Aliases for ADAMTS15 Gene
External Ids for ADAMTS15 Gene
Previous GeneCards Identifiers for ADAMTS15 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
GeneCards Summary for ADAMTS15 Gene
ADAMTS15 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 15) is a Protein Coding gene. Diseases associated with ADAMTS15 include Spondyloepimetaphyseal Dysplasia, Missouri Type and Jacobsen Syndrome. Among its related pathways are Metabolism of proteins and O-glycosylation of TSR domain-containing proteins. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS1.