Aliases for ADAM22 Gene
External Ids for ADAM22 Gene
Previous GeneCards Identifiers for ADAM22 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
GeneCards Summary for ADAM22 Gene
ADAM22 (ADAM Metallopeptidase Domain 22) is a Protein Coding gene. Diseases associated with ADAM22 include Limbic Encephalitis and Epilepsy, Familial Temporal Lobe, 1. Among its related pathways are Notch Signaling Pathway (sino) and LGI-ADAM interactions. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and integrin binding. An important paralog of this gene is ADAM11.
UniProtKB/Swiss-Prot for ADAM22 Gene
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.