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This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alte... See more...
Aliases for ADAM12 Gene
Aliases for ADAM12 Gene
External Ids for ADAM12 Gene
- HGNC: 190
- NCBI Entrez Gene: 8038
- Ensembl: ENSG00000148848
- OMIM®: 602714
- UniProtKB/Swiss-Prot: O43184
Previous GeneCards Identifiers for ADAM12 Gene
- GC10M126678
- GC10M126907
- GC10M127744
- GC10M127278
- GC10M127693
- GC10M121392
Summaries for ADAM12 Gene
-
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
GeneCards Summary for ADAM12 Gene
ADAM12 (ADAM Metallopeptidase Domain 12) is a Protein Coding gene. Diseases associated with ADAM12 include Lung Cancer and Ectopic Pregnancy. Among its related pathways are Development Angiotensin activation of ERK and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and metallopeptidase activity. An important paralog of this gene is ADAM19.
UniProtKB/Swiss-Prot Summary for ADAM12 Gene
-
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Additional gene information for ADAM12 Gene
- HGNC (190)
- NCBI Entrez Gene (8038)
- Ensembl (ENSG00000148848)
- OMIM® (602714)
- UniProtKB/Swiss-Prot (O43184)
- Open Targets Platform(ENSG00000148848)
- Monarch Initiative
- Alliance of Genome Resources
- Search for ADAM12 at DataMed
- Search for ADAM12 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAM12 Gene
Genomics for ADAM12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ADAM12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ADAM12 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAM12
- Top Transcription factor binding sites by QIAGEN in the ADAM12 gene promoter:
-
- C/EBPalpha
- MyoD
- Pbx1a
- POU2F1
- POU2F1a
Genomic Locations for ADAM12 Gene
Latest Assembly
- chr10:126,012,381-126,388,477
- (GRCh38/hg38)
- Size:
- 376,097 bases
- Orientation:
- Minus strand
Previous Assembly
- chr10:127,700,960-128,077,046
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 376,087 bases
- Orientation:
- Minus strand
- chr10:127,700,950-128,077,024
- (GRCh37/hg19 by Ensembl)
- Size:
- 376,075 bases
- Orientation:
- Minus strand
Genomic View for ADAM12 Gene
Genes around ADAM12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.2 by HGNC
- 10q26.2 by Entrez Gene
- 10q26.2 by Ensembl
ADAM12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAM12 Gene
Proteins for ADAM12 Gene
-
Protein details for ADAM12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43184-ADA12_HUMAN
- Recommended name:
- Disintegrin and metalloproteinase domain-containing protein 12
- Protein Accession:
- O43184
- O60470
- Q5JRP0
- Q5JRP1
- Q6P9E3
- Q6UWB0
Protein attributes for ADAM12 Gene
- Size:
- 909 amino acids
- Molecular mass:
- 99542 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A. Interacts with FST3. Interacts with RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.
Protein Expression for ADAM12 Gene
Selected DME Specific Peptides for ADAM12 Gene
- O43184:
-
- EEGEECDCG
- GEECDCG
- CCNATTC
Post-translational modifications for ADAM12 Gene
- The precursor is cleaved by a furin endopeptidase.
-
Glycosylation at Asn111, Asn149, Asn381, Asn452, and Asn651
- NX_O43184 (NX_O43184-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ADAM12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ADAM12 Antibody
- G Biosciences Immunotag™ ADAM12 Antibody
- Novus Biologicals Antibodies for ADAM12
-
Abcam antibodies for ADAM12
- Invitrogen Antibodies for ADAM12 (AFLGC-ADAM12)
-
Boster Bio Antibodies for ADAM12
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADAM12
- Sino Biological Antibodies for ADAM12
Protein products for research
-
OriGene Purified Proteins for ADAM12
- Search Origene for MassSpec and Protein Over-expression Lysates for ADAM12
- Origene Custom Protein Services for ADAM12
- Sino Biological Recombinant Proteins for ADAM12
- Sino Biological Cell Lysates for ADAM12
- ProSpec Recombinant Proteins for ADAM12
-
Abcam proteins for ADAM12
Domains & Families for ADAM12 Gene
Gene Families for ADAM12 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Protein Domains for ADAM12 Gene
- InterPro:
- Blocks:
-
- Disintegrin
- Metalloendopeptidase M12B
- ADAM, cysteine-rich
Suggested Antigen Peptide Sequences for ADAM12 Gene
- GenScript: Design optimal peptide antigens:
-
- Meltrin-alpha (ADA12_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O43184UniProtKB/Swiss-Prot:
ADA12_HUMAN :- The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
- Domain:
-
- The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
- The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Function for ADAM12 Gene
Molecular function for ADAM12 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
- GENATLAS Biochemistry:
- a disintegrin and metalloprotease (active) domain 12,membrane anchored cell surface protein,with two alternatively spliced isoforms L and S,expressed in term placenta,in adult skeletal,cardiac,smooth muscle,bone,required for myotube formation and in osteoblast differentiation,involved in tumor cell adhesion
Enzyme Numbers (IUBMB) for ADAM12 Gene
Phenotypes From GWAS Catalog for ADAM12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25825872 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | IEA,TAS | 9417060 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for ADAM12 Gene
- MGI mutant phenotypes for ADAM12:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADAM12:
Animal Models for ADAM12 Gene
- MGI Knock Outs for ADAM12:
-
- Adam12 Adam12<tm1Asf>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADAM12 - Starting at $85 >
- * ADAM12 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM12
miRNA for ADAM12 Gene
- miRTarBase miRNAs that target ADAM12
-
- hsa-miR-29b-3p (MIRT005667)
- mmu-miR-297a-5p (MIRT013018)
- hsa-miR-1-3p (MIRT023733)
- hsa-miR-218-5p (MIRT441266)
- hsa-miR-135b-5p (MIRT732742)
- hsa-miR-29a-3p (MIRT733083)
- hsa-miR-29c-3p (MIRT733084)
- hsa-miR-30b-3p (MIRT733085)
- hsa-miR-30d-3p (MIRT733086)
- hsa-miR-200b-3p (MIRT733087)
- hsa-miR-200c-3p (MIRT733088)
- hsa-miR-1185-5p (MIRT783114)
- hsa-miR-1224-5p (MIRT783139)
- hsa-miR-129-5p (MIRT783441)
- hsa-miR-1304-5p (MIRT783709)
- hsa-miR-33a-5p (MIRT784886)
- hsa-miR-33b-5p (MIRT784891)
- hsa-miR-3605-5p (MIRT784932)
- hsa-miR-3679-5p (MIRT785211)
- hsa-miR-3915 (MIRT785443)
- hsa-miR-4689 (MIRT786412)
- hsa-miR-586 (MIRT787939)
- hsa-miR-6858-5p (MIRT789102)
- hsa-miR-8055 (MIRT789646)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM12
- Browse OriGene Inhibitory RNA Products For ADAM12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM12
Clone products for research
- Applied Biological Materials (abm): Clones for ADAM12 - Starting at $45 >
- * ADAM12 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204810
- MG225285
- MR204810
- MR204810L3
- MR204810L4
- MR225285
- MR225285L1
- MR225285L2
- MR225285L3
- MR225285L4
- RC212501
- RC212501L1
- RC212501L2
- RC212501L3
- RC212501L4
- RC222280
- RC222280L3
- RC222280L4
- RC239446
- RC239451
- RC239761
- RG212501
- RG222280
- MR204810L3V
- MR204810L4V
- MR225285L1V
- MR225285L2V
- MR225285L3V
- MR225285L4V
- RC212501L1V
- RC212501L2V
- RC212501L3V
- RC212501L4V
- RC222280L3V
- RC222280L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADAM12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM12
Cell Lines for research
-
Horizon Cell Lines for ADAM12
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM12 Gene
Localization for ADAM12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAM12 Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
- [Isoform 3]: Secreted.
- [Isoform 4]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ADAM12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Development Dopamine D2 receptor transactivation of EGFR |
Development Alpha-2 adrenergic receptor activation of ERK
.66
|
Development Dopamine D2 receptor transactivation of EGFR
.66
|
| 2 | Actin Dynamics Signaling Pathway | ||
| 3 | Autophagy Pathway | ||
| 4 | Notch Signaling Pathway (sino) | ||
| 5 | Matrix Metalloproteinases |
Inhibition of Matrix Metalloproteinases
.69
|
|
Pathways by source for ADAM12 Gene
3 Sino Biological pathways for ADAM12 Gene
2 BioSystems pathways for ADAM12 Gene
2 Reactome pathways for ADAM12 Gene
3 GeneGo (Thomson Reuters) pathways for ADAM12 Gene
- Development Alpha-2 adrenergic receptor activation of ERK
- Development Angiotensin activation of ERK
- Development Dopamine D2 receptor transactivation of EGFR
1 Qiagen pathway for ADAM12 Gene
- Inhibition of Matrix Metalloproteinases
Interacting Proteins for ADAM12 Gene
Selected Interacting proteins:
O43184-ADA12_HUMAN
ENSP00000357668
for ADAM12 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ADAM12
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007520 | myoblast fusion | TAS | 7566181 |
| GO:0030198 | extracellular matrix organization | TAS | -- |
| GO:0045766 | positive regulation of angiogenesis | IMP | 28637396 |
Transcripts for ADAM12 Gene
mRNA/cDNA for ADAM12 Gene
- 5 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368676 3313 nts (view in UCSC)
- ENST00000368679 7938 nts (view in UCSC)
- ENST00000448723 1145 nts (view in UCSC)
- ENST00000467145 600 nts (view in UCSC)
- ENST00000482291 597 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ADAM12 - Starting at $85 >
- * ADAM12 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ADAM12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM12
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM12
- Browse OriGene Inhibitory RNA Products For ADAM12
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAM12
Clone products for research
- Applied Biological Materials (abm): Clones for ADAM12 - Starting at $45 >
- * ADAM12 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204810
- MG225285
- MR204810
- MR204810L3
- MR204810L4
- MR225285
- MR225285L1
- MR225285L2
- MR225285L3
- MR225285L4
- RC212501
- RC212501L1
- RC212501L2
- RC212501L3
- RC212501L4
- RC222280
- RC222280L3
- RC222280L4
- RC239446
- RC239451
- RC239761
- RG212501
- RG222280
- MR204810L3V
- MR204810L4V
- MR225285L1V
- MR225285L2V
- MR225285L3V
- MR225285L4V
- RC212501L1V
- RC212501L2V
- RC212501L3V
- RC212501L4V
- RC222280L3V
- RC222280L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADAM12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ADAM12
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for ADAM12 Gene
- GeneLoc Exon Structure for
- ADAM12
Expression for ADAM12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Limb (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Forelimb Dorsal Muscles
- Mononuclear Myocytes Hindlimb Dorsal Muscle
- Mononuclear Myocytes Forelimb Ventral Muscles
- Mesenchymal Condensate Cells Stylopod
- Bone (Muscoskeletal System)
- Gut Tube (Gastrointestinal Tract)
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
- Brain (Nervous System)
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Intermediate Mesoderm (Gastrulation Derivatives)
- Lung (Respiratory System)
- Kidney (Urinary System)
- Dermis (Integumentary System)
- Fibroblasts
- Oligodendrocytes (Nervous System)
- Spinal Cord (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ADAM12 Gene
This gene is overexpressed in Ovary (x4.1).
This gene is overexpressed in Placenta (47.9) and Heart (17.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAM12 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAM12
SOURCE GeneReport for Unigene cluster for ADAM12 Gene:
Hs.594351mRNA Expression by UniProt/SwissProt for ADAM12 Gene:
O43184-ADA12_HUMAN
Tissue specificity:
Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
Evidence on tissue expression from TISSUES for ADAM12 Gene
- Nervous system(3)
Primer products for research
-
OriGene qPCR primer pairs for ADAM12
-
OriGene qPCR primer pairs and template standards for ADAM12
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM12 Gene
Orthologs for ADAM12 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADAM12 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ADAM12 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ADAM12 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Adam12 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Adam12 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ADAM12 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ADAM12 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ADAM12 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | adam12 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | adam12 29 30 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP013468 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | mmd 31 |
|
|
|
| Worm (Caenorhabditis elegans) |
Secernentea | adm-2 29 |
|
||
| adm-1 31 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for ADAM12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ADAM12 Gene
- ENSEMBL:
- Gene Tree for ADAM12 (if available)
- TreeFam:
- Gene Tree for ADAM12 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ADAM12: view image
- Alliance of Genome Resources:
- Additional Orthologs for ADAM12
Paralogs for ADAM12 Gene
Paralogs for ADAM12 Gene
(17) SIMAP similar genes for ADAM12 Gene using alignment to 3 proteins:
- ADA12_HUMAN
- Q5JRP2_HUMAN
- U5NE98_HUMAN
Variants for ADAM12 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAM12 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112264074 | Benign: not provided | 126,118,141(-) |
T/C NM_001288973.2(ADAM12):c.500A>G (p.Lys167Arg) |
MISSENSE | |
| rs11244826 | Benign: not provided | 126,135,643(-) |
A/G NM_001288973.2(ADAM12):c.357T>C (p.His119=) |
SYNONYMOUS | |
| rs114788194 | Benign: not provided | 126,038,277(-) |
G/A NM_001288973.2(ADAM12):c.2313C>T (p.Gly771=) |
SYNONYMOUS | |
| rs115100580 | Benign: not provided | 126,046,075(-) |
T/C NM_001288973.2(ADAM12):c.1975A>G (p.Met659Val) |
MISSENSE | |
| rs116311901 | Benign: not provided | 126,039,436(-) |
C/G NM_001288973.2(ADAM12):c.2105-7G>C |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.38;
54.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADAM12 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM12 Gene
Disorders for ADAM12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
|
| ectopic pregnancy |
|
|
| benign giant cell tumor |
|
|
| pre-eclampsia |
|
|
| down syndrome |
|
|
Search ADAM12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ADAM12
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM12 Gene
Publications for ADAM12 Gene
- A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. (PMID: 9417060) Gilpin BJ … Wewer UM (The Journal of biological chemistry 1998) 2 3 4 22
- A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease. (PMID: 19837132) Laumet G … Lambert JC (Neuroscience letters 2010) 3 22 40
- Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. (PMID: 19268722) Kerna I … Tamm AO (Osteoarthritis and cartilage 2009) 3 22 40
- RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. (PMID: 18621736) Bourd-Boittin K … Théret N (The Journal of biological chemistry 2008) 3 4 22
- Cellular roles of ADAM12 in health and disease. (PMID: 18342566) Kveiborg M … Wewer UM (The international journal of biochemistry & cell biology 2008) 2 3 22
ExternalLinks
Products for ADAM12 Gene
- View all 7 R&D Systems ADAM12 (ADAM12) Products
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- antibodies-online: Show 19 available ADAM12 Antibodies ranked by validation data
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Sources for ADAM12 Gene
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