ADAM29 Gene (Protein Coding)

ADAM Metallopeptidase Domain 29

GC04P174831
GIFtS:
38
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein... See more...

Aliases for ADAM29 Gene

Aliases for ADAM29 Gene

  • ADAM Metallopeptidase Domain 29 2 3 5
  • Cancer/Testis Antigen 73 2 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 29 3 4
  • A Disintegrin And Metalloproteinase Domain 29 2 3
  • CT73 3 4
  • Testis Secretory Sperm-Binding Protein Li 207a 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Metallaproteinase-Disintegrin (ADAM29) 3
  • EC 3.4.24.58 52
  • EC 3.4.24 52
  • ADAM 29 4
  • Svph1 3

External Ids for ADAM29 Gene

Previous GeneCards Identifiers for ADAM29 Gene

  • GC04P176797
  • GC04P176390
  • GC04P176535
  • GC04P176214
  • GC04P176076
  • GC04P175839
  • GC04P171588
  • GC04P175751

Summaries for ADAM29 Gene

Entrez Gene Summary for ADAM29 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM29 Gene

ADAM29 (ADAM Metallopeptidase Domain 29) is a Protein Coding gene. Diseases associated with ADAM29 include Melanoma. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM20.

UniProtKB/Swiss-Prot Summary for ADAM29 Gene

  • May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

Additional gene information for ADAM29 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAM29 Gene

Genomics for ADAM29 Gene

GeneHancer (GH) Regulatory Elements for ADAM29 Gene

Promoters and enhancers for ADAM29 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J174828 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.4 -367 1.8 EP300 USF1 TEAD4 REST CLOCK AFF1 SAP30 NFYB POLR2A MIER1 ADAM29 GLRA3 LOC101928551 lnc-ADAM29-3
GH04J174918 Promoter 0.4 EPDnew 500.2 +88.7 88719 0.1 PKNOX1 ADAM29 ENSG00000250200 lnc-GLRA3-2 piR-59136-022 LOC101928551
GH04J174960 Promoter 0.3 EPDnew 500.1 +131.1 131068 0.1 ADAM29 ENSG00000250431 ENSG00000250200 lnc-GLRA3-2
GH04J175428 Enhancer 0.2 FANTOM5 4.9 +598.6 598626 0.4 ADAM29 lnc-ADAM29-1 lnc-GPM6A-2
GH04J174870 Enhancer 0.6 Ensembl ENCODE 0.3 +41.3 41333 0.8 ZNF217 CTBP1 FOXA2 SNIP1 DPF2 SMARCE1 ENSG00000250596 piR-59136-022 ADAM29 LOC101928551 lnc-GLRA3-2 ENSG00000250200
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAM29 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAM29

Top Transcription factor binding sites by QIAGEN in the ADAM29 gene promoter:
  • AML1a
  • Cart-1
  • GATA-1
  • Nkx2-2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for ADAM29 Gene

Genomic Locations for ADAM29 Gene
chr4:174,829,668-174,978,180
(GRCh38/hg38)
Size:
148,513 bases
Orientation:
Plus strand
chr4:175,750,819-175,899,331
(GRCh37/hg19)
Size:
148,513 bases
Orientation:
Plus strand

Genomic View for ADAM29 Gene

Genes around ADAM29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM29 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADAM29 Gene

Proteins for ADAM29 Gene

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  • Protein details for ADAM29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKF5-ADA29_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 29
    Protein Accession:
    Q9UKF5
    Secondary Accessions:
    • Q4W5F3
    • Q9UHP1
    • Q9UKF3
    • Q9UKF4

    Protein attributes for ADAM29 Gene

    Size:
    820 amino acids
    Molecular mass:
    92759 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM29 Gene

Protein Expression for ADAM29 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ADAM29 Gene

Q9UKF5:
  • EEGEECDCG
  • GEECDCG
  • GGSVDSGP

Post-translational modifications for ADAM29 Gene

  • Glycosylation at Asn217, Asn320, Asn368, Asn428, Asn469, Asn538, Asn545, Asn558, and Asn564
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM29 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADAM29 Gene

Gene Families for ADAM29 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADAM29 Gene

Blocks:
  • Disintegrin
  • Metalloendopeptidase M12B
  • ADAM, cysteine-rich
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADAM29 Gene

GenScript: Design optimal peptide antigens:
  • Cancer/testis antigen 73 (ADA29_HUMAN)
  • cDNA FLJ76062, highly similar to Homo sapiens a disintegrin and metalloproteinase domain 29(ADAM29), transcript variant 1, mRNA (Q4W5F3_HUMAN)
genes like me logo Genes that share domains with ADAM29: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ADAM29 Gene

Function for ADAM29 Gene

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Molecular function for ADAM29 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.
GENATLAS Biochemistry:
a disintegrin and metalloprotease domain 29,membrane anchored cell surface adhesion protein,testis specific with alternatively spliced isoforms

Enzyme Numbers (IUBMB) for ADAM29 Gene

Phenotypes From GWAS Catalog for ADAM29 Gene

Gene Ontology (GO) - Molecular Function for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 10512762
genes like me logo Genes that share ontologies with ADAM29: view
genes like me logo Genes that share phenotypes with ADAM29: view

Animal Model Products

miRNA for ADAM29 Gene

miRTarBase miRNAs that target ADAM29

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAM29 Gene

Localization for ADAM29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM29 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM29 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10512762
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM29: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAM29 Gene

Pathways & Interactions for ADAM29 Gene

PathCards logo

SuperPathways for ADAM29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADAM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007283 spermatogenesis TAS 10512762
genes like me logo Genes that share ontologies with ADAM29: view

No data available for Pathways by source and SIGNOR curated interactions for ADAM29 Gene

Drugs & Compounds for ADAM29 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for ADAM29 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ADAM29 Gene

7 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM29 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h · 9i
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - - - - -
SP10: - - -
SP11: - - - - - - - - - -
SP12: -
SP13: - - - - - - - - - - -

Relevant External Links for ADAM29 Gene

GeneLoc Exon Structure for
ADAM29

Expression for ADAM29 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM29 Gene

mRNA expression in normal human tissues for ADAM29 Gene
mRNA expression by BioGPS for ADAM29 GenemRNA expression by GTEx for ADAM29 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM29 Gene

This gene is overexpressed in Testis (x47.6).

Protein differential expression in normal tissues from HIPED for ADAM29 Gene

This gene is overexpressed in Plasma (34.6) and Liver, secretome (32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM29 Gene



Protein tissue co-expression partners for ADAM29 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAM29

SOURCE GeneReport for Unigene cluster for ADAM29 Gene:

Hs.126838

mRNA Expression by UniProt/SwissProt for ADAM29 Gene:

Q9UKF5-ADA29_HUMAN
Tissue specificity: Expressed specifically in testes.
genes like me logo Genes that share expression patterns with ADAM29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM29 Gene

Orthologs for ADAM29 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ADAM29 31 30
  • 98.82 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ADAM29 30
  • 76.59 (n)
-- 31
  • 47 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Adam29 17 31 30
  • 70.71 (n)
dog
(Canis familiaris)
 Mammalia ADAM29 31 30
  • 70.55 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 41 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 37 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves -- 31
  • 37 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 38 (a)
 ManyToMany
-- 31
  • 38 (a)
 ManyToMany
-- 31
  • 38 (a)
 ManyToMany
-- 31
  • 38 (a)
 ManyToMany
-- 31
  • 38 (a)
 ManyToMany
-- 31
  • 37 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Neu3 31
  • 16 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea adm-2 31
  • 22 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 31 (a)
 ManyToMany
-- 31
  • 30 (a)
 ManyToMany
Species where no ortholog for ADAM29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ADAM29 Gene

ENSEMBL:
Gene Tree for ADAM29 (if available)
TreeFam:
Gene Tree for ADAM29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAM29: view image

Paralogs for ADAM29 Gene

Paralogs for ADAM29 Gene

(11) SIMAP similar genes for ADAM29 Gene using alignment to 4 proteins:

  • ADA29_HUMAN
  • D6RBU0_HUMAN
  • D6RHU0_HUMAN
  • D6RIU9_HUMAN

Pseudogenes.org Pseudogenes for ADAM29 Gene

genes like me logo Genes that share paralogs with ADAM29: view

Variants for ADAM29 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAM29 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs140083180 A cutaneous metastatic melanoma sample p.Ile257Phe
rs150047888 A cutaneous metastatic melanoma sample p.Gly403Asp
rs267600087 A cutaneous metastatic melanoma sample p.Glu111Lys
rs267600089 A cutaneous metastatic melanoma sample p.Gly305Glu
rs267600090 A cutaneous metastatic melanoma sample p.Asp345Asn

Additional dbSNP identifiers (rs#s) for ADAM29 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAM29 Gene

Variant ID Type Subtype PubMed ID
esv3603238 CNV gain 21293372
esv3603241 CNV loss 21293372
nsv830156 CNV gain 17160897

Variation tolerance for ADAM29 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM29 Gene

Human Gene Mutation Database (HGMD)
ADAM29
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM29 Gene

Disorders for ADAM29 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM29 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADA29_HUMAN
  • Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis. {ECO:0000269 PubMed:21618342}.

Additional Disease Information for ADAM29

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADAM29: view

No data available for Genatlas for ADAM29 Gene

Publications for ADAM29 Gene

  1. Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4. (PMID: 10644455) Xu R … Li C (Genomics 1999) 2 3 4 23 54
  2. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. (PMID: 21618342) Wei X … Samuels Y (Human mutation 2011) 3 4 54
  3. The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia. (PMID: 15802535) Oppezzo P … French Cooperative Group on CLL (Blood 2005) 3 23 54
  4. Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression. (PMID: 10512762) Cerretti DP … Nelson N (Biochemical and biophysical research communications 1999) 3 4 54
  5. ADAM29 Expression in Human Breast Cancer and its Effects on Breast Cancer Cells In Vitro. (PMID: 26977022) Zhao M … Song M (Anticancer research 2016) 3 54

ExternalLinks

View latest publications for ADAM29 gene in Mastermind

Products for ADAM29 Gene

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Sources for ADAM29 Gene