This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protei... See more...

Aliases for ADAM33 Gene

Aliases for ADAM33 Gene

  • ADAM Metallopeptidase Domain 33 2 3 5
  • Disintegrin And Metalloproteinase Domain-Containing Protein 33 3 4
  • A Disintegrin And Metalloproteinase Domain 33 2 3
  • C20orf153 3 4
  • DJ964F7.1 2 3
  • ADAM 33 3 4
  • Disintegrin And Reprolysin Metalloproteinase Family Protein 3
  • Chromosome 20 Open Reading Frame 153 2
  • A Disintegrin And Metalloprotease 33 3
  • DKFZp434K0521 2
  • EC 3.4.24.- 4
  • ADAM33 5

External Ids for ADAM33 Gene

Previous HGNC Symbols for ADAM33 Gene

  • C20orf153

Previous GeneCards Identifiers for ADAM33 Gene

  • GC20M003637
  • GC20M003643

Summaries for ADAM33 Gene

Entrez Gene Summary for ADAM33 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

GeneCards Summary for ADAM33 Gene

ADAM33 (ADAM Metallopeptidase Domain 33) is a Protein Coding gene. Diseases associated with ADAM33 include Asthma and Allergic Asthma. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is ADAM19.

Gene Wiki entry for ADAM33 Gene

Additional gene information for ADAM33 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAM33 Gene

Genomics for ADAM33 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADAM33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J003676 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 624.1 +2.5 2498 6.1 CTCF TEAD4 PRDM10 IKZF1 ZNF692 ZNF143 ZIC2 RXRB PATZ1 REST ADAM33 HSPA12B SIGLEC1 PTPRA CENPB lnc-SIGLEC1-1 NONHSAG031158.2 GFRA4
GH20J004187 Promoter 0.3 EPDnew 600 -505.3 -505250 0.1 ADAM33 ADRA1D PRNP LINC01433 lnc-PANK2-2 SMOX MN298678-039
GH20J003795 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.4 -122.4 -122425 19.3 CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 REST CDC25B LINC01730 PANK2-AS1 VPS16 PCED1A SPEF1 UBOX5 ADAM33 C20orf194 PTPRA
GH20J004012 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.6 -333.2 -333181 7.3 GATAD2A HNRNPL PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ CTCF ZNF692 RNF24 PANK2-AS1 PANK2 ADAM33 RPL21P2 ENSG00000205300 AP5S1 SMOX HSALNG0128292 piR-57460-391
GH20J003044 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.6 +636.0 636045 3.2 GATAD2A HNRNPL PRDM10 ZNF629 TFE3 SIX5 ZNF692 POLR2A ZNF7 BACH1 MRPS26 VPS16 PCED1A ZNF343 NOP56 PANK2-AS1 STK35 ADAM33 SNRPB ITPA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAM33 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAM33

Top Transcription factor binding sites by QIAGEN in the ADAM33 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • E47
  • GR
  • GR-alpha
  • GR-beta
  • p300
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for ADAM33 Gene

Genomic Locations for ADAM33 Gene
chr20:3,667,965-3,682,246
(GRCh38/hg38)
Size:
14,282 bases
Orientation:
Minus strand
chr20:3,648,612-3,662,893
(GRCh37/hg19)
Size:
14,282 bases
Orientation:
Minus strand

Genomic View for ADAM33 Gene

Genes around ADAM33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM33 Gene

Proteins for ADAM33 Gene

  • Protein details for ADAM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ11-ADA33_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 33
    Protein Accession:
    Q9BZ11
    Secondary Accessions:
    • A0A1K6
    • Q5JT75
    • Q5JT76
    • Q8N0W6

    Protein attributes for ADAM33 Gene

    Size:
    813 amino acids
    Molecular mass:
    87739 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 3]: By similarity with mouse isoform.

    Three dimensional structures from OCA and Proteopedia for ADAM33 Gene

    Alternative splice isoforms for ADAM33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM33 Gene

Post-translational modifications for ADAM33 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn109, Asn145, Asn231, Asn276, and Asn448
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADAM33 Gene

Domains & Families for ADAM33 Gene

Gene Families for ADAM33 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADAM33 Gene

Suggested Antigen Peptide Sequences for ADAM33 Gene

GenScript: Design optimal peptide antigens:
  • Disintegrin and metalloproteinase domain-containing protein 33 (ADA33_HUMAN)
  • ADAM33 protein (Q6P5U4_HUMAN)
  • A disintegrin and metalloprotease domain 33 (Q8N6B9_HUMAN)
  • cDNA FLJ38634 fis, clone HHDPC2001432, weakly similar to ADAM 12 (EC 3.4.24.-) (Q8N8Z9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BZ11

UniProtKB/Swiss-Prot:

ADA33_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAM33: view

Function for ADAM33 Gene

Enzyme Numbers (IUBMB) for ADAM33 Gene

Phenotypes From GWAS Catalog for ADAM33 Gene

Gene Ontology (GO) - Molecular Function for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity NAS 11814695
GO:0005515 protein binding IPI --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view
genes like me logo Genes that share phenotypes with ADAM33: view

Animal Models for ADAM33 Gene

MGI Knock Outs for ADAM33:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM33

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM33

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM33 Gene

Localization for ADAM33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM33 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM33 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view

Pathways & Interactions for ADAM33 Gene

PathCards logo

SuperPathways for ADAM33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADAM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 11814695
genes like me logo Genes that share ontologies with ADAM33: view

No data available for Pathways by source and SIGNOR curated interactions for ADAM33 Gene

Drugs & Compounds for ADAM33 Gene

No Compound Related Data Available

Transcripts for ADAM33 Gene

mRNA/cDNA for ADAM33 Gene

3 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM33

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM33 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: - - - - - - - - - - -
SP6:
SP7: - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13:
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: -
SP17:
SP18: -
SP19:

ExUns: 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15: - - - - -
SP16:
SP17: -
SP18:
SP19:

Relevant External Links for ADAM33 Gene

GeneLoc Exon Structure for
ADAM33

Expression for ADAM33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAM33

SOURCE GeneReport for Unigene cluster for ADAM33 Gene:

Hs.173716

mRNA Expression by UniProt/SwissProt for ADAM33 Gene:

Q9BZ11-ADA33_HUMAN
Tissue specificity: Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.

Evidence on tissue expression from TISSUES for ADAM33 Gene

  • Lung(2.6)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with ADAM33: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM33 Gene

Orthologs for ADAM33 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM33 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADAM33 30 31
  • 97.95 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADAM33 30 31
  • 82.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADAM33 30 31
  • 81.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Adam33 30 17 31
  • 78.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adam33 30
  • 78.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia ADAM33 31
  • 51 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADAM33 30 31
  • 66.97 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADAM33 31
  • 42 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adam33 30
  • 60.01 (n)
Zebrafish
(Danio rerio)
Actinopterygii adam19a 30 31
  • 60.34 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta mmd 32
  • 31 (a)
Worm
(Caenorhabditis elegans)
Secernentea adm-1 32
  • 29 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
Species where no ortholog for ADAM33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADAM33 Gene

ENSEMBL:
Gene Tree for ADAM33 (if available)
TreeFam:
Gene Tree for ADAM33 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAM33: view image

Paralogs for ADAM33 Gene

(11) SIMAP similar genes for ADAM33 Gene using alignment to 7 proteins:

  • ADA33_HUMAN
  • A2A2L3_HUMAN
  • Q08AM2_HUMAN
  • Q08AM3_HUMAN
  • Q6P5U4_HUMAN
  • Q8N6B9_HUMAN
  • Q8N8Z9_HUMAN
genes like me logo Genes that share paralogs with ADAM33: view

Variants for ADAM33 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAM33 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
221543 Uncertain Significance: Ductal breast carcinoma 3,672,809(-) GCATTGGAGAGGCAAG
717578 Benign: not provided 3,675,034(-) T/C MISSENSE_VARIANT
717744 Likely Benign: not provided 3,672,848(-) G/A MISSENSE_VARIANT
729623 Likely Benign: not provided 3,669,610(-) G/A SYNONYMOUS_VARIANT
769070 Benign: not provided 3,669,598(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ADAM33 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAM33 Gene

Variant ID Type Subtype PubMed ID
esv3575355 CNV gain 25503493
nsv520565 CNV loss 19592680

Variation tolerance for ADAM33 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.51; 82.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM33 Gene

Human Gene Mutation Database (HGMD)
ADAM33
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM33 Gene

Disorders for ADAM33 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ADAM33 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
allergic asthma
  • atopic asthma
pulmonary disease, chronic obstructive
  • copd
bronchitis
  • acute bronchitis
intrinsic asthma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADA33_HUMAN
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:12110844, ECO:0000269 PubMed:16773130, ECO:0000269 PubMed:19237393}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for ADAM33

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADAM33: view

No data available for Genatlas for ADAM33 Gene

Publications for ADAM33 Gene

  1. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. (PMID: 12110844) Van Eerdewegh P … Keith TP (Nature 2002) 3 4 23 41
  2. Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort. (PMID: 19237393) Blakey JD … Hall IP (Thorax 2009) 3 4 41
  3. Association of ADAM33 gene polymorphisms with adult concomitant allergic rhinitis and asthma in Chinese Han population. (PMID: 18752037) Zhang X … Zhang J (Molecular biology reports 2009) 3 23 41
  4. Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. (PMID: 20003279) Wang X … Lv F (BMC medical genetics 2009) 3 23 41
  5. Association between ADAM33 polymorphisms and asthma in a Thai population. (PMID: 19317339) Thongngarm T … Thongnoppakhun W (Asian Pacific journal of allergy and immunology 2008) 3 23 41

Products for ADAM33 Gene

Sources for ADAM33 Gene