Aliases for ADCY10 Gene
External Ids for ADCY10 Gene
Previous GeneCards Identifiers for ADCY10 Gene
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
GeneCards Summary for ADCY10 Gene
ADCY10 (Adenylate Cyclase 10) is a Protein Coding gene. Diseases associated with ADCY10 include Hypercalciuria, Absorptive, 2 and Idiopathic Hypercalciuria. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and manganese ion binding.
UniProtKB/Swiss-Prot Summary for ADCY10 Gene
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).