Aliases for ADAT2 Gene

Aliases for ADAT2 Gene

  • Adenosine Deaminase TRNA Specific 2 2 3 5
  • TRNA-Specific Adenosine-34 Deaminase Subunit ADAT2 3 4
  • Deaminase Domain-Containing Protein 1 3 4
  • TRNA-Specific Adenosine Deaminase 2 3 4
  • Deaminase Domain Containing 1 2 3
  • DJ20N2.1 2 3
  • DEADC1 3 4
  • TAD2 2 3
  • Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog (S. Cerevisiae) 2
  • Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog 3
  • TRNA-Specific Adenosine Deaminase 2 Homolog 3
  • EC 3.5.4.33 4
  • EC 3.5.4 51
  • DJ20N2 3
  • ADAT2 5

External Ids for ADAT2 Gene

Previous HGNC Symbols for ADAT2 Gene

  • DEADC1

Previous GeneCards Identifiers for ADAT2 Gene

  • GC06M143789
  • GC06M141307

Summaries for ADAT2 Gene

GeneCards Summary for ADAT2 Gene

ADAT2 (Adenosine Deaminase TRNA Specific 2) is a Protein Coding gene. Diseases associated with ADAT2 include Thyroid Gland Anaplastic Carcinoma. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include hydrolase activity and tRNA-specific adenosine deaminase activity. An important paralog of this gene is ADAT3.

UniProtKB/Swiss-Prot Summary for ADAT2 Gene

  • Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

Additional gene information for ADAT2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAT2 Gene

Genomics for ADAT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADAT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAT2

Top Transcription factor binding sites by QIAGEN in the ADAT2 gene promoter:
  • aMEF-2
  • CREB
  • deltaCREB
  • GATA-1
  • HFH-1
  • LCR-F1
  • MEF-2
  • MEF-2A
  • POU3F2
  • YY1

Genomic Locations for ADAT2 Gene

Genomic Locations for ADAT2 Gene
chr6:143,422,832-143,450,750
(GRCh38/hg38)
Size:
27,919 bases
Orientation:
Minus strand
chr6:143,743,969-143,771,841
(GRCh37/hg19)
Size:
27,873 bases
Orientation:
Minus strand

Genomic View for ADAT2 Gene

Genes around ADAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAT2 Gene

Proteins for ADAT2 Gene

  • Protein details for ADAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6V5-ADAT2_HUMAN
    Recommended name:
    tRNA-specific adenosine deaminase 2
    Protein Accession:
    Q7Z6V5
    Secondary Accessions:
    • A6NL12
    • B3KWY3
    • Q7Z327
    • Q8IY39

    Protein attributes for ADAT2 Gene

    Size:
    191 amino acids
    Molecular mass:
    21046 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37955.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADAT2 Gene

    Alternative splice isoforms for ADAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAT2 Gene

Selected DME Specific Peptides for ADAT2 Gene

Q7Z6V5:
  • TKNATRHAEMVA
  • LYVTVEPC
  • RFGGCGSV

Post-translational modifications for ADAT2 Gene

No Post-translational modifications

Domains & Families for ADAT2 Gene

Gene Families for ADAT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADAT2 Gene

InterPro:
Blocks:
  • Cytidine/deoxycytidylate deaminase, zinc-binding region
ProtoNet:

Suggested Antigen Peptide Sequences for ADAT2 Gene

GenScript: Design optimal peptide antigens:
  • tRNA-specific adenosine-34 deaminase subunit ADAT2 (ADAT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z6V5

UniProtKB/Swiss-Prot:

ADAT2_HUMAN :
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
genes like me logo Genes that share domains with ADAT2: view

Function for ADAT2 Gene

Molecular function for ADAT2 Gene

UniProtKB/Swiss-Prot Function:
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33; Evidence={ECO:0000305};.

Enzyme Numbers (IUBMB) for ADAT2 Gene

Phenotypes From GWAS Catalog for ADAT2 Gene

Gene Ontology (GO) - Molecular Function for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008251 tRNA-specific adenosine deaminase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAT2: view
genes like me logo Genes that share phenotypes with ADAT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAT2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAT2 Gene

Localization for ADAT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAT2 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0052718 tRNA-specific adenosine-34 deaminase complex IBA 21873635
genes like me logo Genes that share ontologies with ADAT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAT2 Gene

Pathways & Interactions for ADAT2 Gene

PathCards logo

SuperPathways for ADAT2 Gene

genes like me logo Genes that share pathways with ADAT2: view

Pathways by source for ADAT2 Gene

Gene Ontology (GO) - Biological Process for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002100 tRNA wobble adenosine to inosine editing IBA 21873635
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with ADAT2: view

No data available for SIGNOR curated interactions for ADAT2 Gene

Drugs & Compounds for ADAT2 Gene

No Compound Related Data Available

Transcripts for ADAT2 Gene

mRNA/cDNA for ADAT2 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAT2

Alternative Splicing Database (ASD) splice patterns (SP) for ADAT2 Gene

No ASD Table

Relevant External Links for ADAT2 Gene

GeneLoc Exon Structure for
ADAT2

Expression for ADAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAT2 Gene

Protein differential expression in normal tissues from HIPED for ADAT2 Gene

This gene is overexpressed in Fetal testis (47.9) and CD4 Tcells (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAT2 Gene



Protein tissue co-expression partners for ADAT2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAT2

SOURCE GeneReport for Unigene cluster for ADAT2 Gene:

Hs.709561

Evidence on tissue expression from TISSUES for ADAT2 Gene

  • Intestine(4.3)
  • Nervous system(2.1)
  • Thyroid gland(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with ADAT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAT2 Gene

Orthologs for ADAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADAT2 30 31
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADAT2 30 31
  • 90.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DEADC1 31
  • 90 (a)
OneToOne
ADAT2 30
  • 88.66 (n)
Rat
(Rattus norvegicus)
Mammalia Adat2 30
  • 85.51 (n)
Oppossum
(Monodelphis domestica)
Mammalia ADAT2 31
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Adat2 30 17 31
  • 83.94 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ADAT2 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADAT2 30 31
  • 72.12 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADAT2 31
  • 47 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adat2 30
  • 73.96 (n)
Zebrafish
(Danio rerio)
Actinopterygii adat2 30 31
  • 71.84 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013244 30
  • 53.72 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5292 30 31
  • 52.02 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea CELE_JC8.4 30
  • 51.83 (n)
JC8.4 31
  • 41 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAD2 31 33
  • 25 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons emb2191 30
  • 55.49 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0321900 30
  • 54.12 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 53 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tad2 30
  • 47.24 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1858 30
Species where no ortholog for ADAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADAT2 Gene

ENSEMBL:
Gene Tree for ADAT2 (if available)
TreeFam:
Gene Tree for ADAT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAT2: view image

Paralogs for ADAT2 Gene

Paralogs for ADAT2 Gene

Pseudogenes.org Pseudogenes for ADAT2 Gene

genes like me logo Genes that share paralogs with ADAT2: view

Variants for ADAT2 Gene

Additional dbSNP identifiers (rs#s) for ADAT2 Gene

Variation tolerance for ADAT2 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ADAT2 Gene

Disorders for ADAT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
thyroid gland anaplastic carcinoma
  • anaplastic thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ADAT2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ADAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAT2 Gene

Publications for ADAT2 Gene

  1. RNA editing by adenosine deaminases generates RNA and protein diversity. (PMID: 12457566) Schaub M … Keller W (Biochimie 2002) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ADAT2 Gene

Sources for ADAT2 Gene