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Aliases for ADCK2 Gene

Aliases for ADCK2 Gene

  • AarF Domain Containing Kinase 2 2 3 5
  • Uncharacterized AarF Domain-Containing Protein Kinase 2 3 4
  • AARF 3 4
  • Putative Ubiquinone Biosynthesis Protein AarF 3
  • EC 2.7.11.- 4

External Ids for ADCK2 Gene

Previous GeneCards Identifiers for ADCK2 Gene

  • GC07P139703
  • GC07P139780
  • GC07P139826
  • GC07P140019
  • GC07P140372
  • GC07P134668

Summaries for ADCK2 Gene

GeneCards Summary for ADCK2 Gene

ADCK2 (AarF Domain Containing Kinase 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is ADCK1.

UniProtKB/Swiss-Prot for ADCK2 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Additional gene information for ADCK2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK2 Gene

Genomics for ADCK2 Gene

GeneHancer (GH) Regulatory Elements for ADCK2 Gene

Promoters and enhancers for ADCK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J140672 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 620.6 +1.7 1664 4.8 HDGF ZFX CTCF MNT NKRF ZNF687 ZSCAN21 MAFK ZBTB7A YY1 ADCK2 DENND2A BRAF SLC37A3 KDM7A NDUFB2
GH07J140922 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.6 +251.3 251276 4 MTA3 CC2D1A SP1 CTCF ZFX ZNF148 NKRF MLLT1 CEBPG RERE BRAF LOC105375536 NDUFB2 MRPS33 NDUFB2-AS1 ADCK2 RNU6-85P
GH07J140637 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 8.2 -33.1 -33086 5.6 HDGF ZNF652 ZSCAN21 MCM2 YY1 SP7 PRDM1 MZF1 GLIS2 ZNF488 ENSG00000285904 LOC105375535 DENND2A SLC37A3 NDUFB2 NDUFB2-AS1 BRAF PARP12 ADCK2 TMEM178B
GH07J140695 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.3 +24.1 24115 3.1 HDGF SP1 ELF3 ZFX MNT SIX5 NKRF POLR2A MLLT1 ZNF121 NDUFB2 NDUFB2-AS1 SLC37A3 ENSG00000270157 AGK TMEM178B ADCK2
GH07J140603 Enhancer 1 Ensembl ENCODE dbSUPER 17 -65.5 -65455 7.9 ZNF24 RXRA SP1 MNT ZSCAN5C FOS FOSL2 ZFP64 ADCK2 TMEM178B ENSG00000201354 DENND2A MKRN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADCK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADCK2 gene promoter:
  • AML1a
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1
  • STAT3

Genomic Locations for ADCK2 Gene

Genomic Locations for ADCK2 Gene
chr7:140,672,925-140,696,261
(GRCh38/hg38)
Size:
23,337 bases
Orientation:
Plus strand
chr7:140,372,953-140,396,061
(GRCh37/hg19)
Size:
23,109 bases
Orientation:
Plus strand

Genomic View for ADCK2 Gene

Genes around ADCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK2 Gene

Proteins for ADCK2 Gene

  • Protein details for ADCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z695-ADCK2_HUMAN
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 2
    Protein Accession:
    Q7Z695
    Secondary Accessions:
    • Q96CN6
    • Q9Y6T5

    Protein attributes for ADCK2 Gene

    Size:
    626 amino acids
    Molecular mass:
    68982 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14107.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ADCK2 Gene

Post-translational modifications for ADCK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK2 Gene

No data available for DME Specific Peptides for ADCK2 Gene

Domains & Families for ADCK2 Gene

Gene Families for ADCK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADCK2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADCK2 Gene

GenScript: Design optimal peptide antigens:
  • AarF domain containing kinase 2, isoform CRA_a (A4D1T6_HUMAN)
  • Uncharacterized aarF domain-containing protein kinase 2 (ADCK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z695

UniProtKB/Swiss-Prot:

ADCK2_HUMAN :
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK2: view

Function for ADCK2 Gene

Molecular function for ADCK2 Gene

UniProtKB/Swiss-Prot Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Enzyme Numbers (IUBMB) for ADCK2 Gene

Phenotypes From GWAS Catalog for ADCK2 Gene

Gene Ontology (GO) - Molecular Function for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 27499296
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with ADCK2: view
genes like me logo Genes that share phenotypes with ADCK2: view

Animal Models for ADCK2 Gene

MGI Knock Outs for ADCK2:
  • Adck2 Adck2<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCK2

CRISPR Products

miRNA for ADCK2 Gene

miRTarBase miRNAs that target ADCK2

Clone Products

  • Applied Biological Materials (abm): Clones for ADCK2 - Now 50% OFF >
  • * ADCK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ADCK2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for ADCK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCK2 Gene

Localization for ADCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCK2 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
mitochondrion 0
nucleus 0
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCK2: view

Pathways & Interactions for ADCK2 Gene

PathCards logo

SuperPathways for ADCK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with ADCK2: view

No data available for Pathways by source and SIGNOR curated interactions for ADCK2 Gene

Drugs & Compounds for ADCK2 Gene

No Compound Related Data Available

Transcripts for ADCK2 Gene

mRNA/cDNA for ADCK2 Gene

Unigene Clusters for ADCK2 Gene

AarF domain containing kinase 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ADCK2 - Now 50% OFF >
  • * ADCK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ADCK2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for ADCK2

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK2 Gene

No ASD Table

Relevant External Links for ADCK2 Gene

GeneLoc Exon Structure for
ADCK2
ECgene alternative splicing isoforms for
ADCK2

Expression for ADCK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCK2 Gene

Protein differential expression in normal tissues from HIPED for ADCK2 Gene

This gene is overexpressed in Heart (55.5) and Peripheral blood mononuclear cells (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCK2 Gene



Protein tissue co-expression partners for ADCK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADCK2 Gene:

ADCK2

SOURCE GeneReport for Unigene cluster for ADCK2 Gene:

Hs.744886

Evidence on tissue expression from TISSUES for ADCK2 Gene

  • Muscle(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ADCK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCK2 Gene

Orthologs for ADCK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADCK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCK2 35 34
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADCK2 35 34
  • 83.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADCK2 35 34
  • 81.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adck2 17 35 34
  • 78.25 (n)
rat
(Rattus norvegicus)
Mammalia Adck2 34
  • 77.89 (n)
oppossum
(Monodelphis domestica)
Mammalia ADCK2 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCK2 35 34
  • 65.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCK2 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adck2 34
  • 61.3 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC572087 34
  • 60.19 (n)
ADCK2 35
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.7 35 34
  • 48.26 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR222W 34
  • 47.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPL109C 34
  • 46.11 (n)
-- 35
  • 28 (a)
OneToOne
-- 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24795g 34
  • 45.87 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05600 34
  • 47.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21C3.03 34
  • 46.43 (n)
Species where no ortholog for ADCK2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCK2 Gene

ENSEMBL:
Gene Tree for ADCK2 (if available)
TreeFam:
Gene Tree for ADCK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADCK2: view image

Paralogs for ADCK2 Gene

Paralogs for ADCK2 Gene

genes like me logo Genes that share paralogs with ADCK2: view

Variants for ADCK2 Gene

Sequence variations from dbSNP and Humsavar for ADCK2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000308372 -- 140,684,226(+) G/C intron_variant
rs1000345757 -- 140,690,438(+) A/C intron_variant
rs1000388316 -- 140,674,494(+) T/A intron_variant
rs1000420817 -- 140,690,883(+) G/A intron_variant
rs1000724997 -- 140,676,352(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADCK2 Gene

Variant ID Type Subtype PubMed ID
nsv1119143 CNV deletion 24896259
nsv831157 CNV gain 17160897
nsv831158 CNV loss 17160897

Variation tolerance for ADCK2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.98; 94.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADCK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCK2 Gene

Disorders for ADCK2 Gene

Additional Disease Information for ADCK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADCK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCK2 Gene

Publications for ADCK2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. ADCK4-Associated Glomerulopathy Causes Adolescence-Onset FSGS. (PMID: 25967120) Korkmaz E … PodoNet Consortium (Journal of the American Society of Nephrology : JASN 2016) 3 58

Products for ADCK2 Gene

Sources for ADCK2 Gene

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