCY4 Gene

Localization for ADCY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY4 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY4 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 11549699
GO:0005886 plasma membrane IEA,TAS --
GO:0008074 guanylate cyclase complex, soluble IBA --
GO:0016020 membrane IEA,ISS --
genes like me logo Genes that share ontologies with ADCY4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADCY4 Gene

Pathways & Interactions for ADCY4 Gene

SuperPathways for ADCY4 Gene

SuperPathway Contained pathways
1 DAG and IP3 signaling
2 Aldosterone synthesis and secretion
3 RET signaling
4 Circadian entrainment
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with ADCY4: view

SIGNOR curated interactions for ADCY4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006171 cAMP biosynthetic process ISS,IEA --
GO:0006182 cGMP biosynthetic process IBA --
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADCY4: view

Drugs & Compounds for ADCY4 Gene

(15) Drugs for ADCY4 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0
NADH Approved Nutra 0
Pyruvic acid Approved, Investigational Nutra 0

(1) Additional Compounds for ADCY4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8

(5) Tocris Compounds for ADCY4 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
KH 7 Selective soluble adenylyl cyclase inhibitor 330676-02-3
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9

(1) ApexBio Compounds for ADCY4 Gene

Compound Action Cas Number
Forskolin 66575-29-9
genes like me logo Genes that share compounds with ADCY4: view

Drug Products

Transcripts for ADCY4 Gene

mRNA/cDNA for ADCY4 Gene

Unigene Clusters for ADCY4 Gene

Adenylate cyclase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
SP1: - - - - - -
SP2:
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for ADCY4 Gene

GeneLoc Exon Structure for
ADCY4
ECgene alternative splicing isoforms for
ADCY4

Expression for ADCY4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCY4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADCY4 Gene

This gene is overexpressed in Heart (45.0) and Placenta (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCY4 Gene



Protein tissue co-expression partners for ADCY4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADCY4 Gene:

ADCY4

SOURCE GeneReport for Unigene cluster for ADCY4 Gene:

Hs.443428

mRNA Expression by UniProt/SwissProt for ADCY4 Gene:

Q8NFM4-ADCY4_HUMAN
Tissue specificity: Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level).

Evidence on tissue expression from TISSUES for ADCY4 Gene

  • Lung(4.2)
  • Spleen(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ADCY4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY4 Gene

Orthologs for ADCY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY4 34 33
  • 99.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADCY4 34 33
  • 89.97 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY4 34 33
  • 89.31 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy4 16 34 33
  • 86.75 (n)
rat
(Rattus norvegicus)
Mammalia Adcy4 33
  • 86.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ADCY4 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ADCY4 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy4 33
  • 63.46 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01111926.1 34
  • 70 (a)
ManyToMany
adcy2b 34
  • 52 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 34 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acy-4 35
  • 49 (a)
acy-2 34 35
  • 29 (a)
OneToMany
Species where no ortholog for ADCY4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY4 Gene

ENSEMBL:
Gene Tree for ADCY4 (if available)
TreeFam:
Gene Tree for ADCY4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADCY4: view image

Paralogs for ADCY4 Gene

Paralogs for ADCY4 Gene

(11) SIMAP similar genes for ADCY4 Gene using alignment to 8 proteins:

  • ADCY4_HUMAN
  • G3V258_HUMAN
  • G3V262_HUMAN
  • H0YJ57_HUMAN
  • H0YLM0_HUMAN
  • H0YN72_HUMAN
  • Q6ZTM6_HUMAN
  • Q96KY6_HUMAN
genes like me logo Genes that share paralogs with ADCY4: view

Variants for ADCY4 Gene

Sequence variations from dbSNP and Humsavar for ADCY4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000125361 -- 24,321,788(-) C/T intron_variant
rs1000305647 -- 24,336,474(-) G/A upstream_transcript_variant
rs1000433857 -- 24,321,060(-) G/A intron_variant
rs1000675087 -- 24,319,871(-) G/A coding_sequence_variant, synonymous_variant
rs1001129793 -- 24,336,745(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY4 Gene

Variant ID Type Subtype PubMed ID
esv3362635 CNV insertion 20981092
nsv516237 CNV loss 19592680
nsv564059 CNV loss 21841781
nsv564060 CNV loss 21841781

Variation tolerance for ADCY4 Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADCY4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY4 Gene

Disorders for ADCY4 Gene

Additional Disease Information for ADCY4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADCY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY4 Gene

Publications for ADCY4 Gene

  1. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) Côté M … Gallo-Payet N (The Journal of clinical endocrinology and metabolism 2001) 3 4 22 58
  2. Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PMID: 21228062) Bogard AS … Ostrom RS (The Journal of pharmacology and experimental therapeutics 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. (PMID: 12503609) Ludwig MG … Seuwen K (Journal of receptor and signal transduction research 2002) 3 4 58

Products for ADCY4 Gene

Sources for ADCY4 Gene

Content
Loading form....