This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alte... See more...

Aliases for ADAM12 Gene

Aliases for ADAM12 Gene

  • ADAM Metallopeptidase Domain 12 2 3 5
  • MLTN 2 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 12 3 4
  • Meltrin-Alpha 3 4
  • MCMPMltna 2 3
  • A Disintegrin And Metalloproteinase Domain 12 (Meltrin Alpha) 2
  • Metalloprotease-Disintegrin 12 Transmembrane 3
  • Meltrin Alpha 2
  • EC 3.4.24.58 51
  • EC 3.4.24.- 4
  • ADAM12-OT1 3
  • EC 3.4.24 51
  • ADAM 12 4
  • ADAM12 5
  • CAR10 3
  • MLTNA 3
  • MCMP 3

External Ids for ADAM12 Gene

Previous GeneCards Identifiers for ADAM12 Gene

  • GC10M126678
  • GC10M126907
  • GC10M127744
  • GC10M127278
  • GC10M127693
  • GC10M121392

Summaries for ADAM12 Gene

Entrez Gene Summary for ADAM12 Gene

  • This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

GeneCards Summary for ADAM12 Gene

ADAM12 (ADAM Metallopeptidase Domain 12) is a Protein Coding gene. Diseases associated with ADAM12 include Lung Cancer and Ectopic Pregnancy. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and metallopeptidase activity. An important paralog of this gene is ADAM19.

UniProtKB/Swiss-Prot Summary for ADAM12 Gene

  • Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).

Gene Wiki entry for ADAM12 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAM12 Gene

Genomics for ADAM12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ADAM12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J126382 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 605.2 +2.3 2328 6.4 CTCF ZNF692 ZIC2 PATZ1 EZH2 SCRT2 RAD21 CEBPB ZEB1 JUN ADAM12 lnc-DHX32-4 SAR1AP2 DHX32
GH10J126227 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +159.8 159805 3.1 CREB1 ATF7 YBX1 ZNF600 JUND TARDBP CTBP1 ZNF580 FOS MAFK ADAM12 lnc-C10orf90-5 RF00001-052 RNA5SP328 lnc-DHX32-4 DHX32
GH10J126420 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 11.7 -35.0 -35026 5.9 POLR2A CEBPB NFE2 FOS CHD2 JUN RCOR1 JUND NFYA NFYB LINC00601 ADAM12 LOC728158 LOC112267914 C10orf90
GH10J126239 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.7 +143.8 143845 9.7 CREB1 PRDM10 ZNF629 ZNF692 PRDM1 ZIC2 ZSCAN4 ZNF600 ZNF561 ARNT lnc-C10orf90-5 ADAM12 piR-60720 lnc-DHX32-4 DHX32
GH10J126409 Enhancer 0.6 ENCODE dbSUPER 12 -20.8 -20750 0.2 CEBPB EP300 NR2F1 ADAM12 lnc-C10orf90-4 ENSG00000287609 C10orf90
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAM12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAM12

Top Transcription factor binding sites by QIAGEN in the ADAM12 gene promoter:
  • C/EBPalpha
  • MyoD
  • Pbx1a
  • POU2F1
  • POU2F1a

Genomic Locations for ADAM12 Gene

Genomic Locations for ADAM12 Gene
chr10:126,012,381-126,388,477
(GRCh38/hg38)
Size:
376,097 bases
Orientation:
Minus strand
chr10:127,700,950-128,077,127
(GRCh37/hg19)
Size:
376,178 bases
Orientation:
Minus strand

Genomic View for ADAM12 Gene

Genes around ADAM12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM12 Gene

Proteins for ADAM12 Gene

  • Protein details for ADAM12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43184-ADA12_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 12
    Protein Accession:
    O43184
    Secondary Accessions:
    • O60470
    • Q5JRP0
    • Q5JRP1
    • Q6P9E3
    • Q6UWB0

    Protein attributes for ADAM12 Gene

    Size:
    909 amino acids
    Molecular mass:
    99542 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A. Interacts with FST3. Interacts with RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.

    Alternative splice isoforms for ADAM12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM12 Gene

Selected DME Specific Peptides for ADAM12 Gene

O43184:
  • EEGEECDCG
  • GEECDCG
  • CCNATTC

Post-translational modifications for ADAM12 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn111, Asn149, Asn381, Asn452, and Asn651
  • Modification sites at PhosphoSitePlus

Protein Products

  • Signalway Proteins for ADAM12
  • Abcam proteins for ADAM12

Domains & Families for ADAM12 Gene

Gene Families for ADAM12 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for ADAM12 Gene

Suggested Antigen Peptide Sequences for ADAM12 Gene

GenScript: Design optimal peptide antigens:
  • Meltrin-alpha (ADA12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43184

UniProtKB/Swiss-Prot:

ADA12_HUMAN :
  • The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
Domain:
  • The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
genes like me logo Genes that share domains with ADAM12: view

Function for ADAM12 Gene

Molecular function for ADAM12 Gene

UniProtKB/Swiss-Prot Function:
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 12,membrane anchored cell surface protein,with two alternatively spliced isoforms L and S,expressed in term placenta,in adult skeletal,cardiac,smooth muscle,bone,required for myotube formation and in osteoblast differentiation,involved in tumor cell adhesion

Enzyme Numbers (IUBMB) for ADAM12 Gene

Phenotypes From GWAS Catalog for ADAM12 Gene

Gene Ontology (GO) - Molecular Function for ADAM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 25825872
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA,TAS 9417060
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAM12: view
genes like me logo Genes that share phenotypes with ADAM12: view

Animal Models for ADAM12 Gene

MGI Knock Outs for ADAM12:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM12

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM12 Gene

Localization for ADAM12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM12 Gene

[Isoform 1]: Cell membrane. Single-pass type I membrane protein.
[Isoform 2]: Secreted.
[Isoform 3]: Secreted.
[Isoform 4]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM12 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM12: view

Pathways & Interactions for ADAM12 Gene

PathCards logo

SuperPathways for ADAM12 Gene

SuperPathway Contained pathways
1 MAPK Erk Pathway
2 Development Dopamine D2 receptor transactivation of EGFR
.66
.66
3 Autophagy Pathway
4 Notch Signaling Pathway (sino)
5 Matrix Metalloproteinases
.69
genes like me logo Genes that share pathways with ADAM12: view

Pathways by source for ADAM12 Gene

2 BioSystems pathways for ADAM12 Gene
2 Reactome pathways for ADAM12 Gene
3 GeneGo (Thomson Reuters) pathways for ADAM12 Gene
  • Development Alpha-2 adrenergic receptor activation of ERK
  • Development Angiotensin activation of ERK
  • Development Dopamine D2 receptor transactivation of EGFR
1 Qiagen pathway for ADAM12 Gene
  • Inhibition of Matrix Metalloproteinases

SIGNOR curated interactions for ADAM12 Gene

Activates:

Gene Ontology (GO) - Biological Process for ADAM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007155 cell adhesion IEA --
GO:0007520 myoblast fusion TAS 7566181
GO:0030198 extracellular matrix organization TAS --
GO:0045766 positive regulation of angiogenesis IMP 28637396
genes like me logo Genes that share ontologies with ADAM12: view

Drugs & Compounds for ADAM12 Gene

(1) Drugs for ADAM12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ADAM12: view

Transcripts for ADAM12 Gene

mRNA/cDNA for ADAM12 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM12

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4:

Relevant External Links for ADAM12 Gene

GeneLoc Exon Structure for
ADAM12

Expression for ADAM12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM12 Gene

This gene is overexpressed in Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for ADAM12 Gene

This gene is overexpressed in Placenta (47.9) and Heart (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAM12 Gene



Protein tissue co-expression partners for ADAM12 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAM12

SOURCE GeneReport for Unigene cluster for ADAM12 Gene:

Hs.594351

mRNA Expression by UniProt/SwissProt for ADAM12 Gene:

O43184-ADA12_HUMAN
Tissue specificity: Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.

Evidence on tissue expression from TISSUES for ADAM12 Gene

  • Nervous system(3.2)
  • Muscle(2.2)
  • Skin(2.1)
  • Heart(2.1)
  • Liver(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with ADAM12: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM12 Gene

Orthologs for ADAM12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM12 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADAM12 30 31
  • 99.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ADAM12 30 31
  • 85.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ADAM12 30 31
  • 84.76 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Adam12 30 17 31
  • 83.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Adam12 30
  • 82.93 (n)
Oppossum
(Monodelphis domestica)
Mammalia ADAM12 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ADAM12 30 31
  • 72.81 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ADAM12 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia adam12 30
  • 66.82 (n)
Zebrafish
(Danio rerio)
Actinopterygii adam12 30 31
  • 66.59 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013468 30
  • 46.66 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta mmd 32
  • 35 (a)
Worm
(Caenorhabditis elegans)
Secernentea adm-2 30
  • 44.74 (n)
adm-1 32
  • 31 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for ADAM12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADAM12 Gene

ENSEMBL:
Gene Tree for ADAM12 (if available)
TreeFam:
Gene Tree for ADAM12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAM12: view image

Paralogs for ADAM12 Gene

(17) SIMAP similar genes for ADAM12 Gene using alignment to 3 proteins:

  • ADA12_HUMAN
  • Q5JRP2_HUMAN
  • U5NE98_HUMAN
genes like me logo Genes that share paralogs with ADAM12: view

Variants for ADAM12 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAM12 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
709836 Benign: not provided 126,046,075(-) T/C MISSENSE_VARIANT
714492 Benign: not provided 126,038,280(-) T/C SYNONYMOUS_VARIANT
716775 Benign: not provided 126,135,643(-) A/G SYNONYMOUS_VARIANT
725176 Likely Benign: not provided 126,064,870(-) G/A SYNONYMOUS_VARIANT
780917 Benign: not provided 126,118,141(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ADAM12 Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAM12 Gene

Variant ID Type Subtype PubMed ID
dgv172e199 CNV deletion 23128226
dgv533n106 CNV deletion 24896259
esv1001364 CNV deletion 20482838
esv1412557 CNV insertion 17803354
esv1413579 CNV deletion 17803354
esv2286058 CNV deletion 18987734
esv2396699 CNV deletion 18987734
esv2493187 CNV deletion 19546169
esv2557304 CNV insertion 19546169
esv2658457 CNV deletion 23128226
esv2665460 CNV deletion 23128226
esv275509 CNV loss 21479260
esv2759788 CNV gain 17122850
esv2761638 CNV loss 21179565
esv2762885 CNV loss 21179565
esv3244 CNV loss 18987735
esv3260163 CNV deletion 24192839
esv3547005 CNV deletion 23714750
esv3579217 CNV loss 25503493
esv3624848 CNV loss 21293372
esv3624849 CNV gain 21293372
esv3624850 CNV gain 21293372
esv3624852 CNV gain 21293372
esv3624853 CNV loss 21293372
esv3624854 CNV gain 21293372
esv3624855 CNV gain 21293372
esv3624857 CNV loss 21293372
esv3624858 CNV loss 21293372
esv3624859 CNV loss 21293372
esv3891896 CNV gain 25118596
esv7617 CNV loss 19470904
nsv1045509 CNV gain 25217958
nsv1070897 CNV deletion 25765185
nsv1111043 CNV tandem duplication 24896259
nsv1145489 CNV deletion 24896259
nsv1146258 CNV deletion 26484159
nsv467477 CNV loss 19166990
nsv512190 CNV loss 21212237
nsv516813 CNV gain+loss 19592680
nsv524124 CNV loss 19592680
nsv552294 CNV loss 21841781
nsv7600 CNV insertion 18451855
nsv8739 CNV gain 18304495

Variation tolerance for ADAM12 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM12 Gene

Human Gene Mutation Database (HGMD)
ADAM12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM12 Gene

Disorders for ADAM12 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ADAM12 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
ectopic pregnancy
  • eccyesis
benign giant cell tumor
  • giant cell tumors
pre-eclampsia
  • toxemia of pregnancy
down syndrome
  • trisomy 21
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ADAM12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADAM12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM12 Gene

Publications for ADAM12 Gene

  1. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. (PMID: 9417060) Gilpin BJ … Wewer UM (The Journal of biological chemistry 1998) 2 3 4 23
  2. A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease. (PMID: 19837132) Laumet G … Lambert JC (Neuroscience letters 2010) 3 23 41
  3. Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. (PMID: 19268722) Kerna I … Tamm AO (Osteoarthritis and cartilage 2009) 3 23 41
  4. RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. (PMID: 18621736) Bourd-Boittin K … Théret N (The Journal of biological chemistry 2008) 3 4 23
  5. Cellular roles of ADAM12 in health and disease. (PMID: 18342566) Kveiborg M … Wewer UM (The international journal of biochemistry & cell biology 2008) 2 3 23

Products for ADAM12 Gene

Sources for ADAM12 Gene