Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein... See more...
Aliases for ADAM9 Gene
Aliases for ADAM9 Gene
- ADAM Metallopeptidase Domain 9 2 3 5
- MCMP 2 3 4
- MDC9 2 3 4
- Disintegrin And Metalloproteinase Domain-Containing Protein 9 3 4
- Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
- Cellular Disintegrin-Related Protein 3 4
- Myeloma Cell Metalloproteinase 3 4
- Cone Rod Dystrophy 9 2 3
- KIAA0021 2 4
- Mltng 2 3
External Ids for ADAM9 Gene
- HGNC: 216
- NCBI Entrez Gene: 8754
- Ensembl: ENSG00000168615
- OMIM®: 602713
- UniProtKB/Swiss-Prot: Q13443
Previous HGNC Symbols for ADAM9 Gene
- CORD9
Previous GeneCards Identifiers for ADAM9 Gene
- GC08P038441
- GC08P039068
- GC08P038595
- GC08P038871
- GC08P038974
- GC08P038975
- GC08P037387
Summaries for ADAM9 Gene
-
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ADAM9 Gene
ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Cone-Rod Dystrophy 2. Among its related pathways are Degradation of the extracellular matrix and Notch Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM12.
UniProtKB/Swiss-Prot Summary for ADAM9 Gene
-
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
-
[Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP).
Additional gene information for ADAM9 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAM9 Gene
Genomics for ADAM9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADAM9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADAM9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAM9
- Top Transcription factor binding sites by QIAGEN in the ADAM9 gene promoter:
-
- AML1a
- FOXI1
- FOXL1
- HFH-3
- Pax-2
- Pax-2a
- Pax-2b
- SRF
- SRF (504 AA)
- YY1
Genomic Locations for ADAM9 Gene
Latest Assembly
- chr8:38,996,754-39,105,445
- (GRCh38/hg38)
- Size:
- 108,692 bases
- Orientation:
- Plus strand
Previous Assembly
- chr8:38,854,492-38,962,780
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 108,289 bases
- Orientation:
- Plus strand
Alternative Locations (GRCh38/hg38)
- chr8(ALT_REF_LOCI_1):7,546-10,944 (+)
Genomic View for ADAM9 Gene
Genes around ADAM9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p11.22 by HGNC
- 8p11.22 by Entrez Gene
- 8p11.22 by Ensembl
ADAM9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAM9 Gene
Proteins for ADAM9 Gene
-
Protein details for ADAM9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13443-ADAM9_HUMAN
- Recommended name:
- Disintegrin and metalloproteinase domain-containing protein 9
- Protein Accession:
- Q13443
- B7ZLN7
- Q10718
- Q8NFM6
Protein attributes for ADAM9 Gene
- Size:
- 819 amino acids
- Molecular mass:
- 90556 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Interacts with SH3GL2 and SNX9 through its cytoplasmic tail (PubMed:10531379). Interacts with ITGA6.
- Miscellaneous:
-
- [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for ADAM9 Gene
Selected DME Specific Peptides for ADAM9 Gene
- Q13443:
-
- RYVELFIVVD
- GEECDCG
- LVGLEIW
- GGSVDSGP
- HELGHNLG
- KCHGHGVC
Post-translational modifications for ADAM9 Gene
- Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9.
- Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA).
-
Glycosylation at Asn125, Asn144, Asn154, Asn231, Asn381, and Asn487
- NX_Q13443 (NX_Q13443-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- ADAM9_HUMAN (1181)
Other Protein References for ADAM9 Gene
- ENSEMBL proteins:
-
- ENSP00000503374
- ENSP00000503418
- ENSP00000420257
- ENSP00000504583
- ENSP00000502895
- ENSP00000503206
- ENSP00000504373
- ENSP00000503215
- ENSP00000503584
- ENSP00000503648
- ENSP00000503079
- ENSP00000504471
- ENSP00000504640
- ENSP00000503932
- ENSP00000502865
- ENSP00000503523
- ENSP00000503454
- ENSP00000419446
- ENSP00000417066
- ENSP00000418437
- ENSP00000369249
- ENSP00000418737
- ENSP00000503906
- Q13443.201
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ADAM9 Antibody
- G Biosciences Immunotag™ ADAM9 Antibody
- GeneTex Anti-ADAM9 antibody
- Novus Biologicals Antibodies for ADAM9
-
Abcam antibodies for ADAM9
- Invitrogen Antibodies for ADAM9 (AFLGC-ADAM9)
- antibodies-online: Show 20 available ADAM9 Antibodies ranked by validation data
- Compare Top ADAM9 Antibodies
-
Recommended
- 72 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 42 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Biorbyt antibodies for ADAM9
-
Boster Bio Antibodies for ADAM9
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADAM9
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADAM9
- Origene Custom Protein Services for ADAM9
- Sino Biological Recombinant Proteins for ADAM9
- Sino Biological Cell Lysates for ADAM9
-
Abcam proteins for ADAM9
Assay products for research
- RayBiotech Human ADAM9 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for ADAM9
- Novus Biologicals ELISA Kits for ADAM9
- antibodies-online: Show 59 available ADAM9 Elisa Kits ranked by validation data
- Compare Top ADAM9 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for ADAM9
Domains & Families for ADAM9 Gene
Gene Families for ADAM9 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ADAM9 Gene
- InterPro:
- Blocks:
-
- Type I EGF
- Disintegrin
- Metalloendopeptidase M12B
- ADAM, cysteine-rich
Suggested Antigen Peptide Sequences for ADAM9 Gene
- GenScript: Design optimal peptide antigens:
-
- Myeloma cell metalloproteinase (ADAM9_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ADAM9 Gene
Function for ADAM9 Gene
Molecular function for ADAM9 Gene
- UniProtKB/Swiss-Prot Function:
- Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Synthesized as an inactive form which is proteolytically cleaved to generate an active enzyme. Processing at the upstream site is particularly important for activation of the proenzyme, whereas processing at the boundary between the pro-domain and the catalytic domain does not appear to be essential. Inhibited by hydroxamic acid-based inhibitors.
- GENATLAS Biochemistry:
- a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely expressed,also expressed in meyloma cells
Enzyme Numbers (IUBMB) for ADAM9 Gene
Phenotypes From GWAS Catalog for ADAM9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IEA,IMP | 22480688 |
| GO:0005080 | protein kinase C binding | ISS | 8647900 |
| GO:0005178 | integrin binding | IPI | 17704059 |
| GO:0005515 | protein binding | IPI | 10527948 |
| GO:0005518 | collagen binding | IMP | 15361064 |
Phenotypes for ADAM9 Gene
- MGI mutant phenotypes for ADAM9:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADAM9:
-
- Increased vaccinia virus (VACV) infection
- Increased G1 DNA content
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- G0/1 arrest
- Decreased caspase 3/7 activity
- Increased viability with tamoxifen
Animal Models for ADAM9 Gene
- MGI Knock Outs for ADAM9:
-
- Adam9 Adam9<tm1Bbl>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADAM9 - Starting at $85 >
- * ADAM9 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ADAM9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM9
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM9
miRNA for ADAM9 Gene
- miRTarBase miRNAs that target ADAM9
-
- hsa-miR-373-3p (MIRT002555)
- hsa-miR-126-3p (MIRT007266)
- hsa-miR-126-5p (MIRT007267)
- mmu-miR-30e-5p (MIRT013424)
- mmu-miR-181a-5p (MIRT014322)
- hsa-miR-26b-5p (MIRT030283)
- hsa-miR-23a-3p (MIRT050441)
- hsa-miR-125a-5p (MIRT054873)
- hsa-miR-1252-3p (MIRT402486)
- hsa-miR-3646 (MIRT402487)
- mmu-miR-467f (MIRT584960)
- mmu-miR-338-5p (MIRT584961)
- mmu-miR-669f-3p (MIRT584962)
- mmu-miR-466f-3p (MIRT584963)
- hsa-miR-3941 (MIRT609479)
- hsa-miR-603 (MIRT609480)
- hsa-miR-362-3p (MIRT609481)
- hsa-miR-329-3p (MIRT609482)
- hsa-miR-8485 (MIRT609483)
- hsa-miR-4520-5p (MIRT628488)
- hsa-miR-4799-5p (MIRT705902)
- hsa-miR-4666a-5p (MIRT705903)
- hsa-miR-633 (MIRT705904)
- hsa-miR-7114-3p (MIRT705905)
- hsa-miR-1180-5p (MIRT705906)
- hsa-miR-1228-3p (MIRT705907)
- hsa-miR-4495 (MIRT705908)
- hsa-miR-451b (MIRT705909)
- hsa-miR-30e-5p (MIRT705910)
- hsa-miR-30b-5p (MIRT705911)
- hsa-miR-30d-5p (MIRT705912)
- hsa-miR-30a-5p (MIRT705913)
- hsa-miR-30c-5p (MIRT705914)
- hsa-miR-543 (MIRT705915)
- mmu-miR-126a-3p (MIRT732786)
- hsa-miR-33a-5p (MIRT733344)
- hsa-miR-140-5p (MIRT735471)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM9
- Browse OriGene Inhibitory RNA Products For ADAM9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM9
Clone products for research
- Applied Biological Materials (abm): Clones for ADAM9 - Starting at $45 >
- * ADAM9 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ADAM9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM9
No data available for Transcription Factor Targets and HOMER Transcription for ADAM9 Gene
Localization for ADAM9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAM9 Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Endoplasmic reticulum (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA,ISS | 8647900 |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005925 | focal adhesion | HDA | 21423176 |
| GO:0009986 | cell surface | ISS | 8647900 |
Pathways & Interactions for ADAM9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Degradation of the extracellular matrix | ||
| 2 | Adhesion |
-
|
|
| 3 | Cytoskeletal Signaling | ||
| 4 | A-beta Pathways: Plaque Formation and APP Metabolism | ||
| 5 | Notch Signaling Pathway (sino) | ||
Pathways by source for ADAM9 Gene
1 Sino Biological pathway for ADAM9 Gene
1 BioSystems pathway for ADAM9 Gene
3 Reactome pathways for ADAM9 Gene
1 GeneGo (Thomson Reuters) pathway for ADAM9 Gene
- Development Endothelin-1/EDNRA transactivation of EGFR
1 R&D Systems pathway for ADAM9 Gene
2 Cell Signaling Technology pathways for ADAM9 Gene
Interacting Proteins for ADAM9 Gene
Selected Interacting proteins:
Q13443-ADAM9_HUMAN
ENSP00000419446
for ADAM9 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ADAM9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000186 | activation of MAPKK activity | IDA | 17704059 |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006509 | membrane protein ectodomain proteolysis | IBA,IMP | 22480688 |
| GO:0007155 | cell adhesion | IMP | 11162558 |
| GO:0007160 | cell-matrix adhesion | IMP | 15361064 |
Transcripts for ADAM9 Gene
mRNA/cDNA for ADAM9 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 28 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000379917 3836 nts (view in UCSC)
- ENST00000463437 2838 nts (view in UCSC)
- ENST00000466936 2053 nts (view in UCSC)
- ENST00000468065 3755 nts (view in UCSC)
- ENST00000481058 7079 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADAM9 - Starting at $85 >
- * ADAM9 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ADAM9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM9
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM9
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM9
- Browse OriGene Inhibitory RNA Products For ADAM9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM9
Clone products for research
- Applied Biological Materials (abm): Clones for ADAM9 - Starting at $45 >
- * ADAM9 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ADAM9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM9
Relevant External Links for ADAM9 Gene
- GeneLoc Exon Structure for
- ADAM9
Expression for ADAM9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Amniocyte (35.5) and Adrenal (17.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAM9 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAM9
SOURCE GeneReport for Unigene cluster for ADAM9 Gene:
Hs.591852mRNA Expression by UniProt/SwissProt for ADAM9 Gene:
Q13443-ADAM9_HUMAN
Tissue specificity:
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
Evidence on tissue expression from TISSUES for ADAM9 Gene
- Lung(4.6)
- Bone marrow(4.4)
- Heart(3)
- Nervous system(2.9)
- Kidney(2.8)
- Spleen(2.7)
- Muscle(2.5)
- Intestine(2.5)
- Liver(2.4)
- Skin(2.3)
- Stomach(2.3)
- Lymph node(2.2)
- Thyroid gland(2.1)
- Blood(2.1)
- Adrenal gland(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM9 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- endocrine
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- eye
- head
- lacrimal apparatus
- pituitary gland
Thorax:
- breast
Pelvis:
- ovary
- penis
- prostate
- testicle
- uterus
- vagina
- vulva
General:
- blood
- blood vessel
- hair
- peripheral nervous system
- skin
Primer products for research
-
OriGene qPCR primer pairs for ADAM9
-
OriGene qPCR primer pairs and template standards for ADAM9
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues for ADAM9 Gene
Orthologs for ADAM9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADAM9 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ADAM9 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ADAM9 29 |
|
||
| ADAM-9 30 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Adam9 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Adam9 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ADAM9 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ADAM9 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ADAM9 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adam9 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | adam9-A 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | adam9 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | mmd 31 |
|
|
|
| Neu3 30 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | adm-1 31 |
|
|
|
| adm-2 30 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany |
- Species where no ortholog for ADAM9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ADAM9 Gene
- ENSEMBL:
- Gene Tree for ADAM9 (if available)
- TreeFam:
- Gene Tree for ADAM9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADAM9: view image
- Alliance of Genome Resources:
- Additional Orthologs for ADAM9
Paralogs for ADAM9 Gene
Paralogs for ADAM9 Gene
(16) SIMAP similar genes for ADAM9 Gene using alignment to 5 proteins:
- ADAM9_HUMAN
- A0AVL1_HUMAN
- C9J6H5_HUMAN
- C9JPM3_HUMAN
- F8WC54_HUMAN
Variants for ADAM9 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAM9 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1003384 | Uncertain Significance: not provided | 39,077,271(+) |
A/T NM_003816.3(ADAM9):c.1741A>T (p.Ile581Leu) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| 1004268 | Uncertain Significance: not provided | 39,077,385(+) |
G/A NM_003816.3(ADAM9):c.1855G>A (p.Glu619Lys) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| 1004484 | Uncertain Significance: not provided | 39,023,238(+) |
G/A NM_003816.3(ADAM9):c.827G>A (p.Gly276Asp) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| 1004642 | Uncertain Significance: not provided | 39,023,317(+) |
G/C NM_003816.3(ADAM9):c.906G>C (p.Gln302His) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| 1005098 | Uncertain Significance: not provided | 39,103,669(+) |
C/T NM_003816.3(ADAM9):c.2429C>T (p.Pro810Leu) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1147428 | CNV | insertion | 17803354 |
| esv2659169 | CNV | deletion | 23128226 |
| esv2736897 | CNV | deletion | 23290073 |
| esv2795 | CNV | loss | 18987735 |
| esv3543384 | CNV | deletion | 23714750 |
| esv3543385 | CNV | deletion | 23714750 |
| esv9208 | CNV | gain | 19470904 |
| nsv1076079 | CNV | deletion | 25765185 |
| nsv1115088 | CNV | deletion | 24896259 |
| nsv1118049 | CNV | deletion | 24896259 |
| nsv1136005 | CNV | deletion | 24896259 |
| nsv1148609 | CNV | deletion | 26484159 |
| nsv1151331 | CNV | insertion | 26484159 |
| nsv477373 | CNV | novel sequence insertion | 20440878 |
| nsv515080 | CNV | gain | 21397061 |
| nsv524818 | CNV | loss | 19592680 |
| nsv6162 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.25;
62.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADAM9 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM9 Gene
Disorders for ADAM9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cone-rod dystrophy 9 |
|
|
| cone-rod dystrophy 2 |
|
|
| retinitis pigmentosa |
|
|
| alveolar soft part sarcoma |
|
|
| skin melanoma |
|
|
Search ADAM9 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ADAM9_HUMAN- Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. {ECO:0000269 PubMed:19409519}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for ADAM9
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for ADAM9 Gene
Publications for ADAM9 Gene
- Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. (PMID: 19409519) Parry DA … Inglehearn CF (American journal of human genetics 2009) 2 3 4 72
- MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PMID: 8647900) Weskamp G … Blobel CP (The Journal of cell biology 1996) 2 3 4 22
- CORD9 a new locus for arCRD: mapping to 8p11, estimation of frequency, evaluation of a candidate gene. (PMID: 11581183) Danciger M … Farber DB (Investigative ophthalmology & visual science 2001) 2 3 72
- Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. (PMID: 19237226) Cong L … Jia J (Neurobiology of aging 2011) 3 40
- Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins. (PMID: 19543729) Işeri OD … Gündüz U (Cancer chemotherapy and pharmacology 2010) 3 22
ExternalLinks
Products for ADAM9 Gene
- View all 11 R&D Systems ADAM9 (ADAM9) Products
- View all R&D Systems ADAM9 (ADAM9) Proteins and Enzymes
- View all 6 R&D Systems ADAM9 (ADAM9) Primary Antibodies
- View all R&D Systems ADAM9 (ADAM9) ELISAs
- View all 3 R&D Systems ADAM9 (ADAM9) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom ADAM9 antibody, protein, and immunoassay development services
- Custom Antibody Services
- Custom Assay ServicesOriGene ELISA Kits for ADAM9
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADAM9
- Origene Custom Protein Services for ADAM9
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM9
- Browse OriGene Inhibitory RNA Products For ADAM9
- OriGene qPCR primer pairs for ADAM9
- OriGene qPCR primer pairs and template standards for ADAM9
- OriGene CRISPR knockouts for ADAM9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADAM9
- Sino Biological Human cDNA Clone for ADAM9
- Sino Biological Recombinant Proteins for ADAM9
- Sino Biological Cell Lysates for ADAM9
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ADAM9
- Novus Biologicals ELISA Kits for ADAM9
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ADAM9
- Abcam proteins for ADAM9
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for ADAM9 (AFLGC-ADAM9)
- VectorBuilder Custom and pre-made DNA vectors for ADAM9 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ADAM9 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ADAM9 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ADAM9 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ADAM9
- antibodies-online: Show 20 available ADAM9 Antibodies ranked by validation data
- Compare Top ADAM9 Antibodies
- Recommended
- 72 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 42 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Show 59 available ADAM9 Elisa Kits ranked by validation data
- Compare Top ADAM9 Elisa Kits
- Quality Products:
- antibodies-online: Show 11 available ADAM9 Proteins ranked by validation data
- Compare Top ADAM9 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ADAM9
- Search Santa Cruz Biotechnology (SCBT) for ADAM9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADAM9
- Custom Antibody ServicesProSci Antibodies for ADAM9
- Search for ADAM9 Proteins at ProSci
- Horizon Cell Lines for ADAM9
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM9
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ADAM9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM9
- Biorbyt antibodies for ADAM9
Sources for ADAM9 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources