Aliases for ADAM7 Gene
External Ids for ADAM7 Gene
Previous GeneCards Identifiers for ADAM7 Gene
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]
GeneCards Summary for ADAM7 Gene
ADAM7 (ADAM Metallopeptidase Domain 7) is a Protein Coding gene. Diseases associated with ADAM7 include Melanoma. Among its related pathways are Notch Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAM28.
UniProtKB/Swiss-Prot for ADAM7 Gene
May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).