Aliases for ADAT2 Gene

Aliases for ADAT2 Gene

  • Adenosine Deaminase TRNA Specific 2 2 3 5
  • TRNA-Specific Adenosine-34 Deaminase Subunit ADAT2 3 4
  • Deaminase Domain-Containing Protein 1 3 4
  • TRNA-Specific Adenosine Deaminase 2 3 4
  • Deaminase Domain Containing 1 2 3
  • DEADC1 3 4
  • Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog (S. Cerevisiae) 2
  • Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog 3
  • TRNA-Specific Adenosine Deaminase 2 Homolog 3
  • EC 4
  • DJ20N2.1 3
  • EC 3.5.4 54
  • DJ20N2 3
  • TAD2 3

External Ids for ADAT2 Gene

Previous HGNC Symbols for ADAT2 Gene

  • DEADC1

Previous GeneCards Identifiers for ADAT2 Gene

  • GC06M143789
  • GC06M141307

Summaries for ADAT2 Gene

GeneCards Summary for ADAT2 Gene

ADAT2 (Adenosine Deaminase TRNA Specific 2) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include hydrolase activity and tRNA-specific adenosine deaminase activity. An important paralog of this gene is ADAT3.

UniProtKB/Swiss-Prot Summary for ADAT2 Gene

  • Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

Additional gene information for ADAT2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAT2 Gene

Genomics for ADAT2 Gene

GeneHancer (GH) Regulatory Elements for ADAT2 Gene

Promoters and enhancers for ADAT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAT2 gene promoter:
  • aMEF-2
  • CREB
  • deltaCREB
  • GATA-1
  • HFH-1
  • LCR-F1
  • MEF-2
  • MEF-2A
  • POU3F2
  • YY1

Genomic Locations for ADAT2 Gene

Genomic Locations for ADAT2 Gene
27,919 bases
Minus strand
27,873 bases
Minus strand

Genomic View for ADAT2 Gene

Genes around ADAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAT2 Gene

Proteins for ADAT2 Gene

  • Protein details for ADAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA-specific adenosine deaminase 2
    Protein Accession:
    Secondary Accessions:
    • A6NL12
    • B3KWY3
    • Q7Z327
    • Q8IY39

    Protein attributes for ADAT2 Gene

    191 amino acids
    Molecular mass:
    21046 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    • Sequence=AAH37955.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADAT2 Gene

    Alternative splice isoforms for ADAT2 Gene


neXtProt entry for ADAT2 Gene

Selected DME Specific Peptides for ADAT2 Gene


Post-translational modifications for ADAT2 Gene

No Post-translational modifications

Domains & Families for ADAT2 Gene

Gene Families for ADAT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ADAT2 Gene

GenScript: Design optimal peptide antigens:
  • tRNA-specific adenosine-34 deaminase subunit ADAT2 (ADAT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
genes like me logo Genes that share domains with ADAT2: view

Function for ADAT2 Gene

Molecular function for ADAT2 Gene

UniProtKB/Swiss-Prot Function:
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=; Evidence=. ;.

Enzyme Numbers (IUBMB) for ADAT2 Gene

Phenotypes From GWAS Catalog for ADAT2 Gene

Gene Ontology (GO) - Molecular Function for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008251 tRNA-specific adenosine deaminase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAT2: view
genes like me logo Genes that share phenotypes with ADAT2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAT2 Gene

Localization for ADAT2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAT2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
mitochondrion 1
plasma membrane 0
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0052718 tRNA-specific adenosine-34 deaminase complex IBA 21873635
genes like me logo Genes that share ontologies with ADAT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAT2 Gene

Pathways & Interactions for ADAT2 Gene

PathCards logo

SuperPathways for ADAT2 Gene

genes like me logo Genes that share pathways with ADAT2: view

Pathways by source for ADAT2 Gene

Gene Ontology (GO) - Biological Process for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002100 tRNA wobble adenosine to inosine editing IBA 21873635
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with ADAT2: view

No data available for SIGNOR curated interactions for ADAT2 Gene

Drugs & Compounds for ADAT2 Gene

No Compound Related Data Available

Transcripts for ADAT2 Gene

mRNA/cDNA for ADAT2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAT2 Gene

No ASD Table

Relevant External Links for ADAT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAT2 Gene

Protein differential expression in normal tissues from HIPED for ADAT2 Gene

This gene is overexpressed in Fetal testis (47.9) and CD4 Tcells (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAT2 Gene

Protein tissue co-expression partners for ADAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAT2 Gene:


SOURCE GeneReport for Unigene cluster for ADAT2 Gene:


Evidence on tissue expression from TISSUES for ADAT2 Gene

  • Intestine(4.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with ADAT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAT2 Gene

Orthologs for ADAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAT2 33 32
  • 99.48 (n)
(Canis familiaris)
Mammalia ADAT2 33 32
  • 90.83 (n)
(Bos Taurus)
Mammalia DEADC1 33
  • 90 (a)
ADAT2 32
  • 88.66 (n)
(Rattus norvegicus)
Mammalia Adat2 32
  • 85.51 (n)
(Monodelphis domestica)
Mammalia ADAT2 33
  • 84 (a)
(Mus musculus)
Mammalia Adat2 17 33 32
  • 83.94 (n)
(Ornithorhynchus anatinus)
Mammalia ADAT2 33
  • 83 (a)
(Gallus gallus)
Aves ADAT2 33 32
  • 72.12 (n)
(Anolis carolinensis)
Reptilia ADAT2 33
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adat2 32
  • 73.96 (n)
(Danio rerio)
Actinopterygii adat2 33 32
  • 71.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013244 32
  • 53.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5292 33 32
  • 52.02 (n)
(Caenorhabditis elegans)
Secernentea CELE_JC8.4 32
  • 51.83 (n)
JC8.4 33
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAD2 35 33
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons emb2191 32
  • 55.49 (n)
(Oryza sativa)
Liliopsida Os03g0321900 32
  • 54.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 53 (a)
Cin.1858 32
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tad2 32
  • 47.24 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1858 32
Species where no ortholog for ADAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAT2 Gene

Gene Tree for ADAT2 (if available)
Gene Tree for ADAT2 (if available)
Evolutionary constrained regions (ECRs) for ADAT2: view image

Paralogs for ADAT2 Gene

Paralogs for ADAT2 Gene Pseudogenes for ADAT2 Gene

genes like me logo Genes that share paralogs with ADAT2: view

Variants for ADAT2 Gene

Sequence variations from dbSNP and Humsavar for ADAT2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs116692495 benign, uncertain-significance, not specified, Peroxisome biogenesis disorder 1A (Zellweger) 143,451,039(-) A/G upstream_transcript_variant
rs138955442 uncertain-significance, Peroxisome biogenesis disorder 1A (Zellweger) 143,450,796(-) T/C upstream_transcript_variant
rs184934783 likely-benign, Peroxisome biogenesis disorder 1A (Zellweger) 143,450,846(-) T/C/G upstream_transcript_variant
rs367803197 uncertain-significance, Peroxisome biogenesis disorder 1A (Zellweger) 143,451,093(-) C/A/T upstream_transcript_variant
rs545482337 uncertain-significance, Peroxisome biogenesis disorder 1A (Zellweger) 143,450,868(-) G/C upstream_transcript_variant

Variation tolerance for ADAT2 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADAT2 Gene

Disorders for ADAT2 Gene

Additional Disease Information for ADAT2

No disorders were found for ADAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAT2 Gene

Publications for ADAT2 Gene

  1. RNA editing by adenosine deaminases generates RNA and protein diversity. (PMID: 12457566) Schaub M … Keller W (Biochimie 2002) 2 3 4 56
  2. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 56
  5. Detection of a Subset of Posttranscriptional Transfer RNA Modifications in Vivo with a Restriction Fragment Length Polymorphism-Based Method. (PMID: 28703578) Wulff TF … Torres AG (Biochemistry 2017) 3 56

Products for ADAT2 Gene

Sources for ADAT2 Gene