This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008] See more...

Aliases for ADAMDEC1 Gene

Aliases for ADAMDEC1 Gene

  • ADAM Like Decysin 1 2 3 5
  • A Disintegrin And Metalloproteinase Domain-Like Protein Decysin-1 3 4
  • ADAM-Like Protein Decysin-1 3 4
  • ADAM DEC1 3 4
  • M12.219 2 3
  • Disintegrin Protease 3
  • EC 3.4.24.- 4
  • ADAMDEC1 5
  • Decysin 3

External Ids for ADAMDEC1 Gene

Previous GeneCards Identifiers for ADAMDEC1 Gene

  • GC08P023974
  • GC08P024595
  • GC08P024263
  • GC08P024297
  • GC08P022786
  • GC08P024241

Summaries for ADAMDEC1 Gene

Entrez Gene Summary for ADAMDEC1 Gene

  • This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMDEC1 Gene

ADAMDEC1 (ADAM Like Decysin 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM28.

UniProtKB/Swiss-Prot Summary for ADAMDEC1 Gene

  • May play an important role in the control of the immune response and during pregnancy.

Additional gene information for ADAMDEC1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAMDEC1 Gene

Genomics for ADAMDEC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADAMDEC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J024383 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 610.4 +2.1 2143 5.4 SP1 CTCF NFRKB ZNF143 RELA RAD21 TCF12 IKZF2 TRIM22 PKNOX1 ADAMDEC1 ADAM28 ADAM7 piR-57296 LOC101929294 ENSG00000253535
GH08J024228 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.8 -155.0 -154965 1.5 CTCF REST RAD21 TRIM22 SCRT2 SMC3 GTF2F1 MAX RFX5 STAT1 ADAMDEC1 ENSG00000253535 ENSG00000253891 HSALNG0064038 ADAM28 STC1
GH08J024355 Enhancer 0.6 Ensembl dbSUPER 17 -27.0 -26984 3 CEBPB FOXA1 FOXA2 SPI1 ATF2 ADAMDEC1 ENSG00000253535 piR-41525-650 piR-41405-096 ADAM28 LOC101929294
GH08J024366 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -15.0 -14999 5.8 ATF7 ZNF7 IRF2 SP1 CEBPA EED SOX13 ARID3A DPF2 RUNX3 ADAM28 ENSG00000253535 ADAMDEC1 piR-38351-449 LOC101929294
GH08J024225 Enhancer 0.5 Ensembl ENCODE dbSUPER 11.8 -158.5 -158530 0.7 ADAMDEC1 ENSG00000253535 ENSG00000253891 HSALNG0064038 ADAM28 STC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAMDEC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAMDEC1

Top Transcription factor binding sites by QIAGEN in the ADAMDEC1 gene promoter:
  • E4BP4
  • FOXO1
  • FOXO1a
  • FOXO3b
  • FOXO4
  • HSF1 (long)
  • HSF1short
  • RSRFC4
  • Sox5
  • TBP

Genomic Locations for ADAMDEC1 Gene

Genomic Locations for ADAMDEC1 Gene
chr8:24,384,285-24,406,013
(GRCh38/hg38)
Size:
21,729 bases
Orientation:
Plus strand
chr8:24,241,798-24,263,526
(GRCh37/hg19)
Size:
21,729 bases
Orientation:
Plus strand

Genomic View for ADAMDEC1 Gene

Genes around ADAMDEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMDEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMDEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMDEC1 Gene

Proteins for ADAMDEC1 Gene

  • Protein details for ADAMDEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15204-ADEC1_HUMAN
    Recommended name:
    ADAM DEC1
    Protein Accession:
    O15204
    Secondary Accessions:
    • B7ZAK5

    Protein attributes for ADAMDEC1 Gene

    Size:
    470 amino acids
    Molecular mass:
    52775 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMDEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMDEC1 Gene

Post-translational modifications for ADAMDEC1 Gene

  • Glycosylation at Asn61, Asn184, Asn237, and Asn466
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ADEC1_HUMAN (1910)

Other Protein References for ADAMDEC1 Gene

Antibody Products

  • Biorbyt antibodies for ADAMDEC1
  • Boster Bio Antibodies for ADAMDEC1

No data available for DME Specific Peptides for ADAMDEC1 Gene

Domains & Families for ADAMDEC1 Gene

Gene Families for ADAMDEC1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ADAMDEC1 Gene

Suggested Antigen Peptide Sequences for ADAMDEC1 Gene

GenScript: Design optimal peptide antigens:
  • A disintegrin and metalloproteinase domain-like protein decysin-1 (ADEC1_HUMAN)
  • cDNA, FLJ79221, highly similar to ADAM DEC1 (EC 3.4.24.-) (Adisintegrin and metalloproteinase domain-like protein decysin 1) (B7ZAK5_HUMAN)
genes like me logo Genes that share domains with ADAMDEC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Function for ADAMDEC1 Gene

Molecular function for ADAMDEC1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the control of the immune response and during pregnancy.
UniProtKB/Swiss-Prot Induction:
Induced during DC maturation and up-regulated in response to T-cell signals. In macrophage up-regulated by bacterial lipopolysaccharides (LPS). Up-regulated by 1-alpha,25-dihydroxyvitamin D3 during differentiation of primary monocyte into macrophage.

Enzyme Numbers (IUBMB) for ADAMDEC1 Gene

Phenotypes From GWAS Catalog for ADAMDEC1 Gene

Gene Ontology (GO) - Molecular Function for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity NAS 9271581
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding NAS 12037602
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAMDEC1: view
genes like me logo Genes that share phenotypes with ADAMDEC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMDEC1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAMDEC1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAMDEC1 Gene

Localization for ADAMDEC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAMDEC1 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytoskeleton 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0062023 collagen-containing extracellular matrix HDA 25037231
genes like me logo Genes that share ontologies with ADAMDEC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAMDEC1 Gene

Pathways & Interactions for ADAMDEC1 Gene

PathCards logo

SuperPathways for ADAMDEC1 Gene

No Data Available

Interacting Proteins for ADAMDEC1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000256412 O15204-ADEC1_HUMAN for ADAMDEC1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ADAMDEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006955 immune response NAS 12037602
GO:0007162 negative regulation of cell adhesion NAS 9271581
genes like me logo Genes that share ontologies with ADAMDEC1: view

No data available for Pathways by source and SIGNOR curated interactions for ADAMDEC1 Gene

Drugs & Compounds for ADAMDEC1 Gene

No Compound Related Data Available

Transcripts for ADAMDEC1 Gene

mRNA/cDNA for ADAMDEC1 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAMDEC1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMDEC1 Gene

No ASD Table

Relevant External Links for ADAMDEC1 Gene

GeneLoc Exon Structure for
ADAMDEC1

Expression for ADAMDEC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAMDEC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMDEC1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x25.5) and Colon - Transverse (x22.4).

Protein differential expression in normal tissues from HIPED for ADAMDEC1 Gene

This gene is overexpressed in Plasma (60.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMDEC1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAMDEC1

SOURCE GeneReport for Unigene cluster for ADAMDEC1 Gene:

Hs.521459

mRNA Expression by UniProt/SwissProt for ADAMDEC1 Gene:

O15204-ADEC1_HUMAN
Tissue specificity: Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.

Evidence on tissue expression from TISSUES for ADAMDEC1 Gene

  • Intestine(5)
  • Bone marrow(4.3)
  • Lung(4.2)
  • Lymph node(2.7)
  • Spleen(2.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ADAMDEC1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAMDEC1 Gene

Orthologs for ADAMDEC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADAMDEC1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADAMDEC1 30 31
  • 99.29 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADAMDEC1 30 31
  • 84.01 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Adamdec1 30 17 31
  • 77.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADAMDEC1 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ADAMDEC1 31
  • 55 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADAMDEC1 31
  • 55 (a)
OneToOne
Species where no ortholog for ADAMDEC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ADAMDEC1 Gene

ENSEMBL:
Gene Tree for ADAMDEC1 (if available)
TreeFam:
Gene Tree for ADAMDEC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAMDEC1: view image

Paralogs for ADAMDEC1 Gene

(8) SIMAP similar genes for ADAMDEC1 Gene using alignment to 2 proteins:

  • ADEC1_HUMAN
  • E5RK05_HUMAN
genes like me logo Genes that share paralogs with ADAMDEC1: view

Variants for ADAMDEC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAMDEC1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
717905 Benign: not provided 24,392,304(+) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
781120 Benign: not provided 24,393,296(+) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
781121 Benign: not provided 24,394,146(+) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
781134 Benign: not provided 24,398,876(+) A/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
781135 Benign: not provided 24,398,999(+) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ADAMDEC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAMDEC1 Gene

Variant ID Type Subtype PubMed ID
esv3572639 CNV loss 25503493
esv3891377 CNV loss 25118596
nsv831271 CNV gain 17160897

Variation tolerance for ADAMDEC1 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAMDEC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAMDEC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMDEC1 Gene

Disorders for ADAMDEC1 Gene

Additional Disease Information for ADAMDEC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ADAMDEC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMDEC1 Gene

Publications for ADAMDEC1 Gene

  1. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation. (PMID: 14632642) Fritsche J … Kreutz M (Immunology 2003) 3 4 23
  2. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. (PMID: 9271581) Mueller CG … Liu YJ (The Journal of experimental medicine 1997) 2 3 4
  3. Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism. (PMID: 18449420) Berger M … Schambeck CM (Thrombosis and haemostasis 2008) 3 41
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ADAMDEC1 Gene

  • Biorbyt antibodies for ADAMDEC1

Sources for ADAMDEC1 Gene