Aliases for ADAM9 Gene
- ADAM Metallopeptidase Domain 9 2 3 5
- Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
- Cellular Disintegrin-Related Protein 3 4
- Myeloma Cell Metalloproteinase 3 4
- Cone Rod Dystrophy 9 2 3
- Mltng 3 4
- MCMP 3 4
- MDC9 3 4
- Disintegrin And Metalloproteinase Domain-Containing Protein 9 3
- A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma) 2
External Ids for ADAM9 Gene
Previous HGNC Symbols for ADAM9 Gene
Previous GeneCards Identifiers for ADAM9 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ADAM9 Gene
ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Retinitis Pigmentosa. Among its related pathways are Notch Signaling Pathway (sino) and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM29.
UniProtKB/Swiss-Prot for ADAM9 Gene
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP).