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Aliases for ADAMTS7 Gene

Aliases for ADAMTS7 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 7 2 3 5
  • COMPase 2 3 4
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 7 2 3
  • A Disintegrin And Metalloprotease With Thrombospondin Motifs-7 Preproprotein 2 3
  • ADAM-TS 7 3 4
  • ADAM-TS7 3 4
  • ADAMTS-7 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7 3
  • EC 3.4.24.- 4

External Ids for ADAMTS7 Gene

Previous GeneCards Identifiers for ADAMTS7 Gene

  • GC15P074116
  • GC15M072142
  • GC15M076627
  • GC15M076767
  • GC15M076839
  • GC15M079051
  • GC15M055809

Summaries for ADAMTS7 Gene

Entrez Gene Summary for ADAMTS7 Gene

  • The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAMTS7 Gene

ADAMTS7 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 7) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS12.

UniProtKB/Swiss-Prot for ADAMTS7 Gene

  • Metalloprotease that may play a role in the degradation of COMP.

Additional gene information for ADAMTS7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS7 Gene

Genomics for ADAMTS7 Gene

GeneHancer (GH) Regulatory Elements for ADAMTS7 Gene

Promoters and enhancers for ADAMTS7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J078810 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +0.2 249 2.4 INSM2 SIN3A ZNF335 GLIS2 ZNF366 ZNF143 KLF13 ZBTB11 ZNF398 ZFP69B ADAMTS7 MORF4L1
GH15J078858 Enhancer 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 26.3 -48.9 -48892 3.4 MLX SIN3A IRF4 BRCA1 NCOA2 YY1 ETS1 GTF3C2 ZNF121 ZNF213 TRK-CTT1-2 IREB2 ENSG00000259562 ADAMTS7 MORF4L1 ENSG00000259322 WDR61 TBC1D2B ADAMTS7P3 CTSH
GH15J078871 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.2 -62.3 -62343 4.6 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 ZNF585B GLIS1 RCOR2 MORF4L1 IREB2 ENSG00000259562 PSMA4 TBC1D2B RNU6-415P ENSG00000260988 WDR61 ENSG00000177699 ENSG00000259322
GH15J078564 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 9.4 +245.6 245637 2.2 HDGF ARNT ARID4B SIN3A TCF12 ELK1 ZNF143 SP3 NCOA1 SREBF1 CHRNA5 PSMA4 IREB2 TBC1D2B HYKK MORF4L1 ADAMTS7 CRABP1 RASGRF1 ENSG00000261762
GH15J078824 Enhancer 1.3 VISTA Ensembl ENCODE 9 -14.2 -14173 2.2 FOXA2 ARID4B TCF12 RXRA SP5 ZHX2 REST PPARG KAT8 NFIL3 ADAMTS7 LOC646934 LOC390614 MORF4L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAMTS7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAMTS7 gene promoter:
  • MAZR
  • Arnt
  • AhR
  • Elk-1
  • NF-1/L
  • NF-1
  • Sp1
  • Sox5
  • Cdc5

Genomic Locations for ADAMTS7 Gene

Genomic Locations for ADAMTS7 Gene
52,262 bases
Minus strand
52,229 bases
Minus strand

Genomic View for ADAMTS7 Gene

Genes around ADAMTS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS7 Gene

Proteins for ADAMTS7 Gene

  • Protein details for ADAMTS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 7
    Protein Accession:
    Secondary Accessions:
    • Q14F51
    • Q6P7J9

    Protein attributes for ADAMTS7 Gene

    1686 amino acids
    Molecular mass:
    184095 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with COMP.
    • Sequence=AAD56358.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for ADAMTS7 Gene

Post-translational modifications for ADAMTS7 Gene

  • N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate.
  • May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed.
  • Glycosylation at Thr1214, posLast=11291129, Asn778, posLast=693693, and posLast=9494
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAMTS7 Gene

Domains & Families for ADAMTS7 Gene

Gene Families for ADAMTS7 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ADAMTS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAMTS7: view

Function for ADAMTS7 Gene

Molecular function for ADAMTS7 Gene

UniProtKB/Swiss-Prot Function:
Metalloprotease that may play a role in the degradation of COMP.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is between 7.5 and 9.5. {ECO:0000269 PubMed:16585064};
UniProtKB/Swiss-Prot Induction:
Up-regulated in articular cartilage and synovium from arthritis patients.
GENATLAS Biochemistry:
a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 7,extracellular matrix protein

Enzyme Numbers (IUBMB) for ADAMTS7 Gene

Phenotypes From GWAS Catalog for ADAMTS7 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IDA 18485748
GO:0005515 protein binding IPI 18485748
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 10464288
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAMTS7: view
genes like me logo Genes that share phenotypes with ADAMTS7: view

Animal Models for ADAMTS7 Gene

MGI Knock Outs for ADAMTS7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMTS7

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADAMTS7 Gene

Localization for ADAMTS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS7 Gene

Secreted, extracellular space, extracellular matrix. Note=Also found associated with the external cell surface. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAMTS7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADAMTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with ADAMTS7: view

Pathways & Interactions for ADAMTS7 Gene

genes like me logo Genes that share pathways with ADAMTS7: view

Gene Ontology (GO) - Biological Process for ADAMTS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0032331 negative regulation of chondrocyte differentiation IDA 22247065
GO:0036066 protein O-linked fucosylation TAS --
GO:0051603 proteolysis involved in cellular protein catabolic process IMP 18485748
GO:0071347 cellular response to interleukin-1 IMP 18485748
genes like me logo Genes that share ontologies with ADAMTS7: view

No data available for SIGNOR curated interactions for ADAMTS7 Gene

Drugs & Compounds for ADAMTS7 Gene

No Compound Related Data Available

Transcripts for ADAMTS7 Gene

mRNA/cDNA for ADAMTS7 Gene

Unigene Clusters for ADAMTS7 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS7 Gene

No ASD Table

Relevant External Links for ADAMTS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAMTS7 Gene

mRNA differential expression in normal tissues according to GTEx for ADAMTS7 Gene

This gene is overexpressed in Heart - Atrial Appendage (x8.7).

Protein differential expression in normal tissues from HIPED for ADAMTS7 Gene

This gene is overexpressed in Gallbladder (42.6) and Platelet (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS7 Gene

Protein tissue co-expression partners for ADAMTS7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAMTS7 Gene:


SOURCE GeneReport for Unigene cluster for ADAMTS7 Gene:


mRNA Expression by UniProt/SwissProt for ADAMTS7 Gene:

Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.
genes like me logo Genes that share expression patterns with ADAMTS7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMTS7 Gene

Orthologs for ADAMTS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAMTS7 34
  • 98 (a)
(Canis familiaris)
Mammalia ADAMTS7 34 33
  • 83.85 (n)
(Bos Taurus)
Mammalia ADAMTS7 34 33
  • 82.43 (n)
(Ornithorhynchus anatinus)
Mammalia ADAMTS7 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Adamts7 33
  • 78.56 (n)
(Mus musculus)
Mammalia Adamts7 16 34 33
  • 78.08 (n)
(Monodelphis domestica)
Mammalia ADAMTS7 34
  • 62 (a)
(Gallus gallus)
Aves ADAMTS7 34 33
  • 64.23 (n)
(Anolis carolinensis)
Reptilia ADAMTS7 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts7 33
  • 62.63 (n)
(Danio rerio)
Actinopterygii LOC560364 33
  • 61.59 (n)
CT030048.2 34
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4096 34 35 33
  • 52.89 (n)
CG3622 35
  • 25 (a)
stl 34
  • 21 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001113 33
  • 51.82 (n)
(Caenorhabditis elegans)
Secernentea T19D2.1 35
  • 27 (a)
adt-2 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for ADAMTS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS7 Gene

Gene Tree for ADAMTS7 (if available)
Gene Tree for ADAMTS7 (if available)
Evolutionary constrained regions (ECRs) for ADAMTS7: view image

Paralogs for ADAMTS7 Gene

(8) SIMAP similar genes for ADAMTS7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTS7: view

Variants for ADAMTS7 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS7 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000008302 -- 78,799,052(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000179486 -- 78,758,934(-) C/T downstream_transcript_variant
rs1000282700 -- 78,768,265(-) G/A intron_variant
rs1000411137 -- 78,807,100(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000446333 -- 78,798,714(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS7 Gene

Variant ID Type Subtype PubMed ID
nsv977740 CNV duplication 23825009
nsv977739 CNV duplication 23825009
nsv952004 CNV deletion 24416366
nsv94789 CNV insertion 16902084
nsv1116464 OTHER inversion 24896259
esv994389 CNV deletion 20482838
esv988480 CNV insertion 20482838
esv33573 CNV gain+loss 17666407
esv3193587 CNV deletion 24192839
esv2749916 CNV deletion 23290073
esv2665394 CNV deletion 23128226
esv1505425 CNV insertion 17803354
dgv308e201 CNV deletion 23290073

Variation tolerance for ADAMTS7 Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.83; 83.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAMTS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS7 Gene

Disorders for ADAMTS7 Gene

Additional Disease Information for ADAMTS7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADAMTS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS7 Gene

Publications for ADAMTS7 Gene

  1. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. (PMID: 10464288) Hurskainen TL … Apte SS (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. (PMID: 21239051) Reilly MP … Rader DJ (Lancet (London, England) 2011) 3 44 58
  3. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PMID: 21378988) Coronary Artery Disease (C4D) Genetics Consortium (Nature genetics 2011) 3 44 58
  4. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 44 58
  5. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. (PMID: 19098927) Liu CJ (Nature clinical practice. Rheumatology 2009) 3 22 58

Products for ADAMTS7 Gene

Sources for ADAMTS7 Gene

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