Aliases for ADARB1 Gene
- Adenosine Deaminase RNA Specific B1 2 3 5
- DRADA2 2 3 4
- ADAR2 2 3 4
- RED1 2 3 4
- Adenosine Deaminase, RNA-Specific, B1 (Homolog Of Rat RED1) 2 3
- Double-Stranded RNA-Specific Editase 1 3 4
- RNA-Editing Enzyme 1 3 4
- DRABA2 2 3
- DsRNA Adenosine Deaminase DRADA2 3
- DsRNA Adenosine Deaminase 4
- RNA Editing Deaminase 1 3
- RNA-Editing Deaminase 1 4
External Ids for ADARB1 Gene
Previous GeneCards Identifiers for ADARB1 Gene
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADARB1 Gene
ADARB1 (Adenosine Deaminase RNA Specific B1) is a Protein Coding gene. Diseases associated with ADARB1 include Neurodevelopmental Disorder With Hypotonia, Microcephaly, And Seizures and Dyschromatosis Symmetrica Hereditaria. Among its related pathways are ATP/ITP metabolism and C6 deamination of adenosine. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is ADARB2.
UniProtKB/Swiss-Prot Summary for ADARB1 Gene
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.
[Isoform 1]: Has a lower catalytic activity than isoform 2.
[Isoform 2]: Has a higher catalytic activity than isoform 1.