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This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to ... See more...
Aliases for ADCY4 Gene
Aliases for ADCY4 Gene
External Ids for ADCY4 Gene
- HGNC: 235
- Entrez Gene: 196883
- Ensembl: ENSG00000129467
- OMIM: 600292
- UniProtKB: Q8NFM4
Previous GeneCards Identifiers for ADCY4 Gene
- GC14M022160
- GC14M018574
- GC14M022777
- GC14M023857
- GC14M024787
- GC14M004902
Summaries for ADCY4 Gene
-
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
GeneCards Summary for ADCY4 Gene
ADCY4 (Adenylate Cyclase 4) is a Protein Coding gene. Diseases associated with ADCY4 include Amelogenesis Imperfecta, Type Ia and Amelogenesis Imperfecta, Type Iv. Among its related pathways are Adenylate cyclase inhibitory pathway and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY2.
UniProtKB/Swiss-Prot Summary for ADCY4 Gene
-
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
-
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.
Additional gene information for ADCY4 Gene
- HGNC(235)
- Entrez Gene(196883)
- Ensembl(ENSG00000129467)
- OMIM(600292)
- UniProtKB(Q8NFM4)
- Open Targets Platform(ENSG00000129467)
- Search for ADCY4 at DataMed
- Search for ADCY4 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADCY4 Gene
Genomics for ADCY4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADCY4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADCY4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADCY4
- Top Transcription factor binding sites by QIAGEN in the ADCY4 gene promoter:
-
- AML1a
- STAT3
Genomic Locations for ADCY4 Gene
Genomic Locations for ADCY4 Gene
- chr14:24,318,349-24,335,093
- (GRCh38/hg38)
- Size:
- 16,745 bases
- Orientation:
- Minus strand
- chr14:24,787,555-24,804,299
- (GRCh37/hg19)
- Size:
- 16,745 bases
- Orientation:
- Minus strand
Genomic View for ADCY4 Gene
Genes around ADCY4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by HGNC
- 14q12 by Entrez Gene
- 14q12 by Ensembl
ADCY4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADCY4 Gene
Proteins for ADCY4 Gene
-
Protein details for ADCY4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NFM4-ADCY4_HUMAN
- Recommended name:
- Adenylate cyclase type 4
- Protein Accession:
- Q8NFM4
- B3KV74
- D3DS75
- Q17R40
- Q6ZTM6
- Q96ML7
Protein attributes for ADCY4 Gene
- Size:
- 1077 amino acids
- Molecular mass:
- 119794 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB71270.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ADCY4 Gene
Selected DME Specific Peptides for ADCY4 Gene
- Q8NFM4:
-
- LNELFGKFD
- RIKILGDCYYC
- ADIVGFT
- KIQVTEET
- TVNVASR
- TRYLESWGAA
- WQYDVWS
- EKIKTIG
- DVTLANHME
- RLDFLWK
- ATGVDINMRVG
- NNFHSLYVKRHQ
- ASRMEST
- ECLRLLNEII
Post-translational modifications for ADCY4 Gene
Other Protein References for ADCY4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ADCY4 Antibody
-
Custom Antibody ServicesOriGene Antibodies for ADCY4
- Novus Biologicals Antibodies for ADCY4
- Invitrogen Antibodies for ADCY4 (AFLGC-Adcy4)
- antibodies-online: Show 17 available ADCY4 Antibodies ranked by validation data
- Compare Top ADCY4 Antibodies
-
Recommended
- 24 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 48 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Biorbyt antibodies for ADCY4
-
Boster Bio Antibodies for ADCY4
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADCY4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADCY4
- Origene Custom Protein Services for ADCY4
- Novus Biologicals proteins for ADCY4
-
Signalway Proteins for ADCY4
Assay Products
- Novus Biologicals ELISA Kits for ADCY4
- antibodies-online: Show 24 available ADCY4 Elisa Kits ranked by validation data
- Compare Top ADCY4 Elisa Kits
-
Quality Products:
Domains & Families for ADCY4 Gene
Gene Families for ADCY4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ADCY4 Gene
- InterPro:
- Blocks:
-
- Adenylate cyclase-like
- ProtoNet:
Suggested Antigen Peptide Sequences for ADCY4 Gene
- GenScript: Design optimal peptide antigens:
-
- Adenylyl cyclase 4 (ADCY4_HUMAN)
- cDNA FLJ16344 fis, clone TESTI2032643, moderately similar to ADENYLATE CYCLASE, TYPE IV (EC 4.6.1.1) (Q6ZN83_HUMAN)
- cDNA FLJ44504 fis, clone UTERU3001240, highly similar to Adenylate cyclase, type IV (EC 4.6.1.1) (Q6ZTM6_HUMAN)
- ADCY4 protein (Q96KY6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8NFM4UniProtKB/Swiss-Prot:
ADCY4_HUMAN :- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
- Domain:
-
- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
- Family:
-
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Function for ADCY4 Gene
Molecular function for ADCY4 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence={ECO:0000250|UniProtKB:P26770};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by forskolin. Insensitive to calcium/calmodulin. Stimulated by GNAS and by the G-protein beta and gamma subunit complex.
- GENATLAS Biochemistry:
- adenylate cyclase,type IV
Enzyme Numbers (IUBMB) for ADCY4 Gene
Phenotypes From GWAS Catalog for ADCY4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004016 | adenylate cyclase activity | IEA,ISS | -- |
| GO:0005080 | protein kinase C binding | IDA | 17081159 |
| GO:0005515 | protein binding | IPI | 17081159 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for ADCY4 Gene
- MGI mutant phenotypes for ADCY4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ADCY4:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased IL-8 secretion
- Reduced mammosphere formation
- Decreased viability
- Weakly decreased NFAT1-GFP nuclear translocation
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased cell number in G1, small nuclei in G1
Animal Models for ADCY4 Gene
- MGI Knock Outs for ADCY4:
-
- Adcy4 Adcy4<tm1Dgen>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADCY4 - Select products 50% OFF >
- * ADCY4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ADCY4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADCY4
- Browse OriGene Inhibitory RNA Products For ADCY4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY4
Clone Products
- Applied Biological Materials (abm): Clones for ADCY4 - Select products 50% OFF >
- * ADCY4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ADCY4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY4
Cell Line Products
-
Horizon Cell Lines for ADCY4
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADCY4 Gene
Localization for ADCY4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADCY4 Gene
- Cell membrane. Multi-pass membrane protein. Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 11549699 |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA,ISS | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADCY4 Gene
Pathways & Interactions for ADCY4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling |
.93
|
Beta-2 adrenergic-dependent CFTR expression
.50
Neurophysiological process PGE2-induced pain processing
.38
Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
.33
Development Beta-adrenergic receptors signaling via cAMP
.32
Development Role of Activin A in cell differentiation and proliferation
.32
.01
|
| 2 | RET signaling |
.92
|
|
| 3 | Aldosterone synthesis and secretion |
.41
|
.41
|
| 4 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 5 | Adenylate cyclase inhibitory pathway | ||
Pathways by source for ADCY4 Gene
6 BioSystems pathways for ADCY4 Gene
44 Reactome pathways for ADCY4 Gene
2 PharmGKB pathways for ADCY4 Gene
49 KEGG pathways for ADCY4 Gene
12 GeneGo (Thomson Reuters) pathways for ADCY4 Gene
- Beta-2 adrenergic-dependent CFTR expression
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
- Development Beta-adrenergic receptors regulation of ERK
- Development Beta-adrenergic receptors signaling via cAMP
- Development Endothelin-1/EDNRA signaling
23 Qiagen pathways for ADCY4 Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
- Breast Cancer Regulation by Stathmin1
- cAMP Pathway
Interacting Proteins for ADCY4 Gene
Selected Interacting proteins:
Q8NFM4-ADCY4_HUMAN
ENSP00000312126
for ADCY4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ADCY4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003091 | renal water homeostasis | TAS | -- |
| GO:0006171 | cAMP biosynthetic process | IEA,ISS | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | ISS | -- |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | TAS | -- |
Drugs & Compounds for ADCY4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
(5) Tocris Compounds for ADCY4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Forskolin | Adenylyl cyclase activator | 66575-29-9 |
| KH 7 | Selective soluble adenylyl cyclase inhibitor | 330676-02-3 |
| MDL 12330A hydrochloride | Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor | 40297-09-4 |
| NKH 477 | Water-soluble adenylyl cyclase activator | 138605-00-2 |
| SQ 22536 | Adenylyl cyclase inhibitor | 17318-31-9 |
(1) ApexBio Compounds for ADCY4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Forskolin | 66575-29-9 |
Transcripts for ADCY4 Gene
mRNA/cDNA for ADCY4 Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000310677 3415 nts (view in UCSC)
- ENST00000557056 3990 nts (view in UCSC)
- ENST00000555684 846 nts (view in UCSC)
- ENST00000554577 5276 nts (view in UCSC)
- ENST00000554068 3404 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADCY4 - Select products 50% OFF >
- * ADCY4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ADCY4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADCY4
- Browse OriGene Inhibitory RNA Products For ADCY4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY4
Clone Products
- Applied Biological Materials (abm): Clones for ADCY4 - Select products 50% OFF >
- * ADCY4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ADCY4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY4
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||
| SP11: |
Relevant External Links for ADCY4 Gene
- GeneLoc Exon Structure for
- ADCY4
Expression for ADCY4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Bone (Muscoskeletal System)
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
-
Tooth
- Dental Mesenchymal Cells Branchial Arch 1
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Adipose (Muscoskeletal System)
This gene is overexpressed in Heart (45.0) and Placenta (24.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCY4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADCY4
SOURCE GeneReport for Unigene cluster for ADCY4 Gene:
Hs.443428mRNA Expression by UniProt/SwissProt for ADCY4 Gene:
Q8NFM4-ADCY4_HUMAN
Tissue specificity:
Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level).
Evidence on tissue expression from TISSUES for ADCY4 Gene
- Lung(4.5)
- Spleen(4.4)
- Blood(2.7)
- Nervous system(2.5)
- Muscle(2.5)
- Heart(2.5)
- Skin(2.4)
- Kidney(2.4)
- Intestine(2.3)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for ADCY4
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY4 Gene
Orthologs for ADCY4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADCY4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ADCY4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ADCY4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Adcy4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Adcy4 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ADCY4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | ADCY4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adcy4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CABZ01111926.1 31 |
|
ManyToMany | |
| adcy2b 31 |
|
ManyToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ac76E 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | acy-4 32 |
|
|
|
| acy-2 31 32 |
|
OneToMany |
- Species where no ortholog for ADCY4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ADCY4 Gene
- ENSEMBL:
- Gene Tree for ADCY4 (if available)
- TreeFam:
- Gene Tree for ADCY4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADCY4: view image
Paralogs for ADCY4 Gene
Paralogs for ADCY4 Gene
(11) SIMAP similar genes for ADCY4 Gene using alignment to 8 proteins:
- ADCY4_HUMAN
- G3V258_HUMAN
- G3V262_HUMAN
- H0YJ57_HUMAN
- H0YLM0_HUMAN
- H0YN72_HUMAN
- Q6ZTM6_HUMAN
- Q96KY6_HUMAN
Variants for ADCY4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADCY4 Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 774711 | Benign: not provided | 24,318,572(-) | C/A | INTRON_VARIANT |
Residual Variation Intolerance Score:
16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.37;
53.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADCY4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADCY4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY4 Gene
Disorders for ADCY4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amelogenesis imperfecta, type ia |
|
|
| amelogenesis imperfecta, type iv |
|
|
| chronic meningitis |
|
|
| specific language impairment |
|
|
Search ADCY4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADCY4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ADCY4 Gene
Publications for ADCY4 Gene
- Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) Côté M … Gallo-Payet N (The Journal of clinical endocrinology and metabolism 2001) 3 4 23
- Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PMID: 21228062) Bogard AS … Ostrom RS (The Journal of pharmacology and experimental therapeutics 2011) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. (PMID: 12503609) Ludwig MG … Seuwen K (Journal of receptor and signal transduction research 2002) 3 4
ExternalLinks
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Sources for ADCY4 Gene
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