Aliases for ADAM8 Gene
External Ids for ADAM8 Gene
Previous GeneCards Identifiers for ADAM8 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
GeneCards Summary for ADAM8 Gene
ADAM8 (ADAM Metallopeptidase Domain 8) is a Protein Coding gene. Diseases associated with ADAM8 include Asthma and Orthostatic Intolerance. Among its related pathways are Degradation of the extracellular matrix and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is ADAM12.
UniProtKB/Swiss-Prot Summary for ADAM8 Gene
Possible involvement in extravasation of leukocytes.