This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008] See more...

Aliases for ADARB2 Gene

Aliases for ADARB2 Gene

  • Adenosine Deaminase RNA Specific B2 (Inactive) 2 3 5
  • ADAR3 2 3 4
  • RED2 2 3 4
  • Adenosine Deaminase, RNA-Specific, B2 (RED2 Homolog Rat) 2 3
  • Adenosine Deaminase, RNA-Specific, B2 (Non-Functional) 2 3
  • Double-Stranded RNA-Specific Editase B2 3 4
  • RNA-Dependent Adenosine Deaminase 3 3 4
  • DsRNA Adenosine Deaminase B2 3 4
  • RNA-Editing Deaminase 2 3 4
  • RNA-Editing Enzyme 2 3 4
  • Adenosine Deaminase, RNA-Specific, B2 (RED1 Homolog Rat) 3
  • Adenosine Deaminase, RNA-Specific, B2 2
  • Homolog Of Rat BLUE 3
  • RED2 Homolog (Rat) 2
  • RED2 Homolog 3
  • EC 51
  • EC 3.5.-.- 4
  • EC 3.5.4 51
  • ADARB2 5
  • HRED2 2

External Ids for ADARB2 Gene

Previous GeneCards Identifiers for ADARB2 Gene

  • GC10U990001
  • GC10M001182
  • GC10M001219

Summaries for ADARB2 Gene

Entrez Gene Summary for ADARB2 Gene

  • This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADARB2 Gene

ADARB2 (Adenosine Deaminase RNA Specific B2 (Inactive)) is a Protein Coding gene. Diseases associated with ADARB2 include Dyschromatosis Symmetrica Hereditaria and Juvenile Astrocytoma. Among its related pathways are ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is ADARB1.

UniProtKB/Swiss-Prot Summary for ADARB2 Gene

  • Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.

Gene Wiki entry for ADARB2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADARB2 Gene

Genomics for ADARB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADARB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J001736 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.3 324 1.6 SP1 POLR2A STAT3 ZNF143 SMAD5 IKZF2 RELA TRIM22 EZH2 PKNOX1 ADARB2 HSALNG0075564 IDI1
GH10J001197 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE dbSUPER 613.6 +538.7 538732 3.3 ZNF692 USF1 NFIC ZFP69B NFIB SMARCA4 ADARB2 lnc-IDI1-3 GTPBP4 lnc-ADARB2-6 LINC00200 IDI1
GH10J001239 Promoter/Enhancer 0.9 Ensembl ENCODE 58.1 +499.5 499484 6.1 FOXA1 ZIC2 EZH2 CEBPA YY1 POLR2A FOXP1 WT1 ZFHX2 TFAP4 ADARB2 lnc-IDI1-6 piR-45012-033 LINC00200 IDI1
GH10J001287 Enhancer 1 Ensembl ENCODE dbSUPER 38.5 +448.7 448676 3.7 FOXA1 SCRT2 ZFX ESRRA ZNF217 JUND KLF9 DPF2 FOSL2 MAZ ADARB2 ENSG00000225140 ENSG00000282390 piR-40110-034 LINC00200 IDI1
GH10J001254 Enhancer 0.7 Ensembl dbSUPER 46.6 +481.9 481924 3.2 CREB1 SCRT2 EED RUNX3 CBFB SCRT1 NBN HDGF IRF5 MLLT1 ADARB2 piR-37972-035 lnc-IDI1-6 LINC00200 IDI1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADARB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADARB2

Top Transcription factor binding sites by QIAGEN in the ADARB2 gene promoter:
  • aMEF-2
  • AML1a
  • Brachyury
  • c-Myb
  • GATA-1
  • Hlf
  • MEF-2A
  • Pbx1a
  • SRY
  • ZIC2

Genomic Locations for ADARB2 Gene

Genomic Locations for ADARB2 Gene
560,213 bases
Minus strand
556,418 bases
Minus strand

Genomic View for ADARB2 Gene

Genes around ADARB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADARB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADARB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADARB2 Gene

Proteins for ADARB2 Gene

  • Protein details for ADARB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Double-stranded RNA-specific editase B2
    Protein Accession:
    Secondary Accessions:
    • B2RPJ5
    • Q5VUT6
    • Q5VW42

    Protein attributes for ADARB2 Gene

    739 amino acids
    Molecular mass:
    80621 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADARB2 Gene


neXtProt entry for ADARB2 Gene

Selected DME Specific Peptides for ADARB2 Gene


Post-translational modifications for ADARB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADARB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADARB2 Gene

Gene Families for ADARB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ADARB2 Gene

  • Adenosine deaminase/editase

Suggested Antigen Peptide Sequences for ADARB2 Gene

GenScript: Design optimal peptide antigens:
  • ADARB2 protein (A4VCH5_HUMAN)
  • cDNA FLJ30545 fis, clone BRAWH2001418, highly similar to Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (Q5VW42_HUMAN)
  • ADARB2 protein (Q86X17_HUMAN)
  • dsRNA adenosine deaminase B2 (RED2_HUMAN)
genes like me logo Genes that share domains with ADARB2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ADARB2 Gene

Function for ADARB2 Gene

Molecular function for ADARB2 Gene

UniProtKB/Swiss-Prot Function:
Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.
GENATLAS Biochemistry:
double stranded RNA editing deaminase 2

Enzyme Numbers (IUBMB) for ADARB2 Gene

Phenotypes From GWAS Catalog for ADARB2 Gene

Gene Ontology (GO) - Molecular Function for ADARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003725 double-stranded RNA binding TAS,IBA 21873635
GO:0003726 double-stranded RNA adenosine deaminase activity IBA 21873635
GO:0003727 single-stranded RNA binding TAS 10836796
GO:0004000 adenosine deaminase activity IEA,TAS 10836796
genes like me logo Genes that share ontologies with ADARB2: view
genes like me logo Genes that share phenotypes with ADARB2: view

Animal Models for ADARB2 Gene

MGI Knock Outs for ADARB2:
  • Adarb2 Adarb2<tm1b(KOMP)Mbp>

Animal Model Products

  • Taconic Biosciences Mouse Models for ADARB2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADARB2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADARB2 Gene

Localization for ADARB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADARB2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADARB2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005730 nucleolus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with ADARB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADARB2 Gene

Pathways & Interactions for ADARB2 Gene

PathCards logo

SuperPathways for ADARB2 Gene

SuperPathway Contained pathways
1 ATP/ITP metabolism
genes like me logo Genes that share pathways with ADARB2: view

Pathways by source for ADARB2 Gene

1 GeneGo (Thomson Reuters) pathway for ADARB2 Gene
  • ATP/ITP metabolism

Gene Ontology (GO) - Biological Process for ADARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006382 adenosine to inosine editing IBA 21873635
GO:0006396 RNA processing IEA,IBA 21873635
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with ADARB2: view

No data available for SIGNOR curated interactions for ADARB2 Gene

Drugs & Compounds for ADARB2 Gene

(1) Drugs for ADARB2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Apoptosis inducer in CLL cells 105

(2) Additional Compounds for ADARB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for ADARB2 Gene

Compound Action Cas Number
Cladribine Apoptosis inducer in CLL cells 4291-63-8
genes like me logo Genes that share compounds with ADARB2: view

Drug Products

Transcripts for ADARB2 Gene

mRNA/cDNA for ADARB2 Gene

14 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADARB2

Alternative Splicing Database (ASD) splice patterns (SP) for ADARB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - -

Relevant External Links for ADARB2 Gene

GeneLoc Exon Structure for

Expression for ADARB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADARB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADARB2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.8), Brain - Substantia nigra (x5.5), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for ADARB2 Gene

This gene is overexpressed in Fetal Liver (31.8), Breast (24.0), and Fetal heart (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADARB2 Gene

Protein tissue co-expression partners for ADARB2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADARB2

SOURCE GeneReport for Unigene cluster for ADARB2 Gene:


mRNA Expression by UniProt/SwissProt for ADARB2 Gene:

Tissue specificity: Brain specific. Expressed at higher levels in astrocytomas as compared to the normal brain tissue.

Evidence on tissue expression from TISSUES for ADARB2 Gene

  • Nervous system(4.9)
  • Skin(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with ADARB2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADARB2 Gene

Orthologs for ADARB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADARB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADARB2 30 31
  • 98.53 (n)
(Canis familiaris)
Mammalia ADARB2 30
  • 83.31 (n)
-- 31
  • 80 (a)
-- 31
  • 77 (a)
(Bos Taurus)
Mammalia ADARB2 30 31
  • 80.81 (n)
(Mus musculus)
Mammalia Adarb2 30 17 31
  • 80.54 (n)
(Rattus norvegicus)
Mammalia Adarb2 30
  • 80.08 (n)
(Monodelphis domestica)
Mammalia ADARB2 31
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ADARB2 31
  • 75 (a)
(Gallus gallus)
Aves ADARB2 30 31
  • 72.85 (n)
(Anolis carolinensis)
Reptilia ADARB2 31
  • 70 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adarb2 30
  • 67.47 (n)
(Danio rerio)
Actinopterygii adarb2 30 31
  • 68.22 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Adar 31
  • 38 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
Species where no ortholog for ADARB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ADARB2 Gene

Gene Tree for ADARB2 (if available)
Gene Tree for ADARB2 (if available)
Evolutionary constrained regions (ECRs) for ADARB2: view image

Paralogs for ADARB2 Gene

Paralogs for ADARB2 Gene

(5) SIMAP similar genes for ADARB2 Gene using alignment to 5 proteins:

  • Q5VW42_HUMAN
  • Q5VW43_HUMAN
  • Q86X17_HUMAN
genes like me logo Genes that share paralogs with ADARB2: view

Variants for ADARB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADARB2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
719185 Likely Benign: not provided 1,363,730(-) C/T SYNONYMOUS_VARIANT
720443 Benign: not provided 1,363,121(-) C/T SYNONYMOUS_VARIANT
723798 Benign: not provided 1,271,025(-) G/A SYNONYMOUS_VARIANT
749228 Likely Benign: not provided 1,242,292(-) A/G SYNONYMOUS_VARIANT
773917 Benign: not provided 1,363,207(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ADARB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADARB2 Gene

Variant ID Type Subtype PubMed ID
dgv120n67 CNV gain 20364138
dgv335n106 CNV insertion 24896259
dgv336n106 CNV deletion 24896259
dgv337n106 CNV deletion 24896259
dgv338n106 CNV deletion 24896259
dgv342e59 CNV duplication 20981092
dgv344e59 CNV duplication 20981092
dgv345e59 CNV duplication 20981092
dgv655n100 CNV gain 25217958
dgv656n100 CNV gain 25217958
dgv75e201 CNV deletion 23290073
dgv76e201 CNV deletion 23290073
dgv77e201 CNV deletion 23290073
dgv78e201 CNV deletion 23290073
dgv79e201 CNV deletion 23290073
dgv80e201 CNV deletion 23290073
dgv81e201 CNV deletion 23290073
dgv82e201 CNV deletion 23290073
dgv925n54 CNV gain 21841781
dgv926n54 CNV gain 21841781
dgv927n54 CNV loss 21841781
dgv928n54 CNV loss 21841781
dgv929n54 CNV gain+loss 21841781
dgv930n54 CNV loss 21841781
dgv931n54 CNV gain 21841781
esv1004371 CNV insertion 20482838
esv1008495 CNV insertion 20482838
esv1009491 CNV deletion 20482838
esv1032656 CNV insertion 17803354
esv1082929 CNV deletion 17803354
esv1105125 CNV insertion 17803354
esv1159013 CNV insertion 17803354
esv1227692 CNV insertion 17803354
esv1231222 CNV insertion 17803354
esv1258640 CNV insertion 17803354
esv1269144 CNV deletion 17803354
esv1278410 CNV insertion 17803354
esv1309284 CNV insertion 17803354
esv1327835 CNV insertion 17803354
esv1352224 CNV deletion 17803354
esv1372493 CNV deletion 17803354
esv1388155 CNV deletion 17803354
esv1398797 CNV deletion 17803354
esv1416852 CNV deletion 17803354
esv1424351 CNV insertion 17803354
esv1437533 CNV insertion 17803354
esv1493086 CNV deletion 17803354
esv1522620 CNV deletion 17803354
esv1523107 CNV deletion 17803354
esv1537660 CNV insertion 17803354
esv1541589 CNV deletion 17803354
esv1543111 CNV deletion 17803354
esv1567608 CNV insertion 17803354
esv1588804 CNV deletion 17803354
esv1589394 CNV deletion 17803354
esv1593452 CNV deletion 17803354
esv1595476 CNV deletion 17803354
esv1608725 CNV deletion 17803354
esv1613053 CNV deletion 17803354
esv1631254 CNV deletion 17803354
esv1637733 CNV insertion 17803354
esv1647895 CNV insertion 17803354
esv1670054 CNV insertion 17803354
esv1761080 CNV deletion 17803354
esv1921685 CNV deletion 18987734
esv2128674 CNV deletion 18987734
esv21703 CNV gain 19812545
esv22010 CNV loss 19812545
esv22298 CNV loss 19812545
esv2247605 CNV deletion 18987734
esv22628 CNV gain 19812545
esv23314 CNV gain 19812545
esv23632 CNV loss 19812545
esv2474802 CNV deletion 19546169
esv24883 CNV loss 19812545
esv2505047 CNV deletion 19546169
esv2505756 CNV deletion 19546169
esv25433 CNV gain 19812545
esv25831 CNV gain 19812545
esv2649249 CNV deletion 19546169
esv2656665 CNV deletion 23128226
esv2658549 CNV deletion 23128226
esv2659246 CNV deletion 23128226
esv2660097 CNV deletion 23128226
esv2664083 CNV deletion 23128226
esv2664107 CNV deletion 23128226
esv2666228 CNV deletion 23128226
esv2672872 CNV deletion 23128226
esv2729507 CNV deletion 23290073
esv2729518 CNV deletion 23290073
esv2729529 CNV deletion 23290073
esv2729540 CNV deletion 23290073
esv2729551 CNV deletion 23290073
esv2729562 CNV deletion 23290073
esv2729573 CNV deletion 23290073
esv2729585 CNV deletion 23290073
esv2729596 CNV deletion 23290073
esv2729607 CNV deletion 23290073
esv2729618 CNV deletion 23290073
esv2729629 CNV deletion 23290073
esv2729640 CNV deletion 23290073
esv2729651 CNV deletion 23290073
esv2729662 CNV deletion 23290073
esv2729684 CNV deletion 23290073
esv2729707 CNV deletion 23290073
esv2729718 CNV deletion 23290073
esv2729729 CNV deletion 23290073
esv2729740 CNV deletion 23290073
esv2729751 CNV deletion 23290073
esv2729784 CNV deletion 23290073
esv2729795 CNV deletion 23290073
esv2729807 CNV deletion 23290073
esv2729818 CNV deletion 23290073
esv2729829 CNV deletion 23290073
esv2729840 CNV deletion 23290073
esv2729851 CNV deletion 23290073
esv2729862 CNV deletion 23290073
esv2729873 CNV deletion 23290073
esv2729884 CNV deletion 23290073
esv2729895 CNV deletion 23290073
esv2729918 CNV deletion 23290073
esv2729929 CNV deletion 23290073
esv2729940 CNV deletion 23290073
esv2729951 CNV deletion 23290073
esv2729962 CNV deletion 23290073
esv2729973 CNV deletion 23290073
esv2729984 CNV deletion 23290073
esv2729995 CNV deletion 23290073
esv2730006 CNV deletion 23290073
esv2730017 CNV deletion 23290073
esv2730029 CNV deletion 23290073
esv2730040 CNV deletion 23290073
esv2730051 CNV deletion 23290073
esv2730062 CNV deletion 23290073
esv2730073 CNV deletion 23290073
esv2730084 CNV deletion 23290073
esv2730106 CNV deletion 23290073
esv2730117 CNV deletion 23290073
esv2730128 CNV deletion 23290073
esv2730140 CNV deletion 23290073
esv2730151 CNV deletion 23290073
esv2730162 CNV deletion 23290073
esv2730173 CNV deletion 23290073
esv2730184 CNV deletion 23290073
esv2730195 CNV deletion 23290073
esv2730206 CNV deletion 23290073
esv2730273 CNV deletion 23290073
esv2730384 CNV deletion 23290073
esv2730395 CNV deletion 23290073
esv2730406 CNV deletion 23290073
esv2730417 CNV deletion 23290073
esv2730428 CNV deletion 23290073
esv2730439 CNV deletion 23290073
esv2730450 CNV deletion 23290073
esv2730461 CNV deletion 23290073
esv2730473 CNV deletion 23290073
esv2730484 CNV deletion 23290073
esv2730495 CNV deletion 23290073
esv2730506 CNV deletion 23290073
esv2730517 CNV deletion 23290073
esv2730528 CNV deletion 23290073
esv27475 CNV loss 19812545
esv2759724 CNV loss 17122850
esv2761563 CNV loss 21179565
esv2762837 CNV loss 21179565
esv28216 CNV gain+loss 19812545
esv28240 CNV gain 19812545
esv28361 CNV gain+loss 19812545
esv2859 CNV loss 18987735
esv3152 CNV loss 18987735
esv3305675 CNV mobile element insertion 20981092
esv3310506 CNV novel sequence insertion 20981092
esv3381443 CNV insertion 20981092
esv3396299 CNV duplication 20981092
esv3419994 CNV insertion 20981092
esv3423 CNV loss 18987735
esv3423659 CNV insertion 20981092
esv3545718 CNV deletion 23714750
esv3545719 CNV deletion 23714750
esv3545721 CNV deletion 23714750
esv3545725 CNV deletion 23714750
esv3545728 CNV deletion 23714750
esv3545730 CNV deletion 23714750
esv3622098 CNV loss 21293372
esv3622099 CNV loss 21293372
esv3622101 CNV gain 21293372
esv3622102 CNV loss 21293372
esv3622103 CNV loss 21293372
esv3622105 CNV loss 21293372
esv3622106 CNV gain 21293372
esv3622107 CNV loss 21293372
esv3622108 CNV loss 21293372
esv3622110 CNV loss 21293372
esv3846 CNV loss 18987735
esv3891738 CNV loss 25118596
esv5029 CNV loss 18987735
esv5670 CNV loss 19470904
esv6414 CNV gain 19470904
esv8410 CNV loss 19470904
esv988420 CNV insertion 20482838
esv991635 CNV insertion 20482838
esv991990 CNV deletion 20482838
esv998686 CNV deletion 20482838
esv998745 CNV deletion 20482838
nsv1040045 CNV loss 25217958
nsv1040953 CNV loss 25217958
nsv1041498 CNV gain 25217958
nsv1042322 CNV gain 25217958
nsv1043619 CNV loss 25217958
nsv1046041 CNV gain 25217958
nsv1054432 CNV gain 25217958
nsv1054555 CNV gain 25217958
nsv1068264 CNV deletion 25765185
nsv1068657 CNV deletion 25765185
nsv1069439 CNV deletion 25765185
nsv1069440 CNV deletion 25765185
nsv1071614 CNV deletion 25765185
nsv1122478 CNV deletion 24896259
nsv1124342 CNV deletion 24896259
nsv1124351 CNV deletion 24896259
nsv1133145 CNV tandem duplication 24896259
nsv1133960 CNV deletion 24896259
nsv1133961 CNV deletion 24896259
nsv1133962 CNV deletion 24896259
nsv1135763 CNV deletion 24896259
nsv1137380 CNV deletion 24896259
nsv1139515 CNV duplication 24896259
nsv1140908 CNV deletion 24896259
nsv1142086 CNV tandem duplication 24896259
nsv1144454 CNV deletion 24896259
nsv1147182 CNV deletion 26484159
nsv1150524 CNV deletion 26484159
nsv1151635 CNV deletion 26484159
nsv1153632 CNV duplication 26484159
nsv1153951 CNV insertion 26484159
nsv1161922 CNV duplication 26073780
nsv1161923 CNV duplication 26073780
nsv24116 CNV insertion 16902084
nsv24360 CNV deletion 16902084
nsv24658 CNV deletion 16902084
nsv25073 CNV deletion 16902084
nsv25176 CNV deletion 16902084
nsv25304 CNV deletion 16902084
nsv433508 CNV loss 18776910
nsv472745 CNV novel sequence insertion 20440878
nsv474444 CNV novel sequence insertion 20440878
nsv477845 CNV novel sequence insertion 20440878
nsv509340 CNV insertion 20534489
nsv512137 CNV loss 21212237
nsv512138 CNV loss 21212237
nsv517780 CNV loss 19592680
nsv519127 CNV loss 19592680
nsv527883 CNV gain 19592680
nsv527999 CNV gain 19592680
nsv528115 CNV gain 19592680
nsv549768 CNV gain 21841781
nsv549787 CNV loss 21841781
nsv549788 CNV gain 21841781
nsv549789 CNV loss 21841781
nsv549790 CNV loss 21841781
nsv549791 CNV loss 21841781
nsv549792 CNV loss 21841781
nsv549795 CNV gain+loss 21841781
nsv549796 CNV loss 21841781
nsv549797 CNV loss 21841781
nsv5543 CNV insertion 18451855
nsv5554 CNV insertion 18451855
nsv819780 CNV loss 19587683
nsv821012 CNV deletion 20802225
nsv821076 CNV deletion 20802225
nsv821498 CNV duplication 20802225
nsv825212 CNV gain 20364138
nsv825213 CNV loss 20364138
nsv951233 CNV deletion 24416366
nsv951234 CNV deletion 24416366
nsv951235 CNV deletion 24416366

Variation tolerance for ADARB2 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.90; 67.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADARB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADARB2 Gene

Disorders for ADARB2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADARB2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dyschromatosis symmetrica hereditaria
  • dsh
juvenile astrocytoma
  • pediatric astrocytoma
pigmentation disease
  • pigmentation disorders
dermatopathia pigmentosa reticularis
  • dpr
aicardi-goutieres syndrome
  • aicardi-goutieres syndrome 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADARB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADARB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADARB2 Gene

Publications for ADARB2 Gene

  1. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. (PMID: 10836796) Chen CX … Nishikura K (RNA (New York, N.Y.) 2000) 2 3 4 23
  2. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. (PMID: 20011587) Sebastiani P … Perls TT (PloS one 2009) 3 23 41
  3. Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15. (PMID: 9272162) Mittaz L … Scott HS (Human genetics 1997) 2 3 23
  4. Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. (PMID: 20709820) Kong X … ECLIPSE Study NETT Investigators (American journal of respiratory and critical care medicine 2011) 3 41
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for ADARB2 Gene

Sources for ADARB2 Gene