Aliases for ADAMTS17 Gene
External Ids for ADAMTS17 Gene
Previous GeneCards Identifiers for ADAMTS17 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
GeneCards Summary for ADAMTS17 Gene
ADAMTS17 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17) is a Protein Coding gene. Diseases associated with ADAMTS17 include Weill-Marchesani Syndrome 4 and Weill-Marchesani Syndrome. Among its related pathways are Metabolism of proteins and O-glycosylation of TSR domain-containing proteins. Gene Ontology (GO) annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS19.