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Aliases for ADAM23 Gene

Aliases for ADAM23 Gene

  • ADAM Metallopeptidase Domain 23 2 3 5
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 3 3 4
  • MDC-3 3 4
  • MDC3 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 23 3
  • A Disintegrin And Metalloproteinase Domain 23 2
  • ADAM 23 4

External Ids for ADAM23 Gene

Previous GeneCards Identifiers for ADAM23 Gene

  • GC02P205525
  • GC02P206032
  • GC02P207272
  • GC02P207510
  • GC02P207133
  • GC02P207018
  • GC02P199158

Summaries for ADAM23 Gene

Entrez Gene Summary for ADAM23 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]

GeneCards Summary for ADAM23 Gene

ADAM23 (ADAM Metallopeptidase Domain 23) is a Protein Coding gene. Among its related pathways are Developmental Biology and LGI-ADAM interactions. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM22.

UniProtKB/Swiss-Prot for ADAM23 Gene

  • May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.

Gene Wiki entry for ADAM23 Gene

Additional gene information for ADAM23 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM23 Gene

Genomics for ADAM23 Gene

GeneHancer (GH) Regulatory Elements for ADAM23 Gene

Promoters and enhancers for ADAM23 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J206443 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 +0.2 162 1 CTCF MXI1 ZIC2 ZNF335 GLIS2 POLR2A PATZ1 SCRT2 PRDM10 ZNF600 ADAM23 GC02P206607
GH02J205729 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.5 -710.9 -710934 5.6 FOXA2 BACH1 ZNF316 POLR2A FOSL2 FOS NFE2 MAFK EZH2 NFE2L2 ENSG00000225216 NRP2 ADAM23 GC02P205736
GH02J206368 Enhancer 0.5 Ensembl ENCODE 10.6 -74.9 -74903 1.2 ATF2 ADAM23 GPR1 GC02P206391 GC02P206342
GH02J206246 Enhancer 0.5 Ensembl 10.1 -197.2 -197238 0.2 NBN ATF7 ELF1 DPF2 IRF4 RUNX3 GPR1 RN7SKP200 ZDBF2 SNORA41 EEF1B2 ADAM23 LOC100132849 HMGN1P6 GPR1-AS
GH02J206389 Enhancer 0.2 ENCODE 11.5 -53.4 -53422 1.4 GC02P206391 ADAM23 GPR1 NDUFS1 GC02P206342
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAM23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAM23 gene promoter:
  • deltaCREB
  • CREB
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • E4BP4
  • USF-1
  • USF1
  • Brachyury

Genomic Locations for ADAM23 Gene

Genomic Locations for ADAM23 Gene
177,592 bases
Plus strand
177,589 bases
Plus strand

Genomic View for ADAM23 Gene

Genes around ADAM23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM23 Gene

Proteins for ADAM23 Gene

  • Protein details for ADAM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 23
    Protein Accession:
    Secondary Accessions:
    • A2RU59

    Protein attributes for ADAM23 Gene

    832 amino acids
    Molecular mass:
    91926 Da
    Quaternary structure:
    • Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3.

    Alternative splice isoforms for ADAM23 Gene


neXtProt entry for ADAM23 Gene

Post-translational modifications for ADAM23 Gene

  • Glycosylation at Asn732, posLast=664664, Asn548, Asn547, Asn263, Asn100, posLast=9696, and Asn76
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM23 Gene

No data available for DME Specific Peptides for ADAM23 Gene

Domains & Families for ADAM23 Gene

Gene Families for ADAM23 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADAM23 Gene

Graphical View of Domain Structure for InterPro Entry



  • A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
  • A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
genes like me logo Genes that share domains with ADAM23: view

Function for ADAM23 Gene

Molecular function for ADAM23 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
GENATLAS Biochemistry:
a disintegrin and metalloprotease domain 23,membrane anchored cell surface adhesion protein,expressed in the brain

Phenotypes From GWAS Catalog for ADAM23 Gene

Gene Ontology (GO) - Molecular Function for ADAM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 9693107
GO:0005515 protein binding IPI 20463223
GO:0008237 metallopeptidase activity IEA,TAS 9693107
genes like me logo Genes that share ontologies with ADAM23: view
genes like me logo Genes that share phenotypes with ADAM23: view

Animal Models for ADAM23 Gene

MGI Knock Outs for ADAM23:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM23

miRNA for ADAM23 Gene

miRTarBase miRNAs that target ADAM23

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM23 Gene

Localization for ADAM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM23 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform Gamma: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM23 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADAM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9693107
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM23: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAM23 Gene

Pathways & Interactions for ADAM23 Gene

genes like me logo Genes that share pathways with ADAM23: view

Pathways by source for ADAM23 Gene

2 Reactome pathways for ADAM23 Gene

Gene Ontology (GO) - Biological Process for ADAM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0007417 central nervous system development TAS 9693107
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with ADAM23: view

No data available for SIGNOR curated interactions for ADAM23 Gene

Drugs & Compounds for ADAM23 Gene

(1) Additional Compounds for ADAM23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM23: view

Transcripts for ADAM23 Gene

mRNA/cDNA for ADAM23 Gene

Unigene Clusters for ADAM23 Gene

ADAM metallopeptidase domain 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM23 Gene

No ASD Table

Relevant External Links for ADAM23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM23 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM23 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x4.5), Heart - Left Ventricle (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for ADAM23 Gene

This gene is overexpressed in Frontal cortex (50.8), Brain (8.8), and Spinal cord (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM23 Gene

Protein tissue co-expression partners for ADAM23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAM23 Gene:


SOURCE GeneReport for Unigene cluster for ADAM23 Gene:


mRNA Expression by UniProt/SwissProt for ADAM23 Gene:

Tissue specificity: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.

Evidence on tissue expression from TISSUES for ADAM23 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ADAM23: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM23 Gene

Orthologs for ADAM23 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAM23 34 33
  • 99.88 (n)
(Canis familiaris)
Mammalia ADAM23 34 33
  • 92.95 (n)
(Bos Taurus)
Mammalia ADAM23 34 33
  • 92.31 (n)
(Ornithorhynchus anatinus)
Mammalia ADAM23 34
  • 91 (a)
(Mus musculus)
Mammalia Adam23 16 34 33
  • 88.77 (n)
(Rattus norvegicus)
Mammalia Adam23 33
  • 87.6 (n)
(Monodelphis domestica)
Mammalia ADAM23 34
  • 85 (a)
(Gallus gallus)
Aves ADAM23 34 33
  • 77.97 (n)
(Anolis carolinensis)
Reptilia ADAM23 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adam23 33
  • 71.57 (n)
Str.12051 33
(Danio rerio)
Actinopterygii ADAM23 (2 of 2) 34
  • 67 (a)
wu:fj40f01 33
  • 65.73 (n)
adam23a 34
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta mmd 34 35
  • 16 (a)
(Caenorhabditis elegans)
Secernentea adm-1 35
  • 30 (a)
unc-71 34
  • 19 (a)
Species where no ortholog for ADAM23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM23 Gene

Gene Tree for ADAM23 (if available)
Gene Tree for ADAM23 (if available)
Evolutionary constrained regions (ECRs) for ADAM23: view image

Paralogs for ADAM23 Gene

Paralogs for ADAM23 Gene

(14) SIMAP similar genes for ADAM23 Gene using alignment to 7 proteins:

  • H7C2M6_HUMAN
  • Q53RX4_HUMAN
  • Q53TC0_HUMAN
  • Q53TK5_HUMAN
genes like me logo Genes that share paralogs with ADAM23: view

Variants for ADAM23 Gene

Sequence variations from dbSNP and Humsavar for ADAM23 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000002980 -- 206,483,157(+) A/G intron_variant
rs1000006541 -- 206,500,604(+) C/T intron_variant
rs1000029130 -- 206,615,308(+) G/T intron_variant
rs1000032401 -- 206,613,839(+) T/G intron_variant
rs1000033702 -- 206,604,582(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM23 Gene

Variant ID Type Subtype PubMed ID
nsv954824 CNV duplication 24416366
nsv954823 CNV duplication 24416366
nsv584247 CNV gain 21841781
nsv478360 CNV novel sequence insertion 20440878
nsv477754 CNV novel sequence insertion 20440878
nsv472414 CNV novel sequence insertion 20440878
nsv1153377 CNV insertion 26484159
nsv1126576 CNV deletion 24896259
nsv1116823 CNV deletion 24896259
nsv1072485 CNV deletion 25765185
nsv1011347 CNV gain 25217958
esv3594069 CNV loss 21293372
esv3344531 CNV insertion 20981092

Variation tolerance for ADAM23 Gene

Residual Variation Intolerance Score: 9.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 31.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM23 Gene

Disorders for ADAM23 Gene

Additional Disease Information for ADAM23

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADAM23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM23 Gene

Publications for ADAM23 Gene

  1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K … Tanaka I (The Biochemical journal 1998) 2 3 4 22 58
  2. Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. (PMID: 14697522) Sun YP … Zhao S (Gene 2004) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Association and interaction analyses of eight genes under asthma linkage peaks. (PMID: 19824886) Ferreira MA … Duffy DL (Allergy 2009) 3 44 58
  5. ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism. (PMID: 10749942) Cal S … López-Otín C (Molecular biology of the cell 2000) 3 4 58

Products for ADAM23 Gene

Sources for ADAM23 Gene

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