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Aliases for ADAM7 Gene

Aliases for ADAM7 Gene

  • ADAM Metallopeptidase Domain 7 2 3 5
  • A Disintegrin And Metalloproteinase Domain 7 2 3
  • Sperm Maturation-Related Glycoprotein GP-83 3 4
  • ADAM 7 3 4
  • GP83 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 7 3
  • Epididymal Apical Protein I 3
  • ADAM-7 3
  • GP-83 3
  • EAPI 3

External Ids for ADAM7 Gene

Previous GeneCards Identifiers for ADAM7 Gene

  • GC08P024031
  • GC08P024652
  • GC08P024321
  • GC08P024322
  • GC08P022843

Summaries for ADAM7 Gene

Entrez Gene Summary for ADAM7 Gene

  • This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]

GeneCards Summary for ADAM7 Gene

ADAM7 (ADAM Metallopeptidase Domain 7) is a Protein Coding gene. Diseases associated with ADAM7 include Melanoma. Among its related pathways are Notch Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and endopeptidase activity. An important paralog of this gene is ADAM28.

UniProtKB/Swiss-Prot for ADAM7 Gene

  • May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).

Additional gene information for ADAM7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM7 Gene

Genomics for ADAM7 Gene

GeneHancer (GH) Regulatory Elements for ADAM7 Gene

Promoters and enhancers for ADAM7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J024440 Promoter 0.5 EPDnew 650.7 +0.1 77 0.1 ADAM7 LOC101929315 LOC101929294 GC08P024271 GC08P024089 ENSG00000253535
GH08J024383 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 -54.5 -54502 5.4 CTCF PKNOX1 NFRKB EBF1 BATF KLF5 RAD21 RELA TEAD3 ZNF547 ADAMDEC1 ADAM28 ADAM7 PIR51295 GC08P024271 LOC101929294 GC08P024089 ENSG00000253535
GH08J024418 Enhancer 0.6 Ensembl ENCODE 11.7 -22.1 -22101 0.5 CTCF CEBPB ADAM7 LOC101929315 PIR51295 LOC101929294 GC08P024271 GC08P024089 ENSG00000253535
GH08J024420 Enhancer 0.5 ENCODE 11.7 -21.5 -21527 0.2 CTCF ZNF654 SMC3 CEBPB RAD21 ADAM7 PIR51295 LOC101929294 GC08P024271 GC08P024089 ENSG00000253535
GH08J024509 Enhancer 0.5 ENCODE 10.9 +68.6 68576 0.5 JUND BACH1 NFE2 FOSL2 MAFK ADAM7 LOC101929315 LOC101929294 GC08P024271 ENSG00000253535 GC08P024089
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAM7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAM7 gene promoter:

Genomic Locations for ADAM7 Gene

Genomic Locations for ADAM7 Gene
chr8:24,440,930-24,526,970
(GRCh38/hg38)
Size:
86,041 bases
Orientation:
Plus strand
chr8:24,298,443-24,384,483
(GRCh37/hg19)

Genomic View for ADAM7 Gene

Genes around ADAM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM7 Gene

Proteins for ADAM7 Gene

  • Protein details for ADAM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2U9-ADAM7_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 7
    Protein Accession:
    Q9H2U9
    Secondary Accessions:
    • A8K8X7
    • O75959
    • Q6PEJ6

    Protein attributes for ADAM7 Gene

    Size:
    754 amino acids
    Molecular mass:
    85669 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM7 Gene

Post-translational modifications for ADAM7 Gene

  • Glycosylation at posLast=668668, Asn584, posLast=184184, Asn174, posLast=167167, and Asn84
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM7 Gene

No data available for DME Specific Peptides for ADAM7 Gene

Domains & Families for ADAM7 Gene

Gene Families for ADAM7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ADAM7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAM7: view

No data available for UniProtKB/Swiss-Prot for ADAM7 Gene

Function for ADAM7 Gene

Molecular function for ADAM7 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity).

Phenotypes From GWAS Catalog for ADAM7 Gene

Gene Ontology (GO) - Molecular Function for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAM7: view
genes like me logo Genes that share phenotypes with ADAM7: view

Animal Models for ADAM7 Gene

MGI Knock Outs for ADAM7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM7

Clone Products

  • Addgene plasmids for ADAM7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADAM7 Gene

Localization for ADAM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM7 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAM7 Gene

Pathways & Interactions for ADAM7 Gene

SuperPathways for ADAM7 Gene

SuperPathway Contained pathways
1 Notch Signaling Pathway (sino)
genes like me logo Genes that share pathways with ADAM7: view

Pathways by source for ADAM7 Gene

1 Sino Biological pathway for ADAM7 Gene

Interacting Proteins for ADAM7 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000175238%0d%0a9606.ENSP00000387356%0d%0a9606.ENSP00000261681%0d%0a9606.ENSP00000387278%0d%0a9606.ENSP00000381425%0d%0a9606.ENSP00000337907%0d%0a
Selected Interacting proteins: Q9H2U9-ADAM7_HUMAN ENSP00000175238 for ADAM7 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ADAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAM7: view

No data available for SIGNOR curated interactions for ADAM7 Gene

Drugs & Compounds for ADAM7 Gene

No Compound Related Data Available

Transcripts for ADAM7 Gene

mRNA/cDNA for ADAM7 Gene

(12) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAM7 Gene

ADAM metallopeptidase domain 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for ADAM7

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM7 Gene

No ASD Table

Relevant External Links for ADAM7 Gene

GeneLoc Exon Structure for
ADAM7
ECgene alternative splicing isoforms for
ADAM7

Expression for ADAM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM7 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM7 Gene

This gene is overexpressed in Testis (x41.1) and Pancreas (x6.5).

Protein differential expression in normal tissues from HIPED for ADAM7 Gene

This gene is overexpressed in Fetal ovary (44.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM7 Gene



Protein tissue co-expression partners for ADAM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAM7 Gene:

ADAM7

SOURCE GeneReport for Unigene cluster for ADAM7 Gene:

Hs.116147

mRNA Expression by UniProt/SwissProt for ADAM7 Gene:

Q9H2U9-ADAM7_HUMAN
Tissue specificity: Not detected in healthy melanocytes. Expressed in melanoma cells.
genes like me logo Genes that share expression patterns with ADAM7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM7 Gene

Orthologs for ADAM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM7 34 33
  • 99.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM7 34 33
  • 82.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM7 34 33
  • 81.68 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adam7 16 34 33
  • 76.79 (n)
rat
(Rattus norvegicus)
Mammalia Adam7 33
  • 76.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAM7 34
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM7 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii adam28 34
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-1 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
OneToMany
Species where no ortholog for ADAM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAM7 Gene

ENSEMBL:
Gene Tree for ADAM7 (if available)
TreeFam:
Gene Tree for ADAM7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAM7: view image

Paralogs for ADAM7 Gene

Paralogs for ADAM7 Gene

(16) SIMAP similar genes for ADAM7 Gene using alignment to 5 proteins:

  • ADAM7_HUMAN
  • C9JK28_HUMAN
  • E5RK87_HUMAN
  • Q6PEJ6_HUMAN
  • Q86XK9_HUMAN
genes like me logo Genes that share paralogs with ADAM7: view

Variants for ADAM7 Gene

Sequence variations from dbSNP and Humsavar for ADAM7 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1034941983 cutaneous metastatic melanoma sample 24,499,308(+) G/A coding_sequence_variant, missense_variant
rs137990671 A cutaneous metastatic melanoma sample 24,442,511(+) C/T coding_sequence_variant, missense_variant
rs150319320 A cutaneous metastatic melanoma sample 24,441,148(+) C/T coding_sequence_variant, missense_variant
rs267601866 A cutaneous metastatic melanoma sample 24,442,526(+) C/T coding_sequence_variant, missense_variant
rs267601867 A cutaneous metastatic melanoma sample 24,465,702(+) C/G/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM7 Gene

Variant ID Type Subtype PubMed ID
dgv452n21 CNV loss 19592680
dgv7141n100 CNV loss 25217958
esv1005603 CNV deletion 20482838
esv1347031 CNV insertion 17803354
esv1752768 CNV deletion 17803354
esv2672980 CNV deletion 23128226
esv2736766 CNV deletion 23290073
esv3424387 CNV insertion 20981092
esv3543243 CNV deletion 23714750
esv3891377 CNV loss 25118596
nsv1076071 CNV deletion 25765185
nsv397333 CNV insertion 16902084

Variation tolerance for ADAM7 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.97; 87.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM7 Gene

Human Gene Mutation Database (HGMD)
ADAM7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM7 Gene

Disorders for ADAM7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards
Search ADAM7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ADAM7_HUMAN
  • Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis. {ECO:0000269 PubMed:21618342}.

Additional Disease Information for ADAM7

genes like me logo Genes that share disorders with ADAM7: view

No data available for Genatlas for ADAM7 Gene

Publications for ADAM7 Gene

  1. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PMID: 21618342) Wei X … Samuels Y (Human mutation 2011) 3 4 58
  2. Cloning and characterization of a complementary DNA encoding a human epididymis-associated disintegrin and metalloprotease 7 protein. (PMID: 11514362) Lin YC … Liu HW (Biology of reproduction 2001) 3 22 58
  3. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. (PMID: 23218918) Sprooten E … McIntosh AM (Psychiatry research 2013) 3 58
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 44 58
  5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 44 58

Products for ADAM7 Gene

Sources for ADAM7 Gene

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