Aliases for ADAMTS8 Gene
External Ids for ADAMTS8 Gene
Previous GeneCards Identifiers for ADAMTS8 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAMTS8 Gene
ADAMTS8 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 8) is a Protein Coding gene. Diseases associated with ADAMTS8 include Keshan Disease and Colorectal Cancer, Hereditary Nonpolyposis, Type 2. Among its related pathways are Degradation of the extracellular matrix and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include heparin binding and integrin binding. An important paralog of this gene is ADAMTS1.
UniProtKB/Swiss-Prot Summary for ADAMTS8 Gene
Has anti-angiogenic properties.