Aliases for ADAMTS14 Gene
External Ids for ADAMTS14 Gene
Previous GeneCards Identifiers for ADAMTS14 Gene
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
GeneCards Summary for ADAMTS14 Gene
ADAMTS14 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14) is a Protein Coding gene. Diseases associated with ADAMTS14 include Tibialis Tendinitis and Patellar Tendinitis. Among its related pathways are Degradation of the extracellular matrix and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include peptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAMTS3.
UniProtKB/Swiss-Prot Summary for ADAMTS14 Gene
Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form (PubMed:31152061).