Aliases for ADAMTS20 Gene
External Ids for ADAMTS20 Gene
Previous GeneCards Identifiers for ADAMTS20 Gene
The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]
GeneCards Summary for ADAMTS20 Gene
ADAMTS20 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 20) is a Protein Coding gene. Diseases associated with ADAMTS20 include Peters-Plus Syndrome and Hemophagocytic Lymphohistiocytosis, Familial, 2. Among its related pathways are Metabolism of proteins and O-glycosylation of TSR domain-containing proteins. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAMTS9.
UniProtKB/Swiss-Prot Summary for ADAMTS20 Gene
May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.