Aliases for ADAMTS5 Gene
- ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 2 3 5
- Aggrecanase-2 2 3 4
- A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2) 2 3
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11 3 4
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 3 4
- ADAM-TS 11 3 4
- ADAM-TS 5 3 4
- ADAMTS-11 3 4
External Ids for ADAMTS5 Gene
Previous GeneCards Identifiers for ADAMTS5 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAMTS5 Gene
ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include Osteoarthritis and Arthritis. Among its related pathways are Degradation of the extracellular matrix and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTS15.
UniProtKB/Swiss-Prot Summary for ADAMTS5 Gene
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.