Aliases for ADAM12 Gene
Aliases for ADAM12 Gene
External Ids for ADAM12 Gene
- HGNC: 190
- Entrez Gene: 8038
- Ensembl: ENSG00000148848
- OMIM: 602714
- UniProtKB: O43184
Previous GeneCards Identifiers for ADAM12 Gene
- GC10M126678
- GC10M126907
- GC10M127744
- GC10M127278
- GC10M127693
- GC10M121392
Summaries for ADAM12 Gene
-
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
GeneCards Summary for ADAM12 Gene
ADAM12 (ADAM Metallopeptidase Domain 12) is a Protein Coding gene. Diseases associated with ADAM12 include Lung Cancer and Ectopic Pregnancy. Among its related pathways are Notch Signaling Pathway (sino) and Development Dopamine D2 receptor transactivation of EGFR. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and metallopeptidase activity. An important paralog of this gene is ADAM19.
UniProtKB/Swiss-Prot for ADAM12 Gene
-
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Additional gene information for ADAM12 Gene
- Monarch Initiative
- Search for ADAM12 at DataMed
- Search for ADAM12 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM12 Gene
Genomics for ADAM12 Gene
GeneHancer (GH) Regulatory Elements for ADAM12 Gene
Promoters and enhancers for ADAM12 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J126382 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 655.3 | +2.4 | 2409 | 6.4 | CTCF MXI1 JUN ZIC2 RAD21 ZEB1 ZNF335 GLIS2 ZNF213 POLR2A | ADAM12 SAR1AP2 | |
| GH10J126227 | Enhancer | 1.1 | FANTOM5 ENCODE dbSUPER | 13.7 | +160.6 | 160574 | 1.7 | ZNF282 SOX6 YBX1 ZBTB7B ATF2 CTBP1 JUND TARDBP ZNF580 CREB1 | ADAM12 GC10M126242 RNA5SP328 | |
| GH10J126242 | Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 8.2 | +143.2 | 143189 | 6.6 | PKNOX1 ARNT FEZF1 ZNF2 BRCA1 GLIS2 ZNF213 FOS DEK SP3 | GC10M126242 ADAM12 PIR55719 GC10M126270 | |
| GH10J126420 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 11.7 | -34.9 | -34945 | 5.9 | JUN GTF3C2 POLR2A NFYB RCOR1 NFE2 FOS MAFK NFE2L2 CHD2 | LINC00601 LOC728158 EDRF1-AS1 ADAM12 EDRF1 GC10P126409 LOC105378549 C10orf90 | |
| GH10J126409 | Enhancer | 0.6 | ENCODE dbSUPER | 12 | -20.7 | -20669 | 0.2 | NR2F1 CEBPB EP300 | GC10P126409 ADAM12 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADAM12 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ADAM12 gene promoter:
Regulatory Element Products
Genomic Locations for ADAM12 Gene
Genomic Locations for ADAM12 Gene
- chr10:126,012,381-126,388,558
- (GRCh38/hg38)
- Size:
- 376,178 bases
- Orientation:
- Minus strand
- chr10:127,700,950-128,077,127
- (GRCh37/hg19)
Genomic View for ADAM12 Gene
Genes around ADAM12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.2 by Entrez Gene
- 10q26.2 by HGNC
- 10q26.2 by Ensembl
ADAM12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAM12 Gene
Proteins for ADAM12 Gene
-
Protein details for ADAM12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43184-ADA12_HUMAN
- Recommended name:
- Disintegrin and metalloproteinase domain-containing protein 12
- Protein Accession:
- O43184
- O60470
- Q5JRP0
- Q5JRP1
- Q6P9E3
- Q6UWB0
Protein attributes for ADAM12 Gene
- Size:
- 909 amino acids
- Molecular mass:
- 99542 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A. Interacts with FST3. Interacts with RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.
Protein Expression for ADAM12 Gene
Post-translational modifications for ADAM12 Gene
- The precursor is cleaved by a furin endopeptidase.
- Glycosylation at posLast=651651, posLast=452452, posLast=381381, posLast=149149, and posLast=111111
- Modification sites at PhosphoSitePlus
Other Protein References for ADAM12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ADAM12 (ADAM12)
- Novus Biologicals Antibodies for ADAM12
- Invitrogen Antibodies for ADAM12
- GeneTex ADAM12 Antibody for ADAM12
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADAM12
- Sino Biological Antibodies for ADAM12
Protein Products
- R&D Systems Proteins and Enzymes for ADAM12
-
OriGene Purified Proteins for ADAM12
- Search Origene for MassSpec and Protein Over-expression Lysates for ADAM12
- Origene Custom Protein Services for ADAM12
- Sino Biological Cell Lysates for ADAM12
- Sino Biological Recombinant Proteins for ADAM12
- ProSpec Recombinant Proteins for ADAM12
- Search GeneTex for Proteins for ADAM12
-
ProSci Proteins for ADAM12
No data available for DME Specific Peptides for ADAM12 Gene
Domains & Families for ADAM12 Gene
Gene Families for ADAM12 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Protein Domains for ADAM12 Gene
Suggested Antigen Peptide Sequences for ADAM12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43184UniProtKB/Swiss-Prot:
ADA12_HUMAN :- The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
- Domain:
-
- The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
- The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function for ADAM12 Gene
Molecular function for ADAM12 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
- GENATLAS Biochemistry:
- a disintegrin and metalloprotease (active) domain 12,membrane anchored cell surface protein,with two alternatively spliced isoforms L and S,expressed in term placenta,in adult skeletal,cardiac,smooth muscle,bone,required for myotube formation and in osteoblast differentiation,involved in tumor cell adhesion
Enzyme Numbers (IUBMB) for ADAM12 Gene
Phenotypes From GWAS Catalog for ADAM12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 15280379 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | TAS,IEA | 9417060 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for ADAM12 Gene
- MGI mutant phenotypes for ADAM12:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADAM12:
Animal Models for ADAM12 Gene
- MGI Knock Outs for ADAM12:
-
- Adam12 Adam12<tm1Asf>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADAM12
-
CRISPR Products
-
OriGene CRISPR knockouts for ADAM12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM12
- genomics-online: gRNA clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
- Applied Biological Materials CRISPR for ADAM12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM12
- GenScript: Design CRISPR guide RNA sequences for ADAM12
miRNA for ADAM12 Gene
- miRTarBase miRNAs that target ADAM12
-
- hsa-mir-29b-3p (MIRT005667)
- hsa-mir-1-3p (MIRT023733)
- hsa-mir-218-5p (MIRT441266)
- hsa-mir-135b-5p (MIRT732742)
- hsa-mir-29a-3p (MIRT733083)
- hsa-mir-29c-3p (MIRT733084)
- hsa-mir-30b-3p (MIRT733085)
- hsa-mir-30d-3p (MIRT733086)
- hsa-mir-200b-3p (MIRT733087)
- hsa-mir-200c-3p (MIRT733088)
- hsa-mir-1185-5p (MIRT783114)
- hsa-mir-1224-5p (MIRT783139)
- hsa-mir-129-5p (MIRT783441)
- hsa-mir-1304-5p (MIRT783709)
- hsa-mir-33a-5p (MIRT784886)
- hsa-mir-33b-5p (MIRT784891)
- hsa-mir-3605-5p (MIRT784932)
- hsa-mir-3679-5p (MIRT785211)
- hsa-mir-3915 (MIRT785443)
- hsa-mir-4689 (MIRT786412)
- hsa-mir-586 (MIRT787939)
- hsa-mir-6858-5p (MIRT789102)
- hsa-mir-8055 (MIRT789646)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM12
- Browse OriGene Inhibitory RNA Products For ADAM12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM12
- genomics-online: shRNA clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ADAM12
- VectorBuilder custom plasmid, inducible vectors for ADAM12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM12
- Applied Biological Materials Clones for ADAM12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADAM12
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM12 Gene
Localization for ADAM12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAM12 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
- Isoform 3: Secreted.
- Isoform 4: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for ADAM12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MAPK-Erk Pathway |
.38
.38
|
|
| 2 | Development Dopamine D2 receptor transactivation of EGFR | ||
| 3 | Notch Signaling Pathway (sino) | ||
| 4 | Matrix Metalloproteinases | ||
| 5 | Signaling by GPCR | ||
Pathways by source for ADAM12 Gene
5 Sino Biological pathways for ADAM12 Gene
2 BioSystems pathways for ADAM12 Gene
2 Reactome pathways for ADAM12 Gene
3 GeneGo (Thomson Reuters) pathways for ADAM12 Gene
1 Qiagen pathway for ADAM12 Gene
Interacting Proteins for ADAM12 Gene
Selected Interacting proteins:
O43184-ADA12_HUMAN
ENSP00000357668
for ADAM12 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for ADAM12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007520 | myoblast fusion | TAS | 7566181 |
| GO:0030198 | extracellular matrix organization | TAS | -- |
| GO:0045766 | positive regulation of angiogenesis | IMP | 28637396 |
Transcripts for ADAM12 Gene
mRNA/cDNA for ADAM12 Gene
- (518) Selected AceView cDNA sequences:
- (8) Additional mRNA sequences :
- (8) REFSEQ mRNAs :
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000494661 372 bps (uc057wtn.1)
- ENST00000485388 381 bps (uc057wtl.1)
- ENST00000482291 597 bps (uc057wtk.1)
- ENST00000467145 600 bps (uc057wtj.1)
- ENST00000448723 1145 bps (uc057wtm.1)
Unigene Clusters for ADAM12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ADAM12
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM12
- genomics-online: gRNA clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
- Applied Biological Materials CRISPR for ADAM12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM12
- GenScript: Design CRISPR guide RNA sequences for ADAM12
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM12
- Browse OriGene Inhibitory RNA Products For ADAM12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM12
- genomics-online: shRNA clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ADAM12
- VectorBuilder custom plasmid, inducible vectors for ADAM12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM12
- Applied Biological Materials Clones for ADAM12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
Expression for ADAM12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
- Mononuclear Myocytes Thoracic Epaxial Myotome
-
Limb (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Forelimb Dorsal Muscles
- Mononuclear Myocytes Forelimb Ventral Muscles
- Mononuclear Myocytes Hindlimb Dorsal Muscle
- Zeugopod
- Bone (Muscoskeletal System)
- Gut Tube (Gastrointestinal Tract)
- Brain (Nervous System)
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Mesenchymal Condensate Cells Stylopod
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
- Neural Tube (Nervous System)
- Spinal Cord (Nervous System)
- Oligodendrocytes (Nervous System)
- Fibroblasts
- Dermis (Integumentary System)
- Kidney (Urinary System)
- Lung (Respiratory System)
- Intermediate Mesoderm (Gastrulation Derivatives)
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ADAM12 Gene
This gene is overexpressed in Ovary (x4.1).
This gene is overexpressed in Placenta (47.9) and Heart (17.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAM12 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADAM12 Gene:
ADAM12SOURCE GeneReport for Unigene cluster for ADAM12 Gene:
Hs.594351mRNA Expression by UniProt/SwissProt for ADAM12 Gene:
O43184-ADA12_HUMAN
Tissue specificity:
Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
Evidence on tissue expression from TISSUES for ADAM12 Gene
- Nervous system(2.6)
Primer Products
-
OriGene qPCR primer pairs and template standards for ADAM12
-
OriGene qPCR primer pairs for ADAM12
- genomics-online: primer clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM12 Gene
Orthologs for ADAM12 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADAM12 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ADAM12 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ADAM12 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Adam12 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adam12 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADAM12 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADAM12 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADAM12 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adam12 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | adam12 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP013468 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mmd 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | adm-2 33 |
|
||
| adm-1 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ADAM12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ADAM12 Gene
- ENSEMBL:
- Gene Tree for ADAM12 (if available)
- TreeFam:
- Gene Tree for ADAM12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADAM12: view image
Paralogs for ADAM12 Gene
Paralogs for ADAM12 Gene
(17) SIMAP similar genes for ADAM12 Gene using alignment to 3 proteins:
- ADA12_HUMAN
- Q5JRP2_HUMAN
- U5NE98_HUMAN
Variants for ADAM12 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs151030407 | A cutaneous metastatic melanoma sample | 126,017,332(-) | G/A/C | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| VAR_036143 | A breast cancer sample | p.Asp301His | |||
| VAR_036144 | A breast cancer sample | p.Gly479Glu | |||
| VAR_036145 | A breast cancer sample | p.Leu792Phe | |||
| VAR_066310 | A cutaneous metastatic melanoma sample | p.Gly712Glu |
Residual Variation Intolerance Score:
20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.38;
54.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADAM12 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM12 Gene
Disorders for ADAM12 Gene
(5) MalaCards diseases for ADAM12 Gene - From: LncRNADisease, HGMD, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
|
| ectopic pregnancy |
|
|
| giant cell tumor |
|
|
| orofaciodigital syndrome viii |
|
|
| pre-eclampsia |
|
Search ADAM12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADAM12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM12 Gene
Publications for ADAM12 Gene
- A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. (PMID: 9417060) Gilpin BJ … Wewer UM (The Journal of biological chemistry 1998) 2 3 4 22 58
- A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease. (PMID: 19837132) Laumet G … Lambert JC (Neuroscience letters 2010) 3 22 44 58
- Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. (PMID: 19268722) Kerna I … Tamm AO (Osteoarthritis and cartilage 2009) 3 22 44 58
- Cellular roles of ADAM12 in health and disease. (PMID: 18342566) Kveiborg M … Wewer UM (The international journal of biochemistry & cell biology 2008) 2 3 22 58
- RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. (PMID: 18621736) Bourd-Boittin K … Théret N (The Journal of biological chemistry 2008) 3 4 22 58
Products for ADAM12 Gene
- R&D Systems Antibodies for ADAM12 (ADAM12)
- R&D Systems Proteins and Enzymes for ADAM12
- R&D Systems ELISAs and other biochemical assays for ADAM12 (ADAM12)
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody Services
- Custom Assay Services
- OriGene Purified Proteins for ADAM12
- Search Origene for MassSpec and Protein Over-expression Lysates for ADAM12
- Origene Custom Protein Services for ADAM12
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM12
- Browse OriGene Inhibitory RNA Products For ADAM12
- OriGene qPCR primer pairs and template standards for ADAM12
- OriGene qPCR primer pairs for ADAM12
- OriGene CRISPR knockouts for ADAM12
- OriGene ORF clones in human for ADAM12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADAM12
- GenScript: Next-day shipping of latest version cDNA ORF clones for ADAM12 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ADAM12
- GenScript Custom Assay Services for ADAM12
- GenScript Custom overexpressing Cell Line Services for ADAM12
- GenScript: Design CRISPR guide RNA sequences for ADAM12
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ADAM12
- Sino Biological Human cDNA Clone for ADAM12
- Sino Biological Cell Lysates for ADAM12
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- Sino Biological Antibodies for ADAM12
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ADAM12
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- ProSpec Recombinant Proteins for ADAM12
- VectorBuilder custom plasmid, inducible vectors for ADAM12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM12
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 90 available ADAM12 Antibodies ranked by validation data
- Compare Top ADAM12 Antibodies
- antibodies-online: Search results for 33 available ADAM12 Elisa Kits ranked by validation data
- Compare Top ADAM12 Elisa Kits
- antibodies-online: Search results for 17 available ADAM12 Proteins ranked by validation data
- Compare Top ADAM12 Proteins
- GeneTex ADAM12 Antibody for ADAM12
- Search GeneTex for Proteins for ADAM12
- Santa Cruz Biotechnology (SCBT) Antibodies for ADAM12
- Search Santa Cruz Biotechnology (SCBT) for ADAM12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADAM12
- Search for ADAM12 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ADAM12
- Horizon Cell Lines for ADAM12
- genomics-online: cdna clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
- orf clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
- genomics-online: gRNA clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
- genomics-online: primer clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
- genomics-online: shRNA clones - Search results for 80 available ADAM12 gene related products
- Overview of 80 available ADAM12 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM12
- GeneCopoeia miRNA 3'UTR Target clone products for ADAM12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM12
Sources for ADAM12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio