Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAMTS16 Gene

Aliases for ADAMTS16 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 16 2 3 5
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 16 2 3
  • ADAM-TS 16 3 4
  • ADAM-TS16 3 4
  • ADAMTS-16 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 16 3
  • EC 3.4.24.- 4
  • ADAMTS16s 3
  • KIAA2029 4

External Ids for ADAMTS16 Gene

Previous GeneCards Identifiers for ADAMTS16 Gene

  • GC05P005281
  • GC05P005173
  • GC05P005193
  • GC05P005113

Summaries for ADAMTS16 Gene

Entrez Gene Summary for ADAMTS16 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]

GeneCards Summary for ADAMTS16 Gene

ADAMTS16 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 16) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS18.

Additional gene information for ADAMTS16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS16 Gene

Genomics for ADAMTS16 Gene

GeneHancer (GH) Regulatory Elements for ADAMTS16 Gene

Promoters and enhancers for ADAMTS16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J005139 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 656.2 -0.3 -267 1.7 CTCF MXI1 ZNF777 KLF14 ZIC2 ZNF335 ZFHX2 GLIS2 POLR2A PATZ1 ADAMTS16 CTD-2297D10.2
GH05J005418 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 11.3 +281.0 281024 5.6 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF610 ICE1 LOC101929200 LINC02145 ADAMTS16 CTD-2297D10.2
GH05J005181 Enhancer 0.8 Ensembl ENCODE 10.4 +42.9 42879 2.6 USF1 NANOG MAX BACH1 SIN3A USF2 ETS1 POLR2A POU5F1 ADAMTS16 CTD-2297D10.2 ENSG00000250866 ALG3P1
GH05J005178 Enhancer 0.5 ENCODE 10.2 +39.2 39231 1.7 SP1 POLR2A NANOG GLIS1 POU5F1 ZFP36 ADAMTS16 CTD-2297D10.2 ENSG00000250866 ALG3P1
GH05J005145 Enhancer 0.5 ENCODE 9.5 +5.8 5812 1.4 FOSL1 SP1 JUND ELF1 FOSL2 RUNX3 ZNF112 ADAMTS16 ENSG00000250866
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAMTS16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAMTS16 gene promoter:
  • AML1a
  • ATF6
  • Nkx5-1
  • RORalpha1
  • Cdc5
  • NCX
  • E47
  • Pax-3
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)

Genomic Locations for ADAMTS16 Gene

Genomic Locations for ADAMTS16 Gene
179,975 bases
Plus strand
179,975 bases
Plus strand

Genomic View for ADAMTS16 Gene

Genes around ADAMTS16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS16 Gene

Proteins for ADAMTS16 Gene

  • Protein details for ADAMTS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 16
    Protein Accession:
    Secondary Accessions:
    • C6G490
    • Q8IVE2

    Protein attributes for ADAMTS16 Gene

    1224 amino acids
    Molecular mass:
    136203 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTS16 Gene


neXtProt entry for ADAMTS16 Gene

Post-translational modifications for ADAMTS16 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • Glycosylation at Asn935, posLast=905905, Asn835, posLast=780780, posLast=741741, Asn310, and posLast=156156
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAMTS16 Gene

Domains & Families for ADAMTS16 Gene

Gene Families for ADAMTS16 Gene

Graphical View of Domain Structure for InterPro Entry



  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAMTS16: view

Function for ADAMTS16 Gene

Enzyme Numbers (IUBMB) for ADAMTS16 Gene

Phenotypes From GWAS Catalog for ADAMTS16 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS16: view
genes like me logo Genes that share phenotypes with ADAMTS16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMTS16

miRNA for ADAMTS16 Gene

miRTarBase miRNAs that target ADAMTS16

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS16 Gene

Localization for ADAMTS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS16 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAMTS16 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ADAMTS16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAMTS16 Gene

Pathways & Interactions for ADAMTS16 Gene

genes like me logo Genes that share pathways with ADAMTS16: view

Gene Ontology (GO) - Biological Process for ADAMTS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0003073 regulation of systemic arterial blood pressure IEA --
GO:0006508 proteolysis IEA --
GO:0048232 male gamete generation IEA --
GO:1902017 regulation of cilium assembly IEA --
genes like me logo Genes that share ontologies with ADAMTS16: view

No data available for SIGNOR curated interactions for ADAMTS16 Gene

Drugs & Compounds for ADAMTS16 Gene

No Compound Related Data Available

Transcripts for ADAMTS16 Gene

mRNA/cDNA for ADAMTS16 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS16 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS16 Gene

No ASD Table

Relevant External Links for ADAMTS16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAMTS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS16 Gene

This gene is overexpressed in Ovary (x11.6), Brain - Cerebellum (x10.4), and Brain - Cerebellar Hemisphere (x9.6).

Protein differential expression in normal tissues from HIPED for ADAMTS16 Gene

This gene is overexpressed in Colon muscle (43.8), Bone (16.2), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTS16 Gene

Protein tissue co-expression partners for ADAMTS16 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAMTS16 Gene:


SOURCE GeneReport for Unigene cluster for ADAMTS16 Gene:


mRNA Expression by UniProt/SwissProt for ADAMTS16 Gene:

Tissue specificity: Expressed in fetal lung and kidney and in adult prostate and ovary.

Evidence on tissue expression from TISSUES for ADAMTS16 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ADAMTS16: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMTS16 Gene

Orthologs for ADAMTS16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTS16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAMTS16 34 33
  • 99.19 (n)
(Canis familiaris)
Mammalia ADAMTS16 34 33
  • 84.78 (n)
(Bos Taurus)
Mammalia ADAMTS16 34 33
  • 82.63 (n)
(Rattus norvegicus)
Mammalia Adamts16 33
  • 80.76 (n)
(Mus musculus)
Mammalia Adamts16 16 34 33
  • 80.62 (n)
(Monodelphis domestica)
Mammalia ADAMTS16 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ADAMTS16 34
  • 77 (a)
(Anolis carolinensis)
Reptilia ADAMTS16 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts16 33
  • 69.45 (n)
(Danio rerio)
Actinopterygii adamts16 33
  • 65.32 (n)
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3622 35
  • 28 (a)
CG14869 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea C37C3.6b 35
  • 32 (a)
C37C3.6a 35
  • 32 (a)
T19D2.1 35
  • 31 (a)
gon-1 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for ADAMTS16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAMTS16 Gene

Gene Tree for ADAMTS16 (if available)
Gene Tree for ADAMTS16 (if available)
Evolutionary constrained regions (ECRs) for ADAMTS16: view image

Paralogs for ADAMTS16 Gene

(14) SIMAP similar genes for ADAMTS16 Gene using alignment to 4 proteins:

  • B2G3Q1_HUMAN
  • L8E9K8_HUMAN
genes like me logo Genes that share paralogs with ADAMTS16: view

Variants for ADAMTS16 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS16 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000007273 -- 5,177,066(+) C/T intron_variant
rs1000019463 -- 5,264,177(+) C/T intron_variant
rs1000031313 -- 5,220,747(+) A/G intron_variant
rs1000038571 -- 5,259,203(+) G/T intron_variant
rs1000041117 -- 5,214,630(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS16 Gene

Variant ID Type Subtype PubMed ID
nsv830194 CNV gain 17160897
nsv596940 CNV loss 21841781
nsv596939 CNV loss 21841781
nsv596938 CNV loss 21841781
nsv596937 CNV gain 21841781
nsv526817 CNV loss 19592680
nsv472318 CNV novel sequence insertion 20440878
nsv4691 CNV insertion 18451855
nsv1131868 CNV deletion 24896259
nsv1120147 OTHER inversion 24896259
nsv1024784 CNV gain 25217958
nsv1015679 CNV loss 25217958
esv5491 CNV loss 19470904
esv3603894 CNV gain 21293372
esv3603889 CNV gain 21293372
esv3603885 CNV gain 21293372
esv3372631 CNV insertion 20981092
esv3352829 CNV duplication 20981092
esv3305509 CNV mobile element insertion 20981092
esv2759318 CNV loss 17122850
esv2729674 CNV deletion 23290073
esv2729672 CNV deletion 23290073
esv2729671 CNV deletion 23290073
esv2729670 CNV deletion 23290073
esv25455 CNV loss 19812545

Variation tolerance for ADAMTS16 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.35; 97.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAMTS16 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS16 Gene

Disorders for ADAMTS16 Gene

Additional Disease Information for ADAMTS16

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADAMTS16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTS16 Gene

Publications for ADAMTS16 Gene

  1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PMID: 11867212) Cal S … López-Otín C (Gene 2002) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Positional identification of variants of Adamts16 linked to inherited hypertension. (PMID: 19423552) Joe B … Bouchard C (Human molecular genetics 2009) 3 22 58
  4. Characterization and regulation of ADAMTS-16. (PMID: 19635554) Surridge AK … Clark IM (Matrix biology : journal of the International Society for Matrix Biology 2009) 3 22 58
  5. ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion. (PMID: 28088271) Pekcan MK … Erel Ö (The Kaohsiung journal of medical sciences 2017) 3 58

Products for ADAMTS16 Gene

Sources for ADAMTS16 Gene

Loading form....