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This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
ADCY2 (Adenylate Cyclase 2) is a Protein Coding gene. Diseases associated with ADCY2 include Spinocerebellar Ataxia, Autosomal Recessive 16 and Cutaneous Anthrax. Among its related pathways are Adenylate cyclase inhibitory pathway and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and phosphorus-oxygen lyase activity. An important paralog of this gene is ADCY4.
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | ISS | -- |
GO:0004016 | adenylate cyclase activity | IBA,NAS | 1427768 |
GO:0005524 | ATP binding | IEA | -- |
GO:0008179 | adenylate cyclase binding | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,IDA | 11549699 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA,ISS | -- |
GO:0016020 | membrane | IEA,ISS | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | DAG and IP3 signaling |
.93
|
Beta-2 adrenergic-dependent CFTR expression
.50
Neurophysiological process PGE2-induced pain processing
.38
Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
.33
Development Beta-adrenergic receptors signaling via cAMP
.32
Development Role of Activin A in cell differentiation and proliferation
.32
.01
|
2 | RET signaling |
.92
|
|
3 | Aldosterone synthesis and secretion |
.41
|
.41
|
4 | G-Beta Gamma Signaling |
G-Beta Gamma Signaling
.46
GHRH Signaling
.46
CRHR Pathway
.44
|
Relaxin Pathway
.37
Hedgehog Signaling in Mammals
.32
Signaling in Gap Junctions
.30
|
5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003091 | renal water homeostasis | TAS | -- |
GO:0006171 | cAMP biosynthetic process | ISS | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | ISS | -- |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Aurothioglucose | Approved, Withdrawn | Pharma | Target | 0 | ||
Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1669 | ||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Phosphoric acid | Approved | Pharma | 0 | |||
NADH | Approved | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
Compound | Action | Cas Number |
---|---|---|
Forskolin | Adenylyl cyclase activator | 66575-29-9 |
KH 7 | Selective soluble adenylyl cyclase inhibitor | 330676-02-3 |
MDL 12330A hydrochloride | Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor | 40297-09-4 |
NKH 477 | Water-soluble adenylyl cyclase activator | 138605-00-2 |
SQ 22536 | Adenylyl cyclase inhibitor | 17318-31-9 |
Compound | Action | Cas Number |
---|---|---|
1,9-Dideoxyforskolin | 64657-18-7 | |
Forskolin | 66575-29-9 | |
KH 7 | 330676-02-3 | |
MDL 12330A hydrochloride | adenylate cyclase inhibitor | 40297-09-4 |
N6-methyladenosine (m6A) | adenylate cyclase regulator | 1867-73-8 |
NKH 477 | 138605-00-2 | |
NKY 80 | 299442-43-6 | |
SQ 22536 | 17318-31-9 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Platypus (Ornithorhynchus anatinus) |
Mammalia | ADCY2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ADCY2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ADCY2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ADCY2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Adcy2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Adcy2 30 |
|
||
Chicken (Gallus gallus) |
Aves | ADCY2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ADCY2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | adcy2a 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Ac76E 30 31 32 |
|
OneToMany | |
rut 32 |
|
|
|||
ACXD 32 |
|
|
|||
ACXA 32 |
|
|
|||
ACXB 32 |
|
|
|||
ACXC 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010436 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | acy-4 32 |
|
|
|
acy-2 31 32 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
719095 | Benign: not provided | 7,804,593(+) | C/G | SYNONYMOUS_VARIANT | |
782447 | Benign: not provided | 7,712,907(+) | ATC/A | INTRON_VARIANT | |
rs386352276 | Uncertain Significance: not provided | 7,520,818(+) | C/G | SYNONYMOUS_VARIANT | |
rs13166360 | - | p.Val147Leu | |||
rs34043481 | - | p.Val163Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia, autosomal recessive 16 |
|
|
cutaneous anthrax |
|
|
sleeping sickness |
|
|