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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal T... See more...
Aliases for ADAMTS8 Gene
Aliases for ADAMTS8 Gene
External Ids for ADAMTS8 Gene
- HGNC: 224
- NCBI Entrez Gene: 11095
- Ensembl: ENSG00000134917
- OMIM®: 605175
- UniProtKB/Swiss-Prot: Q9UP79
Previous GeneCards Identifiers for ADAMTS8 Gene
- GC11M132275
- GC11M131787
- GC11M130308
- GC11M129812
- GC11M129780
- GC11M126229
Summaries for ADAMTS8 Gene
-
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAMTS8 Gene
ADAMTS8 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 8) is a Protein Coding gene. Diseases associated with ADAMTS8 include Keshan Disease and Colorectal Cancer, Hereditary Nonpolyposis, Type 2. Among its related pathways are O-linked glycosylation and Diseases of glycosylation. Gene Ontology (GO) annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is ADAMTS1.
UniProtKB/Swiss-Prot Summary for ADAMTS8 Gene
-
Has anti-angiogenic properties.
Additional gene information for ADAMTS8 Gene
- HGNC (224)
- NCBI Entrez Gene (11095)
- Ensembl (ENSG00000134917)
- OMIM® (605175)
- UniProtKB/Swiss-Prot (Q9UP79)
- Open Targets Platform(ENSG00000134917)
- Search for ADAMTS8 at DataMed
- Search for ADAMTS8 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAMTS8 Gene
Genomics for ADAMTS8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADAMTS8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADAMTS8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAMTS8
- Top Transcription factor binding sites by QIAGEN in the ADAMTS8 gene promoter:
-
- AML1a
- ATF-2
- C/EBPbeta
- CUTL1
- FOXO1
- FOXO1a
- Hlf
Genomic Locations for ADAMTS8 Gene
Latest Assembly
- chr11:130,404,923-130,428,609
- (GRCh38/hg38)
- Size:
- 23,687 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:130,274,818-130,298,504
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 23,687 bases
- Orientation:
- Minus strand
- chr11:130,274,820-130,298,888
- (GRCh37/hg19 by Ensembl)
- Size:
- 24,069 bases
- Orientation:
- Minus strand
Genomic View for ADAMTS8 Gene
Genes around ADAMTS8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.3 by HGNC
- 11q24.3 by Entrez Gene
- 11q24.3 by Ensembl
ADAMTS8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAMTS8 Gene
Proteins for ADAMTS8 Gene
-
Protein details for ADAMTS8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UP79-ATS8_HUMAN
- Recommended name:
- A disintegrin and metalloproteinase with thrombospondin motifs 8
- Protein Accession:
- Q9UP79
- Q9NZS0
Protein attributes for ADAMTS8 Gene
- Size:
- 889 amino acids
- Molecular mass:
- 96460 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for ADAMTS8 Gene
Selected DME Specific Peptides for ADAMTS8 Gene
- Q9UP79:
-
- CSRTCGGGV
- SCSVIED
- DKCGVCGG
- GQCVKAGCD
Post-translational modifications for ADAMTS8 Gene
- The precursor is cleaved by a furin endopeptidase.
- Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
-
Glycosylation at Asn344, Asn400, Asn465, Asn490, and Asn599
- NX_Q9UP79 (NX_Q9UP79-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ADAMTS8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for ADAMTS8
- Invitrogen Antibodies for ADAMTS8 (AFLGC-ADAMTS8)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADAMTS8
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for ADAMTS8
- Origene Custom Protein Services for ADAMTS8
- antibodies-online: Show 5 available ADAMTS8 Proteins ranked by validation data
- Compare Top ADAMTS8 Proteins
-
Quality Products:
-
Abcam proteins for ADAMTS8
Domains & Families for ADAMTS8 Gene
Gene Families for ADAMTS8 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for ADAMTS8 Gene
- InterPro:
- Blocks:
-
- Thrombospondin, type I
- Disintegrin
- Thrombospondin type 1 repeat signature
- Metalloendopeptidase M12B
- ADAM-TS Spacer 1
- ProtoNet:
Suggested Antigen Peptide Sequences for ADAMTS8 Gene
- GenScript: Design optimal peptide antigens:
-
- METH-8 (ATS8_HUMAN)
- ADAMTS8 protein (Q29RW5_HUMAN)
- ADAMTS8 protein (Q5FWF1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UP79UniProtKB/Swiss-Prot:
ATS8_HUMAN :- The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
- Domain:
-
- The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Function for ADAMTS8 Gene
Molecular function for ADAMTS8 Gene
- UniProtKB/Swiss-Prot Function:
- Has anti-angiogenic properties.
Enzyme Numbers (IUBMB) for ADAMTS8 Gene
Phenotypes From GWAS Catalog for ADAMTS8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IBA | 21873635 |
| GO:0005178 | integrin binding | TAS | 10438512 |
| GO:0008201 | heparin binding | IEA | -- |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | TAS | 10438512 |
Phenotypes for ADAMTS8 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for ADAMTS8
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADAMTS8 - Starting at $85 >
- * ADAMTS8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ADAMTS8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAMTS8
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAMTS8
miRNA for ADAMTS8 Gene
- miRTarBase miRNAs that target ADAMTS8
-
- mmu-miR-301b-3p (MIRT007748)
- hsa-miR-548s (MIRT495323)
- hsa-miR-3926 (MIRT495324)
- hsa-miR-6882-3p (MIRT495325)
- hsa-miR-4312 (MIRT495326)
- hsa-miR-190b (MIRT495327)
- hsa-miR-190a-5p (MIRT495328)
- hsa-miR-4475 (MIRT495330)
- hsa-miR-335-3p (MIRT650016)
- hsa-miR-664b-3p (MIRT650017)
- hsa-miR-579-3p (MIRT650018)
- hsa-miR-5696 (MIRT650019)
- hsa-miR-4729 (MIRT650020)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAMTS8
- Browse OriGene Inhibitory RNA Products For ADAMTS8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAMTS8
Clone products for research
- Applied Biological Materials (abm): Clones for ADAMTS8 - Starting at $45 >
- * ADAMTS8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ADAMTS8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAMTS8
Cell Lines for research
-
Horizon Cell Lines for ADAMTS8
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS8 Gene
Localization for ADAMTS8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS8 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| endoplasmic reticulum | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0031012 | extracellular matrix | IBA | 21873635 |
| GO:0062023 | colocalizes_with collagen-containing extracellular matrix | ISS | 22261194 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAMTS8 Gene
Pathways & Interactions for ADAMTS8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | O-glycosylation of TSR domain-containing proteins | ||
| 2 | Degradation of the extracellular matrix | ||
| 3 | Diseases of glycosylation | ||
| 4 | Metabolism of proteins | ||
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for ADAMTS8 Gene
Interacting Proteins for ADAMTS8 Gene
GPS-Prot Interaction Network for ADAMTS8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | TAS | 10438512 |
| GO:0030198 | extracellular matrix organization | IBA | 21873635 |
| GO:0035435 | phosphate ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for ADAMTS8 Gene
Transcripts for ADAMTS8 Gene
mRNA/cDNA for ADAMTS8 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000257359 3628 nts (view in UCSC)
- ENST00000531752 2250 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADAMTS8 - Starting at $85 >
- * ADAMTS8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ADAMTS8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAMTS8
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAMTS8
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAMTS8
- Browse OriGene Inhibitory RNA Products For ADAMTS8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAMTS8
Clone products for research
- Applied Biological Materials (abm): Clones for ADAMTS8 - Starting at $45 >
- * ADAMTS8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ADAMTS8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAMTS8
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: |
Relevant External Links for ADAMTS8 Gene
- GeneLoc Exon Structure for
- ADAMTS8
Expression for ADAMTS8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for ADAMTS8 Gene
This gene is overexpressed in Lung (x8.5) and Artery - Aorta (x4.1).
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS8 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAMTS8
SOURCE GeneReport for Unigene cluster for ADAMTS8 Gene:
Hs.271605mRNA Expression by UniProt/SwissProt for ADAMTS8 Gene:
Q9UP79-ATS8_HUMAN
Tissue specificity:
Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney.
Evidence on tissue expression from TISSUES for ADAMTS8 Gene
- Lung(4.5)
Primer products for research
-
OriGene qPCR primer pairs for ADAMTS8
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMTS8 Gene
Orthologs for ADAMTS8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADAMTS8 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ADAMTS8 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Adamts8 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Adamts8 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | ADAMTS8 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ADAMTS8 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ADAMTS8 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ADAMTS8 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ADAMTS8 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adamts8 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | adamts8a 30 31 |
|
OneToMany | |
| adamts15b 31 |
|
OneToMany |
- Species where no ortholog for ADAMTS8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ADAMTS8 Gene
- ENSEMBL:
- Gene Tree for ADAMTS8 (if available)
- TreeFam:
- Gene Tree for ADAMTS8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADAMTS8: view image
Paralogs for ADAMTS8 Gene
Paralogs for ADAMTS8 Gene
(12) SIMAP similar genes for ADAMTS8 Gene using alignment to 3 proteins:
- ATS8_HUMAN
- Q29RW5_HUMAN
- Q5FWF1_HUMAN
Variants for ADAMTS8 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAMTS8 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs199760382 | Uncertain Significance: Oromandibular-limb hypogenesis spectrum | 130,406,119(-) |
G/T NM_007037.6(ADAMTS8):c.2109C>A (p.Tyr703Ter) |
NONSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.82;
94.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADAMTS8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADAMTS8
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS8 Gene
Disorders for ADAMTS8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| keshan disease |
|
|
| colorectal cancer, hereditary nonpolyposis, type 2 |
|
|
Search ADAMTS8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADAMTS8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ADAMTS8 Gene
Publications for ADAMTS8 Gene
- METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PMID: 10438512) Vázquez F … Iruela-Arispe ML (The Journal of biological chemistry 1999) 2 3 4 23
- ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11. (PMID: 10610729) Georgiadis KE … Apte SS (Genomics 1999) 3 4 23
- Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 41
- ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (PMID: 15296936) Collins-Racie LA … LaVallie ER (Matrix biology : journal of the International Society for Matrix Biology 2004) 3 23
- METH-2 silencing and promoter hypermethylation in NSCLC. (PMID: 15328519) Dunn JR … Liloglou T (British journal of cancer 2004) 3 23
ExternalLinks
Products for ADAMTS8 Gene
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- Taconic Biosciences Mouse Models for ADAMTS8
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
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- VectorBuilder Custom and pre-made DNA vectors for ADAMTS8 (ie. gene expression, shRNA knockdown, CRISPR)
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Sources for ADAMTS8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB