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Aliases for ADAM12 Gene

Aliases for ADAM12 Gene

  • ADAM Metallopeptidase Domain 12 2 3 5
  • Meltrin-Alpha 3 4
  • MLTN 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 12 3
  • A Disintegrin And Metalloproteinase Domain 12 (Meltrin Alpha) 2
  • Metalloprotease-Disintegrin 12 Transmembrane 3
  • Meltrin Alpha 2
  • EC 3.4.24.- 4
  • ADAM12-OT1 3
  • MCMPMltna 3
  • ADAM 12 4
  • CAR10 3
  • MLTNA 3
  • MCMP 3

External Ids for ADAM12 Gene

Previous GeneCards Identifiers for ADAM12 Gene

  • GC10M126678
  • GC10M126907
  • GC10M127744
  • GC10M127278
  • GC10M127693
  • GC10M121392

Summaries for ADAM12 Gene

Entrez Gene Summary for ADAM12 Gene

  • This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

GeneCards Summary for ADAM12 Gene

ADAM12 (ADAM Metallopeptidase Domain 12) is a Protein Coding gene. Diseases associated with ADAM12 include Lung Cancer and Ectopic Pregnancy. Among its related pathways are Notch Signaling Pathway (sino) and Development Dopamine D2 receptor transactivation of EGFR. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and metallopeptidase activity. An important paralog of this gene is ADAM19.

UniProtKB/Swiss-Prot for ADAM12 Gene

  • Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).

Gene Wiki entry for ADAM12 Gene

Additional gene information for ADAM12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM12 Gene

Genomics for ADAM12 Gene

GeneHancer (GH) Regulatory Elements for ADAM12 Gene

Promoters and enhancers for ADAM12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J126382 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 655.3 +2.4 2409 6.4 CTCF MXI1 JUN ZIC2 RAD21 ZEB1 ZNF335 GLIS2 ZNF213 POLR2A ADAM12 SAR1AP2
GH10J126227 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 13.7 +160.6 160574 1.7 ZNF282 SOX6 YBX1 ZBTB7B ATF2 CTBP1 JUND TARDBP ZNF580 CREB1 ADAM12 GC10M126242 RNA5SP328
GH10J126242 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.2 +143.2 143189 6.6 PKNOX1 ARNT FEZF1 ZNF2 BRCA1 GLIS2 ZNF213 FOS DEK SP3 GC10M126242 ADAM12 GC10M126270 PIR55719
GH10J126420 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 -34.9 -34945 5.9 JUN GTF3C2 POLR2A NFYB RCOR1 NFE2 FOS MAFK NFE2L2 CHD2 LINC00601 LOC728158 EDRF1-AS1 ADAM12 EDRF1 GC10P126409 LOC105378549 C10orf90
GH10J126409 Enhancer 0.6 ENCODE dbSUPER 12 -20.7 -20669 0.2 NR2F1 CEBPB EP300 GC10P126409 ADAM12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAM12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAM12 gene promoter:
  • MyoD
  • Pbx1a
  • C/EBPalpha
  • POU2F1a
  • POU2F1

Genomic Locations for ADAM12 Gene

Genomic Locations for ADAM12 Gene
376,178 bases
Minus strand
376,178 bases
Minus strand

Genomic View for ADAM12 Gene

Genes around ADAM12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM12 Gene

Proteins for ADAM12 Gene

  • Protein details for ADAM12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 12
    Protein Accession:
    Secondary Accessions:
    • O60470
    • Q5JRP0
    • Q5JRP1
    • Q6P9E3
    • Q6UWB0

    Protein attributes for ADAM12 Gene

    909 amino acids
    Molecular mass:
    99542 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A. Interacts with FST3. Interacts with RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.

    Alternative splice isoforms for ADAM12 Gene


neXtProt entry for ADAM12 Gene

Post-translational modifications for ADAM12 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at posLast=651651, posLast=452452, posLast=381381, posLast=149149, and posLast=111111
  • Modification sites at PhosphoSitePlus

Protein Products

  • Abcam proteins for ADAM12

No data available for DME Specific Peptides for ADAM12 Gene

Domains & Families for ADAM12 Gene

Gene Families for ADAM12 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Suggested Antigen Peptide Sequences for ADAM12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
  • The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAM12: view

Function for ADAM12 Gene

Molecular function for ADAM12 Gene

UniProtKB/Swiss-Prot Function:
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 12,membrane anchored cell surface protein,with two alternatively spliced isoforms L and S,expressed in term placenta,in adult skeletal,cardiac,smooth muscle,bone,required for myotube formation and in osteoblast differentiation,involved in tumor cell adhesion

Enzyme Numbers (IUBMB) for ADAM12 Gene

Phenotypes From GWAS Catalog for ADAM12 Gene

Gene Ontology (GO) - Molecular Function for ADAM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 15280379
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity TAS,IEA 9417060
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAM12: view
genes like me logo Genes that share phenotypes with ADAM12: view

Animal Models for ADAM12 Gene

MGI Knock Outs for ADAM12:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM12 Gene

Localization for ADAM12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM12 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM12 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
mitochondrion 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADAM12: view

Pathways & Interactions for ADAM12 Gene

genes like me logo Genes that share pathways with ADAM12: view

SIGNOR curated interactions for ADAM12 Gene


Gene Ontology (GO) - Biological Process for ADAM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0007520 myoblast fusion TAS 7566181
GO:0030198 extracellular matrix organization TAS --
GO:0045766 positive regulation of angiogenesis IMP 28637396
genes like me logo Genes that share ontologies with ADAM12: view

Drugs & Compounds for ADAM12 Gene

(1) Drugs for ADAM12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ADAM12: view

Transcripts for ADAM12 Gene

Unigene Clusters for ADAM12 Gene

ADAM metallopeptidase domain 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -

Relevant External Links for ADAM12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM12 Gene

This gene is overexpressed in Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for ADAM12 Gene

This gene is overexpressed in Placenta (47.9) and Heart (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAM12 Gene

Protein tissue co-expression partners for ADAM12 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAM12 Gene:


SOURCE GeneReport for Unigene cluster for ADAM12 Gene:


mRNA Expression by UniProt/SwissProt for ADAM12 Gene:

Tissue specificity: Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.

Evidence on tissue expression from TISSUES for ADAM12 Gene

  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with ADAM12: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM12 Gene

Orthologs for ADAM12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAM12 34 33
  • 99.2 (n)
(Canis familiaris)
Mammalia ADAM12 34 33
  • 85.83 (n)
(Bos Taurus)
Mammalia ADAM12 34 33
  • 84.76 (n)
(Mus musculus)
Mammalia Adam12 16 34 33
  • 83.26 (n)
(Rattus norvegicus)
Mammalia Adam12 33
  • 82.93 (n)
(Monodelphis domestica)
Mammalia ADAM12 34
  • 73 (a)
(Gallus gallus)
Aves ADAM12 34 33
  • 72.81 (n)
(Anolis carolinensis)
Reptilia ADAM12 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adam12 33
  • 66.82 (n)
(Danio rerio)
Actinopterygii adam12 34 33
  • 66.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013468 33
  • 46.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta mmd 35
  • 35 (a)
(Caenorhabditis elegans)
Secernentea adm-2 33
  • 44.74 (n)
adm-1 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for ADAM12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM12 Gene

Gene Tree for ADAM12 (if available)
Gene Tree for ADAM12 (if available)
Evolutionary constrained regions (ECRs) for ADAM12: view image

Paralogs for ADAM12 Gene

Paralogs for ADAM12 Gene

(17) SIMAP similar genes for ADAM12 Gene using alignment to 3 proteins:

  • U5NE98_HUMAN
genes like me logo Genes that share paralogs with ADAM12: view

Variants for ADAM12 Gene

Sequence variations from dbSNP and Humsavar for ADAM12 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs151030407 A cutaneous metastatic melanoma sample 126,017,332(-) G/A/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
VAR_036143 A breast cancer sample p.Asp301His
VAR_036144 A breast cancer sample p.Gly479Glu
VAR_036145 A breast cancer sample p.Leu792Phe
VAR_066310 A cutaneous metastatic melanoma sample p.Gly712Glu

Structural Variations from Database of Genomic Variants (DGV) for ADAM12 Gene

Variant ID Type Subtype PubMed ID
dgv172e199 CNV deletion 23128226
dgv533n106 CNV deletion 24896259
esv1001364 CNV deletion 20482838
esv1412557 CNV insertion 17803354
esv1413579 CNV deletion 17803354
esv2286058 CNV deletion 18987734
esv2396699 CNV deletion 18987734
esv2493187 CNV deletion 19546169
esv2557304 CNV insertion 19546169
esv2658457 CNV deletion 23128226
esv2665460 CNV deletion 23128226
esv275509 CNV loss 21479260
esv2759788 CNV gain 17122850
esv2761638 CNV loss 21179565
esv2762885 CNV loss 21179565
esv3244 CNV loss 18987735
esv3260163 CNV deletion 24192839
esv3547005 CNV deletion 23714750
esv3579217 CNV loss 25503493
esv3624848 CNV loss 21293372
esv3624849 CNV gain 21293372
esv3624850 CNV gain 21293372
esv3624852 CNV gain 21293372
esv3624853 CNV loss 21293372
esv3624854 CNV gain 21293372
esv3624855 CNV gain 21293372
esv3624857 CNV loss 21293372
esv3624858 CNV loss 21293372
esv3624859 CNV loss 21293372
esv3891896 CNV gain 25118596
esv7617 CNV loss 19470904
nsv1045509 CNV gain 25217958
nsv1070897 CNV deletion 25765185
nsv1111043 CNV tandem duplication 24896259
nsv1145489 CNV deletion 24896259
nsv1146258 CNV deletion 26484159
nsv467477 CNV loss 19166990
nsv512190 CNV loss 21212237
nsv516813 CNV gain+loss 19592680
nsv524124 CNV loss 19592680
nsv552294 CNV loss 21841781
nsv7600 CNV insertion 18451855
nsv8739 CNV gain 18304495

Variation tolerance for ADAM12 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM12 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM12 Gene

Disorders for ADAM12 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ADAM12 Gene - From: HGMD, LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
ectopic pregnancy
  • eccyesis
giant cell tumor
  • giant cell neoplasm
orofaciodigital syndrome viii
  • ofd8
  • toxemia of pregnancy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADAM12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADAM12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM12 Gene

Publications for ADAM12 Gene

  1. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. (PMID: 9417060) Gilpin BJ … Wewer UM (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease. (PMID: 19837132) Laumet G … Lambert JC (Neuroscience letters 2010) 3 22 44 58
  3. Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. (PMID: 19268722) Kerna I … Tamm AO (Osteoarthritis and cartilage 2009) 3 22 44 58
  4. Cellular roles of ADAM12 in health and disease. (PMID: 18342566) Kveiborg M … Wewer UM (The international journal of biochemistry & cell biology 2008) 2 3 22 58
  5. RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. (PMID: 18621736) Bourd-Boittin K … Théret N (The Journal of biological chemistry 2008) 3 4 22 58

Products for ADAM12 Gene

Sources for ADAM12 Gene

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