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This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
ADCY4 (Adenylate Cyclase 4) is a Protein Coding gene. Diseases associated with ADCY4 include Amelogenesis Imperfecta, Type Ia and Amelogenesis Imperfecta, Type Iv. Among its related pathways are Adenylate cyclase inhibitory pathway and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY2.
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004016 | adenylate cyclase activity | IEA,ISS | -- |
GO:0005080 | protein kinase C binding | IDA | 17081159 |
GO:0005515 | protein binding | IPI | 17081159 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,IDA | 11549699 |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA,ISS | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | DAG and IP3 signaling |
.93
|
Beta-2 adrenergic-dependent CFTR expression
.50
Neurophysiological process PGE2-induced pain processing
.38
Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
.33
Development Beta-adrenergic receptors signaling via cAMP
.32
Development Role of Activin A in cell differentiation and proliferation
.32
.01
|
2 | RET signaling |
.92
|
|
3 | Aldosterone synthesis and secretion |
.41
|
.41
|
4 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
5 | Adenylate cyclase inhibitory pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003091 | renal water homeostasis | TAS | -- |
GO:0006171 | cAMP biosynthetic process | IEA,ISS | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | ISS | -- |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
Compound | Action | Cas Number |
---|---|---|
Forskolin | Adenylyl cyclase activator | 66575-29-9 |
KH 7 | Selective soluble adenylyl cyclase inhibitor | 330676-02-3 |
MDL 12330A hydrochloride | Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor | 40297-09-4 |
NKH 477 | Water-soluble adenylyl cyclase activator | 138605-00-2 |
SQ 22536 | Adenylyl cyclase inhibitor | 17318-31-9 |
Compound | Action | Cas Number |
---|---|---|
Forskolin | 66575-29-9 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: |
ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||
SP10: | - | ||||||||||||||||||||||||||||||||
SP11: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ADCY4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ADCY4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ADCY4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Adcy4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Adcy4 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ADCY4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | ADCY4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adcy4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01111926.1 31 |
|
ManyToMany | |
adcy2b 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Ac76E 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | acy-4 32 |
|
|
|
acy-2 31 32 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
774711 | Benign: not provided | 24,318,572(-) | C/A | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
amelogenesis imperfecta, type ia |
|
|
amelogenesis imperfecta, type iv |
|
|
chronic meningitis |
|
|
specific language impairment |
|
|