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Aliases for ADAMTS15 Gene

Aliases for ADAMTS15 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif 15 2 3 5
  • ADAM-TS 15 3 4
  • ADAM-TS15 3 4
  • ADAMTS-15 3 4
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 15, Preproprotein 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 15 2
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 15 3
  • Metalloprotease Disintegrin 15 With Thrombospondin Domains 3
  • EC 56
  • EC 56
  • EC 3.4.24.- 4
  • EC 3.4.24 56

External Ids for ADAMTS15 Gene

Previous GeneCards Identifiers for ADAMTS15 Gene

  • GC11P132319
  • GC11P131831
  • GC11P130352
  • GC11P129856
  • GC11P129824
  • GC11P126273
  • GC11P130318

Summaries for ADAMTS15 Gene

Entrez Gene Summary for ADAMTS15 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]

GeneCards Summary for ADAMTS15 Gene

ADAMTS15 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 15) is a Protein Coding gene. Diseases associated with ADAMTS15 include Peters-Plus Syndrome. Among its related pathways are Metabolism of proteins and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAMTS1.

Additional gene information for ADAMTS15 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS15 Gene

Genomics for ADAMTS15 Gene

GeneHancer (GH) Regulatory Elements for ADAMTS15 Gene

Promoters and enhancers for ADAMTS15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I130447 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.3 +1.2 1226 4.5 HDGF KLF17 ZNF76 SIN3A FEZF1 ZNF2 RAD21 ZEB1 ZNF335 GLIS2 ADAMTS15 GC11P130513
GH11I130896 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +448.8 448814 3.2 FOXA2 JUN MAX YY1 POLR2A FOSL2 FOS RXRA REST FOXA1 SNX19 ADAMTS8 LOC103611081 LINC02551 ADAMTS15 GC11P130904 GC11M130881
GH11I130476 Enhancer 1 Ensembl ENCODE dbSUPER 12.1 +29.8 29762 4.9 JUN CEBPB NR2F2 SP1 JUND FOS FOSL2 PRDM10 EGR2 ADAMTS15 ADAMTS8 LINC02551 LOC103611081 GC11P130513
GH11I130388 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.7 -59.2 -59245 2.7 CTCF FOXA2 ZBTB6 TEAD1 FOXA3 HMG20A RAD21 RARA ZNF7 TEAD3 ADAMTS8 ADAMTS15 LOC646383 GC11P130399 GC11P130370 PIR51323
GH11I130846 Enhancer 1 Ensembl ENCODE dbSUPER 10.8 +398.9 398872 3.3 PKNOX1 JUN MAX MNT EP300 RFX5 SP1 FOSL1 JUND POLR2A GC11P130847 SNX19 ADAMTS8 ADAMTS15 LINC02551
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAMTS15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAMTS15 gene promoter:

Genomic Locations for ADAMTS15 Gene

Genomic Locations for ADAMTS15 Gene
27,672 bases
Plus strand

Genomic View for ADAMTS15 Gene

Genes around ADAMTS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS15 Gene

Proteins for ADAMTS15 Gene

  • Protein details for ADAMTS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 15
    Protein Accession:
    Secondary Accessions:
    • Q32MI6

    Protein attributes for ADAMTS15 Gene

    950 amino acids
    Molecular mass:
    103287 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAMTS15 Gene

Selected DME Specific Peptides for ADAMTS15 Gene


Post-translational modifications for ADAMTS15 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at posLast=141141, posLast=591591, posLast=623623, and posLast=679679
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADAMTS15 Gene

Gene Families for ADAMTS15 Gene

Suggested Antigen Peptide Sequences for ADAMTS15 Gene

Graphical View of Domain Structure for InterPro Entry



  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAMTS15: view

Function for ADAMTS15 Gene

Enzyme Numbers (IUBMB) for ADAMTS15 Gene

Phenotypes From GWAS Catalog for ADAMTS15 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008201 heparin binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS15: view

Phenotypes for ADAMTS15 Gene

genes like me logo Genes that share phenotypes with ADAMTS15: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAMTS15 Gene

Localization for ADAMTS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS15 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAMTS15 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADAMTS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with ADAMTS15: view

Pathways & Interactions for ADAMTS15 Gene

genes like me logo Genes that share pathways with ADAMTS15: view

Gene Ontology (GO) - Biological Process for ADAMTS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAMTS15: view

No data available for SIGNOR curated interactions for ADAMTS15 Gene

Drugs & Compounds for ADAMTS15 Gene

No Compound Related Data Available

Transcripts for ADAMTS15 Gene

mRNA/cDNA for ADAMTS15 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAMTS15 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS15 Gene

No ASD Table

Relevant External Links for ADAMTS15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTS15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAMTS15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS15 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.6).

Protein differential expression in normal tissues from HIPED for ADAMTS15 Gene

This gene is overexpressed in Heart (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAMTS15 Gene

Protein tissue co-expression partners for ADAMTS15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAMTS15 Gene:


SOURCE GeneReport for Unigene cluster for ADAMTS15 Gene:


mRNA Expression by UniProt/SwissProt for ADAMTS15 Gene:

Tissue specificity: Expressed in fetal liver and kidney, but not in any of the adult tissues examined.
genes like me logo Genes that share expression patterns with ADAMTS15: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMTS15 Gene

Orthologs for ADAMTS15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAMTS15 33 34
  • 99.16 (n)
(Monodelphis domestica)
Mammalia ADAMTS15 34
  • 90 (a)
(Bos Taurus)
Mammalia ADAMTS15 33 34
  • 89.26 (n)
(Rattus norvegicus)
Mammalia Adamts15 33
  • 88.6 (n)
(Mus musculus)
Mammalia Adamts15 33 16 34
  • 87.89 (n)
(Canis familiaris)
Mammalia ADAMTS15 33 34
  • 86.19 (n)
(Ornithorhynchus anatinus)
Mammalia ADAMTS15 34
  • 84 (a)
(Gallus gallus)
Aves ADAMTS15 33 34
  • 76.17 (n)
(Anolis carolinensis)
Reptilia ADAMTS15 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts15 33
  • 65.68 (n)
Str.13514 33
(Danio rerio)
Actinopterygii adamts15b 34
  • 63 (a)
adamts15a 34
  • 62 (a)
Species where no ortholog for ADAMTS15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS15 Gene

Gene Tree for ADAMTS15 (if available)
Gene Tree for ADAMTS15 (if available)

Paralogs for ADAMTS15 Gene

(9) SIMAP similar genes for ADAMTS15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTS15: view

Variants for ADAMTS15 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs776537988 A colorectal cancer sample 130,473,277(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
VAR_036151 A colorectal cancer sample p.Cys878Gly
rs1000062615 -- 130,453,049(+) A/G intron_variant
rs1000153626 -- 130,461,916(+) A/C intron_variant
rs1000201193 -- 130,464,123(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS15 Gene

Variant ID Type Subtype PubMed ID
esv2759871 CNV loss 17122850
nsv508660 CNV deletion 20534489
nsv550 CNV insertion 18451855
nsv8877 CNV gain 18304495

Variation tolerance for ADAMTS15 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.36; 76.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAMTS15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS15 Gene

Disorders for ADAMTS15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAMTS15 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
peters-plus syndrome
  • krause-kivlin syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADAMTS15

genes like me logo Genes that share disorders with ADAMTS15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAMTS15 Gene

Publications for ADAMTS15 Gene

  1. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains. (PMID: 11867212) Cal S … López-Otín C (Gene 2002) 2 3 4 58
  2. Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. (PMID: 19458070) Viloria CG … López-Otín C (Cancer research 2009) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2017) 3 58
  5. Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma. (PMID: 28323982) Gueye NA … Apte SS (The Journal of clinical endocrinology and metabolism 2017) 3 58

Products for ADAMTS15 Gene

Sources for ADAMTS15 Gene

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