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Aliases for ADAT2 Gene

Aliases for ADAT2 Gene

  • Adenosine Deaminase, TRNA Specific 2 2 3 5
  • TRNA-Specific Adenosine-34 Deaminase Subunit ADAT2 3 4
  • Deaminase Domain-Containing Protein 1 3 4
  • Deaminase Domain Containing 1 2 3
  • DEADC1 3 4
  • Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog (S. Cerevisiae) 2
  • Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog 3
  • TRNA-Specific Adenosine Deaminase 2 Homolog 3
  • TRNA-Specific Adenosine Deaminase 2 3
  • EC 3.5.4.33 4
  • DJ20N2.1 3
  • DJ20N2 3
  • TAD2 3

External Ids for ADAT2 Gene

Previous HGNC Symbols for ADAT2 Gene

  • DEADC1

Previous GeneCards Identifiers for ADAT2 Gene

  • GC06M143789
  • GC06M141307

Summaries for ADAT2 Gene

GeneCards Summary for ADAT2 Gene

ADAT2 (Adenosine Deaminase, TRNA Specific 2) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include hydrolase activity and tRNA-specific adenosine deaminase activity.

UniProtKB/Swiss-Prot for ADAT2 Gene

  • Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

Additional gene information for ADAT2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAT2 Gene

Genomics for ADAT2 Gene

GeneHancer (GH) Regulatory Elements for ADAT2 Gene

Promoters and enhancers for ADAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J143449 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 738.3 +0.0 44 3 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ADAT2 PEX3 RNA5SP221 LTV1 ENSG00000270890 VDAC1P8 PLAGL1 TUBB8P2 ENSG00000225752
GH06J142940 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 33.9 +506.3 506271 8.3 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 GLIS1 HIVEP2 ADAT2 VDAC1P8 LTV1 TUBB8P2 ENSG00000270890 ENSG00000233138 AIG1 FUCA2 ENSG00000232618
GH06J143510 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 28.6 -60.5 -60527 2.2 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZFP41 MEF2D FUCA2 LOC105378035 LTV1 VDAC1P8 ADAT2 ENSG00000270890 PLAGL1 GC06M143473
GH06J143058 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 23 +388.4 388447 7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC AIG1 HIVEP2 VDAC1P8 LTV1 ADAT2 ENSG00000270890 ENSG00000232618 ENSG00000227192 ENSG00000225752
GH06J144214 Enhancer 1.3 Ensembl ENCODE 40 -765.5 -765545 3 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 ZNF610 GC06P144217 TRL-TAA1-1 ADAT2 LTV1 ENSG00000270890 VDAC1P8 TUBB8P2 PLAGL1 SF3B5 TPT1P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAT2 gene promoter:
  • LCR-F1
  • HFH-1
  • GATA-1
  • deltaCREB
  • CREB
  • YY1
  • aMEF-2
  • MEF-2
  • MEF-2A
  • POU3F2

Genomic Locations for ADAT2 Gene

Genomic Locations for ADAT2 Gene
chr6:143,422,832-143,450,750
(GRCh38/hg38)
Size:
27,919 bases
Orientation:
Minus strand
chr6:143,743,969-143,771,841
(GRCh37/hg19)
Size:
27,873 bases
Orientation:
Minus strand

Genomic View for ADAT2 Gene

Genes around ADAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAT2 Gene

Proteins for ADAT2 Gene

  • Protein details for ADAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6V5-ADAT2_HUMAN
    Recommended name:
    tRNA-specific adenosine deaminase 2
    Protein Accession:
    Q7Z6V5
    Secondary Accessions:
    • A6NL12
    • B3KWY3
    • Q7Z327
    • Q8IY39

    Protein attributes for ADAT2 Gene

    Size:
    191 amino acids
    Molecular mass:
    21046 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37955.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADAT2 Gene

    Alternative splice isoforms for ADAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAT2 Gene

Post-translational modifications for ADAT2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ADAT2 Gene

Domains & Families for ADAT2 Gene

Gene Families for ADAT2 Gene

Suggested Antigen Peptide Sequences for ADAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6V5

UniProtKB/Swiss-Prot:

ADAT2_HUMAN :
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
genes like me logo Genes that share domains with ADAT2: view

Function for ADAT2 Gene

Molecular function for ADAT2 Gene

UniProtKB/Swiss-Prot Function:
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
UniProtKB/Swiss-Prot CatalyticActivity:
Adenine(34) in tRNA + H(2)O = hypoxanthine(34) in tRNA + NH(3).

Enzyme Numbers (IUBMB) for ADAT2 Gene

Phenotypes From GWAS Catalog for ADAT2 Gene

Gene Ontology (GO) - Molecular Function for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008251 tRNA-specific adenosine deaminase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAT2: view
genes like me logo Genes that share phenotypes with ADAT2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAT2 Gene

Localization for ADAT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAT2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0052718 tRNA-specific adenosine-34 deaminase complex IBA --
genes like me logo Genes that share ontologies with ADAT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAT2 Gene

Pathways & Interactions for ADAT2 Gene

genes like me logo Genes that share pathways with ADAT2: view

Pathways by source for ADAT2 Gene

Gene Ontology (GO) - Biological Process for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002100 tRNA wobble adenosine to inosine editing IEA --
GO:0006400 tRNA modification IBA,TAS --
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with ADAT2: view

No data available for SIGNOR curated interactions for ADAT2 Gene

Drugs & Compounds for ADAT2 Gene

No Compound Related Data Available

Transcripts for ADAT2 Gene

mRNA/cDNA for ADAT2 Gene

Unigene Clusters for ADAT2 Gene

Adenosine deaminase, tRNA-specific 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAT2 Gene

No ASD Table

Relevant External Links for ADAT2 Gene

GeneLoc Exon Structure for
ADAT2
ECgene alternative splicing isoforms for
ADAT2

Expression for ADAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAT2 Gene

Protein differential expression in normal tissues from HIPED for ADAT2 Gene

This gene is overexpressed in Fetal testis (47.9) and CD4 Tcells (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAT2 Gene



Protein tissue co-expression partners for ADAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAT2 Gene:

ADAT2

SOURCE GeneReport for Unigene cluster for ADAT2 Gene:

Hs.709561

Evidence on tissue expression from TISSUES for ADAT2 Gene

  • Intestine(4.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with ADAT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAT2 Gene

Orthologs for ADAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAT2 34 33
  • 99.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADAT2 34 33
  • 90.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DEADC1 34
  • 90 (a)
OneToOne
ADAT2 33
  • 88.66 (n)
rat
(Rattus norvegicus)
Mammalia Adat2 33
  • 85.51 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAT2 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adat2 16 34 33
  • 83.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADAT2 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAT2 34 33
  • 72.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAT2 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adat2 33
  • 73.96 (n)
zebrafish
(Danio rerio)
Actinopterygii adat2 34 33
  • 71.84 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013244 33
  • 53.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5292 34 33
  • 52.02 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_JC8.4 33
  • 51.83 (n)
JC8.4 34
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAD2 36 34
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons emb2191 33
  • 55.49 (n)
rice
(Oryza sativa)
Liliopsida Os03g0321900 33
  • 54.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToOne
Cin.1858 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tad2 33
  • 47.24 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1858 33
Species where no ortholog for ADAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAT2 Gene

ENSEMBL:
Gene Tree for ADAT2 (if available)
TreeFam:
Gene Tree for ADAT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAT2: view image

Paralogs for ADAT2 Gene

Pseudogenes.org Pseudogenes for ADAT2 Gene

genes like me logo Genes that share paralogs with ADAT2: view

No data available for Paralogs for ADAT2 Gene

Variants for ADAT2 Gene

Sequence variations from dbSNP and Humsavar for ADAT2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1043719778 uncertain-significance, Zellweger syndrome 143,450,829(-) G/C upstream_transcript_variant
rs116692495 benign, uncertain-significance, not specified, Zellweger syndrome 143,451,039(-) A/G upstream_transcript_variant
rs138955442 uncertain-significance, Zellweger syndrome 143,450,796(-) T/C upstream_transcript_variant
rs184934783 likely-benign, Zellweger syndrome 143,450,846(-) T/C/G upstream_transcript_variant
rs367803197 uncertain-significance, Zellweger syndrome 143,451,093(-) C/A/T upstream_transcript_variant

Variation tolerance for ADAT2 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADAT2 Gene

Disorders for ADAT2 Gene

Additional Disease Information for ADAT2

No disorders were found for ADAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAT2 Gene

Publications for ADAT2 Gene

  1. RNA editing by adenosine deaminases generates RNA and protein diversity. (PMID: 12457566) Schaub M … Keller W (Biochimie 2002) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Detection of a Subset of Posttranscriptional Transfer RNA Modifications in Vivo with a Restriction Fragment Length Polymorphism-Based Method. (PMID: 28703578) Wulff TF … Torres AG (Biochemistry 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ADAT2 Gene

Sources for ADAT2 Gene

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