This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member ... See more...

Aliases for ADAM19 Gene

Aliases for ADAM19 Gene

  • ADAM Metallopeptidase Domain 19 2 3 5
  • MLTNB 2 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 19 3 4
  • A Disintegrin And Metalloproteinase Domain 19 (Meltrin Beta) 2 3
  • Metalloprotease And Disintegrin Dendritic Antigen Marker 3 4
  • MADDAM 3 4
  • Metalloprotease-Disintegrin Meltrin Beta 3
  • Meltrin Beta 2
  • Meltrin-Beta 4
  • EC 3.4.24.- 4
  • EC 3.4.24 51
  • ADAM 19 4
  • FKSG34 3
  • ADAM19 5

External Ids for ADAM19 Gene

Previous GeneCards Identifiers for ADAM19 Gene

  • GC05M156953
  • GC05M157455
  • GC05M156839
  • GC05M156885
  • GC05M156836
  • GC05M151992

Summaries for ADAM19 Gene

Entrez Gene Summary for ADAM19 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

GeneCards Summary for ADAM19 Gene

ADAM19 (ADAM Metallopeptidase Domain 19) is a Protein Coding gene. Diseases associated with ADAM19 include Alzheimer Disease. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and metalloendopeptidase activity. An important paralog of this gene is ADAM12.

UniProtKB/Swiss-Prot Summary for ADAM19 Gene

  • Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).

Gene Wiki entry for ADAM19 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAM19 Gene

Genomics for ADAM19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADAM19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAM19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAM19

Top Transcription factor binding sites by QIAGEN in the ADAM19 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • c-Myb
  • FosB
  • Fra-1
  • JunB
  • JunD
  • POU3F2
  • STAT5A

Genomic Locations for ADAM19 Gene

Genomic Locations for ADAM19 Gene
chr5:157,395,534-157,575,775
(GRCh38/hg38)
Size:
180,242 bases
Orientation:
Minus strand
chr5:156,822,542-157,002,783
(GRCh37/hg19)
Size:
180,242 bases
Orientation:
Minus strand

Genomic View for ADAM19 Gene

Genes around ADAM19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM19 Gene

Proteins for ADAM19 Gene

  • Protein details for ADAM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H013-ADA19_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 19
    Protein Accession:
    Q9H013
    Secondary Accessions:
    • Q9BZL5
    • Q9UHP2

    Protein attributes for ADAM19 Gene

    Size:
    955 amino acids
    Molecular mass:
    104997 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with SH3PXD2A.

    Alternative splice isoforms for ADAM19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM19 Gene

Selected DME Specific Peptides for ADAM19 Gene

Q9H013:
  • SGGVNMDHS
  • GEECDCG
  • MAHEMGH

Post-translational modifications for ADAM19 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn144, Thr183, Thr191, Thr194, Asn444, Asn447, and Asn645
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM19 Gene

Domains & Families for ADAM19 Gene

Gene Families for ADAM19 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ADAM19 Gene

Suggested Antigen Peptide Sequences for ADAM19 Gene

GenScript: Design optimal peptide antigens:
  • Metalloprotease and disintegrin dendritic antigen marker (ADA19_HUMAN)
  • ADAM19 protein (Q8TBU7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H013

UniProtKB/Swiss-Prot:

ADA19_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAM19: view

Function for ADAM19 Gene

Molecular function for ADAM19 Gene

UniProtKB/Swiss-Prot Function:
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
UniProtKB/Swiss-Prot Induction:
By 1,25(OH)2VD3 in monocytes.
GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 19,membrane anchored cell surface adhesion protein,predominantly expressed in bone,heart,lung,also expressed in somatic tissuesl,involved in myotube formation and putatively in osteoblast differentiation

Enzyme Numbers (IUBMB) for ADAM19 Gene

Phenotypes From GWAS Catalog for ADAM19 Gene

Gene Ontology (GO) - Molecular Function for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IMP 11162584
GO:0005515 protein binding IPI 11162584
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAM19: view
genes like me logo Genes that share phenotypes with ADAM19: view

Animal Models for ADAM19 Gene

MGI Knock Outs for ADAM19:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM19

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM19

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM19 Gene

Localization for ADAM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM19 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM19 gene
Compartment Confidence
plasma membrane 5
nucleus 5
extracellular 4
golgi apparatus 3
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19727588
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM19: view

Pathways & Interactions for ADAM19 Gene

PathCards logo

SuperPathways for ADAM19 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with ADAM19: view

Pathways by source for ADAM19 Gene

1 BioSystems pathway for ADAM19 Gene

SIGNOR curated interactions for ADAM19 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEP 19727588
GO:0006508 proteolysis IEA --
GO:0006509 membrane protein ectodomain proteolysis IEA --
GO:0010628 positive regulation of gene expression IDA 19727588
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with ADAM19: view

Drugs & Compounds for ADAM19 Gene

No Compound Related Data Available

Transcripts for ADAM19 Gene

mRNA/cDNA for ADAM19 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM19

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM19 Gene

No ASD Table

Relevant External Links for ADAM19 Gene

GeneLoc Exon Structure for
ADAM19

Expression for ADAM19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM19 Gene

This gene is overexpressed in Whole Blood (x8.6).

Protein differential expression in normal tissues from HIPED for ADAM19 Gene

This gene is overexpressed in Prostate (60.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM19 Gene



Protein tissue co-expression partners for ADAM19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAM19

SOURCE GeneReport for Unigene cluster for ADAM19 Gene:

Hs.483944

mRNA Expression by UniProt/SwissProt for ADAM19 Gene:

Q9H013-ADA19_HUMAN
Tissue specificity: Expressed in many normal organ tissues and several cancer cell lines.

Evidence on tissue expression from TISSUES for ADAM19 Gene

  • Blood(4.4)
  • Lymph node(4.4)
  • Spleen(4.4)
  • Heart(2.5)
  • Muscle(2.2)
  • Intestine(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ADAM19: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM19 Gene

Orthologs for ADAM19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADAM19 30 31
  • 99.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADAM19 30 31
  • 88.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADAM19 30 31
  • 87.55 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADAM19 31
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Adam19 30 17 31
  • 84.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adam19 30
  • 84.21 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia ADAM19 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADAM19 30 31
  • 66.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADAM19 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adam19 30
  • 62.77 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC571252 30
  • 58.77 (n)
adam19b 31
  • 49 (a)
OneToOne
-- 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003498 30
  • 50.61 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Meltrin 30
  • 47.45 (n)
mmd 32
  • 31 (a)
Worm
(Caenorhabditis elegans)
Secernentea adm-1 32
  • 30 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for ADAM19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADAM19 Gene

ENSEMBL:
Gene Tree for ADAM19 (if available)
TreeFam:
Gene Tree for ADAM19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAM19: view image

Paralogs for ADAM19 Gene

(15) SIMAP similar genes for ADAM19 Gene using alignment to 6 proteins:

  • ADA19_HUMAN
  • E5RIS2_HUMAN
  • E7ENW4_HUMAN
  • E9PD32_HUMAN
  • H0YC66_HUMAN
  • Q8TBU7_HUMAN
genes like me logo Genes that share paralogs with ADAM19: view

Variants for ADAM19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAM19 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
714148 Benign: not provided 157,491,832(-) C/T INTRON_VARIANT
715897 Benign: not provided 157,491,630(-) G/A MISSENSE_VARIANT
719097 Benign: not provided 157,488,315(-) G/C MISSENSE_VARIANT
776088 Benign: not provided 157,488,402(-) C/T MISSENSE_VARIANT
784061 Benign: not provided 157,537,936(-) G/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ADAM19 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAM19 Gene

Variant ID Type Subtype PubMed ID
esv2759389 CNV loss 17122850
esv6935 CNV loss 19470904
esv997268 CNV deletion 20482838
nsv462497 CNV loss 19166990
nsv5089 CNV deletion 18451855
nsv600133 CNV loss 21841781
nsv830526 CNV loss 17160897

Variation tolerance for ADAM19 Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.82; 96.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM19 Gene

Human Gene Mutation Database (HGMD)
ADAM19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM19 Gene

Disorders for ADAM19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAM19 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADAM19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADAM19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM19 Gene

Publications for ADAM19 Gene

  1. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta. (PMID: 11162584) Wei P … Sang QX (Biochemical and biophysical research communications 2001) 3 4 23
  2. Molecular cloning and characterization of a human metalloprotease disintegrin--a novel marker for dendritic cell differentiation. (PMID: 10887142) Fritsche J … Kreutz M (Blood 2000) 3 4 23
  3. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. (PMID: 9806848) Hirohata S … Apte SS (Genomics 1998) 2 3 23
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang KS … Aragam N (Schizophrenia research 2010) 3 41

Products for ADAM19 Gene

  • Signalway ELISA kits for ADAM19

Sources for ADAM19 Gene