Aliases for ADAMTS3 Gene
- ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3 2 3 5
- A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 3 2 3
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 3 3 4
- Procollagen II Amino Propeptide-Processing Enzyme 3 4
- Procollagen II N-Proteinase 3 4
- ADAM-TS 3 3 4
- ADAM-TS3 3 4
- ADAMTS-3 3 4
External Ids for ADAMTS3 Gene
Previous GeneCards Identifiers for ADAMTS3 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]
GeneCards Summary for ADAMTS3 Gene
ADAMTS3 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3) is a Protein Coding gene. Diseases associated with ADAMTS3 include Hennekam Lymphangiectasia-Lymphedema Syndrome 3 and Hennekam Syndrome. Among its related pathways are Collagen chain trimerization and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTS2.
UniProtKB/Swiss-Prot Summary for ADAMTS3 Gene
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.