Aliases for ADAM9 Gene
Aliases for ADAM9 Gene
- ADAM Metallopeptidase Domain 9 2 3 5
- Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
- Cellular Disintegrin-Related Protein 3 4
- Myeloma Cell Metalloproteinase 3 4
- Cone Rod Dystrophy 9 2 3
- Mltng 3 4
- MCMP 3 4
- MDC9 3 4
- Disintegrin And Metalloproteinase Domain-Containing Protein 9 3
- A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma) 2
External Ids for ADAM9 Gene
- HGNC: 216
- Entrez Gene: 8754
- Ensembl: ENSG00000168615
- OMIM: 602713
- UniProtKB: Q13443
Previous HGNC Symbols for ADAM9 Gene
- CORD9
Previous GeneCards Identifiers for ADAM9 Gene
- GC08P038441
- GC08P039068
- GC08P038595
- GC08P038871
- GC08P038974
- GC08P037387
Summaries for ADAM9 Gene
-
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ADAM9 Gene
ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Retinitis Pigmentosa. Among its related pathways are Notch Signaling Pathway (sino) and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM29.
UniProtKB/Swiss-Prot for ADAM9 Gene
-
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
-
Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).
Additional gene information for ADAM9 Gene
- Monarch Initiative
- Search for ADAM9 at DataMed
- Search for ADAM9 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM9 Gene
Genomics for ADAM9 Gene
GeneHancer (GH) Regulatory Elements for ADAM9 Gene
Promoters and enhancers for ADAM9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADAM9 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ADAM9 Gene
Genomic Locations for ADAM9 Gene
- chr8:38,996,869-39,105,261
- (GRCh38/hg38)
- Size:
- 108,393 bases
- Orientation:
- Plus strand
- chr8:38,854,388-38,962,780
- (GRCh37/hg19)
Genomic View for ADAM9 Gene
Genes around ADAM9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p11.22 by Ensembl
- 8p11.22 by Entrez Gene
- 8p11.22 by HGNC
ADAM9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAM9 Gene
Proteins for ADAM9 Gene
-
Protein details for ADAM9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13443-ADAM9_HUMAN
- Recommended name:
- Disintegrin and metalloproteinase domain-containing protein 9
- Protein Accession:
- Q13443
- B7ZLN7
- Q10718
- Q8NFM6
Protein attributes for ADAM9 Gene
- Size:
- 819 amino acids
- Molecular mass:
- 90556 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Interacts with SH3GL2 and SNX9 through its cytoplasmic tail (PubMed:10531379). Interacts with ITGA6.
Protein Expression for ADAM9 Gene
Selected DME Specific Peptides for ADAM9 Gene
- Q13443:
-
- RYVELFIVVD
- GEECDCG
- LVGLEIW
- GGSVDSGP
- HELGHNLG
- KCHGHGVC
Post-translational modifications for ADAM9 Gene
- Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).
- Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.
- Glycosylation at Asn125, posLast=144144, Asn154, Asn231, posLast=381381, and posLast=487487
- Modification sites at PhosphoSitePlus
Other Protein References for ADAM9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ADAM9 (ADAM9)
- Novus Biologicals Antibodies for ADAM9
-
Abcam antibodies for ADAM9
-
Cloud-Clone Corp. Antibodies for ADAM9
- Invitrogen Antibodies for ADAM9
- antibodies-online: Search results for 101 available ADAM9 Antibodies ranked by validation data
- Compare Top ADAM9 Antibodies
-
Recommended
- 40 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 65 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 16 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- GeneTex ADAM9 antibody for ADAM9
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADAM9
Protein Products
- R&D Systems Proteins and Enzymes for ADAM9
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADAM9
- Origene Custom Protein Services for ADAM9
- Novus Biologicals lysates for ADAM9
- Sino Biological Cell Lysates for ADAM9
- Sino Biological Recombinant Proteins for ADAM9
-
Cloud-Clone Corp. Proteins for ADAM9
- Search GeneTex for Proteins for ADAM9
-
Abcam proteins for ADAM9
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for ADAM9
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for ADAM9 (ADAM9)
- Novus Biologicals ELISA Kits for ADAM9
-
Cloud-Clone Corp. Assay Kits for ADAM9
- antibodies-online: Search results for 45 available ADAM9 Elisa Kits ranked by validation data
- Compare Top ADAM9 Elisa Kits
-
Recommended
- 2 Chicken ELISA Kits
- 1 Cow (Bovine) ELISA Kit
- 1 Dog (Canine) ELISA Kit
- 1 Goat ELISA Kit
- 2 Guinea Pig ELISA Kits
- 17 Human ELISA Kits
- 2 Monkey ELISA Kits
- 4 Mouse (Murine) ELISA Kits
- 2 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 9 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
Domains & Families for ADAM9 Gene
Gene Families for ADAM9 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ADAM9 Gene
Suggested Antigen Peptide Sequences for ADAM9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ADAM9 Gene
Function for ADAM9 Gene
Molecular function for ADAM9 Gene
- GENATLAS Biochemistry:
- a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely expressed,also expressed in meyloma cells
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Synthesized as an inactive form which is proteolytically cleaved to generate an active enzyme. Processing at the upstream site is particularly important for activation of the proenzyme, whereas processing at the boundary between the pro-domain and the catalytic domain does not appear to be essential. Inhibited by hydroxamic acid-based inhibitors.
- UniProtKB/Swiss-Prot Function:
- Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
- UniProtKB/Swiss-Prot Function:
- Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).
Enzyme Numbers (IUBMB) for ADAM9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IMP | 22480688 |
| GO:0005080 | protein kinase C binding | ISS | 8647900 |
| GO:0005178 | integrin binding | IPI | 17704059 |
| GO:0005515 | protein binding | IPI | 10527948 |
| GO:0005518 | collagen binding | IMP | 15361064 |
Phenotypes for ADAM9 Gene
- MGI mutant phenotypes for ADAM9:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADAM9:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased G1 DNA content
- G0/1 arrest
- Increased shRNA abundance (Z-score > 2)
- Increased viability with tamoxifen
- Decreased caspase 3/7 activity
Animal Models for ADAM9 Gene
- MGI Knock Outs for ADAM9:
-
- Adam9 tm1Bbl
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADAM9
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAM9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM9 gene
- Search ViGene Biosciences for ADAM9
CRISPR Products
-
OriGene CRISPR knockouts for ADAM9
- genomics-online: gRNA clones - Search results for 103 available ADAM9 gene related products
- Overview of 103 available ADAM9 gene related products
- Applied Biological Materials CRISPR for ADAM9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM9
- GenScript: Design CRISPR guide RNA sequences for ADAM9
miRNA for ADAM9 Gene
- miRTarBase miRNAs that target ADAM9
-
- hsa-mir-373-3p (MIRT002555)
- hsa-mir-126-3p (MIRT007266)
- hsa-mir-126-5p (MIRT007267)
- hsa-mir-26b-5p (MIRT030283)
- hsa-mir-23a-3p (MIRT050441)
- hsa-mir-125a-5p (MIRT054873)
- hsa-mir-1252-3p (MIRT402486)
- hsa-mir-3646 (MIRT402487)
- hsa-mir-3941 (MIRT609479)
- hsa-mir-603 (MIRT609480)
- hsa-mir-362-3p (MIRT609481)
- hsa-mir-329-3p (MIRT609482)
- hsa-mir-8485 (MIRT609483)
- hsa-mir-4520-5p (MIRT628488)
- hsa-mir-4799-5p (MIRT705902)
- hsa-mir-4666a-5p (MIRT705903)
- hsa-mir-633 (MIRT705904)
- hsa-mir-7114-3p (MIRT705905)
- hsa-mir-1180-5p (MIRT705906)
- hsa-mir-1228-3p (MIRT705907)
- hsa-mir-4495 (MIRT705908)
- hsa-mir-451b (MIRT705909)
- hsa-mir-30e-5p (MIRT705910)
- hsa-mir-30b-5p (MIRT705911)
- hsa-mir-30d-5p (MIRT705912)
- hsa-mir-30a-5p (MIRT705913)
- hsa-mir-30c-5p (MIRT705914)
- hsa-mir-543 (MIRT705915)
- hsa-mir-33a-5p (MIRT733344)
- hsa-mir-140-5p (MIRT735471)
miRNA Products
- Search ViGene Biosciences for ADAM9
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM9
- Browse OriGene Inhibitory RNA Products For ADAM9
- genomics-online: shRNA clones - Search results for 103 available ADAM9 gene related products
- Overview of 103 available ADAM9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM9 gene
Clone Products
- Sino Biological Human cDNA Clone for ADAM9
- VectorBuilder custom plasmid, inducible vectors for ADAM9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ADAM9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADAM9
-
ViGene Biosciences adenoviral particle packaged cDNA for ADAM9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAM9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM9 gene
No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for ADAM9 Gene
Localization for ADAM9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAM9 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
- Endoplasmic reticulum (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | ISS | 8647900 |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005925 | focal adhesion | HDA,IDA | 21423176 |
| GO:0009986 | cell surface | ISS | 8647900 |
Pathways & Interactions for ADAM9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Degradation of the extracellular matrix | ||
| 2 | Adhesion |
-
|
|
| 3 | Cytoskeletal Signaling | ||
| 4 | A-beta Pathways: Plaque Formation and APP Metabolism | ||
| 5 | A-beta Signaling Pathways | ||
Pathways by source for ADAM9 Gene
1 Sino Biological pathway for ADAM9 Gene
1 BioSystems pathway for ADAM9 Gene
3 Reactome pathways for ADAM9 Gene
1 GeneGo (Thomson Reuters) pathway for ADAM9 Gene
2 R&D Systems pathways for ADAM9 Gene
2 Cell Signaling Technology pathways for ADAM9 Gene
Interacting Proteins for ADAM9 Gene
Selected Interacting proteins:
Q13443-ADAM9_HUMAN
ENSP00000419446
for ADAM9 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | IDA | 17704059 |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006509 | membrane protein ectodomain proteolysis | IMP | 22480688 |
| GO:0007155 | cell adhesion | IMP | 11162558 |
| GO:0007160 | cell-matrix adhesion | IMP | 15361064 |
Transcripts for ADAM9 Gene
mRNA/cDNA for ADAM9 Gene
- (4) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (198) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ADAM9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ADAM9
- genomics-online: gRNA clones - Search results for 103 available ADAM9 gene related products
- Overview of 103 available ADAM9 gene related products
- Applied Biological Materials CRISPR for ADAM9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM9
- GenScript: Design CRISPR guide RNA sequences for ADAM9
miRNA Products
- Search ViGene Biosciences for ADAM9
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM9
- Browse OriGene Inhibitory RNA Products For ADAM9
- genomics-online: shRNA clones - Search results for 103 available ADAM9 gene related products
- Overview of 103 available ADAM9 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM9 gene
Clone Products
- Sino Biological Human cDNA Clone for ADAM9
- VectorBuilder custom plasmid, inducible vectors for ADAM9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ADAM9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ADAM9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Amniocyte (35.5) and Adrenal (17.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADAM9 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADAM9 Gene:
ADAM9SOURCE GeneReport for Unigene cluster for ADAM9 Gene:
Hs.591852mRNA Expression by UniProt/SwissProt for ADAM9 Gene:
Q13443-ADAM9_HUMAN
Tissue specificity:
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
Evidence on tissue expression from TISSUES for ADAM9 Gene
- Lung(4.6)
- Bone marrow(4.3)
- Heart(2.6)
- Nervous system(2.5)
- Kidney(2.3)
- Muscle(2.1)
- Spleen(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM9 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- endocrine
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- eye
- head
- lacrimal apparatus
- pituitary gland
Thorax:
- breast
Pelvis:
- ovary
- penis
- prostate
- testicle
- uterus
- vagina
- vulva
General:
- blood
- blood vessel
- hair
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs and template standards for ADAM9
-
OriGene qPCR primer pairs for ADAM9
- genomics-online: primer clones - Search results for 103 available ADAM9 gene related products
- Overview of 103 available ADAM9 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for ADAM9 Gene
Orthologs for ADAM9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADAM9 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ADAM9 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ADAM9 33 |
|
||
| ADAM-9 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Adam9 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adam9 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADAM9 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADAM9 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADAM9 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adam9 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | adam9-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | adam9 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | mmd 35 |
|
|
|
| Neu3 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | adm-1 35 |
|
|
|
| adm-2 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for ADAM9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADAM9 Gene
(16) SIMAP similar genes for ADAM9 Gene using alignment to 5 proteins:
Variants for ADAM9 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1026439825 | uncertain-significance, Cone-Rod Dystrophy, Recessive | 39,090,062(+) | T/G | coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant | |
| rs10651669 | benign, not specified, Cone-Rod Dystrophy, Recessive | 39,026,824(+) | TTCTT/TTCTTTCTT | intron_variant | |
| rs113649109 | likely-benign, Cone-Rod Dystrophy, Recessive | 39,021,671(+) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs137853040 | pathogenic, Cone-rod dystrophy 9 | 39,023,177(+) | C/T | coding_sequence_variant, non_coding_transcript_variant, stop_gained | |
| rs137853041 | pathogenic, Cone-rod dystrophy 9, not provided | 39,017,298(+) | C/G/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant, stop_gained |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1147428 | CNV | insertion | 17803354 |
| esv2659169 | CNV | deletion | 23128226 |
| esv2736897 | CNV | deletion | 23290073 |
| esv2795 | CNV | loss | 18987735 |
| esv3543384 | CNV | deletion | 23714750 |
| esv3543385 | CNV | deletion | 23714750 |
| esv9208 | CNV | gain | 19470904 |
| nsv1076079 | CNV | deletion | 25765185 |
| nsv1115088 | CNV | deletion | 24896259 |
| nsv1118049 | CNV | deletion | 24896259 |
| nsv1136005 | CNV | deletion | 24896259 |
| nsv1148609 | CNV | deletion | 26484159 |
| nsv1151331 | CNV | insertion | 26484159 |
| nsv477373 | CNV | novel sequence insertion | 20440878 |
| nsv515080 | CNV | gain | 21397061 |
| nsv524818 | CNV | loss | 19592680 |
| nsv6162 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.25;
62.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADAM9 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM9 Gene
Disorders for ADAM9 Gene
(4) MalaCards diseases for ADAM9 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cone-rod dystrophy 9 |
|
|
| retinitis pigmentosa |
|
|
| alveolar soft part sarcoma |
|
|
| cone-rod dystrophy 2 |
|
|
Search ADAM9 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ADAM9_HUMAN- Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. {ECO:0000269 PubMed:19409519}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ADAM9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ADAM9 Gene
Publications for ADAM9 Gene
- MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PMID: 8647900) Weskamp G … Blobel CP (The Journal of cell biology 1996) 2 3 4 22 58
- Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. (PMID: 19409519) Parry DA … Inglehearn CF (American journal of human genetics 2009) 2 3 4 58
- Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. (PMID: 19237226) Cong L … Jia J (Neurobiology of aging 2011) 3 44 58
- Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins. (PMID: 19543729) Işeri OD … Gündüz U (Cancer chemotherapy and pharmacology 2010) 3 22 58
- ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study. (PMID: 19253070) Oksala N … Lehtimäki T (Annals of medicine 2009) 3 22 58
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Sources for ADAM9 Gene
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