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Aliases for ADAM18 Gene

Aliases for ADAM18 Gene

  • ADAM Metallopeptidase Domain 18 2 3 5
  • Transmembrane Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein III 3 4
  • A Disintegrin And Metalloproteinase Domain 18 2 3
  • Disintegrin And Metalloproteinase Domain-Containing Protein 18 3
  • TMDC III 4
  • TMDCIII 3
  • ADAM 18 4
  • ADAM27 3
  • TMDC3 4

External Ids for ADAM18 Gene

Previous GeneCards Identifiers for ADAM18 Gene

  • GC08P038838
  • GC08P039501
  • GC08P039182
  • GC08P039459
  • GC08P038983
  • GC08P039561
  • GC08P037975

Summaries for ADAM18 Gene

Entrez Gene Summary for ADAM18 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAM18 Gene

ADAM18 (ADAM Metallopeptidase Domain 18) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM2.

UniProtKB/Swiss-Prot for ADAM18 Gene

  • Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).

Gene Wiki entry for ADAM18 Gene

Additional gene information for ADAM18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM18 Gene

Genomics for ADAM18 Gene

GeneHancer (GH) Regulatory Elements for ADAM18 Gene

Promoters and enhancers for ADAM18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J038764 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -816.1 -816093 7.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A YBX1 ZNF2 IRF4 YY1 ENSG00000255201 DDHD2 ADGRA2 NSD3 TACC1 FGFR1 TM2D2 LETM2 EIF4EBP1 ADAM5
GH08J039650 Enhancer 0.4 ENCODE 8.7 +66.8 66753 1.1 CBFA2T3 ZNF592 SPI1 ADAM18 GC08M039702
GH08J039680 Enhancer 0.5 ENCODE 6.9 +96.8 96845 0.8 POLR2A IKZF1 EBF1 MEF2B IKZF2 EZH2 ADAM18 GC08M039702
GH08J039728 Enhancer 0.3 ENCODE 9.6 +143.3 143295 0.8 POU5F1 ADAM18 GC08P039735 GC08P039736 GC08M039702
GH08J039581 Enhancer 0.6 ENCODE 0.7 -2.5 -2532 1.8 MEIS2 PKNOX1 SOX6 TAL1 CBFA2T3 TCF12 CTBP1 NCOR1 CBFA2T2 KDM1A ADAM5 LOC100130964 ADAM3A ADAM18 GC08P039555
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAM18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAM18 gene promoter:
  • CUTL1
  • Evi-1

Genomic Locations for ADAM18 Gene

Genomic Locations for ADAM18 Gene
chr8:39,584,489-39,730,064
(GRCh38/hg38)
Size:
145,576 bases
Orientation:
Plus strand
chr8:39,442,008-39,587,583
(GRCh37/hg19)
Size:
145,576 bases
Orientation:
Plus strand

Genomic View for ADAM18 Gene

Genes around ADAM18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM18 Gene

Proteins for ADAM18 Gene

  • Protein details for ADAM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3Q7-ADA18_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 18
    Protein Accession:
    Q9Y3Q7
    Secondary Accessions:
    • B2R9Y0
    • Q0VAI4
    • Q6IRW9
    • Q6UXJ9

    Protein attributes for ADAM18 Gene

    Size:
    739 amino acids
    Molecular mass:
    82856 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM18 Gene

Post-translational modifications for ADAM18 Gene

  • The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa.
  • Glycosylation at Asn625, Asn611, Asn561, Asn465, posLast=359359, Asn294, Asn177, posLast=156156, posLast=149149, Asn122, Asn76, and posLast=3636
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM18 Gene

No data available for DME Specific Peptides for ADAM18 Gene

Domains & Families for ADAM18 Gene

Gene Families for ADAM18 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ADAM18 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3Q7

UniProtKB/Swiss-Prot:

ADA18_HUMAN :
  • A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
Domain:
  • A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
genes like me logo Genes that share domains with ADAM18: view

Function for ADAM18 Gene

Molecular function for ADAM18 Gene

UniProtKB/Swiss-Prot Function:
Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).

Phenotypes From GWAS Catalog for ADAM18 Gene

Gene Ontology (GO) - Molecular Function for ADAM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 10395895
genes like me logo Genes that share ontologies with ADAM18: view
genes like me logo Genes that share phenotypes with ADAM18: view

Animal Models for ADAM18 Gene

MGI Knock Outs for ADAM18:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM18

miRNA for ADAM18 Gene

miRTarBase miRNAs that target ADAM18

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM18 Gene

Localization for ADAM18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM18 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM18 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ADAM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 10395895
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAM18 Gene

Pathways & Interactions for ADAM18 Gene

SuperPathways for ADAM18 Gene

No Data Available

Interacting Proteins for ADAM18 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265707%0d%0a9606.ENSP00000295400%0d%0a9606.ENSP00000345731%0d%0a9606.ENSP00000387356%0d%0a9606.ENSP00000296509%0d%0a9606.ENSP00000366534%0d%0a
Selected Interacting proteins: ENSP00000265707 Q9Y3Q7-ADA18_HUMAN for ADAM18 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ADAM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA,TAS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ADAM18: view

No data available for Pathways by source and SIGNOR curated interactions for ADAM18 Gene

Drugs & Compounds for ADAM18 Gene

No Compound Related Data Available

Transcripts for ADAM18 Gene

mRNA/cDNA for ADAM18 Gene

Unigene Clusters for ADAM18 Gene

ADAM metallopeptidase domain 18:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM18 Gene

No ASD Table

Relevant External Links for ADAM18 Gene

GeneLoc Exon Structure for
ADAM18
ECgene alternative splicing isoforms for
ADAM18

Expression for ADAM18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM18 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM18 Gene

This gene is overexpressed in Testis (x51.4).

Protein differential expression in normal tissues from HIPED for ADAM18 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM18 Gene



Protein tissue co-expression partners for ADAM18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAM18 Gene:

ADAM18

SOURCE GeneReport for Unigene cluster for ADAM18 Gene:

Hs.127930

mRNA Expression by UniProt/SwissProt for ADAM18 Gene:

Q9Y3Q7-ADA18_HUMAN
Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with ADAM18: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM18 Gene

Orthologs for ADAM18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADAM18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM18 34 33
  • 98.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM18 34 33
  • 85.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM18 34 33
  • 83.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Adam18 16 34 33
  • 74.39 (n)
rat
(Rattus norvegicus)
Mammalia Adam18 33
  • 74.27 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 21 (a)
ManyToMany
Species where no ortholog for ADAM18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAM18 Gene

ENSEMBL:
Gene Tree for ADAM18 (if available)
TreeFam:
Gene Tree for ADAM18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAM18: view image

Paralogs for ADAM18 Gene

Paralogs for ADAM18 Gene

(11) SIMAP similar genes for ADAM18 Gene using alignment to 4 proteins:

  • ADA18_HUMAN
  • E5RIP0_HUMAN
  • E5RK96_HUMAN
  • Q0VAI3_HUMAN

Pseudogenes.org Pseudogenes for ADAM18 Gene

genes like me logo Genes that share paralogs with ADAM18: view

Variants for ADAM18 Gene

Sequence variations from dbSNP and Humsavar for ADAM18 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs267601916 A cutaneous metastatic melanoma sample 39,610,692(+) C/T coding_sequence_variant, intron_variant, missense_variant
rs267601918 A cutaneous metastatic melanoma sample 39,645,460(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
VAR_066313 A cutaneous metastatic melanoma sample p.Val284Gly
VAR_066315 A cutaneous metastatic melanoma sample p.Met362Lys
VAR_066316 A cutaneous metastatic melanoma sample p.Ser536Leu

Structural Variations from Database of Genomic Variants (DGV) for ADAM18 Gene

Variant ID Type Subtype PubMed ID
esv2225914 CNV deletion 18987734
esv2660839 CNV deletion 23128226
esv2736903 CNV deletion 23290073
esv2759608 CNV gain+loss 17122850
esv3307331 CNV mobile element insertion 20981092
esv33750 CNV loss 17666407
esv3425696 CNV insertion 20981092
esv3572694 CNV loss 25503493
esv3616956 CNV loss 21293372
nsv1017740 CNV loss 25217958
nsv1115090 CNV deletion 24896259
nsv510141 OTHER sequence alteration 20534489
nsv522716 CNV loss 19592680
nsv611086 CNV loss 21841781

Variation tolerance for ADAM18 Gene

Residual Variation Intolerance Score: 90.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM18 Gene

Disorders for ADAM18 Gene

Additional Disease Information for ADAM18

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ADAM18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM18 Gene

Publications for ADAM18 Gene

  1. Human tMDC III: a sperm protein with a potential role in oocyte recognition. (PMID: 12200459) Frayne J … Hall L (Molecular human reproduction 2002) 2 3 22 58
  2. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa JR … Partners in Prevention HSV/HIV Transmission Study Team (PloS one 2011) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for ADAM18 Gene

Sources for ADAM18 Gene

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