Aliases for ADAM19 Gene
External Ids for ADAM19 Gene
Previous GeneCards Identifiers for ADAM19 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]
GeneCards Summary for ADAM19 Gene
ADAM19 (ADAM Metallopeptidase Domain 19) is a Protein Coding gene. Diseases associated with ADAM19 include Alzheimer Disease. Among its related pathways are Mesodermal Commitment Pathway and A-beta Signaling Pathways. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and metalloendopeptidase activity. An important paralog of this gene is ADAM12.
UniProtKB/Swiss-Prot Summary for ADAM19 Gene
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).