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Aliases for ADAM22 Gene

Aliases for ADAM22 Gene

  • ADAM Metallopeptidase Domain 22 2 3 5
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 2 2 3 4
  • A Disintegrin And Metalloproteinase Domain 22 2 3
  • Metalloproteinase-Disintegrin ADAM22-3 3 4
  • ADAM 22 3 4
  • MDC2 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 22 3
  • EIEE61 3

External Ids for ADAM22 Gene

Previous GeneCards Identifiers for ADAM22 Gene

  • GC07P086099
  • GC07P087161
  • GC07P087175
  • GC07P087208
  • GC07P087401
  • GC07P087563
  • GC07P082173

Summaries for ADAM22 Gene

Entrez Gene Summary for ADAM22 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

GeneCards Summary for ADAM22 Gene

ADAM22 (ADAM Metallopeptidase Domain 22) is a Protein Coding gene. Diseases associated with ADAM22 include Epileptic Encephalopathy, Early Infantile, 61 and Limbic Encephalitis. Among its related pathways are Notch Signaling Pathway (sino) and Developmental Biology. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and integrin binding. An important paralog of this gene is ADAM11.

UniProtKB/Swiss-Prot for ADAM22 Gene

  • Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Gene Wiki entry for ADAM22 Gene

Additional gene information for ADAM22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM22 Gene

Genomics for ADAM22 Gene

GeneHancer (GH) Regulatory Elements for ADAM22 Gene

Promoters and enhancers for ADAM22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J087933 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.3 251 1.7 HDGF PKNOX1 ATF1 ARID4B SIN3A ZBTB7B ZNF48 YY1 ETS1 GLIS2 ADAM22 ABCB1 GC07M087968
GH07J088111 Enhancer 0.5 ENCODE 18.5 +178.1 178147 1.1 CTCF RFX1 GATA3 TEAD1 TRIM22 RAD21 MIXL1 ADAM22 LOC105375386 GC07P088050
GH07J088115 Enhancer 0.3 ENCODE 18.8 +182.2 182198 1.6 SPI1 ADAM22 LOC105375386 GC07P088050
GH07J088045 Enhancer 0.6 ENCODE 9.2 +111.7 111673 1.6 HDGF RXRA ZSCAN4 YY1 SP1 HNF4G ATF7 MLLT1 HNF4A RCOR1 ADAM22 GC07P088050 GC07M087968
GH07J087967 Enhancer 0.2 ENCODE 9.2 +34.1 34146 0.9 ADAM22 GC07M087968
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAM22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAM22 gene promoter:
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • AREB6
  • POU2F1a
  • POU2F1
  • RSRFC4
  • ATF-2
  • FOXO1
  • FOXO1a

Genomic Locations for ADAM22 Gene

Genomic Locations for ADAM22 Gene
268,747 bases
Plus strand
268,747 bases
Plus strand

Genomic View for ADAM22 Gene

Genes around ADAM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM22 Gene

Proteins for ADAM22 Gene

  • Protein details for ADAM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 22
    Protein Accession:
    Secondary Accessions:
    • O75075
    • O75076
    • Q9P0K2
    • Q9UIA1
    • Q9UKK2

    Protein attributes for ADAM22 Gene

    906 amino acids
    Molecular mass:
    100433 Da
    Quaternary structure:
    • Interacts with LGI1 and can bind to LGI4 (By similarity). Interacts with KCNA2, DLG2 and DLG4 (By similarity). Interacts through its C-terminal region with YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta.

    Three dimensional structures from OCA and Proteopedia for ADAM22 Gene

    Alternative splice isoforms for ADAM22 Gene


neXtProt entry for ADAM22 Gene

Post-translational modifications for ADAM22 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at posLast=675675, Asn634, posLast=519519, and Asn175
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ADAM22
  • Boster Bio Antibodies for ADAM22

No data available for DME Specific Peptides for ADAM22 Gene

Domains & Families for ADAM22 Gene

Gene Families for ADAM22 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAM22: view

No data available for UniProtKB/Swiss-Prot for ADAM22 Gene

Function for ADAM22 Gene

Molecular function for ADAM22 Gene

UniProtKB/Swiss-Prot Function:
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
GENATLAS Biochemistry:
a disintegrin and metalloprotease domain 22,membrane anchored cell surface adhesion protein,expressed in the brain

Phenotypes From GWAS Catalog for ADAM22 Gene

Gene Ontology (GO) - Molecular Function for ADAM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding NAS 9693107
GO:0005515 protein binding IPI 12589811
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with ADAM22: view
genes like me logo Genes that share phenotypes with ADAM22: view

Animal Models for ADAM22 Gene

MGI Knock Outs for ADAM22:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM22

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM22 Gene

Localization for ADAM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM22 Gene

Membrane; Single-pass type I membrane protein. Cell projection, axon.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM22 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IEA 9693107
GO:0030424 axon ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ADAM22: view

Pathways & Interactions for ADAM22 Gene

genes like me logo Genes that share pathways with ADAM22: view

Pathways by source for ADAM22 Gene

1 Sino Biological pathway for ADAM22 Gene
2 Reactome pathways for ADAM22 Gene

Gene Ontology (GO) - Biological Process for ADAM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion NAS 9693107
GO:0007417 central nervous system development TAS 9693107
GO:0008344 adult locomotory behavior IEA --
genes like me logo Genes that share ontologies with ADAM22: view

No data available for SIGNOR curated interactions for ADAM22 Gene

Drugs & Compounds for ADAM22 Gene

No Compound Related Data Available

Transcripts for ADAM22 Gene

Unigene Clusters for ADAM22 Gene

ADAM metallopeptidase domain 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM22 Gene

No ASD Table

Relevant External Links for ADAM22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM22 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.0) and Brain - Cerebellum (x8.1).

Protein differential expression in normal tissues from HIPED for ADAM22 Gene

This gene is overexpressed in Frontal cortex (53.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM22 Gene

Protein tissue co-expression partners for ADAM22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAM22 Gene:


SOURCE GeneReport for Unigene cluster for ADAM22 Gene:


mRNA Expression by UniProt/SwissProt for ADAM22 Gene:

Tissue specificity: Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.

Evidence on tissue expression from TISSUES for ADAM22 Gene

  • Nervous system(4.8)
  • Lymph node(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ADAM22: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM22 Gene

Orthologs for ADAM22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAM22 34 33
  • 99.67 (n)
(Bos Taurus)
Mammalia ADAM22 34 33
  • 93.47 (n)
(Canis familiaris)
Mammalia ADAM22 34 33
  • 92.58 (n)
(Mus musculus)
Mammalia Adam22 16 34 33
  • 88.36 (n)
(Monodelphis domestica)
Mammalia ADAM22 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ADAM22 34
  • 82 (a)
(Gallus gallus)
Aves ADAM22 34 33
  • 79.04 (n)
(Anolis carolinensis)
Reptilia ADAM22 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adam22 33
  • 72.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia MDC11b 33
(Danio rerio)
Actinopterygii zgc:173905 33
  • 66.21 (n)
adam22 34
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta mmd 34 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea unc-71 34
  • 21 (a)
Species where no ortholog for ADAM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM22 Gene

Gene Tree for ADAM22 (if available)
Gene Tree for ADAM22 (if available)
Evolutionary constrained regions (ECRs) for ADAM22: view image

Paralogs for ADAM22 Gene

Paralogs for ADAM22 Gene

(16) SIMAP similar genes for ADAM22 Gene using alignment to 14 proteins:

  • D6W5P7_HUMAN
  • E9PF78_HUMAN
  • G5E951_HUMAN
  • H7C0Q9_HUMAN
  • H7C3I4_HUMAN
  • Q08AL8_HUMAN
  • Q6P667_HUMAN
  • Q75MS7_HUMAN
  • Q86UM2_HUMAN
genes like me logo Genes that share paralogs with ADAM22: view

Variants for ADAM22 Gene

Sequence variations from dbSNP and Humsavar for ADAM22 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000002312 -- 87,984,108(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000008544 -- 88,150,227(+) C/T intron_variant
rs1000036344 -- 88,098,123(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000039261 -- 88,197,777(+) G/A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000042981 -- 88,196,157(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM22 Gene

Variant ID Type Subtype PubMed ID
dgv11490n54 CNV loss 21841781
dgv11491n54 CNV loss 21841781
dgv1930e212 CNV loss 25503493
dgv1931e212 CNV loss 25503493
dgv6523n100 CNV loss 25217958
esv2421625 CNV deletion 20811451
esv2486343 CNV insertion 19546169
esv2674844 CNV deletion 23128226
esv2764029 CNV loss 21179565
esv29888 CNV loss 19812545
esv3377976 CNV insertion 20981092
esv3542044 CNV deletion 23714750
esv3571959 CNV loss 25503493
esv3571963 CNV loss 25503493
esv3614043 CNV loss 21293372
esv3614044 CNV loss 21293372
esv3614045 CNV loss 21293372
esv3614047 CNV loss 21293372
nsv437021 CNV loss 16327808
nsv442056 CNV loss 18776908
nsv473448 CNV novel sequence insertion 20440878
nsv476640 CNV novel sequence insertion 20440878
nsv477049 CNV novel sequence insertion 20440878
nsv514430 CNV loss 21397061
nsv517676 CNV loss 19592680
nsv525073 CNV gain 19592680
nsv529001 CNV loss 19592680
nsv607731 CNV loss 21841781

Variation tolerance for ADAM22 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM22 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM22 Gene

Disorders for ADAM22 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADAM22 Gene - From: HGMD, OMIM, ClinVar, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADAM22

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADAM22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM22 Gene

Publications for ADAM22 Gene

  1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K … Tanaka I (The Biochemical journal 1998) 2 3 4 22 58
  2. ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain. (PMID: 16385342) D'Abaco GM … Novak U (Neurosurgery 2006) 3 4 22 58
  3. The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas. (PMID: 11050470) Harada T … Wada M (Japanese journal of cancer research : Gann 2000) 3 4 22 58
  4. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. (PMID: 10524237) Poindexter K … Cerretti DP (Gene 1999) 2 3 4 58
  5. Biological characterization of ADAM22 variants reveals the importance of a disintegrin domain sequence in cell surface expression. (PMID: 20156119) Sagane K … Akaike A (Journal of receptor and signal transduction research 2010) 3 22 58

Products for ADAM22 Gene

Sources for ADAM22 Gene

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