Aliases for ADAP1 Gene

Aliases for ADAP1 Gene

  • ArfGAP With Dual PH Domains 1 2 3 5
  • Arf-GAP With Dual PH Domain-Containing Protein 1 3 4
  • Putative MAPK-Activating Protein PM25 3 4
  • Centaurin-Alpha-1 3 4
  • Cnt-A1 3 4
  • CENTA1 3 4
  • Centaurin, Alpha 1 2
  • Centaurin-Alpha 3
  • P42IP4 3
  • GCS1L 3

External Ids for ADAP1 Gene

Previous HGNC Symbols for ADAP1 Gene

  • CENTA1

Previous GeneCards Identifiers for ADAP1 Gene

  • GC07M000905
  • GC07M000938

Summaries for ADAP1 Gene

GeneCards Summary for ADAP1 Gene

ADAP1 (ArfGAP With Dual PH Domains 1) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Class I PI3K signaling events. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and inositol 1,3,4,5 tetrakisphosphate binding. An important paralog of this gene is ADAP2.

UniProtKB/Swiss-Prot Summary for ADAP1 Gene

  • GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Gene Wiki entry for ADAP1 Gene

Additional gene information for ADAP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAP1 Gene

Genomics for ADAP1 Gene

GeneHancer (GH) Regulatory Elements for ADAP1 Gene

Promoters and enhancers for ADAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAP1

Top Transcription factor binding sites by QIAGEN in the ADAP1 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • deltaCREB

Genomic Locations for ADAP1 Gene

Genomic Locations for ADAP1 Gene
chr7:897,900-955,407
(GRCh38/hg38)
Size:
57,508 bases
Orientation:
Minus strand
chr7:937,537-995,043
(GRCh37/hg19)
Size:
57,507 bases
Orientation:
Minus strand

Genomic View for ADAP1 Gene

Genes around ADAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAP1 Gene

Proteins for ADAP1 Gene

  • Protein details for ADAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75689-ADAP1_HUMAN
    Recommended name:
    Arf-GAP with dual PH domain-containing protein 1
    Protein Accession:
    O75689
    Secondary Accessions:
    • A4D2Q2
    • B3KRZ4
    • B4DVA6
    • F6XZ68
    • H7C2Q4

    Protein attributes for ADAP1 Gene

    Size:
    374 amino acids
    Molecular mass:
    43395 Da
    Quaternary structure:
    • Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.

    Three dimensional structures from OCA and Proteopedia for ADAP1 Gene

    Alternative splice isoforms for ADAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAP1 Gene

Post-translational modifications for ADAP1 Gene

No data available for DME Specific Peptides for ADAP1 Gene

Domains & Families for ADAP1 Gene

Gene Families for ADAP1 Gene

Protein Domains for ADAP1 Gene

Blocks:
  • Pleckstrin-like
  • HIV Rev interacting protein signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADAP1 Gene

GenScript: Design optimal peptide antigens:
  • Putative MAPK-activating protein PM25 (ADAP1_HUMAN)
genes like me logo Genes that share domains with ADAP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ADAP1 Gene

Function for ADAP1 Gene

Molecular function for ADAP1 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Phenotypes From GWAS Catalog for ADAP1 Gene

Gene Ontology (GO) - Molecular Function for ADAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 10333475
GO:0005515 protein binding IPI 12893243
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA --
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding TAS 12018390
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAP1: view
genes like me logo Genes that share phenotypes with ADAP1: view

Animal Models for ADAP1 Gene

MGI Knock Outs for ADAP1:
  • Adap1 Adap1<tm1a(EUCOMM)Wtsi>

Clone Products

  • Addgene plasmids for ADAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAP1 Gene

Localization for ADAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAP1 Gene

Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAP1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 4
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10333475
GO:0005737 cytoplasm IEA,IDA 10333475
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA 10333475
genes like me logo Genes that share ontologies with ADAP1: view

Pathways & Interactions for ADAP1 Gene

genes like me logo Genes that share pathways with ADAP1: view

Pathways by source for ADAP1 Gene

1 Sino Biological pathway for ADAP1 Gene
2 BioSystems pathways for ADAP1 Gene

SIGNOR curated interactions for ADAP1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for ADAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 10333475
GO:0043087 regulation of GTPase activity IMP 10333475
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ADAP1: view

Drugs & Compounds for ADAP1 Gene

(1) Drugs for ADAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for ADAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAP1: view

Transcripts for ADAP1 Gene

mRNA/cDNA for ADAP1 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for ADAP1

Alternative Splicing Database (ASD) splice patterns (SP) for ADAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: -

Relevant External Links for ADAP1 Gene

GeneLoc Exon Structure for
ADAP1

Expression for ADAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAP1 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for ADAP1 Gene

This gene is overexpressed in Fetal Brain (15.1), Frontal cortex (12.8), Spinal cord (11.8), and Stomach (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAP1

SOURCE GeneReport for Unigene cluster for ADAP1 Gene:

Hs.602573

mRNA Expression by UniProt/SwissProt for ADAP1 Gene:

O75689-ADAP1_HUMAN
Tissue specificity: Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ADAP1 Gene

  • Intestine(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with ADAP1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAP1 Gene

Orthologs for ADAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAP1 30
  • 99.64 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAP1 31
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAP1 31 30
  • 89.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adap1 17 31 30
  • 88.59 (n)
cow
(Bos Taurus)
Mammalia ADAP1 31 30
  • 88.2 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adap1 30
  • 87.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADAP1 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAP1 31 30
  • 78.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAP1 31
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100037843 30
  • 71.57 (n)
MGC76109 30
African clawed frog
(Xenopus laevis)
Amphibia MGC69045 30
zebrafish
(Danio rerio)
Actinopterygii CABZ01073174.1 31
  • 78 (a)
OneToOne
zgc:92360 30
  • 66.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007379 30
  • 54.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8243 31
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W09D10.1 31
  • 16 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE2 31
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8094 31
  • 41 (a)
OneToMany
Species where no ortholog for ADAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAP1 Gene

ENSEMBL:
Gene Tree for ADAP1 (if available)
TreeFam:
Gene Tree for ADAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAP1: view image

Paralogs for ADAP1 Gene

(8) SIMAP similar genes for ADAP1 Gene using alignment to 9 proteins:

  • ADAP1_HUMAN
  • C9JN36_HUMAN
  • F6XZ68_HUMAN
  • H0Y7Q1_HUMAN
  • H7BZT6_HUMAN
  • H7C264_HUMAN
  • H7C2Q4_HUMAN
  • H7C324_HUMAN
  • H7C4B3_HUMAN
genes like me logo Genes that share paralogs with ADAP1: view

Variants for ADAP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAP1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
774872 Benign: not provided 905,180(-) G/C INTRON_VARIANT
776189 Benign: not provided 899,208(-) C/T SYNONYMOUS_VARIANT
rs10256887 - p.Gly241Ser

Additional dbSNP identifiers (rs#s) for ADAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAP1 Gene

Variant ID Type Subtype PubMed ID
dgv11111n54 CNV loss 21841781
dgv11112n54 CNV loss 21841781
dgv11113n54 CNV gain 21841781
dgv11114n54 CNV gain 21841781
dgv11115n54 CNV loss 21841781
dgv3732e59 CNV duplication 20981092
dgv3733e59 CNV duplication 20981092
esv1008204 CNV deletion 20482838
esv1065077 CNV insertion 17803354
esv1134099 CNV deletion 17803354
esv1175595 CNV deletion 17803354
esv1298219 CNV deletion 17803354
esv1449576 CNV insertion 17803354
esv1457769 CNV deletion 17803354
esv1612925 CNV deletion 17803354
esv1647726 CNV deletion 17803354
esv1650528 CNV deletion 17803354
esv1704339 CNV deletion 17803354
esv22202 CNV gain 19812545
esv22922 CNV loss 19812545
esv2615886 CNV insertion 19546169
esv2733676 CNV deletion 23290073
esv2733677 CNV deletion 23290073
esv2733678 CNV deletion 23290073
esv2733679 CNV deletion 23290073
esv2733680 CNV deletion 23290073
esv2733681 CNV deletion 23290073
esv2733682 CNV deletion 23290073
esv2733684 CNV deletion 23290073
esv2733685 CNV deletion 23290073
esv2733686 CNV deletion 23290073
esv2733687 CNV deletion 23290073
esv2733688 CNV deletion 23290073
esv2733689 CNV deletion 23290073
esv2733690 CNV deletion 23290073
esv2733691 CNV deletion 23290073
esv2733692 CNV deletion 23290073
esv29574 CNV gain 19812545
esv3420 CNV loss 18987735
esv3571557 CNV loss 25503493
esv3571558 CNV loss 25503493
esv3611796 CNV gain 21293372
esv3891008 CNV loss 25118596
esv6292 CNV loss 19470904
esv997493 CNV deletion 20482838
nsv1073623 CNV deletion 25765185
nsv1073624 CNV deletion 25765185
nsv1073625 CNV deletion 25765185
nsv1073626 CNV deletion 25765185
nsv1078839 CNV insertion 25765185
nsv1114904 CNV deletion 24896259
nsv1114905 CNV deletion 24896259
nsv1117688 CNV deletion 24896259
nsv1124156 CNV deletion 24896259
nsv1125904 CNV tandem duplication 24896259
nsv1126089 CNV deletion 24896259
nsv1133395 CNV tandem duplication 24896259
nsv1133643 CNV deletion 24896259
nsv1137183 CNV deletion 24896259
nsv1140200 CNV insertion 24896259
nsv1143179 CNV tandem duplication 24896259
nsv1145118 CNV deletion 24896259
nsv1146694 CNV deletion 26484159
nsv1152364 CNV insertion 26484159
nsv1161477 CNV deletion 26073780
nsv366410 CNV deletion 16902084
nsv366941 CNV insertion 16902084
nsv464244 CNV loss 19166990
nsv464245 CNV gain 19166990
nsv475830 CNV novel sequence insertion 20440878
nsv509182 CNV insertion 20534489
nsv511937 CNV loss 21212237
nsv512903 CNV insertion 21212237
nsv512904 CNV insertion 21212237
nsv5611 CNV insertion 18451855
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605702 CNV loss 21841781
nsv605703 CNV loss 21841781
nsv605704 CNV gain 21841781
nsv605705 CNV loss 21841781
nsv605706 CNV loss 21841781
nsv605714 CNV gain+loss 21841781
nsv950784 CNV deletion 24416366

Variation tolerance for ADAP1 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAP1 Gene

Disorders for ADAP1 Gene

Additional Disease Information for ADAP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAP1 Gene

Publications for ADAP1 Gene

  1. Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. (PMID: 10333475) Venkateswarlu K … Cullen PJ (The Biochemical journal 1999) 2 3 4 23 54
  2. Molecular cloning and functional characterization of a human homologue of centaurin-alpha. (PMID: 10448098) Venkateswarlu K … Cullen PJ (Biochemical and biophysical research communications 1999) 3 4 23 54
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41 54
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 41 54
  5. p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor. (PMID: 16341594) Sedehizade F … Reiser G (Neurochemical research 2005) 3 23 54

Products for ADAP1 Gene

Sources for ADAP1 Gene