Aliases for ADAM19 Gene
External Ids for ADAM19 Gene
Previous GeneCards Identifiers for ADAM19 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]
GeneCards Summary for ADAM19 Gene
ADAM19 (ADAM Metallopeptidase Domain 19) is a Protein Coding gene. Diseases associated with ADAM19 include Alzheimer Disease. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and metalloendopeptidase activity. An important paralog of this gene is ADAM12.
UniProtKB/Swiss-Prot Summary for ADAM19 Gene
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).