Aliases for ADAP2 Gene
External Ids for ADAP2 Gene
Previous HGNC Symbols for ADAP2 Gene
Previous GeneCards Identifiers for ADAP2 Gene
The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]
GeneCards Summary for ADAP2 Gene
ADAP2 (ArfGAP With Dual PH Domains 2) is a Protein Coding gene. Diseases associated with ADAP2 include Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb. Among its related pathways are B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include GTPase activator activity and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is ADAP1.
UniProtKB/Swiss-Prot for ADAP2 Gene
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.