Aliases for ADAMTS3 Gene
- ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3 2 3 5
- A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 3 2 3
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 3 3 4
- Procollagen II Amino Propeptide-Processing Enzyme 3 4
- Procollagen II N-Proteinase 3 4
- ADAM-TS 3 3 4
- ADAMTS-4 2 3
- ADAM-TS3 3 4
External Ids for ADAMTS3 Gene
Previous GeneCards Identifiers for ADAMTS3 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAMTS3 Gene
ADAMTS3 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3) is a Protein Coding gene. Diseases associated with ADAMTS3 include Hennekam Lymphangiectasia-Lymphedema Syndrome 3 and Hennekam Syndrome. Among its related pathways are Degradation of the extracellular matrix and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTS14.
UniProtKB/Swiss-Prot Summary for ADAMTS3 Gene
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.