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Aliases for ADAT1 Gene

Aliases for ADAT1 Gene

  • Adenosine Deaminase, TRNA Specific 1 2 3 5
  • TRNA-Specific Adenosine-37 Deaminase 3 4
  • HADAT1 3 4
  • TRNA-Specific Adenosine Deaminase 1 3
  • Adenosine Deaminase Acting On TRNA 3
  • EC 4

External Ids for ADAT1 Gene

Previous GeneCards Identifiers for ADAT1 Gene

  • GC16M066563
  • GC16M076593
  • GC16M075371
  • GC16M075412
  • GC16M074190
  • GC16M075632
  • GC16M061385

Summaries for ADAT1 Gene

Entrez Gene Summary for ADAT1 Gene

  • This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

GeneCards Summary for ADAT1 Gene

ADAT1 (Adenosine Deaminase, TRNA Specific 1) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and tRNA-specific adenosine deaminase activity. An important paralog of this gene is ADAR.

UniProtKB/Swiss-Prot for ADAT1 Gene

  • Specifically deaminates adenosine-37 to inosine in tRNA-Ala.

Additional gene information for ADAT1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAT1 Gene

Genomics for ADAT1 Gene

GeneHancer (GH) Regulatory Elements for ADAT1 Gene

Promoters and enhancers for ADAT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J075619 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 683.3 +1.6 1635 4.9 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ADAT1 BCAR1 GABARAPL2 TMEM231 CHST5 ENSG00000259992
GH16J075624 Enhancer 0.9 ENCODE 661.5 -1.8 -1765 1.2 ARNT FEZF1 BRCA1 NCOA2 TCF12 FOS ATF7 PAF1 NCOA1 TSHZ1 ADAT1 TMEM231 PIR52633
GH16J075646 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 52.1 -25.9 -25885 6 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 KARS TERF2IP ADAT1 BCAR1 TMEM231 CHST5 GC16P075674
GH16J075516 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 52.7 +106.3 106310 2 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TMEM231P1 ADAT1 TMEM231 RFWD3 CHST6 GABARAPL2 KARS CHST5
GH16J075564 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 36.9 +57.1 57077 3.2 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B GABARAPL2 KARS RFWD3 ADAT1 WDR59 GLG1 TMEM231 TMEM170A ENSG00000276408 ENSG00000259992
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAT1 gene promoter:
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • Lmo2
  • E47
  • Tal-1beta
  • Hand1
  • Pax-5

Genomic Locations for ADAT1 Gene

Genomic Locations for ADAT1 Gene
26,343 bases
Minus strand
26,343 bases
Minus strand

Genomic View for ADAT1 Gene

Genes around ADAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAT1 Gene

Proteins for ADAT1 Gene

  • Protein details for ADAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA-specific adenosine deaminase 1
    Protein Accession:
    Secondary Accessions:
    • Q9NVB7
    • Q9UNG3

    Protein attributes for ADAT1 Gene

    502 amino acids
    Molecular mass:
    55392 Da
    Name=1D-myo-inositol hexakisphosphate; Xref=ChEBI:CHEBI:58130;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAT1 Gene


neXtProt entry for ADAT1 Gene

Post-translational modifications for ADAT1 Gene

  • Ubiquitination at posLast=365365
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADAT1 Gene

Domains & Families for ADAT1 Gene

Gene Families for ADAT1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADAT1 Gene


Suggested Antigen Peptide Sequences for ADAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ADAT1 family.
  • Belongs to the ADAT1 family.
genes like me logo Genes that share domains with ADAT1: view

Function for ADAT1 Gene

Molecular function for ADAT1 Gene

UniProtKB/Swiss-Prot Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
UniProtKB/Swiss-Prot CatalyticActivity:
Adenine(37) in tRNA(Ala) + H(2)O = hypoxanthine(37) in tRNA(Ala) + NH(3).

Enzyme Numbers (IUBMB) for ADAT1 Gene

Phenotypes From GWAS Catalog for ADAT1 Gene

Gene Ontology (GO) - Molecular Function for ADAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IMP 10430867
GO:0004000 adenosine deaminase activity IEA --
GO:0008251 tRNA-specific adenosine deaminase activity IMP 10430867
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAT1: view
genes like me logo Genes that share phenotypes with ADAT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAT1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAT1 Gene

Localization for ADAT1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAT1 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ADAT1 Gene

Pathways & Interactions for ADAT1 Gene

genes like me logo Genes that share pathways with ADAT1: view

Pathways by source for ADAT1 Gene

Interacting Proteins for ADAT1 Gene

Gene Ontology (GO) - Biological Process for ADAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0008033 tRNA processing IMP 10430867
genes like me logo Genes that share ontologies with ADAT1: view

No data available for SIGNOR curated interactions for ADAT1 Gene

Drugs & Compounds for ADAT1 Gene

(4) Drugs for ADAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Apoptosis inducer in CLL cells 81
Ammonia Approved Pharma 0
Inosine Approved, Investigational Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with ADAT1: view

Transcripts for ADAT1 Gene

Unigene Clusters for ADAT1 Gene

Adenosine deaminase, tRNA-specific 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: -
SP3: - - -

Relevant External Links for ADAT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADAT1 Gene

This gene is overexpressed in Blymphocyte (41.7) and CD8 Tcells (27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAT1 Gene

Protein tissue co-expression partners for ADAT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAT1 Gene:


SOURCE GeneReport for Unigene cluster for ADAT1 Gene:


mRNA Expression by UniProt/SwissProt for ADAT1 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ADAT1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ADAT1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAT1 Gene

Orthologs for ADAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAT1 34 33
  • 98.94 (n)
(Bos Taurus)
Mammalia ADAT1 34 33
  • 85.83 (n)
(Canis familiaris)
Mammalia ADAT1 34 33
  • 85.65 (n)
(Mus musculus)
Mammalia Adat1 16 34 33
  • 81.89 (n)
(Rattus norvegicus)
Mammalia Adat1 33
  • 81.65 (n)
(Monodelphis domestica)
Mammalia ADAT1 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia ADAT1 34
  • 63 (a)
(Gallus gallus)
Aves ADAT1 34 33
  • 63.99 (n)
(Anolis carolinensis)
Reptilia ADAT1 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adat1 33
  • 60.36 (n)
Str.18961 33
(Danio rerio)
Actinopterygii adat1 34 33
  • 55.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta adat 34 33
  • 50.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009185 33
  • 45.41 (n)
(Caenorhabditis elegans)
Secernentea adr-2 34
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01760 33
  • 44.15 (n)
(Oryza sativa)
Liliopsida Os04g0683500 33
  • 52.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for ADAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAT1 Gene

Gene Tree for ADAT1 (if available)
Gene Tree for ADAT1 (if available)
Evolutionary constrained regions (ECRs) for ADAT1: view image

Paralogs for ADAT1 Gene

Paralogs for ADAT1 Gene

(1) SIMAP similar genes for ADAT1 Gene using alignment to 7 proteins:

  • H3BP18_HUMAN
  • H3BP27_HUMAN
  • H3BU72_HUMAN
  • H3BV89_HUMAN
genes like me logo Genes that share paralogs with ADAT1: view

Variants for ADAT1 Gene

Sequence variations from dbSNP and Humsavar for ADAT1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs193920811 uncertain-significance, Malignant tumor of prostate 75,612,612(-) G/A/C coding_sequence_variant, missense_variant
rs1000019493 -- 75,603,580(-) T/C intron_variant
rs1000052965 -- 75,598,249(-) G/C 3_prime_UTR_variant
rs1000085113 -- 75,598,419(-) C/T 3_prime_UTR_variant
rs1000112630 -- 75,613,488(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAT1 Gene

Variant ID Type Subtype PubMed ID
esv3308244 CNV mobile element insertion 20981092
esv3442847 CNV insertion 20981092
esv3582324 CNV loss 25503493
esv3639101 CNV loss 21293372
nsv1065543 CNV loss 25217958

Variation tolerance for ADAT1 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAT1 Gene

Disorders for ADAT1 Gene

Additional Disease Information for ADAT1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAT1 Gene

Publications for ADAT1 Gene

  1. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. (PMID: 10430867) Maas S … Rich A (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 58
  2. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin BM … Amundadottir LT (Nature genetics 2014) 3 58

Products for ADAT1 Gene

Sources for ADAT1 Gene

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