Aliases for ADCY4 Gene
Aliases for ADCY4 Gene
External Ids for ADCY4 Gene
- HGNC: 235
- Entrez Gene: 196883
- Ensembl: ENSG00000129467
- OMIM: 600292
- UniProtKB: Q8NFM4
Previous GeneCards Identifiers for ADCY4 Gene
- GC14M022160
- GC14M018574
- GC14M022777
- GC14M023857
- GC14M024787
- GC14M004902
Summaries for ADCY4 Gene
-
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
GeneCards Summary for ADCY4 Gene
ADCY4 (Adenylate Cyclase 4) is a Protein Coding gene. Among its related pathways are Ovarian steroidogenesis and G-protein signaling G-Protein alpha-i signaling cascades. Gene Ontology (GO) annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY2.
UniProtKB/Swiss-Prot for ADCY4 Gene
-
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
-
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY4 Gene
Genomics for ADCY4 Gene
GeneHancer (GH) Regulatory Elements for ADCY4 Gene
Promoters and enhancers for ADCY4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADCY4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ADCY4 gene promoter:
Regulatory Element Products
Genomic Locations for ADCY4 Gene
Genomic Locations for ADCY4 Gene
- chr14:24,318,349-24,335,093
- (GRCh38/hg38)
- Size:
- 16,745 bases
- Orientation:
- Minus strand
- chr14:24,787,555-24,804,299
- (GRCh37/hg19)
Genomic View for ADCY4 Gene
Genes around ADCY4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by Entrez Gene
- 14q12 by HGNC
- 14q12 by Ensembl
ADCY4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADCY4 Gene
Proteins for ADCY4 Gene
-
Protein details for ADCY4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NFM4-ADCY4_HUMAN
- Recommended name:
- Adenylate cyclase type 4
- Protein Accession:
- Q8NFM4
- B3KV74
- D3DS75
- Q17R40
- Q6ZTM6
- Q96ML7
Protein attributes for ADCY4 Gene
- Size:
- 1077 amino acids
- Molecular mass:
- 119794 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB71270.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ADCY4 Gene
Post-translational modifications for ADCY4 Gene
Other Protein References for ADCY4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ADCY4
- Novus Biologicals Antibodies for ADCY4
- Invitrogen Antibodies for ADCY4
- GeneTex ADCY4 Antibody for ADCY4
-
Boster Bio Antibodies for ADCY4
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADCY4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADCY4
- Origene Custom Protein Services for ADCY4
- Novus Biologicals proteins for ADCY4
- Search GeneTex for Proteins for ADCY4
No data available for DME Specific Peptides for ADCY4 Gene
Domains & Families for ADCY4 Gene
Gene Families for ADCY4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ADCY4 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADCY4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NFM4UniProtKB/Swiss-Prot:
ADCY4_HUMAN :- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
- Domain:
-
- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
- Family:
-
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Function for ADCY4 Gene
Molecular function for ADCY4 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP = 3,5-cyclic AMP + diphosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by forskolin. Insensitive to calcium/calmodulin. Stimulated by GNAS and by the G-protein beta and gamma subunit complex.
- GENATLAS Biochemistry:
- adenylate cyclase,type IV
Enzyme Numbers (IUBMB) for ADCY4 Gene
Phenotypes From GWAS Catalog for ADCY4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004016 | adenylate cyclase activity | ISS,IEA | -- |
| GO:0004383 | guanylate cyclase activity | IBA | -- |
| GO:0005080 | protein kinase C binding | IDA | 17081159 |
| GO:0005515 | protein binding | IPI | 17081159 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for ADCY4 Gene
- MGI mutant phenotypes for ADCY4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ADCY4:
-
- Moderately decreased NFAT1-GFP nuclear translocation
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased cell number in S
- Decreased IL-8 secretion
Animal Models for ADCY4 Gene
- MGI Knock Outs for ADCY4:
-
- Adcy4 Adcy4<tm1Dgen>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADCY4
-
CRISPR Products
-
OriGene CRISPR knockouts for ADCY4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY4
- genomics-online: gRNA clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
- Applied Biological Materials CRISPR for ADCY4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY4
- GenScript: Design CRISPR guide RNA sequences for ADCY4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADCY4
- Browse OriGene Inhibitory RNA Products For ADCY4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY4
- genomics-online: shRNA clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ADCY4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY4
- Applied Biological Materials Clones for ADCY4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADCY4
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADCY4 Gene
Localization for ADCY4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADCY4 Gene
- Cell membrane; Multi-pass membrane protein. Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 3 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 11549699 |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0008074 | guanylate cyclase complex, soluble | IBA | -- |
| GO:0016020 | membrane | IEA,ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADCY4 Gene
Pathways & Interactions for ADCY4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling |
.93
|
.01
|
| 2 | Aldosterone synthesis and secretion |
.41
|
|
| 3 | RET signaling |
.92
|
|
| 4 | Circadian entrainment | ||
| 5 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
Pathways by source for ADCY4 Gene
6 BioSystems pathways for ADCY4 Gene
44 Reactome pathways for ADCY4 Gene
2 PharmGKB pathways for ADCY4 Gene
46 KEGG pathways for ADCY4 Gene
12 GeneGo (Thomson Reuters) pathways for ADCY4 Gene
23 Qiagen pathways for ADCY4 Gene
Interacting Proteins for ADCY4 Gene
Selected Interacting proteins:
Q8NFM4-ADCY4_HUMAN
ENSP00000312126
for ADCY4 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for ADCY4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003091 | renal water homeostasis | TAS | -- |
| GO:0006171 | cAMP biosynthetic process | ISS,IEA | -- |
| GO:0006182 | cGMP biosynthetic process | IBA | -- |
| GO:0007165 | signal transduction | IBA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
Drugs & Compounds for ADCY4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
(5) Tocris Compounds for ADCY4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Forskolin | Adenylyl cyclase activator | 66575-29-9 |
| KH 7 | Selective soluble adenylyl cyclase inhibitor | 330676-02-3 |
| MDL 12330A hydrochloride | Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor | 40297-09-4 |
| NKH 477 | Water-soluble adenylyl cyclase activator | 138605-00-2 |
| SQ 22536 | Adenylyl cyclase inhibitor | 17318-31-9 |
(1) ApexBio Compounds for ADCY4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Forskolin | 66575-29-9 |
Transcripts for ADCY4 Gene
mRNA/cDNA for ADCY4 Gene
- (159) Selected AceView cDNA sequences:
- (9) Additional mRNA sequences :
- (3) REFSEQ mRNAs :
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000310677 3415 bps (uc001wox.3)
- ENST00000418030 3353 bps (uc001wow.4)
- ENST00000545213 3010 bps (uc059afu.1)
- ENST00000554068 3404 bps (uc001woy.4)
- ENST00000554577 5276 bps (uc059aft.1)
Unigene Clusters for ADCY4 Gene
- Adenylate cyclase 4:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ADCY4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY4
- genomics-online: gRNA clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
- Applied Biological Materials CRISPR for ADCY4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY4
- GenScript: Design CRISPR guide RNA sequences for ADCY4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADCY4
- Browse OriGene Inhibitory RNA Products For ADCY4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY4
- genomics-online: shRNA clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ADCY4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY4
- Applied Biological Materials Clones for ADCY4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||
| SP11: |
Expression for ADCY4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Bone (Muscoskeletal System)
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
-
Tooth
- Dental Mesenchymal Cells Branchial Arch 1
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Adipose (Muscoskeletal System)
This gene is overexpressed in Heart (45.0) and Placenta (24.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCY4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADCY4 Gene:
ADCY4SOURCE GeneReport for Unigene cluster for ADCY4 Gene:
Hs.443428mRNA Expression by UniProt/SwissProt for ADCY4 Gene:
Q8NFM4-ADCY4_HUMAN
Tissue specificity:
Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level).
Evidence on tissue expression from TISSUES for ADCY4 Gene
- Lung(4.2)
- Spleen(4.2)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for ADCY4
- genomics-online: primer clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY4 Gene
Orthologs for ADCY4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADCY4 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ADCY4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ADCY4 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Adcy4 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adcy4 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADCY4 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | ADCY4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adcy4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CABZ01111926.1 34 |
|
ManyToMany | |
| adcy2b 34 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Ac76E 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | acy-4 35 |
|
|
|
| acy-2 34 35 |
|
OneToMany |
- Species where no ortholog for ADCY4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ADCY4 Gene
- ENSEMBL:
- Gene Tree for ADCY4 (if available)
- TreeFam:
- Gene Tree for ADCY4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADCY4: view image
Paralogs for ADCY4 Gene
(11) SIMAP similar genes for ADCY4 Gene using alignment to 8 proteins:
- ADCY4_HUMAN
- G3V258_HUMAN
- G3V262_HUMAN
- H0YJ57_HUMAN
- H0YLM0_HUMAN
- H0YN72_HUMAN
- Q6ZTM6_HUMAN
- Q96KY6_HUMAN
Variants for ADCY4 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000125361 | -- | 24,321,788(-) | C/T | intron_variant | |
| rs1000305647 | -- | 24,336,474(-) | G/A | upstream_transcript_variant | |
| rs1000433857 | -- | 24,321,060(-) | G/A | intron_variant | |
| rs1000675087 | -- | 24,319,871(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs1001129793 | -- | 24,336,745(-) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.37;
53.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADCY4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADCY4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY4 Gene
Disorders for ADCY4 Gene
Additional Disease Information for ADCY4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ADCY4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY4 Gene
Publications for ADCY4 Gene
- Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) Côté M … Gallo-Payet N (The Journal of clinical endocrinology and metabolism 2001) 3 4 22 58
- Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PMID: 21228062) Bogard AS … Ostrom RS (The Journal of pharmacology and experimental therapeutics 2011) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. (PMID: 12503609) Ludwig MG … Seuwen K (Journal of receptor and signal transduction research 2002) 3 4 58
Products for ADCY4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ADCY4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADCY4
- Origene Custom Protein Services for ADCY4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADCY4
- Browse OriGene Inhibitory RNA Products For ADCY4
- OriGene qPCR primer pairs for ADCY4
- OriGene CRISPR knockouts for ADCY4
- OriGene ORF clones in human for ADCY4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADCY4
- GenScript: Next-day shipping of latest version cDNA ORF clones for ADCY4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ADCY4
- GenScript Custom Assay Services for ADCY4
- GenScript Custom overexpressing Cell Line Services for ADCY4
- GenScript: Design CRISPR guide RNA sequences for ADCY4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ADCY4
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ADCY4
- Novus Biologicals proteins for ADCY4
- Novus Biologicals ELISA Kits for ADCY4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for ADCY4
- ApexBio compounds for ADCY4
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADCY4
- VectorBuilder custom plasmid, inducible vectors for ADCY4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 59 available ADCY4 Antibodies ranked by validation data
- Compare Top ADCY4 Antibodies
- antibodies-online: Search results for 18 available ADCY4 Elisa Kits ranked by validation data
- Compare Top ADCY4 Elisa Kits
- antibodies-online: Search results for 8 available ADCY4 Proteins ranked by validation data
- Compare Top ADCY4 Proteins
- GeneTex ADCY4 Antibody for ADCY4
- Search GeneTex for Proteins for ADCY4
- Santa Cruz Biotechnology (SCBT) Antibodies for ADCY4
- Search Santa Cruz Biotechnology (SCBT) for ADCY4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADCY4
- Horizon Cell Lines for ADCY4
- genomics-online: cdna clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
- orf clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
- genomics-online: gRNA clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
- genomics-online: primer clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
- genomics-online: shRNA clones - Search results for 89 available ADCY4 gene related products
- Overview of 89 available ADCY4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY4
- GeneCopoeia miRNA 3'UTR Target clone products for ADCY4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY4
- Boster Bio Antibodies for ADCY4
- Browse Boster Bio ELISA Kits
Sources for ADCY4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio