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This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008] See more...
Aliases for ADCY2 Gene
Aliases for ADCY2 Gene
External Ids for ADCY2 Gene
- HGNC: 233
- Entrez Gene: 108
- Ensembl: ENSG00000078295
- OMIM: 103071
- UniProtKB: Q08462
Previous GeneCards Identifiers for ADCY2 Gene
- GC05P007810
- GC05P007429
- GC05P007449
Summaries for ADCY2 Gene
-
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADCY2 Gene
ADCY2 (Adenylate Cyclase 2) is a Protein Coding gene. Diseases associated with ADCY2 include Spinocerebellar Ataxia, Autosomal Recessive 16 and Cutaneous Anthrax. Among its related pathways are Adenylate cyclase inhibitory pathway and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and phosphorus-oxygen lyase activity. An important paralog of this gene is ADCY4.
UniProtKB/Swiss-Prot Summary for ADCY2 Gene
-
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
-
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.
Additional gene information for ADCY2 Gene
- HGNC(233)
- Entrez Gene(108)
- Ensembl(ENSG00000078295)
- OMIM(103071)
- UniProtKB(Q08462)
- Open Targets Platform(ENSG00000078295)
- Monarch Initiative
- Search for ADCY2 at DataMed
- Search for ADCY2 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADCY2 Gene
Genomics for ADCY2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADCY2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADCY2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADCY2
- Top Transcription factor binding sites by QIAGEN in the ADCY2 gene promoter:
-
- AML1a
- Arnt
- Cart-1
- E47
- GATA-1
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- POU3F2
- Tal-1
Genomic Locations for ADCY2 Gene
Genomic Locations for ADCY2 Gene
- chr5:7,396,138-7,830,081
- (GRCh38/hg38)
- Size:
- 433,944 bases
- Orientation:
- Plus strand
- chr5:7,396,321-7,830,194
- (GRCh37/hg19)
- Size:
- 433,874 bases
- Orientation:
- Plus strand
Genomic View for ADCY2 Gene
Genes around ADCY2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p15.31 by HGNC
- 5p15.31 by Entrez Gene
- 5p15.31 by Ensembl
ADCY2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADCY2 Gene
Proteins for ADCY2 Gene
-
Protein details for ADCY2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08462-ADCY2_HUMAN
- Recommended name:
- Adenylate cyclase type 2
- Protein Accession:
- Q08462
- B7Z2C1
- Q2NKL8
- Q9UDB2
- Q9UPU2
Protein attributes for ADCY2 Gene
- Size:
- 1091 amino acids
- Molecular mass:
- 123603 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with RAF1 (PubMed:15385642). Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex (By similarity).
Protein Expression for ADCY2 Gene
Selected DME Specific Peptides for ADCY2 Gene
- Q08462:
-
- LNELFGKFD
- SRMDSTGV
- RIKILGDCYYC
- ADIVGFT
- TVNVASR
- KIQVTEET
- TRYLESWGAA
- WQYDVWS
- GNVLCGV
- EKIKTIG
- DVTLANHME
- RLDFLWK
- ATGVDINMRVG
- QQERLLLS
- NNFHNLYVKRH
- FASIPDFKEFY
- ECLRLLNEII
Post-translational modifications for ADCY2 Gene
- Phosphorylated by RAF1.
-
Glycosylation at Asn713 and Asn716
- NX_Q08462 (NX_Q08462-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ADCY2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ADCY2 Antibody
- Creative Diagnostics Mouse anti-Human ADCY2 polyclonal antibody
- Creative Biolabs Mouse Anti-ADCY2 Recombinant Antibody (CBFYH-0003)
-
Custom Antibody ServicesOriGene Antibodies for ADCY2
- Novus Biologicals Antibodies for ADCY2
-
Abcam antibodies for ADCY2
- Invitrogen Antibodies for ADCY2 (AFLGC-ADCY2)
-
Boster Bio Antibodies for ADCY2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADCY2
Protein Products
-
OriGene Purified Proteins for ADCY2
- Search Origene for MassSpec and Protein Over-expression Lysates for ADCY2
- Origene Custom Protein Services for ADCY2
-
Abcam proteins for ADCY2
Assay Products
- G Biosciences Immunotag™ Human ADCY2 (Adenylate Cyclase 2) ELISA
- Novus Biologicals ELISA Kits for ADCY2
Domains & Families for ADCY2 Gene
Gene Families for ADCY2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ADCY2 Gene
- InterPro:
- Blocks:
-
- Adenylate cyclase-like
- ProtoNet:
Suggested Antigen Peptide Sequences for ADCY2 Gene
- GenScript: Design optimal peptide antigens:
-
- Adenylyl cyclase 2 (ADCY2_HUMAN)
- cDNA FLJ58757, highly similar to Adenylate cyclase type 2 (EC 4.6.1.1) (B7Z2C1_HUMAN)
- Adenylyl cyclase type II (Q7RTV6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q08462UniProtKB/Swiss-Prot:
ADCY2_HUMAN :- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
- Domain:
-
- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
- Family:
-
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Function for ADCY2 Gene
Molecular function for ADCY2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; Evidence={ECO:0000269|PubMed:15385642};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by forskolin (PubMed:15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642). Phosphorylation by PKC activates the enzyme (By similarity).
- GENATLAS Biochemistry:
- adenylyl cyclase,type II,calmodulin insensitive,brain,lung
Enzyme Numbers (IUBMB) for ADCY2 Gene
Phenotypes From GWAS Catalog for ADCY2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | ISS | -- |
| GO:0004016 | adenylate cyclase activity | IBA,NAS | 1427768 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008179 | adenylate cyclase binding | ISS | -- |
Phenotypes for ADCY2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ADCY2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADCY2 - Select products 50% OFF >
- * ADCY2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ADCY2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY2
miRNA for ADCY2 Gene
- miRTarBase miRNAs that target ADCY2
-
- hsa-miR-6833-5p (MIRT572886)
- hsa-miR-3190-3p (MIRT572887)
- hsa-miR-4680-5p (MIRT572888)
- hsa-miR-7114-5p (MIRT572889)
- hsa-miR-4539 (MIRT572890)
- hsa-miR-146a-3p (MIRT572891)
- hsa-miR-4714-5p (MIRT572892)
- hsa-miR-4318 (MIRT572893)
- hsa-miR-4643 (MIRT572894)
- hsa-miR-5698 (MIRT647008)
- hsa-miR-143-5p (MIRT647009)
- hsa-miR-6879-3p (MIRT647010)
- hsa-miR-4430 (MIRT647011)
- hsa-miR-3652 (MIRT647012)
- hsa-miR-122-5p (MIRT647013)
- hsa-miR-504-3p (MIRT647014)
- hsa-miR-3135b (MIRT647015)
- hsa-miR-6499-3p (MIRT647016)
- hsa-miR-215-3p (MIRT647017)
- hsa-miR-6773-3p (MIRT647018)
- hsa-miR-500b-3p (MIRT647019)
- hsa-miR-3922-5p (MIRT673408)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADCY2
- Browse OriGene Inhibitory RNA Products For ADCY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY2
Clone Products
- Applied Biological Materials (abm): Clones for ADCY2 - Select products 50% OFF >
- * ADCY2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ADCY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY2
Cell Line Products
-
Horizon Cell Lines for ADCY2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADCY2 Gene
Localization for ADCY2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADCY2 Gene
- Membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 11549699 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA,ISS | -- |
| GO:0016020 | membrane | IEA,ISS | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADCY2 Gene
Pathways & Interactions for ADCY2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling |
.93
|
Beta-2 adrenergic-dependent CFTR expression
.50
Neurophysiological process PGE2-induced pain processing
.38
Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
.33
Development Beta-adrenergic receptors signaling via cAMP
.32
Development Role of Activin A in cell differentiation and proliferation
.32
.01
|
| 2 | RET signaling |
.92
|
|
| 3 | Aldosterone synthesis and secretion |
.41
|
.41
|
| 4 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
| 5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
Pathways by source for ADCY2 Gene
8 BioSystems pathways for ADCY2 Gene
44 Reactome pathways for ADCY2 Gene
49 KEGG pathways for ADCY2 Gene
13 GeneGo (Thomson Reuters) pathways for ADCY2 Gene
- Beta-2 adrenergic-dependent CFTR expression
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
- Development Beta-adrenergic receptors regulation of ERK
- Development Beta-adrenergic receptors signaling via cAMP
- Development Endothelin-1/EDNRA signaling
44 Qiagen pathways for ADCY2 Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
- Alpha-Adrenergic Signaling
- BAD Phosphorylation
Interacting Proteins for ADCY2 Gene
GPS-Prot Interaction Network for ADCY2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003091 | renal water homeostasis | TAS | -- |
| GO:0006171 | cAMP biosynthetic process | ISS | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | ISS | -- |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | TAS | -- |
Drugs & Compounds for ADCY2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Aurothioglucose | Approved, Withdrawn | Pharma | Target | 0 | ||
| Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1669 | ||
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| Phosphoric acid | Approved | Pharma | 0 | |||
| NADH | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
(5) Tocris Compounds for ADCY2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Forskolin | Adenylyl cyclase activator | 66575-29-9 |
| KH 7 | Selective soluble adenylyl cyclase inhibitor | 330676-02-3 |
| MDL 12330A hydrochloride | Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor | 40297-09-4 |
| NKH 477 | Water-soluble adenylyl cyclase activator | 138605-00-2 |
| SQ 22536 | Adenylyl cyclase inhibitor | 17318-31-9 |
(8) ApexBio Compounds for ADCY2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1,9-Dideoxyforskolin | 64657-18-7 | |
| Forskolin | 66575-29-9 | |
| KH 7 | 330676-02-3 | |
| MDL 12330A hydrochloride | adenylate cyclase inhibitor | 40297-09-4 |
| N6-methyladenosine (m6A) | adenylate cyclase regulator | 1867-73-8 |
| NKH 477 | 138605-00-2 | |
| NKY 80 | 299442-43-6 | |
| SQ 22536 | 17318-31-9 |
Transcripts for ADCY2 Gene
mRNA/cDNA for ADCY2 Gene
- 1 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000338316 6645 nts (view in UCSC)
- ENST00000484965 571 nts (view in UCSC)
- ENST00000498598 600 nts (view in UCSC)
- ENST00000515681 431 nts (view in UCSC)
- ENST00000513693 1903 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADCY2 - Select products 50% OFF >
- * ADCY2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ADCY2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADCY2
- Browse OriGene Inhibitory RNA Products For ADCY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY2
Clone Products
- Applied Biological Materials (abm): Clones for ADCY2 - Select products 50% OFF >
- * ADCY2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ADCY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY2
Relevant External Links for ADCY2 Gene
- GeneLoc Exon Structure for
- ADCY2
Expression for ADCY2 Gene
mRNA differential expression in normal tissues according to GTEx for ADCY2 Gene
This gene is overexpressed in Muscle - Skeletal (x5.3), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.4), and Brain - Amygdala (x4.1).
This gene is overexpressed in Monocytes (32.6) and Frontal cortex (27.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCY2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADCY2
SOURCE GeneReport for Unigene cluster for ADCY2 Gene:
Hs.481545mRNA Expression by UniProt/SwissProt for ADCY2 Gene:
Q08462-ADCY2_HUMAN
Tissue specificity:
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.
Evidence on tissue expression from TISSUES for ADCY2 Gene
- Nervous system(4.9)
- Muscle(2.5)
- Skin(2.5)
- Blood(2.4)
- Liver(2.4)
- Kidney(2.1)
- Adrenal gland(2.1)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for ADCY2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY2 Gene
Orthologs for ADCY2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ADCY2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ADCY2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ADCY2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ADCY2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Adcy2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Adcy2 30 |
|
||
| Chicken (Gallus gallus) |
Aves | ADCY2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ADCY2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | adcy2a 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ac76E 30 31 32 |
|
OneToMany | |
| rut 32 |
|
|
|||
| ACXD 32 |
|
|
|||
| ACXA 32 |
|
|
|||
| ACXB 32 |
|
|
|||
| ACXC 32 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010436 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | acy-4 32 |
|
|
|
| acy-2 31 32 |
|
OneToMany |
- Species where no ortholog for ADCY2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for ADCY2 Gene
- ENSEMBL:
- Gene Tree for ADCY2 (if available)
- TreeFam:
- Gene Tree for ADCY2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADCY2: view image
Paralogs for ADCY2 Gene
Paralogs for ADCY2 Gene
(9) SIMAP similar genes for ADCY2 Gene using alignment to 5 proteins:
- ADCY2_HUMAN
- B7Z2C1_HUMAN
- D6REB8_HUMAN
- H0YA58_HUMAN
- Q7RTV6_HUMAN
Variants for ADCY2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADCY2 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 719095 | Benign: not provided | 7,804,593(+) | C/G | SYNONYMOUS_VARIANT | |
| 782447 | Benign: not provided | 7,712,907(+) | ATC/A | INTRON_VARIANT | |
| rs386352276 | Uncertain Significance: not provided | 7,520,818(+) | C/G | SYNONYMOUS_VARIANT | |
| rs13166360 | - | p.Val147Leu | |||
| rs34043481 | - | p.Val163Ile |
Residual Variation Intolerance Score:
4.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.97;
74.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADCY2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY2 Gene
Disorders for ADCY2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia, autosomal recessive 16 |
|
|
| cutaneous anthrax |
|
|
| sleeping sickness |
|
|
Search ADCY2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADCY2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ADCY2 Gene
Publications for ADCY2 Gene
- Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) Côté M … Gallo-Payet N (The Journal of clinical endocrinology and metabolism 2001) 3 4 23
- Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. (PMID: 1427768) Stengel D … Hanoune J (Human genetics 1992) 2 3 4
- Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PMID: 21228062) Bogard AS … Ostrom RS (The Journal of pharmacology and experimental therapeutics 2011) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 41
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Products for ADCY2 Gene
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Sources for ADCY2 Gene
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