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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
ADAM29 (ADAM Metallopeptidase Domain 29) is a Protein Coding gene. Diseases associated with ADAM29 include Melanoma. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM20.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J174828 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | -0.3 | -268 | 1.6 | SIN3A REST YY1 SP2 ZNF316 SMARCE1 EHMT2 PKNOX1 TAF1 NCOA1 | ADAM29 GLRA3 LOC101928551 lnc-ADAM29-3 HPGD | |
GH04J174918 | Promoter | 0.3 | EPDnew | 250.2 | +88.7 | 88719 | 0.1 | ADAM29 ENSG00000250200 lnc-GLRA3-2 piR-59136-022 LOC101928551 | ||
GH04J174960 | Promoter | 0.3 | EPDnew | 250.1 | +131.1 | 131068 | 0.1 | ADAM29 ENSG00000250431 lnc-GLRA3-2 ENSG00000250200 | ||
GH04J175428 | Enhancer | 0.2 | FANTOM5 | 4.9 | +598.6 | 598626 | 0.4 | ADAM29 ENSG00000248551 lnc-GPM6A-2 RF00017-4458 GPM6A | ||
GH04J174870 | Enhancer | 0.6 | Ensembl ENCODE | 0.3 | +41.4 | 41432 | 0.6 | ZNF217 CTBP1 SMARCE1 DPF2 | ENSG00000250596 piR-59136-022 LOC101928551 ADAM29 lnc-GLRA3-2 ENSG00000250200 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004222 | metalloendopeptidase activity | IEA | -- |
GO:0008237 | metallopeptidase activity | TAS | 10512762 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0005887 | integral component of plasma membrane | TAS | 10512762 |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0007283 | spermatogenesis | TAS | 10512762 |
GO:0008584 | male gonad development | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f | · | 9g | · | 9h | · | 9i |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP12: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - | - | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ADAM29 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ADAM29 30 |
|
||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Adam29 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ADAM29 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Neu3 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | adm-2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs140083180 | A cutaneous metastatic melanoma sample |
p.Ile257Phe |
|||
rs150047888 | A cutaneous metastatic melanoma sample |
p.Gly403Asp |
|||
rs267600087 | A cutaneous metastatic melanoma sample |
p.Glu111Lys |
|||
rs267600089 | A cutaneous metastatic melanoma sample |
p.Gly305Glu |
|||
rs267600090 | A cutaneous metastatic melanoma sample |
p.Asp345Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3603238 | CNV | gain | 21293372 |
esv3603241 | CNV | loss | 21293372 |
nsv830156 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
melanoma |
|
|