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Aliases for ADAMTS19 Gene

Aliases for ADAMTS19 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 19 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 19 2 3
  • ADAM-TS 19 3 4
  • ADAM-TS19 3 4
  • ADAMTS-19 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 19 3
  • EC 3.4.24.- 4

External Ids for ADAMTS19 Gene

Previous GeneCards Identifiers for ADAMTS19 Gene

  • GC05P128337
  • GC05P129231
  • GC05P128826
  • GC05P128872
  • GC05P128824
  • GC05P123989

Summaries for ADAMTS19 Gene

Entrez Gene Summary for ADAMTS19 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS19 Gene

ADAMTS19 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 19) is a Protein Coding gene. Diseases associated with ADAMTS19 include Peters-Plus Syndrome and Premature Ovarian Failure 1. Among its related pathways are Metabolism of proteins and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS17.

Additional gene information for ADAMTS19 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS19 Gene

Genomics for ADAMTS19 Gene

GeneHancer (GH) Regulatory Elements for ADAMTS19 Gene

Promoters and enhancers for ADAMTS19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I129459 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 560.1 +0.5 512 3.5 CLOCK SIN3A ZNF2 ZNF121 GLIS2 ZNF213 ZNF302 ZNF143 SP3 REST ADAMTS19 ADAMTS19-AS1 PIR62990
GH05I129458 Enhancer 0.5 ENCODE 550.8 -1.3 -1322 0.2 ZNF512B ZNF341 ZNF398 TCF7L2 ADAMTS19 ADAMTS19-AS1 GC05P129398
GH05I129476 Enhancer 0.3 ENCODE 9.5 +17.6 17566 2 ZBTB40 ADAMTS19 ADAMTS19-AS1 PIR62990
GH05I129244 Enhancer 0.4 ENCODE 6.5 -215.1 -215075 1.6 GATA3 JUND ADAMTS19 LOC102723654 LOC105379169
GH05I129495 Enhancer 0.2 ENCODE 11.2 +36.6 36569 2.7 ADAMTS19 ADAMTS19-AS1 PIR62990
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAMTS19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAMTS19 gene promoter:

Genomic Locations for ADAMTS19 Gene

Genomic Locations for ADAMTS19 Gene
278,499 bases
Plus strand

Genomic View for ADAMTS19 Gene

Genes around ADAMTS19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS19 Gene

Proteins for ADAMTS19 Gene

  • Protein details for ADAMTS19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 19
    Protein Accession:

    Protein attributes for ADAMTS19 Gene

    1207 amino acids
    Molecular mass:
    134048 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS19 Gene

Post-translational modifications for ADAMTS19 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at posLast=260260, Asn797, posLast=907907, Asn949, and Asn1009

No data available for DME Specific Peptides for ADAMTS19 Gene

Domains & Families for ADAMTS19 Gene

Gene Families for ADAMTS19 Gene

Suggested Antigen Peptide Sequences for ADAMTS19 Gene

Graphical View of Domain Structure for InterPro Entry



  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAMTS19: view

Function for ADAMTS19 Gene

Enzyme Numbers (IUBMB) for ADAMTS19 Gene

Phenotypes From GWAS Catalog for ADAMTS19 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAMTS19: view
genes like me logo Genes that share phenotypes with ADAMTS19: view

Animal Models for ADAMTS19 Gene

MGI Knock Outs for ADAMTS19:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADAMTS19 Gene

Localization for ADAMTS19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS19 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAMTS19 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Midbody (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAMTS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with ADAMTS19: view

Pathways & Interactions for ADAMTS19 Gene

genes like me logo Genes that share pathways with ADAMTS19: view

Gene Ontology (GO) - Biological Process for ADAMTS19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAMTS19: view

No data available for SIGNOR curated interactions for ADAMTS19 Gene

Drugs & Compounds for ADAMTS19 Gene

No Compound Related Data Available

Transcripts for ADAMTS19 Gene

mRNA/cDNA for ADAMTS19 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS19 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS19 Gene

No ASD Table

Relevant External Links for ADAMTS19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAMTS19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS19 Gene

This gene is overexpressed in Uterus (x8.7) and Cervix - Ectocervix (x5.0).

Protein differential expression in normal tissues from HIPED for ADAMTS19 Gene

This gene is overexpressed in Adipocyte (36.1) and Heart (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMTS19 Gene

Protein tissue co-expression partners for ADAMTS19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAMTS19 Gene:


SOURCE GeneReport for Unigene cluster for ADAMTS19 Gene:


mRNA Expression by UniProt/SwissProt for ADAMTS19 Gene:

Tissue specificity: Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.
genes like me logo Genes that share expression patterns with ADAMTS19: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMTS19 Gene

Orthologs for ADAMTS19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAMTS19 33 34
  • 99.59 (n)
(Bos Taurus)
Mammalia ADAMTS19 33 34
  • 92.12 (n)
(Canis familiaris)
Mammalia ADAMTS19 33 34
  • 91.78 (n)
(Mus musculus)
Mammalia Adamts19 33 16 34
  • 86.64 (n)
(Gallus gallus)
Aves ADAMTS19 33 34
  • 77.95 (n)
(Anolis carolinensis)
Reptilia ADAMTS19 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts19 33
  • 69.99 (n)
Species where no ortholog for ADAMTS19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAMTS19 Gene

Gene Tree for ADAMTS19 (if available)
Gene Tree for ADAMTS19 (if available)

Paralogs for ADAMTS19 Gene

(3) SIMAP similar genes for ADAMTS19 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAMTS19: view

Variants for ADAMTS19 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS19 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
VAR_036154 A breast cancer sample p.Leu360Ile
rs1000008939 -- 129,477,519(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000026617 -- 129,735,725(+) A/G intron_variant
rs1000028984 -- 129,707,071(+) G/A/T intron_variant
rs1000036421 -- 129,614,587(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS19 Gene

Variant ID Type Subtype PubMed ID
esv2663219 CNV deletion 23128226
esv25215 CNV loss 19812545
dgv955e201 CNV deletion 23290073
nsv830487 CNV loss 17160897
nsv830486 CNV gain 17160897
nsv823221 CNV gain 20364138
nsv599705 CNV loss 21841781
nsv599704 CNV gain 21841781
nsv5000 CNV insertion 18451855
nsv1147189 CNV deletion 26484159
nsv1130840 CNV deletion 24896259
nsv1025248 CNV loss 25217958
esv3606763 CNV loss 21293372
esv3606762 CNV loss 21293372
esv3606761 CNV loss 21293372
esv3606759 CNV loss 21293372
esv3606758 CNV loss 21293372
esv3606757 CNV gain 21293372
esv3606756 CNV loss 21293372
esv3570414 CNV loss 25503493
esv2763498 CNV gain 21179565
esv2759377 CNV loss 17122850
esv2752060 CNV gain 17911159
esv2730771 CNV deletion 23290073
esv2730770 CNV deletion 23290073
esv2730769 CNV deletion 23290073
esv2675613 CNV deletion 23128226
esv2671546 CNV deletion 23128226
esv2664922 CNV deletion 23128226

Variation tolerance for ADAMTS19 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.80; 86.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAMTS19 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS19 Gene

Disorders for ADAMTS19 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADAMTS19 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
peters-plus syndrome
  • krause-kivlin syndrome
premature ovarian failure 1
  • pof1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADAMTS19

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADAMTS19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAMTS19 Gene

Publications for ADAMTS19 Gene

  1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PMID: 11867212) Cal S … López-Otín C (Gene 2002) 2 3 4 58
  2. Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression. (PMID: 22445761) Kurose K … Saito Y (Psychiatry research 2012) 3 44 58
  3. Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. (PMID: 19508998) Knauff EA … Dutch POF Consortium (Human reproduction (Oxford, England) 2009) 3 44 58
  4. ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion. (PMID: 28088271) Pekcan MK … Erel Ö (The Kaohsiung journal of medical sciences 2017) 3 58
  5. Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure. (PMID: 25051287) Pyun JA … Kwack K (Menopause (New York, N.Y.) 2015) 3 58

Products for ADAMTS19 Gene

Sources for ADAMTS19 Gene

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