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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein... See more...
Aliases for ADAM9 Gene
Aliases for ADAM9 Gene
- ADAM Metallopeptidase Domain 9 2 3 5
- MCMP 2 3 4
- MDC9 2 3 4
- Disintegrin And Metalloproteinase Domain-Containing Protein 9 3 4
- Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
- Cellular Disintegrin-Related Protein 3 4
- Myeloma Cell Metalloproteinase 3 4
- Cone Rod Dystrophy 9 2 3
- KIAA0021 2 4
- Mltng 2 3
External Ids for ADAM9 Gene
- HGNC: 216
- Entrez Gene: 8754
- Ensembl: ENSG00000168615
- OMIM: 602713
- UniProtKB: Q13443
Previous HGNC Symbols for ADAM9 Gene
- CORD9
Previous GeneCards Identifiers for ADAM9 Gene
- GC08P038441
- GC08P039068
- GC08P038595
- GC08P038871
- GC08P038974
- GC08P038975
- GC08P037387
Summaries for ADAM9 Gene
-
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ADAM9 Gene
ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Cone-Rod Dystrophy 2. Among its related pathways are Degradation of the extracellular matrix and Copper homeostasis. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM12.
UniProtKB/Swiss-Prot Summary for ADAM9 Gene
-
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
-
[Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP).
Additional gene information for ADAM9 Gene
- HGNC(216)
- Entrez Gene(8754)
- Ensembl(ENSG00000168615)
- OMIM(602713)
- UniProtKB(Q13443)
- Open Targets Platform(ENSG00000168615)
- Monarch Initiative
- Search for ADAM9 at DataMed
- Search for ADAM9 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAM9 Gene
Genomics for ADAM9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADAM9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADAM9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAM9
- Top Transcription factor binding sites by QIAGEN in the ADAM9 gene promoter:
-
- AML1a
- FOXI1
- FOXL1
- HFH-3
- Pax-2
- Pax-2a
- Pax-2b
- SRF
- SRF (504 AA)
- YY1
Genomic Locations for ADAM9 Gene
Genomic Locations for ADAM9 Gene
- chr8:38,996,767-39,105,261
- (GRCh38/hg38)
- Size:
- 108,495 bases
- Orientation:
- Plus strand
- chr8:38,854,388-38,962,780
- (GRCh37/hg19)
- Size:
- 108,393 bases
- Orientation:
- Plus strand
Genomic View for ADAM9 Gene
Genes around ADAM9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p11.22 by HGNC
- 8p11.22 by Entrez Gene
- 8p11.22 by Ensembl
ADAM9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAM9 Gene
Proteins for ADAM9 Gene
-
Protein details for ADAM9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13443-ADAM9_HUMAN
- Recommended name:
- Disintegrin and metalloproteinase domain-containing protein 9
- Protein Accession:
- Q13443
- B7ZLN7
- Q10718
- Q8NFM6
Protein attributes for ADAM9 Gene
- Size:
- 819 amino acids
- Molecular mass:
- 90556 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Interacts with SH3GL2 and SNX9 through its cytoplasmic tail (PubMed:10531379). Interacts with ITGA6.
- Miscellaneous:
-
- [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for ADAM9 Gene
Selected DME Specific Peptides for ADAM9 Gene
- Q13443:
-
- RYVELFIVVD
- GEECDCG
- LVGLEIW
- GGSVDSGP
- HELGHNLG
- KCHGHGVC
Post-translational modifications for ADAM9 Gene
- Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.
- Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).
-
Glycosylation at Asn125, Asn144, Asn154, Asn231, Asn381, and Asn487
- NX_Q13443 (NX_Q13443-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- ADAM9_HUMAN (1181)
Other Protein References for ADAM9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ADAM9 Antibody
- GeneTex Anti-ADAM9 antibody
- Novus Biologicals Antibodies for ADAM9
-
Abcam antibodies for ADAM9
- Invitrogen Antibodies for ADAM9 (AFLGC-ADAM9)
- antibodies-online: Show 20 available ADAM9 Antibodies ranked by validation data
- Compare Top ADAM9 Antibodies
-
Recommended
- 72 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 42 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Biorbyt antibodies for ADAM9
-
Boster Bio Antibodies for ADAM9
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADAM9
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADAM9
- Origene Custom Protein Services for ADAM9
- Sino Biological Recombinant Proteins for ADAM9
- Sino Biological Cell Lysates for ADAM9
-
Signalway Proteins for ADAM9
-
Abcam proteins for ADAM9
Assay Products
- RayBiotech Human ADAM9 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for ADAM9
- Novus Biologicals ELISA Kits for ADAM9
- antibodies-online: Show 59 available ADAM9 Elisa Kits ranked by validation data
- Compare Top ADAM9 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for ADAM9
Domains & Families for ADAM9 Gene
Gene Families for ADAM9 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ADAM9 Gene
- InterPro:
- Blocks:
-
- Type I EGF
- Disintegrin
- Metalloendopeptidase M12B
- ADAM, cysteine-rich
- ProtoNet:
Suggested Antigen Peptide Sequences for ADAM9 Gene
- GenScript: Design optimal peptide antigens:
-
- Myeloma cell metalloproteinase (ADAM9_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ADAM9 Gene
Function for ADAM9 Gene
Molecular function for ADAM9 Gene
- UniProtKB/Swiss-Prot Function:
- Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Synthesized as an inactive form which is proteolytically cleaved to generate an active enzyme. Processing at the upstream site is particularly important for activation of the proenzyme, whereas processing at the boundary between the pro-domain and the catalytic domain does not appear to be essential. Inhibited by hydroxamic acid-based inhibitors.
- GENATLAS Biochemistry:
- a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely expressed,also expressed in meyloma cells
Enzyme Numbers (IUBMB) for ADAM9 Gene
Phenotypes From GWAS Catalog for ADAM9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IMP | 22480688 |
| GO:0005080 | protein kinase C binding | ISS | 8647900 |
| GO:0005178 | integrin binding | IPI | 17704059 |
| GO:0005515 | protein binding | IPI | 10527948 |
| GO:0005518 | collagen binding | IMP | 15361064 |
Phenotypes for ADAM9 Gene
- MGI mutant phenotypes for ADAM9:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADAM9:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- G0/1 arrest
- Decreased caspase 3/7 activity
- Increased viability with tamoxifen
Animal Models for ADAM9 Gene
- MGI Knock Outs for ADAM9:
-
- Adam9 Adam9<tm1Bbl>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADAM9 - Select products 50% OFF >
- * ADAM9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ADAM9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM9
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM9
miRNA for ADAM9 Gene
- miRTarBase miRNAs that target ADAM9
-
- hsa-miR-373-3p (MIRT002555)
- hsa-miR-126-3p (MIRT007266)
- hsa-miR-126-5p (MIRT007267)
- mmu-miR-30e-5p (MIRT013424)
- mmu-miR-181a-5p (MIRT014322)
- hsa-miR-26b-5p (MIRT030283)
- hsa-miR-23a-3p (MIRT050441)
- hsa-miR-125a-5p (MIRT054873)
- hsa-miR-1252-3p (MIRT402486)
- hsa-miR-3646 (MIRT402487)
- mmu-miR-467f (MIRT584960)
- mmu-miR-338-5p (MIRT584961)
- mmu-miR-669f-3p (MIRT584962)
- mmu-miR-466f-3p (MIRT584963)
- hsa-miR-3941 (MIRT609479)
- hsa-miR-603 (MIRT609480)
- hsa-miR-362-3p (MIRT609481)
- hsa-miR-329-3p (MIRT609482)
- hsa-miR-8485 (MIRT609483)
- hsa-miR-4520-5p (MIRT628488)
- hsa-miR-4799-5p (MIRT705902)
- hsa-miR-4666a-5p (MIRT705903)
- hsa-miR-633 (MIRT705904)
- hsa-miR-7114-3p (MIRT705905)
- hsa-miR-1180-5p (MIRT705906)
- hsa-miR-1228-3p (MIRT705907)
- hsa-miR-4495 (MIRT705908)
- hsa-miR-451b (MIRT705909)
- hsa-miR-30e-5p (MIRT705910)
- hsa-miR-30b-5p (MIRT705911)
- hsa-miR-30d-5p (MIRT705912)
- hsa-miR-30a-5p (MIRT705913)
- hsa-miR-30c-5p (MIRT705914)
- hsa-miR-543 (MIRT705915)
- mmu-miR-126a-3p (MIRT732786)
- hsa-miR-33a-5p (MIRT733344)
- hsa-miR-140-5p (MIRT735471)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM9
- Browse OriGene Inhibitory RNA Products For ADAM9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM9
Clone Products
- Applied Biological Materials (abm): Clones for ADAM9 - Select products 50% OFF >
- * ADAM9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ADAM9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM9
No data available for Transcription Factor Targets and HOMER Transcription for ADAM9 Gene
Localization for ADAM9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAM9 Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endosome | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Endoplasmic reticulum (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | ISS | 8647900 |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0009986 | cell surface | ISS | 8647900 |
Pathways & Interactions for ADAM9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Degradation of the extracellular matrix | ||
| 2 | Adhesion |
-
|
|
| 3 | Cytoskeletal Signaling | ||
| 4 | A-beta Plaque Formation and APP Metabolism | ||
| 5 | Notch Signaling Pathway (sino) | ||
Pathways by source for ADAM9 Gene
1 Sino Biological pathway for ADAM9 Gene
1 BioSystems pathway for ADAM9 Gene
3 Reactome pathways for ADAM9 Gene
1 GeneGo (Thomson Reuters) pathway for ADAM9 Gene
- Development Endothelin-1/EDNRA transactivation of EGFR
1 R&D Systems pathway for ADAM9 Gene
2 Cell Signaling Technology pathways for ADAM9 Gene
Interacting Proteins for ADAM9 Gene
Selected Interacting proteins:
Q13443-ADAM9_HUMAN
ENSP00000419446
for ADAM9 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ADAM9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | IDA | 17704059 |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006509 | membrane protein ectodomain proteolysis | IMP | 22480688 |
| GO:0007155 | cell adhesion | IMP | 11162558 |
| GO:0007160 | cell-matrix adhesion | IMP | 15361064 |
Drugs & Compounds for ADAM9 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ADAM9 Gene
mRNA/cDNA for ADAM9 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000466936 2053 nts (view in UCSC)
- ENST00000481513 2387 nts (view in UCSC)
- ENST00000487273 4112 nts (view in UCSC)
- ENST00000481873 3793 nts (view in UCSC)
- ENST00000468065 3755 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ADAM9 - Select products 50% OFF >
- * ADAM9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ADAM9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM9
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM9
- Browse OriGene Inhibitory RNA Products For ADAM9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM9
Clone Products
- Applied Biological Materials (abm): Clones for ADAM9 - Select products 50% OFF >
- * ADAM9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ADAM9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM9
Relevant External Links for ADAM9 Gene
- GeneLoc Exon Structure for
- ADAM9
Expression for ADAM9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Amniocyte (35.5) and Adrenal (17.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAM9 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAM9
SOURCE GeneReport for Unigene cluster for ADAM9 Gene:
Hs.591852mRNA Expression by UniProt/SwissProt for ADAM9 Gene:
Q13443-ADAM9_HUMAN
Tissue specificity:
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
Evidence on tissue expression from TISSUES for ADAM9 Gene
- Lung(4.6)
- Bone marrow(4.4)
- Heart(3.2)
- Nervous system(3)
- Kidney(3)
- Spleen(2.7)
- Muscle(2.7)
- Intestine(2.6)
- Liver(2.5)
- Skin(2.5)
- Stomach(2.4)
- Lymph node(2.3)
- Blood(2.3)
- Thyroid gland(2.2)
- Adrenal gland(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM9 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- endocrine
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- eye
- head
- lacrimal apparatus
- pituitary gland
Thorax:
- breast
Pelvis:
- ovary
- penis
- prostate
- testicle
- uterus
- vagina
- vulva
General:
- blood
- blood vessel
- hair
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for ADAM9
-
OriGene qPCR primer pairs and template standards for ADAM9
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for ADAM9 Gene
Orthologs for ADAM9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADAM9 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ADAM9 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ADAM9 30 |
|
||
| ADAM-9 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Adam9 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Adam9 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ADAM9 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ADAM9 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ADAM9 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adam9 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | adam9-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | adam9 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | mmd 32 |
|
|
|
| Neu3 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | adm-1 32 |
|
|
|
| adm-2 31 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for ADAM9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ADAM9 Gene
- ENSEMBL:
- Gene Tree for ADAM9 (if available)
- TreeFam:
- Gene Tree for ADAM9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADAM9: view image
Paralogs for ADAM9 Gene
Paralogs for ADAM9 Gene
(16) SIMAP similar genes for ADAM9 Gene using alignment to 5 proteins:
- ADAM9_HUMAN
- A0AVL1_HUMAN
- C9J6H5_HUMAN
- C9JPM3_HUMAN
- F8WC54_HUMAN
Variants for ADAM9 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAM9 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 677215 | Benign: not provided | 39,082,773(+) | GAAATCTCAGGACTAG | INTRON_VARIANT | |
| 729582 | Conflicting Interpretations: Cone-rod dystrophy 9; not provided | 39,090,069(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 737760 | Benign/Likely Benign: Cone-rod dystrophy 9; not provided | 39,054,572(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 770747 | Benign: not provided | 39,023,332(+) | AT/A | INTRON_VARIANT | |
| 775265 | Benign/Likely Benign: Cone-rod dystrophy 9; not provided | 39,023,298(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1147428 | CNV | insertion | 17803354 |
| esv2659169 | CNV | deletion | 23128226 |
| esv2736897 | CNV | deletion | 23290073 |
| esv2795 | CNV | loss | 18987735 |
| esv3543384 | CNV | deletion | 23714750 |
| esv3543385 | CNV | deletion | 23714750 |
| esv9208 | CNV | gain | 19470904 |
| nsv1076079 | CNV | deletion | 25765185 |
| nsv1115088 | CNV | deletion | 24896259 |
| nsv1118049 | CNV | deletion | 24896259 |
| nsv1136005 | CNV | deletion | 24896259 |
| nsv1148609 | CNV | deletion | 26484159 |
| nsv1151331 | CNV | insertion | 26484159 |
| nsv477373 | CNV | novel sequence insertion | 20440878 |
| nsv515080 | CNV | gain | 21397061 |
| nsv524818 | CNV | loss | 19592680 |
| nsv6162 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.25;
62.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADAM9 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM9 Gene
Disorders for ADAM9 Gene
(10) MalaCards diseases for ADAM9 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cone-rod dystrophy 9 |
|
|
| cone-rod dystrophy 2 |
|
|
| retinitis pigmentosa |
|
|
| alveolar soft part sarcoma |
|
|
| skin melanoma |
|
|
Search ADAM9 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ADAM9_HUMAN- Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. {ECO:0000269 PubMed:19409519}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ADAM9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for ADAM9 Gene
Publications for ADAM9 Gene
- MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PMID: 8647900) Weskamp G … Blobel CP (The Journal of cell biology 1996) 2 3 4 23
- Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. (PMID: 19409519) Parry DA … Inglehearn CF (American journal of human genetics 2009) 2 3 4
- Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. (PMID: 19237226) Cong L … Jia J (Neurobiology of aging 2011) 3 41
- Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins. (PMID: 19543729) Işeri OD … Gündüz U (Cancer chemotherapy and pharmacology 2010) 3 23
- Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions. (PMID: 19505527) Cominetti MR … Selistre-de-Araujo HS (Biochimie 2009) 3 23
ExternalLinks
Products for ADAM9 Gene
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Sources for ADAM9 Gene
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