Aliases for ADCY2 Gene
Aliases for ADCY2 Gene
External Ids for ADCY2 Gene
- HGNC: 233
- Entrez Gene: 108
- Ensembl: ENSG00000078295
- OMIM: 103071
- UniProtKB: Q08462
Previous GeneCards Identifiers for ADCY2 Gene
- GC05P007810
- GC05P007429
- GC05P007449
Summaries for ADCY2 Gene
-
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADCY2 Gene
ADCY2 (Adenylate Cyclase 2) is a Protein Coding gene. Among its related pathways are Melanocyte Development and Pigmentation and Ovarian steroidogenesis. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and phosphorus-oxygen lyase activity. An important paralog of this gene is ADCY4.
UniProtKB/Swiss-Prot for ADCY2 Gene
-
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
-
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.
Additional gene information for ADCY2 Gene
- Monarch Initiative
- Search for ADCY2 at DataMed
- Search for ADCY2 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY2 Gene
Genomics for ADCY2 Gene
GeneHancer (GH) Regulatory Elements for ADCY2 Gene
Promoters and enhancers for ADCY2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05J007393 | Promoter/Enhancer | 2.1 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 669.7 | -0.5 | -496 | 3.5 | CTCF SP3 ZNF362 BACH1 SIN3A ZNF398 REST ZNF335 ZFHX2 GLIS2 | ADCY2 C5orf49 LOC105374645 | |
| GH05J007421 | Enhancer | 0.6 | ENCODE dbSUPER | 16.5 | +26.6 | 26629 | 1.9 | FOXA2 NANOG FOXA1 | ADCY2 LINC02142 ENSG00000249865 LOC105374646 GC05M007635 | |
| GH05J007802 | Enhancer | 0.9 | FANTOM5 ENCODE | 10.8 | +406.9 | 406874 | 0.4 | MAX MAFG CEBPB CEBPG EP300 ATF2 MAFF ZNF316 CREB1 ATF7 | MTRR C5orf49 ENSG00000250761 ADCY2 | |
| GH05J007419 | Enhancer | 0.7 | ENCODE dbSUPER | 12 | +24.4 | 24427 | 2.3 | USF1 FOXA2 NANOG SIN3A CTBP2 ATF2 | ADCY2 LINC02142 ENSG00000249865 ENSG00000250761 LOC105374646 GC05M007635 | |
| GH05J007391 | Enhancer | 0.8 | ENCODE dbSUPER | 5.7 | -4.0 | -3973 | 1.9 | CTCF FOXA2 SIN3A ELF1 RAD21 GABPA SMC3 ZNF143 CUX1 | ENSG00000247732 ADCY2 LOC105374645 LINC02142 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADCY2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ADCY2 Gene
Genomic Locations for ADCY2 Gene
- chr5:7,396,208-7,830,081
- (GRCh38/hg38)
- Size:
- 433,874 bases
- Orientation:
- Plus strand
- chr5:7,396,321-7,830,194
- (GRCh37/hg19)
Genomic View for ADCY2 Gene
Genes around ADCY2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p15.31 by Entrez Gene
- 5p15.31 by HGNC
- 5p15.31 by Ensembl
ADCY2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADCY2 Gene
Proteins for ADCY2 Gene
-
Protein details for ADCY2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08462-ADCY2_HUMAN
- Recommended name:
- Adenylate cyclase type 2
- Protein Accession:
- Q08462
- B7Z2C1
- Q2NKL8
- Q9UDB2
- Q9UPU2
Protein attributes for ADCY2 Gene
- Size:
- 1091 amino acids
- Molecular mass:
- 123603 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with RAF1 (PubMed:15385642). Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex (By similarity).
Protein Expression for ADCY2 Gene
Post-translational modifications for ADCY2 Gene
- Phosphorylated by RAF1.
- Glycosylation at posLast=716716 and Asn713
- Modification sites at PhosphoSitePlus
Other Protein References for ADCY2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ADCY2
- Novus Biologicals Antibodies for ADCY2
- Invitrogen Antibodies for ADCY2
- GeneTex ADCY2 Antibody for ADCY2
-
Boster Bio Antibodies for ADCY2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADCY2
Protein Products
-
OriGene Purified Proteins for ADCY2
- Search Origene for MassSpec and Protein Over-expression Lysates for ADCY2
- Origene Custom Protein Services for ADCY2
- Search GeneTex for Proteins for ADCY2
No data available for DME Specific Peptides for ADCY2 Gene
Domains & Families for ADCY2 Gene
Gene Families for ADCY2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ADCY2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADCY2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q08462UniProtKB/Swiss-Prot:
ADCY2_HUMAN :- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
- Domain:
-
- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
- Family:
-
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Function for ADCY2 Gene
Molecular function for ADCY2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP = 3,5-cyclic AMP + diphosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by forskolin (PubMed:15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642). Phosphorylation by PKC activates the enzyme (By similarity).
- GENATLAS Biochemistry:
- adenylyl cyclase,type II,calmodulin insensitive,brain,lung
Enzyme Numbers (IUBMB) for ADCY2 Gene
Phenotypes From GWAS Catalog for ADCY2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | ISS | -- |
| GO:0004016 | adenylate cyclase activity | NAS,ISS | 1427768 |
| GO:0004383 | guanylate cyclase activity | IBA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008179 | adenylate cyclase binding | ISS | -- |
Phenotypes for ADCY2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ADCY2
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADCY2
-
CRISPR Products
-
OriGene CRISPR knockouts for ADCY2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY2
- genomics-online: gRNA clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
- Applied Biological Materials CRISPR for ADCY2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY2
- GenScript: Design CRISPR guide RNA sequences for ADCY2
miRNA for ADCY2 Gene
- miRTarBase miRNAs that target ADCY2
-
- hsa-mir-6833-5p (MIRT572886)
- hsa-mir-3190-3p (MIRT572887)
- hsa-mir-4680-5p (MIRT572888)
- hsa-mir-7114-5p (MIRT572889)
- hsa-mir-4539 (MIRT572890)
- hsa-mir-146a-3p (MIRT572891)
- hsa-mir-4714-5p (MIRT572892)
- hsa-mir-4318 (MIRT572893)
- hsa-mir-4643 (MIRT572894)
- hsa-mir-5698 (MIRT647008)
- hsa-mir-143-5p (MIRT647009)
- hsa-mir-6879-3p (MIRT647010)
- hsa-mir-4430 (MIRT647011)
- hsa-mir-3652 (MIRT647012)
- hsa-mir-122-5p (MIRT647013)
- hsa-mir-504-3p (MIRT647014)
- hsa-mir-3135b (MIRT647015)
- hsa-mir-6499-3p (MIRT647016)
- hsa-mir-215-3p (MIRT647017)
- hsa-mir-6773-3p (MIRT647018)
- hsa-mir-500b-3p (MIRT647019)
- hsa-mir-3922-5p (MIRT673408)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADCY2
- Browse OriGene Inhibitory RNA Products For ADCY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY2
- genomics-online: shRNA clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ADCY2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY2
- Applied Biological Materials Clones for ADCY2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADCY2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADCY2 Gene
Localization for ADCY2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADCY2 Gene
- Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | ISS,IEA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 11549699 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | ISS | -- |
| GO:0008074 | guanylate cyclase complex, soluble | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADCY2 Gene
Pathways & Interactions for ADCY2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling |
.93
|
.01
|
| 2 | Aldosterone synthesis and secretion |
.41
|
|
| 3 | RET signaling |
.92
|
|
| 4 | G-Beta Gamma Signaling |
.46
.44
|
.37
|
| 5 | Circadian entrainment | ||
Pathways by source for ADCY2 Gene
8 BioSystems pathways for ADCY2 Gene
44 Reactome pathways for ADCY2 Gene
46 KEGG pathways for ADCY2 Gene
13 GeneGo (Thomson Reuters) pathways for ADCY2 Gene
44 Qiagen pathways for ADCY2 Gene
Interacting Proteins for ADCY2 Gene
GPS-Prot Interaction Network for ADCY2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003091 | renal water homeostasis | TAS | -- |
| GO:0006171 | cAMP biosynthetic process | ISS | -- |
| GO:0006182 | cGMP biosynthetic process | IBA | -- |
| GO:0007165 | signal transduction | IBA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
Drugs & Compounds for ADCY2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 | |||
| Aurothioglucose | Approved, Withdrawn | Pharma | Target | 0 | ||
| Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1402 | ||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Magnesium | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
(5) Tocris Compounds for ADCY2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Forskolin | Adenylyl cyclase activator | 66575-29-9 |
| KH 7 | Selective soluble adenylyl cyclase inhibitor | 330676-02-3 |
| MDL 12330A hydrochloride | Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor | 40297-09-4 |
| NKH 477 | Water-soluble adenylyl cyclase activator | 138605-00-2 |
| SQ 22536 | Adenylyl cyclase inhibitor | 17318-31-9 |
(8) ApexBio Compounds for ADCY2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 1,9-Dideoxyforskolin | 64657-18-7 | |
| Forskolin | 66575-29-9 | |
| KH 7 | 330676-02-3 | |
| MDL 12330A hydrochloride | adenylate cyclase inhibitor | 40297-09-4 |
| N6-methyladenosine (m6A) | adenylate cyclase regulator | 1867-73-8 |
| NKH 477 | 138605-00-2 | |
| NKY 80 | 299442-43-6 | |
| SQ 22536 | 17318-31-9 |
Transcripts for ADCY2 Gene
mRNA/cDNA for ADCY2 Gene
- (94) Selected AceView cDNA sequences:
- (14) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000338316 6575 bps (uc003jdz.2)
- ENST00000382531 603 bps (uc063cdy.1)
- ENST00000484965 571 bps (uc063cds.1)
- ENST00000489501 9908 bps (uc063cdz.1)
- ENST00000493243 756 bps (uc063cdx.1)
Unigene Clusters for ADCY2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ADCY2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY2
- genomics-online: gRNA clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
- Applied Biological Materials CRISPR for ADCY2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY2
- GenScript: Design CRISPR guide RNA sequences for ADCY2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADCY2
- Browse OriGene Inhibitory RNA Products For ADCY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY2
- genomics-online: shRNA clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ADCY2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY2
- Applied Biological Materials Clones for ADCY2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ADCY2 Gene
mRNA differential expression in normal tissues according to GTEx for ADCY2 Gene
This gene is overexpressed in Muscle - Skeletal (x5.3), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.4), and Brain - Amygdala (x4.1).
This gene is overexpressed in Monocytes (32.6) and Frontal cortex (27.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCY2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADCY2 Gene:
ADCY2SOURCE GeneReport for Unigene cluster for ADCY2 Gene:
Hs.481545mRNA Expression by UniProt/SwissProt for ADCY2 Gene:
Q08462-ADCY2_HUMAN
Tissue specificity:
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.
Evidence on tissue expression from TISSUES for ADCY2 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs for ADCY2
- genomics-online: primer clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY2 Gene
Orthologs for ADCY2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADCY2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ADCY2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ADCY2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ADCY2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Adcy2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adcy2 33 |
|
||
| chicken (Gallus gallus) |
Aves | ADCY2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADCY2 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | adcy2a 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Ac76E 34 35 33 |
|
OneToMany | |
| rut 35 |
|
|
|||
| ACXD 35 |
|
|
|||
| ACXB 35 |
|
|
|||
| ACXC 35 |
|
|
|||
| ACXA 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010436 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | acy-4 35 |
|
|
|
| acy-2 34 35 |
|
OneToMany |
- Species where no ortholog for ADCY2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ADCY2 Gene
- ENSEMBL:
- Gene Tree for ADCY2 (if available)
- TreeFam:
- Gene Tree for ADCY2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADCY2: view image
Paralogs for ADCY2 Gene
(9) SIMAP similar genes for ADCY2 Gene using alignment to 5 proteins:
- ADCY2_HUMAN
- B7Z2C1_HUMAN
- D6REB8_HUMAN
- H0YA58_HUMAN
- Q7RTV6_HUMAN
Variants for ADCY2 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs386352276 | uncertain-significance, not provided | 7,520,818(+) | C/G | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs1000001751 | -- | 7,503,802(+) | A/G | intron_variant | |
| rs1000016388 | -- | 7,583,627(+) | G/A | intron_variant | |
| rs1000017497 | -- | 7,759,939(+) | T/C | intron_variant | |
| rs1000017523 | -- | 7,708,089(+) | A/T | intron_variant |
Residual Variation Intolerance Score:
4.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.97;
74.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADCY2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY2 Gene
Disorders for ADCY2 Gene
Additional Disease Information for ADCY2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ADCY2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY2 Gene
Publications for ADCY2 Gene
- Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) Côté M … Gallo-Payet N (The Journal of clinical endocrinology and metabolism 2001) 3 4 22 58
- Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. (PMID: 1427768) Stengel D … Hanoune J (Human genetics 1992) 2 3 4 58
- Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PMID: 21228062) Bogard AS … Ostrom RS (The Journal of pharmacology and experimental therapeutics 2011) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 44 58
Products for ADCY2 Gene
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- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ADCY2
- Search Origene for MassSpec and Protein Over-expression Lysates for ADCY2
- Origene Custom Protein Services for ADCY2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ADCY2
- Browse OriGene Inhibitory RNA Products For ADCY2
- OriGene qPCR primer pairs for ADCY2
- OriGene CRISPR knockouts for ADCY2
- OriGene ORF clones in human for ADCY2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADCY2
- GenScript: Next-day shipping of latest version cDNA ORF clones for ADCY2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ADCY2
- GenScript Custom Assay Services for ADCY2
- GenScript Custom overexpressing Cell Line Services for ADCY2
- GenScript: Design CRISPR guide RNA sequences for ADCY2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ADCY2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ADCY2
- Novus Biologicals proteins and lysates for ADCY2
- Novus Biologicals ELISA Kits for ADCY2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for ADCY2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ADCY2
- ApexBio compounds for ADCY2
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADCY2
- VectorBuilder custom plasmid, inducible vectors for ADCY2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 42 available ADCY2 Antibodies ranked by validation data
- Compare Top ADCY2 Antibodies
- antibodies-online: Search results for 12 available ADCY2 Elisa Kits ranked by validation data
- Compare Top ADCY2 Elisa Kits
- antibodies-online: Search results for 10 available ADCY2 Proteins ranked by validation data
- Compare Top ADCY2 Proteins
- GeneTex ADCY2 Antibody for ADCY2
- Search GeneTex for Proteins for ADCY2
- Santa Cruz Biotechnology (SCBT) Antibodies for ADCY2
- Search Santa Cruz Biotechnology (SCBT) for ADCY2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADCY2
- Horizon Cell Lines for ADCY2
- genomics-online: cdna clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
- orf clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
- genomics-online: gRNA clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
- genomics-online: primer clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
- genomics-online: shRNA clones - Search results for 81 available ADCY2 gene related products
- Overview of 81 available ADCY2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADCY2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADCY2
- GeneCopoeia miRNA 3'UTR Target clone products for ADCY2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADCY2
- Boster Bio Antibodies for ADCY2
- Browse Boster Bio ELISA Kits
Sources for ADCY2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio