This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded... See more...

Aliases for ADAM2 Gene

Aliases for ADAM2 Gene

  • ADAM Metallopeptidase Domain 2 2 3 5
  • Cancer/Testis Antigen 15 2 3 4
  • CT15 2 3 4
  • PH30 2 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 2 3 4
  • Fertilin Subunit Beta 3 4
  • PH30-Beta 3 4
  • PH-30b 2 3
  • FTNB 3 4
  • Fertilin Beta 2
  • EC 3.4.24 51
  • ADAM 2 4
  • CRYN1 3
  • CRYN2 3
  • ADAM2 5
  • PH-30 4

External Ids for ADAM2 Gene

Previous HGNC Symbols for ADAM2 Gene

  • FTNB

Previous GeneCards Identifiers for ADAM2 Gene

  • GC08P038997
  • GC08M039646
  • GC08M039342
  • GC08M039618
  • GC08M039326
  • GC08M039720
  • GC08M039601
  • GC08M038134

Summaries for ADAM2 Gene

Entrez Gene Summary for ADAM2 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for ADAM2 Gene

ADAM2 (ADAM Metallopeptidase Domain 2) is a Protein Coding gene. Among its related pathways are Fertilization. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM18.

UniProtKB/Swiss-Prot Summary for ADAM2 Gene

  • Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

Gene Wiki entry for ADAM2 Gene

Additional gene information for ADAM2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAM2 Gene

Genomics for ADAM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J039852 Promoter/Enhancer 1.1 EPDnew ENCODE 600.4 -14.4 -14417 0.5 TFE3 SOX13 FOXA1 RXRB IRF2 GABPA PBX2 SOX6 PKNOX1 CEBPA ADAM2 ENSG00000253332 lnc-IDO1-1 IDO1
GH08J039838 Promoter 0.3 EPDnew 600.7 +0.1 55 0.1 ADAM2 lnc-ZMAT4-6 ADAM18
GH08J039859 Enhancer 0.6 Ensembl ENCODE 12 -21.6 -21640 0.5 FOS JUND JUN ENSG00000253332 lnc-IDO1-1 piR-39972-021 ADAM2 IDO1
GH08J039871 Enhancer 0.3 Ensembl 11.7 -33.9 -33912 2 ZNF316 MAFK ADAM2 ENSG00000253939 ENSG00000253790 TCIM ADAM9 ENSG00000253233 piR-54987-130 IDO1
GH08J039862 Enhancer 0.3 Ensembl 11.8 -24.6 -24612 0.6 JUN ADAM2 piR-36575-071 piR-39972-021 IDO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAM2

Top Transcription factor binding sites by QIAGEN in the ADAM2 gene promoter:
  • Max1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for ADAM2 Gene

Genomic Locations for ADAM2 Gene
chr8:39,743,735-39,838,289
(GRCh38/hg38)
Size:
94,555 bases
Orientation:
Minus strand
chr8:39,601,254-39,695,808
(GRCh37/hg19)
Size:
94,555 bases
Orientation:
Minus strand

Genomic View for ADAM2 Gene

Genes around ADAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM2 Gene

Proteins for ADAM2 Gene

  • Protein details for ADAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99965-ADAM2_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 2
    Protein Accession:
    Q99965
    Secondary Accessions:
    • P78326
    • Q9UQQ8

    Protein attributes for ADAM2 Gene

    Size:
    735 amino acids
    Molecular mass:
    82457 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.

    Alternative splice isoforms for ADAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM2 Gene

Selected DME Specific Peptides for ADAM2 Gene

Q99965:
  • GEECDCG
  • LEAGEECDC

Post-translational modifications for ADAM2 Gene

  • The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
  • Glycosylation at Asn122, Asn220, Asn353, Asn459, and Asn566
  • Modification sites at PhosphoSitePlus

Domains & Families for ADAM2 Gene

Gene Families for ADAM2 Gene

Protein Domains for ADAM2 Gene

InterPro:
Blocks:
  • Disintegrin
  • Metalloendopeptidase M12B
  • ADAM, cysteine-rich
ProtoNet:

Suggested Antigen Peptide Sequences for ADAM2 Gene

GenScript: Design optimal peptide antigens:
  • PH30-beta (ADAM2_HUMAN)
  • cDNA FLJ60930, highly similar to ADAM 2 (A disintegrin and metalloproteinase domain 2) (B4DWY7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99965

UniProtKB/Swiss-Prot:

ADAM2_HUMAN :
  • A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
Domain:
  • A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
genes like me logo Genes that share domains with ADAM2: view

Function for ADAM2 Gene

Molecular function for ADAM2 Gene

UniProtKB/Swiss-Prot Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
GENATLAS Biochemistry:
a disintegrin and metalloprotease (inactive) domain 2,fertilin,subunit beta,membrane anchored cell surface adhesion protein,expressed in male testis,putatively binding to an unknown receptor on oocyte vitelline membrane,may be involved in male fertility

Enzyme Numbers (IUBMB) for ADAM2 Gene

Phenotypes From GWAS Catalog for ADAM2 Gene

Gene Ontology (GO) - Molecular Function for ADAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 9041139
GO:0008237 metallopeptidase activity IEA,TAS 9041139
genes like me logo Genes that share ontologies with ADAM2: view
genes like me logo Genes that share phenotypes with ADAM2: view

Animal Models for ADAM2 Gene

MGI Knock Outs for ADAM2:

Animal Model Products

CRISPR Products

miRNA for ADAM2 Gene

miRTarBase miRNAs that target ADAM2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM2 Gene

Localization for ADAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM2 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9041139
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADAM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAM2 Gene

Pathways & Interactions for ADAM2 Gene

PathCards logo

SuperPathways for ADAM2 Gene

SuperPathway Contained pathways
1 Fertilization
genes like me logo Genes that share pathways with ADAM2: view

Pathways by source for ADAM2 Gene

Gene Ontology (GO) - Biological Process for ADAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007338 single fertilization IEA --
GO:0007339 binding of sperm to zona pellucida TAS --
genes like me logo Genes that share ontologies with ADAM2: view

No data available for SIGNOR curated interactions for ADAM2 Gene

Drugs & Compounds for ADAM2 Gene

(2) Additional Compounds for ADAM2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM2: view

Transcripts for ADAM2 Gene

mRNA/cDNA for ADAM2 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM2

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: -
SP3: - - - - -

Relevant External Links for ADAM2 Gene

GeneLoc Exon Structure for
ADAM2

Expression for ADAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM2 Gene

This gene is overexpressed in Testis (x52.1).

Protein differential expression in normal tissues from HIPED for ADAM2 Gene

This gene is overexpressed in Testis (45.3) and Ovary (23.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM2 Gene



Protein tissue co-expression partners for ADAM2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAM2

SOURCE GeneReport for Unigene cluster for ADAM2 Gene:

Hs.177959

mRNA Expression by UniProt/SwissProt for ADAM2 Gene:

Q99965-ADAM2_HUMAN
Tissue specificity: Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
genes like me logo Genes that share expression patterns with ADAM2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM2 Gene

Orthologs for ADAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADAM2 30 31
  • 99.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADAM2 30 31
  • 80.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADAM2 30 31
  • 77.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adam2 30
  • 69.06 (n)
Mouse
(Mus musculus)
Mammalia Adam2 30 17 31
  • 68.88 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ADAM2 31
  • 48 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADAM2 31
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 41 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
Species where no ortholog for ADAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ADAM2 Gene

ENSEMBL:
Gene Tree for ADAM2 (if available)
TreeFam:
Gene Tree for ADAM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAM2: view image

Paralogs for ADAM2 Gene

(12) SIMAP similar genes for ADAM2 Gene using alignment to 3 proteins:

  • ADAM2_HUMAN
  • B4DWY7_HUMAN
  • Q6P2G0_HUMAN
genes like me logo Genes that share paralogs with ADAM2: view

Variants for ADAM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAM2 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs34800519 - p.Gly10Trp

Additional dbSNP identifiers (rs#s) for ADAM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAM2 Gene

Variant ID Type Subtype PubMed ID
esv2665158 CNV deletion 23128226
esv2667185 CNV deletion 23128226
esv2736904 CNV deletion 23290073
esv3390440 CNV insertion 20981092
esv3616957 CNV loss 21293372
esv3616958 CNV loss 21293372
esv3616960 CNV loss 21293372
nsv526355 CNV loss 19592680
nsv972582 CNV deletion 23825009

Variation tolerance for ADAM2 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM2 Gene

Disorders for ADAM2 Gene

No disorders were found for ADAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM2 Gene

Publications for ADAM2 Gene

  1. Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB). (PMID: 9070941) Burkin HR … Affara NA (Genomics 1997) 2 3 4 23
  2. Molecular cloning of the human fertilin beta subunit. (PMID: 8702389) Gupta SK … Hollis GF (Biochemical and biophysical research communications 1996) 2 3 4 23
  3. Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member. (PMID: 9041139) Vidaeus CM … Herr JC (Molecular reproduction and development 1997) 3 4 23
  4. Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos. (PMID: 18292840) Depa-Martynów M … Jedrzejczak P (Folia histochemica et cytobiologica 2007) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ADAM2 Gene

  • Signalway Proteins for ADAM2

Sources for ADAM2 Gene