Aliases for ADAM30 Gene
External Ids for ADAM30 Gene
Previous GeneCards Identifiers for ADAM30 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is testis-specific and contains a polymorphic region, resulting in isoforms with varying numbers of C-terminal repeats. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADAM30 Gene
ADAM30 (ADAM Metallopeptidase Domain 30) is a Protein Coding gene. Diseases associated with ADAM30 include Inflammatory Bowel Disease 13. Among its related pathways are Fertilization. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM21.
UniProtKB/Swiss-Prot Summary for ADAM30 Gene
Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034).