Aliases for ADAMTS7 Gene
- ADAM Metallopeptidase With Thrombospondin Type 1 Motif 7 2 3 5
- COMPase 2 3 4
- A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 7 2 3
- A Disintegrin And Metalloprotease With Thrombospondin Motifs-7 Preproprotein 2 3
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7 3 4
External Ids for ADAMTS7 Gene
Previous GeneCards Identifiers for ADAMTS7 Gene
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAMTS7 Gene
ADAMTS7 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 7) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and O-glycosylation of TSR domain-containing proteins. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS12.
UniProtKB/Swiss-Prot Summary for ADAMTS7 Gene
Metalloprotease that may play a role in the degradation of COMP.